2024-03-29T13:17:05Z
https://ejournal.undip.ac.id/index.php/ijse/oai
oai:ojs.ejournal.undip.ac.id:article/9539
2016-02-06T11:14:37Z
ijse:MED
nmb a2200000Iu 4500
"151015 2015 eng "
2302-5743
2086-5023
dc
The Efficacy of Dutasteride and Green Tea Combination Towards Angiogenesis and Bleeding on BPH after TURP : Study their effect on VEGF, MVD and Hb
Nugroho, Eriawan Agung
Muslim, Rifki
Riwanto, Ignatius
Pranoto, Soetojo Wirjo
Array
ABSTRACT
Objectives: to find the efficacy dutasteride and green tea in reducing hemorrhage on TURP patients and to evaluate the anti- angiogenesis effect.
Methods: Double Blind Randomized Controlled Trial Post Test Only, with 80 samples, randomized into 4 groups: 1 control group and 3 treatment groups (P1 with 0.5 mg of dutasteride, P2 with a capsul of green tea, and P3 with combination of 0.5 mg dutasteride and a capsul green tea at least 14 days before TURP. We compared the ΔHb define the VEGF expression and MVD count to evaluate the angiogenesis changes between 4 groups. The difference is considered statistically significant with p<.05.
Results: ΔHb (-0.40 + 0.246) pg/ml for control group, (-0.20 + 0.067) pg/ml for P1 group, (-0.18 + 0.081) pg/ml for P2 group, and (-0.14 + 0.092) pg/ml for P3 group. VEGF expression were (20.20 + 17.386), (12.90 + 15.509), (11.60 + 9.121), and (3.60 + 1.667) for control, P1, P2, and P3 group respectively. MVD count were (41.20 + 10.273), (32.75 + 9.318), (26.15 + 7.278), and (18.35 + 7.876) for control, P1, P2, and P3 group respectively. The result from between-subject effect tests showed statistically significant differences in ΔHb (p<0.001), VEGF expression (p<0.001), and MVD count (p<0.001). Dutasteride and green tea significantly reduce the hemorrhage during TURP by decreasing the MVD.
Conclusion: Administration of 0.5 mg dutasteride and 725 mg of green tea, 14 days prior to TURP significantly reduce the hemorrhage during TURP (Δ Hb) by decreasing the MVD
Chemical Engineering Diponegoro University
2015-12-08 08:47:59
application/pdf
https://ejournal.undip.ac.id/index.php/ijse/article/view/9539
International Journal of Science and Engineering; Vol 9, No 2 (2015)
eng
https://ejournal.undip.ac.id/index.php/ijse/article/download/9539/21377
https://ejournal.undip.ac.id/index.php/ijse/article/download/9539/21378
https://ejournal.undip.ac.id/index.php/ijse/article/download/9539/21379
https://ejournal.undip.ac.id/index.php/ijse/article/download/9539/21380
https://ejournal.undip.ac.id/index.php/ijse/article/download/9539/21381
https://ejournal.undip.ac.id/index.php/ijse/article/download/9539/21382
Copyright (c)
oai:ojs.ejournal.undip.ac.id:article/8992
2016-02-06T11:14:37Z
ijse:MED
nmb a2200000Iu 4500
"151015 2015 eng "
2302-5743
2086-5023
dc
Gas Chromatographic Method: Tool for Rapid and Sensitive Analysis of Residual Solvents in Amoxicillin and Ampicillin Tablets
Haque, Sk Manirul
Department of Chemical Engineering and Process Technology, Jubail Industrial College, Royal Commission of Jubail
Hossain, S M Zakir
University of Bahrain
Shanker, Prem
Departments of Quality Control, Blue Circle Organics Pvt Ltd, Ambernath, Maharashtra
Array
A simple and sensitive static head space gas chromatographic (SH-GC) method equipped with FID has been developed and validated for simultaneous determination of residual solvents e.g., methanol, dichloromethane and toluene in two therapeutic drugs such as amoxicillin and ampicillin. The separation was achieved with 30 m long Elite - 5 fused silica capillary column and 0.32 mm inner diameter. The developed SH-GC method offered symmetric peak shape, good resolution and reasonable retention time for all the solvents. Beer’s law was obeyed in the concentration ranges 100 – 1200, 50 – 1000 and 50 – 500 ppm for methanol, dichloromethane and toluene, respectively. The method was validated according to international conference on harmonization (ICH) guidelines in terms of specificity, linearity, precision, accuracy, limit of detection, limit of quantitation, robustness and solution stability. The degrees of linearity of the calibration curves, the percent recoveries, relative standard deviation for the method were also determined. All the validation parameters were within the acceptable range. The developed SH-GC method could, therefore, be suitable for simple and rapid detection of trace levels residual solvents in other pharmaceutical products and thereby it could be used for routine analysis in any analytical laboratory.
Chemical Engineering Diponegoro University
2015-12-08 08:47:59
application/pdf
https://ejournal.undip.ac.id/index.php/ijse/article/view/8992
International Journal of Science and Engineering; Vol 9, No 2 (2015)
eng
https://ejournal.undip.ac.id/index.php/ijse/article/download/8992/20150
Copyright (c)
oai:ojs.ejournal.undip.ac.id:article/9227
2016-02-06T11:14:37Z
ijse:MED
nmb a2200000Iu 4500
"151015 2015 eng "
2302-5743
2086-5023
dc
IDENTIFICATION OF Staphylococcus sp. STRAINS ISOLATED FROM POSITIVE WIDAL BLOOD BASED ON 16S rRNA GENE SEQUENCES
Darmawati, Sri
Muhammadiyah Semarang University
Array
The purpose of this study is to identify 8 strains of Staphylococcus genus members isolated from positive Widal blood (4 strains of Staphylococcus saprophyticus, 1 strain of Staphylococcus warneri, 2 strains of Staphylococcus hominis, 1 strain of Staphylococcus xylosus and 1 strain of Staphylococcus capitis) based on 16S rRNA gene sequences. The methods used in this study are conducting PCR of 16S rRNA gene, cloning genes using T-Vector pMD20 which is transformed to E. coli DH5α, sequencing. The results show that four strains (BA 47.4, BA 19.2, KD 29.5 and TG 09.1) are identified as Stap. Saprophyticus strains of Stap. saprophyticus members of ATCC 15305T (99.01-100% similarity). The strain of TG 01.3 is identified as Stap. Warneri strain of TG 01.3 of Stap. Warneri members of ATCC 27836T (99.74-99.93% similarity), 2strains (KT 29.2 and KD 35.1) are identified as of Stap. hominis members of DSM 20328T (99.4-99.67% similarity). The strain of KT 30.5 is not identified
Chemical Engineering Diponegoro University
2015-12-08 08:47:59
application/pdf
https://ejournal.undip.ac.id/index.php/ijse/article/view/9227
International Journal of Science and Engineering; Vol 9, No 2 (2015)
eng
Copyright (c)