2024-03-29T11:11:00Z
https://ejournal.undip.ac.id/index.php/index/oai
oai:ojs.ejournal.undip.ac.id:article/3824
2012-07-19T12:09:13Z
mmi:ART
Perubahan Kadar Hormon Tiroid pada Penderita Sindroma Nefrotik
Asripurwanti, Asripurwanti
Samad,, Samad
Koesnadi, Lydia
Rochmanaji, W.
Susanto, Rudy
Thyroid hormone, TSH, T4, Nephrotic Syndrome
Thyroid hormones levels in nephrotic syndromeBackground: Nephrotic syndrome is one of the most found kidney disease. A great part (>99%) of circulating thyroid hormones were bound to proteins, thus derangements of blood proteins in nephrotic syndrome are potential to disturb thyroid hormones levels. This study was aimed to compare thyroid hormones levels changes in childhood Nephrotic Syndrome before and after remission.Method: Thirty four nephrotic syndrome patients studied on Department of pediatric of Dr. Kariadi Hospital, Semarang between April 1995 to June 1996 were for albumin, cholesterol, thyroid and thyroid stimulating hormone levels before and after remission and were tested with Wilcoxon signed rank test. The correlation between albumin and thyroxin levels before and after remission. were analyzed with Spearman correlation test.Results: T4 level before remission was 26.89±16.12 nmol/L, TSH 9.36±5.51 IU/ml, and after remission T4 106.63±28.02 nmol/L,TSH 1.78±1.91 μIU/mL. There were significant changes of thyroid hormones levels before and after remission (z=5.09; p=0.000). There were positive correlation between blood protein (albumin) level and thyroid hormone (T4) level in nephrotic syndrome before remission (r=0.51; p=0.000) and after remission (r=0.38; p=0.004). A great proportion of nephrotic syndrome patients, suffered from hypothyroidism and return to euthyroid after remission.Conclusions: Thyroid hormone levels changed during the course of nephrotic syndrome.Keyword : Thyroid hormone, TSH, T4, Nephrotic SyndromeABSTRAKLatar belakang : Sindroma nefrotik merupakan salah satu penyakit ginjal yang terbanyak ditemukan. Hormon tiroid beredar dalam darah berikatan dengan protein, sehingga pada gangguan kadar protein yang berat seperti pada sindroma nefrotik berpotensi mengganggu hormon tiroid. Penelitian ini bertujuan untuk mempelajari perubahan kadar hormon tiroid pada penderita sindroma nefrotik anak sebelum dan sesudah remisi.Metoda : Tiga puluh empat penderita sindroma nefrotik yang dirawat di Bagian Ilmu Kesehatan Anak RSUP Dr. Kariadi Semarang antara bulan April 1995 sampai Juni 1996 diperiksa perbedaan kadar albumin, kolesterol, tiroksin dan TSH sebelum dan sesudah remisi dan diuji dengan uji Wilcoxon signed rank test. Hubungan kadar albumin dan tiroksin pada sindroma nefrotik sebelum dan sesudah remisi di uji dengan uji korelasi Spearman.Hasil : Pada 34 penderita sindroma nefrotik sebelum remisi didapatkan rerata T4 26,89±16,12 nmol/L, TSH 9,36±5,51 IU/ml dan sesudah remisi didapatkan rerata T4 106,63±28,02 nmol/L, TSH rerata 1,78±1,91 μIU/mL. Ada perbedaan bermakna kadar hormon tiroid (T4) dan TSH sebelum dan sesudah remisi (z=5,09; p=0,000). Ada hubungan positif antara kadar albumin darah dengan kadar hormon tiroid darah T4 pada Sindroma nefrotik sebelum remisi (r=0,51; p=0,000) dan setelah remisi (r=0,38; p=0,004). Pada penderita sindroma nefrotik sebagian besar mengalami hipotiroidisme dan kembali euthiroid setelah remisi.Simpulan : Ada perubahan kadar hormon tiroid pada penderita Sindroma Nefrotik sebelum dan sesudah remisi.
MEDIA MEDIKA INDONESIANA
2012-07-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3824
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 2 Year 2008; 95-102
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3824/3508
oai:ojs.ejournal.undip.ac.id:article/4216
2012-12-05T12:05:52Z
mmi:ART
Kadar Testosteron dan Apoptosis pada Sel Penis dan Prostat dengan Pemberian Buceng
Taufiqurrachman, Taufiqurrachman
Buceng, apoptosis, vitality
Increase in testosterone levels and decrease in number of apoptosis in penis and prostate cells by buceng treatmentBackground: Apoptosis is an important biological mechanism in aging process, vitality, and declining of physiological function. Buceng has been traditionally used to delay aging and enhance male vitality. Administration of buceng to enhance Te concentration and decrease apoptosis in penis and prostate cells has not been elucidated. This study is to elucidate the effect of buceng on increase Te concentration and declining of apoptosis in penis and prostate cells of male Sprague Dawley rats.Method: Post test only control group design, 60 male of 90 days old Sprague Dawley rats and ± 300 gram body weight, has been assigned multistage randomly into four group. Group A, the castrated rats, treated with 50 mg buceng. Group B, the rats were not castrated, immediately sacrificed as a positive control. Group C, the castrated rats, got 2 mL of water, as a negative control. Group D, the castrated rats, treated with 6.75 mg mesterolon diluted in water. Manova statistical model was adopted to analyze the difference consentration of Te and apoptosis among groups. Analysis was perfomed by SPSS 13 with 95% confident interval.Result: Manova analysis by Wilk Lambda procedure in four groups indicated that Te concentration, apoptosis in penis and prostate cells among groups were significantly different (p=0.000).Conclusion: This study concludes that the administration of 50 mg buceng for 30 consecutive days could enhance Te concentration and decrease apoptosis in penis and prostate cells.Keywords: Buceng, apoptosis, vitality ABSTRAKLatar belakang: Apoptosis adalah mekanisme biologi penting dalam proses penuaan, penurunan vitalitas, dan penurunan fungsi fisiologis organ. Buceng telah dipakai secara tradisional untuk menghambat penuaan dan meningkatkan vitalitas pria. Efek buceng terhadap peningkatan kadar testosteron (Te) dan penurunan apoptosis sampai sekarang masih belum dibuktikan. Tujuan dari penelitian ini adalah untuk mengungkap efek buceng terhadap peningkatan kadar Te dan penurunan apoptosis sel penis dan prostatpada tikus jantan Sprague Dawley.Metode: Post test only control group design dengan sampel 60 tikus jantan galur Sprague Dawley umur 90 hari dengan berat badan (BB) ±300 gram, dibagi menjadi 4 kelompok secara multistage random masing-masing terdiri dari 15 ekor (ditentukan menurut formula Federer). Kelompok A, tikus dikastrasi, diberi buceng aa 50 mg. Kelompok B, tikus tanpa dikastrasi, langsung dimatikan, sebagai kontrol positif. Kelompok C, tikus dikastrasi, diberi akuades 2 mL, sebagai kontrol negatif. Kelompok D, tikus dikastrasi,diberi mesterolon 6,75 mg yang dilarutkan dalam air. Analisis statistik untuk menguji perbedaan kadar Te dan apoptosis adalah uji Manova. Semua analisis dilakukan dengan metode SPSS 13, dengan tingkat kepercayaan 95%.Hasil: Analisis Manova dengan prosedur Wilk lambda, pada empat kelompok menunjukkan bahwa kadar Te, apoptosis pada sel penis dan prostat di antara kelompok berbeda bermakna (p=0,000).Simpulan: Penelitian ini menyimpulkan bahwa pemberian buceng 50 mg selama 30 hari berturut-turut dapat meningkatkan kadarTe dan penurunan apoptosis pada sel penis dan prostat.
MEDIA MEDIKA INDONESIANA
2012-11-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4216
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012; 50-57
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4216/3842
oai:ojs.ejournal.undip.ac.id:article/4279
2012-12-15T12:07:49Z
mmi:ART
Kadar TNF-, IL-6 dan Trofoblas pada Preeklampsia-Eklampsia
Susian, Indrato Adi
Suharsono, Suharsono
Hadijono, S
TNF-α, IL-6, infarct, apoptosis, placenta, preeclampsia, eclampsia.
The level of TNF-, IL-6 and trophoblast in preeclampsia-eclampsiaBackground: Pre eclampsia–eclampsia (PE-E) is the highest cause of maternal death. Up to the present time, PE-E is still the disease of theories, where the patofisiology is still unclear. Invitro research reported that increase of TNF–α and IL–6 in PE-E will cause the placenta hypoxia. This condition will trigger the secretion of pro inflammatory cytokine from fetoplacenta which will cause the rejection in trophoblast invasion. The purpose of this study was to analyze the association between the TNF–α and IL–6 rate/expression with infarct and placental tissue apoptosis.Methods: The study was done during the period of July 2005–October 2005. The subjects were 17 parturient non PE-E and 18 parturient PE-E who delivered at Dr. Kariadi Hospital Semarang. The TNF–α and IL–6 rate/expression were measured from the blood sample and placental tissue with ELISA method and imunohystochemical by acidine orange painting. The difference of TNF–α and IL–6 rate/expression with the size of infarct and apoptosis were tested by Mann-Whitney test and the correlation with Spearman test.Results: The mean size of infarct in normal subjects was 12.5% compared to PE-E which was 35.3% (p=0.001). The percentage of apoptosis in normal and PE-E subjects were 32.3% and 71.0% respectively (p=0.001). The mean rate of TNF–α of placenta and blood serum in normal and PE-E subjects were 1.7 pg/mL, 2.0 pg/mL, 2.3 pg/mL and 2.8 pg/mL respectively (P1 and P2 <0.001). The mean placenta and blood serum IL-6 in normal and PE-E subjects were 0.6 pg/mL, 1.3 pg/mL, 1.4 pg/mL, and 2.0 pg/mLrespectively showing significant difference between the two groups. There were strong associations between placenta and serum TNF–α and IL–6 with the size of infarct and percentage of placenta apoptosis.Conclusions: The level of pro inflammatory cytokine in serum as well as in placenta of subjects with PE-E is higher than those without PE-E and there is strong correlation between pro inflammatory cytokine expression in serum and placenta with the size of infarct and placental apoptosis.Keywords: TNF-α, IL-6, infarct, apoptosis, placenta, preeclampsia, eclampsia.ABSTRAKLatar Belakang: Preeklampsia-Eklampsia (PE-E) merupakan penyebab kematian maternal paling tinggi. Sampai saat ini PE-E masih merupakan the disease of theories, dengan patofisiologi yang masih belum diketahui dengan jelas. Pada penelitian invitro dilaporkan peningkatan kadar TNF-α dan IL-6 dapat menimbulkan hipoksia plasenta. Hal tersebut dapat memicu sekresi sitokin proinflamasi dari fetoplasenta yang akan menyebabkan penolakan invasi trofoblas. Tujuan penelitian ini adalah untuk mengetahui hubungan antara kadar/ekspresi TNF-α dan IL-6 dengan infark dan apoptosis jaringan plasenta.Metode: Penelitian dilaksanakan pada periode Juli 2005–Oktober 2005. Subjek penelitian adalah 17 parturient non PE-E dan 18 parturient PE-E yang melahirkan di RSUP Dr. Kariadi Semarang. Kadar/ekspresi TNF-α dan IL-6 diukur dari sampel darah vena dan jaringan plasenta dengan metode ELISA dan imunohistokimia (Quantikine, USA). Luas infark plasenta diukur secara makroskopik, apoptosis diukur secara imunohistokimia dengan pengecatan acridine orange. Perbedaan kadar/ekspresi TNF-α, IL-6, luas infark dan persentase apoptosis antara subjek normal dengan PE-E diuji dengan uji Mann-Whitney. Korelasi antara TNF-α dan IL-6 dengan luas infark dan apoptosis diuji dengan uji korelasi Spearman.Hasil: Rerata luas infark subjek normal adalah 12.5%, sedangkan pada PE-E adalah 35.3% (p=0.001). Persentase apoptosis subjek non PE-E dan PE-E adalah 32.3%, dan 71.0% (p=0.001). Rerata kadar TNF-α plasenta subjek non PE-E dan PE-E adalah 1.7 pg/mL, dan 2.0 pg/mL (p<0.001). Rerata kadar TNF-α serum subjek non PE-E dan PE-E adalah 2.3 pg/mL, dan 2.8 pg/mL (p<0.001). Rerata kadar IL-6 plasenta subjek normal adalah 0.6 pg/mL, pada PE-E adalah 1.3 pg/mL (p<0.001). Rerata kadar IL-6 serum subjek non PE-E dan PE-E adalah 1.4 pg/mL, dan 2.0 pg/mL (p<0.001). Dijumpai korelasi kuat antara TNF-α, IL-6 serum dan plasenta dengan luas infark dan persentase apoptosis plasenta (p<0.001).Simpulan: Kadar sitokin proinflamasi pada serum maupun plasenta parturient PE-E lebih tinggi dibanding non PE-E. Ada hubungan antara kadar/ekspresi sitokin proinflamasi pada serum dan plasenta dengan luas infark dan apoptosis jaringan plasenta
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4279
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009; 166-174
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4279/3899
oai:ojs.ejournal.undip.ac.id:article/4305
2013-01-03T10:53:40Z
mmi:ART
Antioksidan Vitamin dan Kerusakan Otot pada Aktivitas Fisik Studi Eksperimen pada Mahasiswa JPOK-FKIP UNS Surakarta
Kiyatno, Kiyatno
Exercise, vitamin antioxidants, muscle damage
Vitamin antioxidants administration toward muscle damage on exercise. An experimental study in students of FKIP–JPOK Sebelas Maret UniversityBackground: Exercise has dual effects, which not only enhance health status and performance but also results in muscular damage. The aim of this study is to determine when the administration of vitamin antioxidants is more effective in reducing the muscular damage.Methods: An experimental quantitative study with a 2x2 factorial research design was used in this study. Forty of total students in third semester of JPOK-FKIP Sebelas Maret University were randomly selected to become the experimental subjects and divided equally into four groups. First and second groups performed exercise with strenuous sub maximal intensity (SSI, running 2x800 m) and took the vitamin antioxidants (30 mg vitamin A, 200 mg vitamin C, 50 mg vitamin E, 15 mg Zn and 25 mcg Se) before runningfor first group and after running for second group respectively. Prior to perform prolonged sub maximal intensity (PSI, running 1500 m) third group took the same antioxidants while fourth group took the antioxidant after doing PSI. 48 hours later, MDA plasma levels were determined by using TBARS in order to measure the muscular damage. T-test was use for analyzing all collected data.Results: There is different effect on muscle damage when vitamin antioxidants were taken before and after exercise (obs.T 3.70> tb.T 1.68), which vitamin antioxidants were taken after exercise has a better muscle damage (MDA 200.60><222.38).Conclusions: The administration of vitamin antioxidants after exercise has a better muscle damage.Keywords: Exercise, vitamin antioxidants, muscle damageABSTRAK Latar belakang: Aktivitas fisik selain membuat tubuh menjadi lebih sehat dan lebih bugar, juga dapat menimbulkan kerusakan otot. Tujuan penelitian untuk mengetahui waktu pemberian antioksidan vitamin yang paling efektif untuk mengurangi kerusakan otot.Metode: Jenis penelitian adalah kuantitatif–eksperimental menggunakan rancangan penelitian faktorial 2x2. Subyek penelitian diambil secara acak sederhana (n=40) mahasiswa JPOK-FKIP UNS semester III, dibagi menjadi 4 kelompok: (1) minum antioksidan vitamin lalu lari 2x800 m (2) lari 2x800 m lalu 20 jam kemudian minum antioksidan vitamin (3) minum antioksidan vitamin lalu lari 1500 m (4) lari 1500 m lalu 20 jam kemudian minum antioksidan vitamin. Kerusakan otot diukur berdasarkankadar MDA plasma dengan metode TBARS 48 jam setelah perlakuan. Antioksidan vitamin terdiri vitamin C 200 mg, vitamin E 50 mg, vitamin A 30 mg, Zn 15 mg, Se 25 mcg. Analisis data menggunakan t-test dengan tingkat kepercayaan 95%, dengan komputer minitab for Window release 13.Hasil: Terjadi perbedaan pengaruh yang bermakna terhadap kerusakan otot antara pemberian antioksidan vitamin sebelum dengan sesudah aktivitas fisik (thit 3,70>ttab 1,68). Pemberian antioksidan vitamin sesudah aktivitas fisik kerusakan otot lebih kecil dibanding sebelum aktivitas fisik. (MDA 200,60><222,38).Simpulan: Pemberian antioksidan vitamin sesudah aktivitas fisik kerusakan otot lebih kecil dibanding sebelum aktivitas fisik.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4305
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 6 YEAR 2009; 277-281
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4305/3926
oai:ojs.ejournal.undip.ac.id:article/11373
2016-07-01T13:19:31Z
mmi:ART
Tempe Koro Benguk (Mucuna pruriens L) dan Pengendalian Glikemi: Studi pada tikus Sprague Dawley yang Diinduksi Streptozotocin
Retnaningsih, Ch.
Darmono, Darmono
Widianarko, Budi
Muis, Fatimah
ABSTRACTVelvet bean tempe and glycemic control in streptozotocin induced Sprague Dawley ratsBackground: Modern treatment combined with functional food rich in antioxidants show the considered to control glycemic status. Such functional food is velvet bean tempe (VBT) rich in flavonoids. The study aimed to analyze the effect of the velvet bean tempe on glycemic control i.e. the blood glucose levelMethods: A randomized controlled group pre test-post test design using 50 male Sprague Dawley (SD) rats aged 2-3 months was carried out for 30 days. The rats were randomly allocated into 5 groups: negative control (C-), positive control (C+), streptozotocin (STZ)+10%VBT, STZ+20% VBT, STZ+30% VBT. Data were analyzed with paired T test, one-way Anova and continued with Duncan’s multiple range test. Analysis of blood glucose levels used with super glucocard II test meter, and for C peptide levels ELISA was used.Result: Supplementation of VBT 20% and VBT10% reduced the level of blood glucose until 46.1% and improve the level of C peptide until 44,3±8,3 pg/ml respectively.Conclusion: Velvet bean tempe has the potency as functional food to help controlling glycemic status.Keywords: Velvet bean tempe, glycemic control, streptozococinABSTRAKLatar belakang: Pengobatan modern dikombinasikan dengan pangan fungsional yang kaya antioksidan dapat menjadi pertimbangan untuk memperbaiki status glikemi. Jenis bahan pangan tersebut adalah tempe koro, memiliki banyak senyawa antioksidan flavonoid. Penelitian ini bertujuan untuk membuktikan pengaruh tempe koro benguk terhadap pengendalian status glikemi pada tikus Sprague Dawley yang diinduksi streptozotocin.Metode: Penelitian randomized pre test-post test control group design, dilakukan menggunakan 50 ekor tikus jantan jenis Sprague Dawley umur 2-3 bulan selama 30 hari yang dibagi kelompok kontrol negatif/C-; positif/ C+; STZ+ tempe koro benguk 10%; STZ+tempe koro benguk 20%; STZ+tempe koro benguk 30%. Dilakukan pemeriksaan glukosa darah menggunakan super glucocard II test meter dan C peptida menggunakan ELISA.Hasil: Asupan tempe koro benguk dalam berbagai dosis menurunkan kadar glukosa hingga 46, 1% dan penurunan terbesar pada tikus yang diberi tempe koro benguk 20%. Selain itu tempe koro benguk dapat meningkatkan kadar C peptida hingga 44,3±8,3 pg/ml, peningkatan terbesar pada tikus yang diberi tempe koro benguk 10%.Simpulan: Tempe koro benguk dapat dipertimbangkan sebagai pangan fungsional dalam mengendalikan glikemi pada tikus hiperglikemi.
MEDIA MEDIKA INDONESIANA
2016-07-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/11373
MEDIA MEDIKA INDONESIANA; 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013; 30-36
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/11373/8859
oai:ojs.ejournal.undip.ac.id:article/21896
2019-01-29T11:26:43Z
mmi:ART
Kekuatan Genggam pada Lansia Wanita Aktif dan Tidak Aktif Berolahraga
S, Gheby Soraya
Murbawani, Etisa Adi
Handgrip strength; exercise activity; elderly woman
Handgrip strength in active and inactive elderly womanBackgrounds: Exercise is one of the factors determining handgrip strength. Lower handgrip strength is an indicator for lower Body Mass Index (BMI). The aim of this study is to compared differences in handgrip strength between active and inactive elderly woman. Methods: This was a cross-sectional study of 26 elderly active woman (spent ≥30 minutes for five times or more a week for exercise) and 26 elderly inactive woman (spent <30 minutes and less than five times a week for exercise). Subject were chosen through purposive sampling. Handgrip strength was measured with handgrip dynamometer. Questionnaire was used for measuring exercise activity. BMI value were obtained from body weight was measurement with digital scale and height measurement with microtoise. Data on energy and protein intake were obtained from food frequency semi quantitative questionnaire (FFSQ). Data analysed were using Kolmogorov-Smirnov, independent t-test, and anacova. Result: Most of active elderly woman (69.2%) had handgrip strength in sufficient category. There were significant differences of handgrip strength between the active and inactive elderly woman (p=0.001) and after being controlled by BMI, energy and protein intake per day (p=0.005). Conclusion: Routine exercise should be recommended to elderly for better handgrip strength.. ABSTRAKLatar belakang: Lansia wanita mempunyai kekuatan genggam yang lebih rendah daripada pria. Kebiasaan olahraga merupakan salah satu faktor yang berpengaruh terhadap kekuatan genggam. Nilai kekuatan genggam merupakan indikator nilai Indeks Massa Tubuh (IMT). Tujuan dari penelitian ini adalah membandingkan kekuatan genggam pada lansia wanita yang aktif dan tidak aktif berolahraga. Metode: Studi cross-sectional pada 26 lansia wanita yang aktif (menghabiskan waktu ≥30 menit dan 5 kali atau lebih dalam seminggu untuk berolahraga) dan 26 lansia wanita yang tidak aktif (menghabiskan waktu <30 menit dan kurang dari 5 kali dalam seminggu untuk berolahraga). Sampel diperoleh dengan cara purposive sampling. Kekuatan genggam diukur menggunakan Handgrip Dynamometer. Kuesioner digunakan untuk mengetahui kebiasaan olahraga. IMT diperoleh dari data berat badan yang diukur dengan timbangan digital dan tinggi badan yang diukur dengan mikrotoa, sedangkan data asupan energi dan protein diperoleh dari Food Frequency Semi Quantitative Questionnaire (FFSQ). Analisis data dengan Kolmogorov-smirnov, Independent t-test dan Anacova. Hasil: Nilai kekuatan genggam sebagian besar lansia wanita yang aktif berolahraga (69,2%) dalam kategori cukup sedangkan sebagian lansia wanita yang tidak aktif berolahraga (53,8%) dalam kategori sangat kurang. Terdapat perbedaan kekuatan genggam sangat bermakna antara lansia wanita yang aktif dan tidak aktif berolahraga (p=0,001) dan setelah dikontrol dengan IMT, asupan energi dan protein (p=0,005).Simpulan: Latihan teratur perlu dilakukan para lansia agar memiliki kekuatan genggam yang baik.
MEDIA MEDIKA INDONESIANA
2010-08-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21896
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 2 YEAR 2010; 62-69
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21896/14630
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3017
2012-04-05T11:15:54Z
mmi:ART
Penggunaan Batang Tanaman Betadin (Jatropha mulitifida Linn) untuk Meningkatkan Jumlah Trombosit pada Mus musculus
Sundaryono, Agus
atropha multifida Linn, trombocyt, flavonoids, Mus musculus
ABSTRACTThe use of plant stem betadin (Jatropha mulitifida Linn) to increase the number of thrombocyt in Mus musculusBackground: Jatropha multifida Linn has been used by the people of Bengkulu as an ornamental plant, some of people use as medicinal for a new wound. That is why known as betadin plants. Jatropha multifida Linn contain flavonoids compound. The aims of this study is to isolate the total flavonoids compound from stems of Jatropha multifida Linn, and then it was used to increase the number of thrombocyt.Methods: Stem Jatropha multifida Linn was isolated by EtOH (96%), the filtrate was evaporated using a rotary evaporator. Fifteen of healthy Mus musculus with 20-50 g, were grouped into 4; group 1 (P0) was treated by aquadest, group 2 (P1) was treated with 0.2 mL of palm oil, group 3 (P2) was treated with a dose of guava extract (0.028 g/kgBW), group 4 (P3) and (P4) were given total flavonoids of Jatropha multifida Linn stems in which each was given with a dose of 0.028g/kgBW and 0,056g/kgBW. After 24 hours of treatment, the thrombocyt changes owere counted under a microscope.Results: The rendement of flavonoids compound in the stem of Jatropha multifida Linn which can be isolated by EtOH is 4%. The flavonoids compound from Jatropha multifida Linn stems at a doses of 0.028 g/kgBW could increased the number of thrombocyt to 543.000/mm3 and at a 0.56 g/kgBW to 813.000/mm3.Conclusion: The flavonoids compoud from Jatropha multifida Linn stems at a doses of 0.028 g/kgBW and doses of 0.56 g/kgBWcould increased the number of thrombocyt at Mus musculus.Keywords: Jatropha multifida Linn, trombocyt, flavonoids, Mus musculusABSTRAKLatar belakang: Jatropha multifida Linn oleh masyarakat Bengkulu digunakan sebagai tanaman hias, sebagian masyarakat ada yang menggunakan sebagai tanaman untuk obat luka baru. Itulah sebabnya maka dikenal dengan tanaman betadin. Batang tanaman Jatropha multifida Linn mengandung senyawa flavonoid. Penelitian ini bertujuan untuk mengisolasi senyawa flavonoid total dari batang tanaman Jatropha multifida Linn, kemudian diujicobakan untuk melihat peningkatan jumlah trombosit pada Mus musculus.Metode: Batang tanaman Jatropha multifida Linn diisolasi dengan maserasi menggunakan EtOH (96%), filtrat diuapkanmenggunakan rotary evaporator. Lima belas Mus musculus sehat dengan berat 20-50 g, dikelompokkan menjadi 4 yaitu kelompok 1 (P0) diberi perlakuan secara oral dengan aquades, kelompok 2 (P1) diberi perlakuan secara oral dengan 0,2 mL minyak manis, kelompok 3 (P2) diberi perlakuan secara oral dengan ekstrak daun jambu biji dengan dosis 0,028 g/kgBB, kelompok 4 (P3) dan kelompok 5 (P4) diberi perlakuan secara oral dengan senyawa flavonoid total batang tanaman Jatropha multifida Linn masingmasingdengan dosis 0,028 g/kgBB dan 0,056 g/kgBB. Setelah 24 jam untuk setiap perlakuan, kenaikan jumlah trombosit dihitung dibawah mikroskop.Hasil: Rendemen flavonoid total dari batang tanaman Jatropha multifida Linn yang dapat diisolasi menggunakan EtOH sebesar 4%. Pemberian senyawa flavonoid total dari batang Jatropha multifida Linn secara oral pada Mus musculus dengan dosis 0,028 g/kgBB mampu meningkatkan jumlah trombosit sebesar 543.000/mm3 dan dosis 0,056 g/kgBB mampu meningkatkan jumlah trombosit sebesar 813.000/mm3.Simpulan: Pemberian senyawa flavonoid total dari batang tanaman Jatropha multifida Linn dengan dosis 0,028 g/kgBB dan 0,056 g/kgBB secara oral mampu meningkatkan jumlah trombosit pada Mus musculus, dan semakin tinggi dosis yang diberikan semakin tinggi kenaikan jumlah trombosit.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3017
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 90-94
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3017/2700
oai:ojs.ejournal.undip.ac.id:article/3251
2012-04-20T08:09:45Z
mmi:ART
Uji Diagnostik Pemeriksaan Osteosklerotik Tulang dengan Sistem Radiografi Digital
Susilo, Susilo
Nagoro, Maesadji Tjokro
Kusminarto, Kusminarto
Budi, Wahyu Setia
Bone osteosclerotic, röntgen images, optimal of COP, Matlab software
ABSTRACTDiagnostic test of bone osteosclerotics examination using digital radiography systemBackground: The interpretation of a conventional röntgen images have a high degree of subjectivity due to the limitation of humansight. The computationally detection help establish the accuracy of diagnosis of the radiologist. According to our knowledge, there has not been previous research on this issue in Indonesia. The research was aimed to examine a Matlab based software to determine the diagnostic value in the diagnosis of osteosclerotic bone.Methods: This study was a diagnostic test which was conducted in Radiology Department of Dr. Kariadi Hospital Semarang, Dr.Sardjito Hospital Yogyakarta and Bethesda Hospital Yogyakarta, April to August 2009. The radiographs of bone osteosclerotic resulted from computed radiography (CR) test results were taken consecutively, interpreted by a radiologist which was supported by the Anatomical Pathology Laboratory examination as a gold standard. Afterwards these steps were done respectively: classify patients as a normal or osteosclerotic patients based on the cut off point that was determined, calculate the value of the diagnostic by analysis of 2x2 tables, determine the area under the curve (AUC) by the procedure of receiver operating characteristic (ROC), anddetermine the optimal of COP (cut off point) using ROC procedure.Results: From the results of diagnostic tests of bone radiographs these following parameter values was obtained: AUC value of 97.6% (95% CI: 94.4%-100%), the optimal cut off point for bone oseosclerotic COP ≥1.05 with a sensitivity value of 93.0% and a specificity of 89.1%. Suitability kappa value of 0.818 K (95% CI: 0.757 to 0.879).Conclusion: The radiographic examination of the results of CR using Matlab-based software can be used to diagnose boneosteosclerotic with high sensitivity and specificity.Keywords: Bone osteosclerotic, röntgen images, optimal of COP, Matlab softwareABSTRAKLatar belakang: Pembacaan foto röntgen secara konvensional memiliki tingkat subyektivitas tinggi karena keterbatasan indrapenglihatan manusia. Pendeteksian secara terkomputasi membantu menegakkan diagnosis para radiolog. Sebagaimana diketahui, belum ada penelitian sebelumnya mengenai masalah ini di Indonesia. Penelitian ini bertujuan menguji perangkat lunak berbasis Matlab untuk menentukan nilai diagnostik pada diagnosis tulang osteosklerotik.Metode: Penelitian ini adalah uji diagnostik yang dilakukan di Bagian Radiologi RSUP Dr. Kariadi Semarang, RSUP Dr. SardjitoYogyakarta dan Rumah Sakit Bethesda Yogyakarta, April-Agustus 2009. Radiograf osteosklerotik tulang hasil pemeriksaan CR (computed radiography) diambil untuk sampel secara konsekutif, kemudian diperiksa oleh radiolog yang didukung oleh pemeriksaan Laboratorium Patologi Anatomi sebagai baku emas. Tahapan yang dilakukan berturut-turut adalah: mengelompokkan pasien sebagai osteosklerotik dan normal berdasar titik potong yang ditentukan, menghitung nilai diagnostik dengan tabel analisis 2x2, menentukan AUC (area under the curve) dengan prosedur ROC (receiver operating characteristic), dan menentukan COP (cut off point) optimal dengan prosedur ROC.Hasil: Hasil uji diagnostik radiograf tulang diperoleh nilai-nilai parameter sebagai berikut: nilai AUC adalah sebesar 97,6% (IK 95%: 94,4%-100%), titik potong optimal untuk osteosklerotik tulang COP ≥1,05 dengan nilai sensitivitas sebesar 93,0% dan spesifisitas sebesar 89,1%. Nilai kesesuaian kappa K sebesar 0,818 (IK 95%: 0,757-0,879).Simpulan: Pemeriksaan radiografi hasil CR menggunakanperangkat lunak berbasis Matlab dapat digunakan untukmendiagnosis osteosklerotik tulang dengan sensitivitas danspesifisitas tinggi
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3251
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 188-193
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3251/2919
oai:ojs.ejournal.undip.ac.id:article/3812
2012-07-18T13:08:15Z
mmi:ART
Osteoporosis dan Faktor Risikonya pada Lansia Etnis Jawa
Fatmah, Fatmah
Osteoporosis, sex, age, education, physical activity, occupational activity level
ABSTRACTOsteoporosis and its risk factors among Javanese elderly.Background: Osteoporosis is marked by the reduction of Bone Mass Density caused by multifactor. Osteoporosis is often found among elderly people, and at present still a problem in public health. At present data on prevalence of osteoporosis among Javanese elderly is not available. The objective of the study was to analyze the prevalence of osteoporosis among the elderly Javanese with its risk factors.Method: The risk of osteoporosis was measured by using Sahara Clinical Bone Sonometer, and T<-2.5 score was the criteria of osteoporosis.Result: The study showed that osteoporosis in the rural was lower than in the urban. Osteoporosis proportion among females was twice bigger than males. There was osteoporosis proportion development based on age group. Level of education, physical activity and occupational activity were related to osteoporosis. Respondents with low level of education had the mean and osteoporosis proportion higher than those with high/middle level of education. Percentage of osteoporosis among elderly with low level of physical and occupational activity was also higher than those who had high level. Calcium and protein intakes had no relevance withosteoporosis occurrence.Conclusions: Rural and urban areas, sex, age, level of education, work status, and weight are osteoporosis risk factors. Sex was the main osteoporosis determinant in this study. Keywords: Osteoporosis, sex, age, education, physical activity, occupational activity level ABSTRAKLatar belakang: Osteoporosis ditandai menurunnya densitas massa tulang yang disebabkan oleh multifaktor. Osteoporosis sering ditemukan pada lansia dan saat ini masih menjadi masalah kesehatan masyarakat. Saat ini informasi data epidemiologi tentang osteoporosis pada lansia etnis Jawa belum diketahui. Tujuan studi adalah untuk menganalisis proporsi dan faktor-faktor risiko osteoporosis lansia Suku Jawa.Metode: Studi cross sectional dilakukan masing-masing di 3 wilayah pedesaan dan perkotaan. Lokasi diperoleh melalui two stages stratified random sampling, sedangkan subyek melalui acak sederhana. Risiko osteoporosis dinilai dengan menggunakan alat Sahara Clinical Bone Sonometer dengan kriteria osteoporosis memiliki nilai skor T<-2,5.Hasil: Diperoleh 812 subyek penelitian. Proporsi osteoporosis di desa sedikit lebih rendah daripada kota. Perempuan memiliki proporsi osteoporosis dua kali lebih besar daripada laki-laki. Terdapat peningkatan osteoporosis berdasarkan umur. Tingkat pendidikan, beban pekerjaan harian, dan aktivitas fisik berhubungan dengan osteoporosis. Responden dengan tingkat pendidikan akhir yang rendah memiliki mean dan proporsi osteoporosis lebih tinggi daripada tingkat pendidikan tinggi/menengah. Persentase osteoporosis responden pada aktivitas fisik rendah dan beban pekerjaan harian rendah lebih tinggi dibandingkan tingkat berat. Asupan kalsium dan protein tidak berhubungan dengan kejadian osteoporosis.Simpulan: Wilayah tinggal, jenis kelamin, umur, tingkat pendidikan akhir, tingkat aktivitas fisik, dan tingkat beban pekerjaan harian merupakan faktor-faktor risiko osteoporosis lansia Etnis Jawa. Jenis kelamin adalah determinan utama osteoporosis dalam studi ini.
MEDIA MEDIKA INDONESIANA
2012-07-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3812
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 2 Year 2008; 57-67
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3812/3496
oai:ojs.ejournal.undip.ac.id:article/4200
2012-11-29T12:01:07Z
mmi:ART
Komposisi Tubuh dan Kesegaran Kardiovaskuler yang Diukur dengan Harvard Step Test dan 20m Shuttle Run Test pada Anak Obesitas
Mexitalia, Maria
Anam, MS
Uemura, Azusa
Yamauchi, Taro
Harvard step test, 20m shuttle run test, physical fitness, obesity
Body composition and cardiovascular fitness measured by Harvard step test and 20m shuttle run test in obese childrenBackground: One of the impacts of obesity are physical and cardiovascular problems. Harvard step test and 20m shuttle run test can be used to measure cardiovascular fitness. Objective of this research is to determine the association between body composition with cardiovascular fitness in obese children measured by Harvard step test (HST) and 20m shuttle run test (SRT).Method: Cross sectional study was conducted to 31 students of Bernardus Elementary School Semarang in August 2010. Body composition (body mass index/BMI and fat percentage) was measured by Tanita BC545. Cardiovascular fitness was measured by HST and 20m SRT. During the step test Polar Vantage? Heart Rate (HR) monitor was attached to the subjects. Data were analyzed with Spearman correlation.Result: The average age was 10.7 (0.68) years. Only 17 children finished level III of Harvard test. The HR recovery never met the normal limit. There was no difference of physical fitness index (PFI) level I, II, and III (p=0.130) but the HR recovery decreased significantly (p=0.020). The mean of VO2max measured by 20m SRT was 20.5 (1.2) ml/kg/min, significantly lower compared with HST 24.2 (2.27) ml/kg/min. There were negative correlation between PFI and BMI (r=-0.381; p=0.034) and VO2max and BMI(r=-0.448; p=0.012).Conclusion: There are negative correlation between body mass index and cardiovascular fitness. However there are difference result of VO2max from Harvard step test comparing with 20m shuttle run test.Keywords: Harvard step test, 20m shuttle run test, physical fitness, obesityABSTRAKLatar belakang: Salah satu dampak obesitas adalah masalah fisik dan kardiovaskuler. Harvard step test (HST) dan 20m shuttle run test (SRT) merupakan tes yang digunakan untuk mengukur tingkat kesegaran kardiovaskuler. Tujuan penelitian adalah mengetahui hubungan komposisi tubuh dengan tingkat kesegaran kardiovaskuler pada anak obesitas menggunakan HST dan 20m SRT.Metode: Penelitian belah lintang dilakukan di SD Bernardus Semarang bulan Agustus 2010. Komposisi tubuh (indeks massa tubuh/ IMT) dan persentase lemak tubuh diukur dengan Tanita BC545. Dilakukan Harvard step test dan denyut jantung selama tes direkam menggunakan Polar Vantage Heart Rate (HR) monitor, serta dilakukan 20m SRT. Data dianalisis dengan uji korelasi Spearman.Hasil: Tiga puluh satu anak obesitas berumur 10,7(0,68) tahun mengikuti penelitian ini. Hanya 17 anak yang bisa menyelesaikan tes Harvard sampai tahap III. Didapatkan rerata HR saat istirahat lebih tinggi dibanding normal. Tidak didapatkan perbedaan physical fitness index (PFI) antara tes I, II, dan III (p=0,130) tetapi didapatkan penurunan HR recovery I, II, dan III yang bermakna (p=0,020). Rerata VO2max SRT 20,5(1,2) ml/kg/menit lebih rendah secara bermakna dibandingkan HST I yaitu 24,2(2,27) ml/kg/menit. Didapatkan hubungan terbalik antara PFI dengan IMT (r=-0,381, p=0,034) dan VO2max dengan IMT (r=-0,448, p=0,012).Simpulan: Didapatkan hubungan terbalik antara indeks massa tubuh dengan kesegaran kardiovaskuler pada anak obesitas, tetapi tidak didapatkan kesesuaian VO2max berdasarkan Harvard step test dan 20m shuttle run test.
MEDIA MEDIKA INDONESIANA
2012-11-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4200
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012; 12-19
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4200/3828
oai:ojs.ejournal.undip.ac.id:article/4273
2013-06-26T12:59:31Z
mmi:ART
Asupan Energi, Karbohidrat, Serat, Beban Glikemik, Latihan Jasmani dan Kadar Gula Darah pada Pasien Diabetes Mellitus Tipe 2
RI, Fitri
Wirawanni, Yekti
Carbohydrate intake, total energy, fiber, glycemic load, exercise, blood glucose levels, type 2 diabetes mellitus
Energy intake, carbohydrate intake, fiber intake, glycemic load, exercise and blood glucose levels in patients with type 2 diabetes mellitusBackgrounds: The worldwide prevalence of type 2 diabetes mellitus (DM) is increasing at epidemic proportion. Dietary patterns and sedentary lifestyle are risk factors of type 2 DM.Objective: The study aimed to examine the association between carbohydrate intake, total energy intake, fiber intake, glycemic load, frequency of exercise and duration of exercise with fasting blood glucose levels and with 2h postprandial blood glucose levels. Method: In this observational study with crossectional approach, 46 adults with type 2 DM. The subjects consisted of 17 male and 29 female. This study was performed at Dr. Kariadi Hospital during February-March 2008. Data on food consumption was obtained using semi quantitative food frequency questionnaire (FFQ) and recall. Data on exercise was obtained using questionnaire. Data on blood glucose level was obtained from medical records. Data analysis used Pearson Product Moment and multiple regression to test this associations.Results: Most (76.1% and 78.3%) subjects had high fasting blood glucose and 2h pp. In bivariate analysis, significant associations with fasting blood glucose level were observed for carbohydrate intake (r=0.638, p=0.000), total energy intake (r=0.539, p=0.000), fiber intake (r=-0.670, p=0.000), glycemic load (r=0.345, p=0.019), frequency of exercise (r=-0.561, p=0.000), and duration of exercise (r=-0.393, p=0.007). Significant associations with 2h postprandial blood glucose level were also observed for total energy intake (r=0.673, p=0.000), fiber intake (r=-0.638, p=0.000), glycemic load (r=0.775, p=0.000), frequency of exercise (r=-0.482, p=0.001), and duration of exercise (r=-0.393, p=0.007). Fiber intake, frequency of exercise and duration of exercise were negatively associated with fasting blood glucose levels and with 2h postprandial blood glucose levels. Carbohydrate intake, total energy intake, fiber intake, glycemic load, frequency of exercise and duration of exercise influenced 69.7% fasting blood glucose levels and 71.3%2h blood glucose levels.Conclusion: The unsuccessful blood glucose level central are associated with food intake glycemic index of the food and physical activity.Keywords: Carbohydrate intake, total energy, fiber, glycemic load, exercise, blood glucose levels, type 2 diabetes mellitus ABSTRAKLatar belakang: Prevalensi diabetes mellitus (DM) tipe 2 meningkat secara epidemologis di seluruh dunia. Pola makan dan pola hidup santai merupakan faktor risiko DM tipe 2.Tujuan: Menjelaskan hubungan asupan energi, asupan karbohidrat, asupan serat, beban glikemik, frekuensi latihan jasmani dan durasi latihan jasmani dengan kadar gula darah puasa dan kadar gula darah 2 jam postprandial (2 jam pp).Metode: Penelitian ini bersifat observasional dengan pendekatan belah lintang dilaksanakan di Rumah Sakit Dr. Kariadi Semarang selama bulan Febuari-Maret 2008 dengan 46 pasien DM sebagai subyek penelitian, yang terdiri atas 17 orang laki-laki dan 29 orang perempuan. Data asupan makanan diperoleh dengan formulir frekuensi makan semi kuantitatif dan recall. Data latihan jasmani diperoleh dengan kuesioner. Data kadar gula darah diperoleh dari buku rekam medik. Analisis data menggunakan korelasiPearson Product Moment dan regresi linear ganda.Hasil: Sebagian besar (76,1%) dan (78,3%) subyek mempunyai kadar gula darah puasa dan 2 jam pp dengan kategori tinggi. Terdapat hubungan bermakna untuk kadargula darah puasa dengan asupan energi (r=0,539, p=0,000), karbohidrat (r=0,638, p=0,000), serat (r=-0,670, p=0,000), beban glikemik (r=0,345, p=0,019), frekuensi latihan jasmani (r=-0,561, p=0,000) dan durasi latihan jasmani (r=-0,393, p=0,007). Terdapat hubungan bermakna antara kadar gula darah 2 jam pp dengan asupan energi (r=0,673, p=0,000), asupan serat (r=-0,638, p=0,000), beban glikemik (r=0,775, p=0,000), frekuensi latihan jasmani (r=-0,482, p=0,001) dan durasi latihan jasmani (r=-0,393, p=0,007). Asupan energi, karbohidrat, serat, beban glikemik, frekuensi latihan jasmani dan durasi latihan jasmani secara bersama-sama mempengaruhi 69,7% kadar gula darah puasa, dan 71,3% kadar gula darah 2 jam pp.Simpulan: Ketidakberhasilan pengendalian kadar gula darah berhubungan dengan asupan dan beban glikemik makanan serta aktivitas fisik yang rendah.
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4273
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 121-131
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4273/3894
oai:ojs.ejournal.undip.ac.id:article/4299
2013-01-02T10:05:21Z
mmi:ART
Determinan Growth Faltering (Guncangan Pertumbuhan) pada Bayi Umur 2-6 Bulan yang Lahir dengan Berat Badan Normal
Purnamasari, Dyah Umiyarni
Kartasurya, Martha I
Kartini, Apoina
Growth faltering, non-exclusive breastfeeding, upper respiratory tract infections, infants, normal birth weight
Growth faltering determinants among 2-6 years old infants born with normal birth weightBackground: Poor growth in infants can be indicated by a decrease in WAZ score, and is started at the age of 3-6 months. Growth faltering can lead to growth failure. Therefore it is important to investigate growth faltering determinants to solve the growth problems.Methods: This case controls study was conducted at Kangkung subdistrict, Kendal district. Cases were the subjects who had growth faltering, and controls were the subjects who had normal growth. Thirty six subjects were included in each group. The determinant variables investigated were non-exclusive breastfeeding, no-colostrum feeding, formula feeding, early complementary food feeding, pacifier used, diarrhea, upper respiratory tract infections and lack of mother’s allocation time for caretaking. Analyses were conducted by bivariate and multivariate logistic regression.Results: Based on the results of bivariate logistic regression analyses, the determinants of growth faltering were: Non-exclusive breastfeeding (OR=3.30; 95%CI:1.15-9.52; PAR=0.61), formula feeding (OR=2.96; 95%CI:1.03-8.53 PAR=0.38), early complementary food feeding at ≤3 months (OR=16; 95%CI: 1.78-143.15) and upper respiratory tract infections (OR=3.35; 95%CI: 1.23-9,10; PAR=0.48). No-colostrum feeding, pacifier used, diarrhea, and lack of mother’s allocation time for caretaking were not the determinants of growth faltering. Multivariate logistic regression analyses showed that non-exclusive breastfeeding (OR=3.43; 95%CI: 1.15-10.17) and upper respiratory tract infections (OR=3.09; 95%CI: 1.09-8.73) were the main determinants of growth faltering.Conclusions: The main determinants of growth faltering among infants aged 2-6 months at Kangkung sub-district were nonexclusive breastfeeding and upper respiratory tract infections. It is recommended to promote exclusive breast-feeding and prevent upper respiratory tract infections among infants.Keywords: Growth faltering, non-exclusive breastfeeding, upper respiratory tract infections, infants, normal birth weight ABSTRAKLatar belakang: Gangguan pada pertumbuhan bayi ditunjukkan dengan penurunan skor Z menurut indeks BB/U, dan pada umumnya dimulai pada umur 2-6 bulan. Gangguan tersebut bila tidak ditangani lebih lanjut akan menjadi growth failure (kegagalan pertumbuhan). Oleh karena itu perlu diketahui faktor determinan growth faltering agar dapat dilakukan pencegahan dan penanggulangan masalah tersebut.Metode penelitian: Penelitian observasional dengan disain penelitian kasus-kontrol, yang dilakukan di Kecamatan Kangkung, Kabupaten Kendal. Subyek adalah bayi yang mengalami growth faltering, dan kontrol adalah bayi yang mengalami pertumbuhan normal. Jumlah subyek masing-masing kelompok kasus dan kontrol adalah 36 subyek. Variabel yang diamati meliputi tidak diberikannya kolostrum, pemberian ASI tidak eksklusif, susu formula, MP-ASI dini, penggunaan kempongan, kejadian diare, ISPA danalokasi waktu asuh ibu. Analisis data dilakukan dengan menggunakan regresi logistik bivariat dan multivariat.Hasil: Berdasarkan analisis regresi logistik bivariat, determinan growth faltering adalah: pemberian ASI tidak eksklusif (OR=3,30; 95%CI: 1,15-9,52; PAR=0,61), susu formula (OR=2,96; 95%CI: 1,03-8,53 PAR=0,38), MP-ASI dini umur ≤3 bulan (OR=16; 95%CI: 1,78-143,15) dan ISPA (OR=3,35; 95%CI: 1,23-9,10; PAR=0,48). Variabel tidak diberikannya kolostrum, penggunaan kempongan, kejadian diare dan alokasi waktu asuh ibu yang kurang bukan merupakan faktor determinan. Analisis regresi multivariat menunjukkan bahwa pemberian ASI tidak eksklusif (OR=3,43; 95%CI: 1,15-10,17) dan kejadian ISPA (OR=3,09; 95%CI:1,09-8,73) merupakan variabel yang paling berpengaruh terhadap kejadian growth faltering.Simpulan: Determinan growth faltering utama pada bayi umur 2-6 bulan di Kecamatan Kangkung adalah Pemberian ASI tidak eksklusif dan kejadian ISPA. Disarankan untuk melakukan penyuluhan tentang pemberian ASI eksklusif dan pencegahan terhadap ISPA pada bayi.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4299
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009; 240-246
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4299/3921
oai:ojs.ejournal.undip.ac.id:article/4581
2013-06-26T12:57:43Z
mmi:ART
Pengembangan Sistem Kewaspadaan Dini Malaria Berbasis Sistem Informasi Lingkungan (EIS-EWSM) Bagi Pengambilan Kebijakan di Daerah Endemis Pedesaan Pulau Ambon
Melianus, Salakory
Development, malaria early warning system, based environmental information systems (EIS-EWSM), endemic areas, Rural Ambon Island
Development of malaria early warning system based environmental information systems (EIS-EWSM) to policy making in endemic areas of rural Ambon IslandBackground: The study on the incidence of malaria by using environment risk approach that emphasizes the linkage relationship between the host (host), agent (agent), and the environment (environment) need to be used more widely in public health in controlling the prevalence, incidence and distribution in an effort to prevent an increase in malaria cases/outbreaks of malaria. Were assessing the environmental parameters that can be used in the preparation of the environmental information system for decisionmaking in malaria endemic areas of Ambon Island, developed a model (prototype) environmental information system test the model (prototype), develop The EWSM, based on existing environmental information.Method: The design of this study was retrospective and prospective study design with time series observational approach; since March-November 2009 (for 9 whole months: dry season, early rain, the peak rainy, early dry/transition).Result: The results of a retrospective study, determined two potential areas of endemic malaria on the island of Ambon, namely: the village of Passo Baguala district city of Ambon, and the village of Hila-Kaitetu Leihitu district of district Central Molluca. Significant environmental risk factors included as model parameters are: density of larvae, ways of handling waste, drainage conditions, the proportion of forest, swamp proportion, the proportion of water bodies, the state of salinity, pH conditions, wind conditions, the state of precipitation, air humidity conditions, the state of air temperature, and density of the vector (Anopheles mosquito).Conclusions: Prepared by GIS, and maps of malaria distribution and map of priority malaria endemic in the village of Passo and Hila village. The EIS-EWSM, is a software that gives early warning outbreaks of malaria on the basis of environmental information. The program is also equipped with installation guide, and guide the application operates.Keywords: Development, malaria early warning system, based environmental information systems (EIS-EWSM), endemic areas, Rural Ambon Island ABSTRAKPendahuluan: Kajian terhadap kejadian malaria dengan menggunakan pendekatan lingkungan risiko yang menitikberatkan pada keterkaitan hubungan antara inang (host), agen (agent), dan lingkungan (environment) perlu digunakan secara lebih luas pada kesehatan masyarakat dalam melakukan pengontrolan terhadap prevalensi, insidensi dan distribusinya sebagai upaya untuk mencegah terjadinya peningkatan kasus Malaria/KLB Malaria. Tujuan khusus yang ingin dicapai dalam penelitian ini sebagai berikut adalah mengkaji parameter lingkungan yang dapat digunakan dalam penyusunan Sistem Informasi Lingkungan Malaria bagi pengambilan kebijakan di daerah Endemis Pulau Ambon, mengembangkan model (prototype) sistem informasinya, melakukan uji coba model (prototype) sistem informasi tersebut, kemudian mengembangkan EWSM.Metode: Rancangan penelitian ini adalah rancangan penelitian retrospektif dan diteruskan secara prospektif dengan pendekatan Time Series observational sejak Maret- Nopember 2009 (musim kemarau, awal hujan, puncak hujan, awal kemarau/pancaroba).Hasil: Hasil studi retrospektif dipakai untuk menentukan dua daerah potensi endemis malaria di pulau Ambon yaitu desa Passo (wilayah Puskesmas Passo) kecamatan Baguala Kota Ambon, dan desa Hila-Kaitetu (wilayah Puskesmas Hila) Kecamatan Leihitu Kabupaten Maluku Tengah. Hasil studi secara prospektif, ditemukan faktor lingkungan risiko yang signifikan dimasukkan sebagai parameter model adalah kepadatan jentik, cara penanganan sampah (konteiner), keadaan drainase, proporsi hutan, proporsi rawa, proporsi tubuh air, keadaan salinitas, keadaan pH, keadaan angin, keadaan curah hujan, keadaan kelembaban udara, keadaan suhu udara, dan kepadatan vektor (nyamuk anopheles).Simpulan: Olahan dengan SIG, menghasilkan peta distribusi malaria serta peta prioritas endemis malaria di desa Passo dan di desa Hila. EIS-EWSM, merupakan software yangmemberikan peringatan dini terjadinya KLB malaria dengan basis informasi lingkungan. Program tersebut dilengkapi pula dengan panduan penginstalan, dan panduan mengoperasikan aplikasi.
MEDIA MEDIKA INDONESIANA
2013-03-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4581
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012; 209-216
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4581/4173
oai:ojs.ejournal.undip.ac.id:article/21831
2019-01-25T14:21:01Z
mmi:ART
Pneumonitis Radiasi pada Penderita Karsinoma Payudara yang Mendapat Terapi Kemoradiasi di RSUP Dr. Kariadi
Fatchoerochman, Fatchoerochman
Zulqarnain, Nasirun
Kuntjoro, Eko
Radiation pneumonitis incidence; breast cancer
Radiation pneumonitis in breast cancer patients who recieved chemoradiation therapy at Dr. Kariadi hospitalBackground: The diagnosis of radiation pneumonitis relied on clinical symptoms and chest x-ray. Radiation pneumonitis will arise 6 to 12 week after external radiation therapy was completed, combination with chemotherapy will increase risk factor of radiation pneumonitis. The aim of this research is to find incidence of radiation pneumonitis among the breast cancer patient with chemoradiation therapy. Method: This study was an analitic descriptive, with subjects were patients with stage II-III breast carcinoma that have finished chemoradiation therapy at Dr. Kariadi hospital from January 1st 2007 to March 31st 2009. They were contacted by telephone or came for control. Radiation was given with dosage of 50 Gy and booster 10 Gy on chest wall. Incidence data of radiation pneumonitis was analyzed. Result: The mean age was 48.7 years. The incidence of radiation pneumonitis was 13 from 32 subjects (40.6%), with 69% was mild degree. As much as 31.3% used CAF regiment, 55.6% CAF-xeloda regiment, 20.0% CEF regiment, and xeloda + CEF-xeloda was 100%. There was no significant difference of radiation pneumonitis proportion based on age (p=0.09) and stadium (p=0.15). Most of the patients examined by chest x-ray with pulmonary symptoms, while no pulmonary symptom disapproved to be taken the chest x-ray. This caused the selection bias, thus the incidence of radiation pneumonitis tend to be high.Conclusion: There were high tendency (40.6%) of radiation pneumonitis incidence at stage II-III breast cancer patient who get chemoradiation therapy at Dr. Kariadi General Hospital, but the most degree of radiation pneumonitis is mild.ABSTRAKLatar belakang: Diagnosis pneumonitis radiasi didasarkan pada gejala klinis dan pemeriksaan x foto toraks. Pneumonitis radiasi akan timbul 6-12 minggu setelah terapi radiasi lengkap dan pemberian kemoterapi akan meningkatkan faktor risiko pneumonitis radiasi. Penelitian ini bertujuan mencari insidens pneumonitis radiasi pada penderita karsinoma payudara.Metode: Penelitian ini adalah deskriptif analitik dengan subjek penderita karsinoma payudara stadium II-III yang telah menyelesaikan terapi kemoradiasi di RSUP Dr. Kariadi pada periode 1 Januari 2007 sampai dengan 31 Maret 2009 yang bisa dihubungi lewat telepon atau datang kontrol. Radioterapi diberikan dengan dosis 50 Gy dan booster 10 Gy pada dinding dada. Data insidens pneumonitis dianalisis secara deskriptif analitik.Hasil: Rerata umur subjek 48,7 tahun. Insidens pneumonitis radiasi sebanyak 40,6%. Sebagian besar (69%) gambaran pnemonitis termasuk dalam kategori ringan. Sebanyak 31,3% menggunakan regimen CAF, 55,6% menggunakan CAF-xeloda, 20,0% menggunakan CEF. Xeloda dan CEF-xeloda masing-masing ditemukan 1 dari 1 subjek (100%). Tidak ada perbedaan bermakna proporsi kejadian pneumonitis radiasi berdasarkan kelompok umur (p=0,09) dan kelompok stadium (p=0,15). Sebagian besar pasien yang bersedia datang untuk dilakukan pemeriksaan x foto toraks PA adalah yang merasa ada kelainan pada paru-parunya, sedangkan yang merasa tidak ada kelainan pada paru-parunya tidak bersedia untuk diperiksa. Hal ini yang menyebabkan adanya selection bias pada subjek penelitian ini sehingga insiden pneumonitis radiasi cenderung tinggi.Simpulan: Insiden pneumonitis radiasi pada penderita karsinoma payudara stadium II-III yang mendapat terapi kemoradiasi di RSUD Dr. Kariadi cenderung tinggi yakni 40,6%, dengan derajat pneumonitis radiasi mild yang terbanyak.
MEDIA MEDIKA INDONESIANA
2010-04-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21831
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010; 37-43
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21831/14587
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3119
2012-04-09T13:23:50Z
mmi:ART
Asupan Mikronutrien, Kadar Hemoglobin dan Kesegaran Jasmani Remaja Putri
Cendani, Citta
Murbawani, Etisa Adi
Female adolescents, physical fitness, hemoglobin, iron, zinc, copper, folic acid, vitamin B6, vitamin B12
ABSTRACTMicronutrient intake, hemoglobin levels and physical fitness amongst female adolescentsBackground: Female adolescents is a group that is suspectible to anemia. Iron, zinc, copper, folic acid, vitamin B6 and vitamin B12 intake are factors among others that influence hemoglobin level. People with anemia would have the low physical fitness. The objective of this study was to understand the association between micronutrient intake (iron, zinc, copper, folic acid, vitamin B6, vitamin B12) with hemoglobin level, and hemoglobin level with physical fitness of female adolescents.Method: The design of this study was a cross sectional and the number of subject were 40 chosen by simple random sampling from 10th and 11th grade students that fulfill the inclusion criteria. Data on nutrients intake were obtained using semi quantitative food frequencies. The hemoglobin level was measured by cyanmethaemoglobin method, whereas physical fitness level was measured byharvard step test.Results: There were 32 subjects (80%) categorized as having very low and low from physical fitness. There were 10 subjects (25%) anemic. Eight subjects had low from physical fitness. There were significant associations between iron, zinc, copper, folic acid and vitamin B6 intake with hemoglobin level. There were no significant association between vitamin B12 with hemoglobin level.Regression analysis showed that iron intake contributed 67.7% variant to hemoglobin level. There were no significant association between hemoglobin level with physical fitness after controlled by nutritional status and physical activity.Conclusion: Intake of Fe, Zn, Cu, folic acid and B6 are associated with hemoglobin level, but hemoglobin level is not associated with physical fitness.Keyword: Female adolescents, physical fitness, hemoglobin, iron, zinc, copper, folic acid, vitamin B6, vitamin B12ABSTRAKLatar belakang: Remaja putri merupakan golongan yang rawan terhadap anemia. Faktor-faktor yang mempengaruhi terjadinya anemia diantaranya adalah asupan mikronutrien seperti besi, seng, tembaga, folat, vitamin B6, vitamin B12. Seseorang yang mengalami anemia dapat memiliki tingkat kesegaran jasmani yang kurang. Tujuan penelitian ini adalah untuk mengetahui hubungan antara asupan mikronutrien (besi, seng, tembaga, folat, vitamin B6, vitamin B12) dengan kadar hemoglobin dan hubungan kadar hemoglobin dengan kesegaran jasmani remaja putri.Metode: Desain penelitian cross sectional dengan jumlah subyek 40 dipilih secara simple random sampling dari kelas X dan XI yang memenuhi kriteria inklusi. Data asupan diperoleh dengan semi quantitative food frequencies. Kadar Hb diukur dengan metodecyanmethaemoglobin, sedangkan tingkat kesegaran jasmani diukur dengan metode harvard step test.Hasil: Sebanyak 32 subyek (80%) termasuk dalam kategori tingkat kesegaran jasmani sangat kurang sampai kurang. Sebanyak 10 subyek (25%) termasuk dalam kategori anemia. Sebanyak 8 subyek diantaranya memiliki tingkat kesegaran jasmani kurang. Ada hubungan antara asupan besi, seng, tembaga, folat, vitamin B6 dengan kadar hemoglobin. Analisis data dengan uji regresi didapatkan bahwa 67,7% kadar hemoglobin dapat dijelaskan oleh asupan zat besi. Tidak ada hubungan antara asupan vitamin B12 dengan kadar hemoglobin. Tidak ada hubungan antara kadar hemoglobin dengan kesegaran jasmani setelah dikontrol dengan status gizi dan aktivitas fisik .Simpulan: Asupan Fe, Zn, Cu, asam folat dan B6 berhubungan dengan kadar hemoglobin, namun kadar hemoglobin tidak berhubungan dengan kesegaran jasmani
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3119
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 1 Year 2011; 26-33
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3119/2799
oai:ojs.ejournal.undip.ac.id:article/3234
2012-04-18T11:17:19Z
mmi:ART
Praktik Inisiasi Menyusu Dini dan Pemberian ASI Eksklusif Studi Kualitatif pada Dua Puskesmas, Kota Semarang
Noer, Etika Ratna
Muis, Siti Fatimah
Aruben, Roni
Early initiation of breastfeeding, exclusive breastfeeding, qualitative
ABSTRACTEarly initiation of breastfeeding and exclusive breastfeeding practice: qualitative study at public health centers, Semarang cityBackground: Early initiation of breastfeeding (EIB) and exclusive breastfeeding (EB) up to six months are two important breastfeeding practices for child’s survival. EIB plays an important role in reducing infant mortality and improve the success of exclusive breastfeeding. Determinants in EIB and EB practices are predisposing, enabling, reinforcing, and environment. This study aimed to investigate determinants in EIB and EB practice until 4 months.Method: This study used a qualitative approach. Data were collected through intensive observations, non-intervention and in-depth interviews to 12 mothers. Data were analyzed using content analysis including data collection, reduction, presentation, and conclusions.Result: All the mothers were successful in the EIB with the help of professional midwife. Exclusive breastfeeding were successful in 3 mothers, partial breastfeeding were practiced by 6 mothers and not breastfeeding or formula feeding were practiced by 3 mothers. Predisposing and reinforcing were two strongly factors that cause the unsucessfull EB practices. The former were lack of knowledge of EB and breastfeeding techniques. The latter were lack of commitment of health providers, family support, and the status ofworking mothers.Conclusion: EIB practice does not ensure the success of EB.Keywords: Early initiation of breastfeeding, exclusive breastfeeding, qualitativeABSTRAKLatar belakang: Inisiasi menyusu dini (IMD) dan ASI eksklusif sejak lahir hingga usia enam bulan merupakan dua praktik pemberian ASI yang penting untuk kelangsungan hidup dan pertumbuhan optimal bayi. IMD berperan penting dalam mengurangi angka kematian bayi dan meningkatkan keberhasilan pemberian ASI eksklusif. Beberapa faktor determinan dalam praktik IMD dan ASI eksklusif yaitu faktor predisposisi (predisposing), pemungkin (enabling), penguat (reinforcing), dan lingkungan. Penelitian inibertujuan untuk mempelajari beberapa faktor determinan pada praktik IMD dan ASI eksklusif selama 4 bulan pada ibu yang melahirkan pada dua puskesmas di kota Semarang. Hasil penelitian ini akan diteruskan sebagai masukan terhadap program peningkatan cakupan pemberian ASI eksklusif.Metode: Penelitian ini menggunakan pendekatan kualitatif pada 12 ibu. Pengumpulan data dilakukan dengan observasi intensif, non intervensi dan menggunakan teknik wawancara mendalam. Data dianalisis dengan cara analisis isi yang bersifat terbuka. Hasil: Semua ibu dapat melakukan praktik IMD dengan bantuan profesionalisme bidan puskesmas. Praktik ASI eksklusif dilaksanakan oleh 3 ibu, ASI parsial pada 6 ibu dan pemberian susu formula oleh 3 ibu. Hambatan utama praktik pemberian ASI eksklusif adalah dari faktor ibu yaitu rendahnya pengetahuan tentang ASI eksklusif dan teknik menyusui. Faktor penghambat lainnya adalah kurangnya komitmen petugas kesehatan, dukungan suami, dan status ibu bekerja.Simpulan: Praktik IMD tidak menjamin keberhasilan pemberian ASI eksklusif.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3234
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 144-150
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3234/2906
oai:ojs.ejournal.undip.ac.id:article/3807
2012-07-18T10:51:44Z
mmi:ART
Auditing Peta Medan Kuman dan Antibiogram sebagai Educated-guess Penanganan Penyakit Infeksi
Wahjono, Hendro
Kristina, Tri Nur
Bacterial mapping, sensitivity, antibiotics.
ABSTRACTBacterial mapping and antibiogran as an educated quess in the management of infectious diseasesBackground: Facing infectious disease problems, rational diagnosis is needed using a foundation of theoretical and concept of clinical microbiology. Surveillance of bacterial mapping and susceptibility of antibiotics should be done routinely and reported as educated-guess.Methods: This was a descriptive study using secondary data from medical record of blood culture and sensitivity test from intensive care units Dr. Kariadi hospital, Semarang in 2005 and 2006.Results: There were several chages in bacterial mapping of blood culture from year 2005 and 2006. Bacterial mapping in ICU and PICU, which in 2005 was dominated by Gram (-) rods changed to Gram (+) cocci in 2006. This study also showed the decreasing effectivity of third and fourth generation of ceholosporin, and carbapenem that offenly used in intensive care units.Conclusion: Changes of bacterial mapping and antibiotic resistance can be caused by overuse and/or misuse of antibiotics therapy or prophylaxis. There should be a better coordination among members of the infectious desease control.Key Words: Bacterial mapping, sensitivity, antibiotics.ABSTRAKLatar belakang: Diagnosis rasional dengan menggunakan landasan teori dan konsep mikrobiologi klinik sangat diperlukan dalam menghadapi masalah medis yang berhubungan dengan infeksi. Survei peta medan kuman dan kepekaan antibiotik yang sering digunakan di RS perlu dilaksanakan secara rutin agar klinisi mempunyai pedoman dalam merancang alternatif tindakan dan terapi antibiotik pilihan.Metode: Penelitian ini merupakan studi deskriptif dengan data skunder dari catatan medik pemeriksaan kultur darah dan tes sensitiviti dari pasien rawat inap di unit perawatan intensif RS Dr Kariadi Semarang pada tahun 2005 dan 2006.Hasil: Gambaran peta medan kuman dari material klinik darah menunjukkan perubahan rangking populasi kuman dari tahun 2005 dan 2006. Peta medan kuman di ICU dan PICU yang pada tahun 2005 didominasi oleh kuman batang Gram (-), pada tahun 2006 berubah menjadi kuman coccus Gram (+). Hasil antibiogram tahun 2006 dari ICU menunjukkan terjadinya penurunan efektifitas antibiotika cephalosporin generasi III, IV, dan carbapenem yang lazim digunakan di unit-unit perawatan intensif.Simpulan dan Saran: Perubahan peta medan kuman dan turunnya efektifitas berbagai antibiotik kemungkinan diakibatkan oleh pemberian terapi atau profilaksis antibiotik yang kurang tepat atau bahkan berlebihan dalam penggunaannya. Perlu peningkatan kerjasama dari tim penanganan penyakit infeksi untuk mengatasi masalah tersebut.
MEDIA MEDIKA INDONESIANA
2012-07-16
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3807
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 1 Year 2008; 17-22
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3807/3491
oai:ojs.ejournal.undip.ac.id:article/4035
2012-09-20T12:12:47Z
mmi:ART
Lingkar Pinggang, Kadar Glukosa Darah, Trigliserida dan Tekanan Darah pada Etnis Minang di Kabupaten Padang Pariaman, Sumatera Barat
Jalal, Fasli
Liputo, Nur Indrawaty
Susanti, Novia
Oenzil, Fadil
Metabolic syndrome, waist circumference, triglyceride, blood sugar and blood pressure
Waist circumference, plasma glucose, serum triglyceride and blood pressure amongst the Minangkabau in Padang Pariaman, West SumateraBackground: The abnormality of waist circumference together with serum triglyceride blood sugar and blood pressure are associated with metabolic syndrome. The increasing incidence of metabolic syndrome is in line with the increasing of central obesity. This study was done to investigate the incidence of metabolic syndrome and the relationship between waist circumference with other components of metabolic syndrome which are serum triglyceride, HDL-cholesterol, plasma glucose and blood pressure.Methods: The study was done amongst the Minangkabau in Padang Pariaman. Design of the study was cross sectional study. The study subjects were 92 chosen by multistage random sampling. Characteristic of the samples and food consumption were collected by interviewing. Waist circumference was measured using method that is recommended by WHO (1995). Blood samples were taken to measure lipid profile and plasma glucose. Blood pressure was measured using sphygmomanometer.Results: The result of the study showed 22.8% of the subjects had metabolic syndrome with high intake of energy, carbohydrateand cholesterol, and low intake of fiber and omega 3. Eighty seven percent and 12.5% of women and men had high waist circumference. A positive association were found between waist circumference and serum triglyceride, blood glucose and blood pressure, however no correlation was found with HDL-cholesterol.Conclusions: Waist circumference is an important indicator for metabolic syndrome. Keywords: Metabolic syndrome, waist circumference, triglyceride, blood sugar and blood pressureABSTRAK Latar Belakang: Lingkar pinggang yang berlebihan adalah salah satu komponen dalam Sindroma Metabolik (SM) bersama dengan tingginya kadar serum trigliserida, glukosa darah, dan tekanan darah. Peningkatan kejadian SM sejalan dengan peningkatan obesitas sentral. Penelitian ini bertujuan memperoleh gambaran kejadian SM dan hubungan lingkar pinggang dengan komponen SM lainnya, yaitu kadar trigliserida, HDL-kolesterol, glukosa darah, dan tekanan darah.Metode: Penelitian dilakukan pada masyarakat Minang di Padang Pariaman dengan desain cross sectional. Pengambilan sampel dilakukan multistage random sampling dengan jumlah sampel 92 orang. Pengumpulan data karakteristik dan konsumsi dilakukan dengan wawancara, pengukuran lingkar pinggang dilakukan dengan cara yang direkomendasikan WHO tahun 1995, juga dilakukan pengambilan sampel darah guna pengukuran profil lipid dan glukosa plasma, sedangkan pengukuran tekanan darah sistolik-diastolik menggunakan sphygmomanometer.Hasil: Hasil penelitian menemukan 22,8% responden ternyata menderita SM, dengan asupan energi tinggi, karbohidrat tinggi, serat rendah, kolesterol tinggi dan asupan omega 3 rendah. Delapan puluh tujuh persen responden wanita dan 12,5% pria memiliki lingkar pinggang besar dari normal. Ditemukan korelasi positif antara lingkar pinggang dengan kadar trigliserida, kadar glukosa plasma dan tekanan darah, namun tidak terhadap kadar HDL-kolesterol.Simpulan: Lingkar pinggang merupakan satu indikator penting penanda Sindroma Metabolik.
MEDIA MEDIKA INDONESIANA
2012-07-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4035
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 3 Year 2008; 129-137
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4035/3707
oai:ojs.ejournal.undip.ac.id:article/4268
2013-06-26T12:59:31Z
mmi:ART
Photodynamic Therapy As an Adjuvant Therapy for Local-Partial Remission of Nasopharyngeal Carcinoma After Standard Therapy in Sardjito Hospital Yogyakarta A Five-Year-Overall Survival Rate Analysis Study
Hariwiyanto, Bambang
Indrasari, Sagung Rai
Herdini, Camelia
IB, Tan
NPC, PDT, 5-year-survival rate
Background: The foremost problems of nasopharyngeal carcinoma (NPC) management are high loco-regional remission, local recurrence and spreading rate post therapy. Photodynamic therapy (PDT) has been done for treatment of tumors less than 1 cm in size and depth in a very difficult location, where radical excision by surgery was not possible. The aim of this study is determining 5-year-overall survival rate of local-partial remission of NPC after standard therapy followed by additional PDT.Method: The survival study is subjected to the 5 years-overall survival rate of local-partial remission. Photosensitizer (FoscanR) 0,15mg/kgBW was injected to NPC patients and followed by 20 joule/cm2, 642 wave length and 100 watts/cm2 irradiants non thermal laser illumination 96 hours after injection. The PDT result was confirmed with biopsy, CT scan, upper abdominal USG, thoracic radiograph and bone survey for 12 weeks after treatment. Follow up was done every 3 months in first year, continued every 6 months in the second year, and followed once a year. The sample collected from January 2005 to December 2010, and 33 cases met the inclusion and exclusion criterias, but only 20 cases were eligible inclusion criteria. The 5 years-overall survival was defined as the time from diagnosis to death from any cause or last follow up, calculated by Kaplan Meier survival analysis.Results: The 5-year-overall survival rate was 50%.Conclusion: PDT as an additional treatment for small local-partial remission in NPC post treatment is an alternative therapy to improve the treatment outcome and survival rate.Keywords: NPC, PDT, 5-year-survival rate ABSTRAK Photodynamic therapy sebagai terapi ajuvan karsinoma nasofaring remisi lokal-parsial setelah terapi standar di RSUP Dr. Sardjito Yogyakarta: Studi analisis angka kehidupan lima tahunLatar belakang: Problem utama terapi standar karsinoma nasofaring (KNF) adalah rendahnya angka keberhasilan terapi, terutama adanya remisi parsial, baik pada tumor primer maupun metastasis. Photodynamic therapy (PDT) telah digunakan untuk pengobatan tumor di superfisial, dengan diameter kurang dari 1 cm, terutama pada tumor yang letaknya tersembunyi dan sulit dioperasi secara radikal. Penelitian ini bertujuan menentukan angka kehidupan 5 tahun pada penderita KNF dengan remisi parsial pada tumorprimernya, setelah diterapi secara standar dan dilakukan PDT sebagai terapi tambahan.Metode: Studi analisis kesintasan terhadap kehidupan 5 tahun penderita KNF yang mengalami remisi lokal-parsial setelah terapi standar dan PDT. Photosensitizer (FoscanR) 0,15mg/kgBW diinjeksikan pada penderita KNF, dan setelah 96 jam, dilanjutkan dengan irradiants non thermal laser illumination sebesar 20 joule/cm2, panjang gelombang 642 dan 100 watts/cm2. Hasil PDT dikonfirmasi dengan biopsi, CT scan, USG abdomen, rontgen thoraks dan bone survey pada 12 minggu setelah terapi. Tahun pertama, dilakukan follow up setiap 3 bulan, di tahun kedua setiap 6 bulan, dan selanjutnya setiap setahun sekali. Sampel didapat dari Januari 2005 sampai Desember 2010, dimana 33 pasien KNF post PDT memenuhi kriteria inklusi dan eksklusi, namun hanya 20 pasien yang memenuhi kriteria inklusi 5-tahun-follow up. Angka kehidupan 5 tahun ditentukan berdasarkan saat diagnosis sampai kematian penderita, atau sampai folllow up terakhir, dihitung dengan analisis kesintasan Kaplan Meier.Hasil: Angka kehidupan keseluruhan selama 5 tahun adalah 50%.Simpulan: PDT sebagai tambahan terapi terhadap KNF yang
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4268
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 86-90
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4268/3889
oai:ojs.ejournal.undip.ac.id:article/4289
2012-12-20T11:19:21Z
mmi:ART
Risk Factors for Mortality in Dengue Shock Syndrome (DSS)
Suharti, Catharina
Setiati, Tatty E
Van Gorp, Eric CM
Djokomoeljanto, Robert J
Trastotenojo, Moeljono S
van der Meer, Jos WM van der Meer
MV Dolmans, Wil
Dengue shock syndrome, mortality, risk factor.
Background: Dengue shock syndrome (DSS) is the most severe form of dengue hemorrhagic fever (DHF) and has a high mortality. There are two major pathological changes in DHF determining the severity of disease, plasma leakage and bleeding. Cytokines released during the immune response to dengue virus have been thought to be mediators of the process.Methods: The study involved 50 children with DSS, of whom 13 (26%) died. We investigated which clinical signs and laboratory findings are related to mortality.Results: We found that gastrointestinal bleeding and bilateral pleural effusion were significantly more frequent in non-survivors than in survivors (p<0.02 and p=0.0006, respectively). Also, mean admission levels of thrombin-antithrombin complexes (TATc) and plasminogen activator inhibitor type 1 (PAI-1), activation markers of coagulation and fibrinolysis, respectively, were significantly higher in non-survivors (p=0.004 and p=0.0006, respectively). In regression analysis, bilateral pleural effusion and admission levels of TATc were significantly associated with mortality (p=0.007 and p=0.048, respectively).Conclusions: Our data provide evidence for a relationship of mortality with pleural effusion, a marker of plasma leakage, and coagulation activation, both characteristic pathological changes in dengue shock syndrome.Keywords: Dengue shock syndrome, mortality, risk factor.ABSTRAKFaktor risiko kematian pada demam berdarah dengue dengan sindroma syok (DSS)Latar belakang: DSS merupakan bentuk klinik yang paling berat dari demam berdarah dengue (DBD) dan mempunyai angka kematian yang tinggi. Terdapat dua kelainan patologik utama pada DBD yang menentukan beratnya penyakit, yakni kebocoran plasma dan perdarahan. Sitokine yang dilepas sewaktu terjadi respon imun virus dengue diduga merupakan mediator proses ini.Metode: Studi dilaksanakan pada 50 penderita DSS anak, dimana 13 (26%) diantaranya meninggal. Investigasi dilakukan untuk mencari temuan klinik dan laboratorik yang berhubungan dengan kematian.Hasil: Perdarahan gastrointestinal dan efusi pleura bilateral secara bermakna lebih banyak ditemukan pada penderita yang meninggal dibandingkan dengan penderita yang hidup (berturut-turut p<0,02 dan p=0,0006). Rerata kadar thrombin-antithrombin complexes (TATc) sewaktu masuk rumah sakit dan kadar plasminogen activator inhibitor type 1 (PAI-1) juga merupakan petanda aktivasi koagulasi dan fibrinolisis, secara bermakna (berturut-turut p=0,004 dan p=0,0006) lebih tinggi pada penderita yang meninggal. Pada analisis regresi didapatkan bahwa efusi pleura bilateral dan kadar TATc sewaktu masuk rumah sakit berhubungan bermakna dengan kematian (berturut-turut p=0,007 dan p=0,048).Simpulan: Data dari studi ini membuktikan adanya hubungan antara kematian dan efusi pleura bilateral (suatu petanda kebocoran plasma) dan aktivasi koagulasi dimana keduanya merupakan kelainan patologik khas untuk DSS.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4289
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009; 213-219
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4289/3910
oai:ojs.ejournal.undip.ac.id:article/4574
2013-06-26T12:57:43Z
mmi:ART
Gamelan Music and Physiological Responses in Patients with Ventilator Support
Suhartini, Suhartini
Kritpacha, Charuwan
Thaniwattananon, Ploenpit
Music intervention, ventilator support, physiological responses
Background: Music is a non-pharmacological nursing intervention that can be used complementarily in the care of patients receiving ventilator support. The study aim was to explore the effects of music intervention on physiological responses for patients receiving ventilator support in intensive care units in Indonesia.Methods: It was a quasi experimental study using a non-equivalent control group and pre-test/post-test design. Forty subjects were assigned into either a control or experimental group (20 subjects/group). The outcome measures were physiologic responses, including systolic and diastolic blood pressure, heart rate, and respiratory rate obtained every 10 minutes for 20 minutes of music intervention. Data analysis used Chi-square test, Fisher-exact test, independent t-test, and paired sample t-test.Result: The findings showed that the subjects who received music intervention demonstrated statistically significant reductions in sympathetic physiological responses (p<0.05). Specifically, there was a significant difference in systolic blood pressure, but there was no significant difference in diastolic blood pressure, heart rates, and respiratory rate between the two groups. In the between groups comparison, it was only diastolic blood pressure that showed the reduction of mean score from pretest to posttest in the experimental group and in the control group.Conclusion: Gamelan intervention gives positive impact to patients with ventilator.Keywords: Music intervention, ventilator support, physiological responses ABSTRAK Musik gamelan dan responfisiologi pada pasien dengan ventilatorLatar belakang: Musik adalah intervensi keperawatan secara non farmakologikal yang dapat digunakan secara komplementari dalam merawat pasien yang menggunakan ventilator. Riset ini bertujuan untuk mengeksplorasi efek intervensi musik dalam menurunkan respon fisiologis pasien dengan ventilator di ruang perawatan intensif di Indonesia.Metode: Penelitian adalah penelitian semu dengan rancangan grup kontrol non-equivalen, pre dan post pengukuran. Ada 40 subyek penelitian yang dikelompokkan dalam grup kontrol dan grup eksperimen. Hasil yang diukur adalah tekanan darah sistolik dan diastolik, denyut jantung, dan frekuensi pernafasan, yang didapatkan dari pengukuran setiap 10 menit dalam 20 menit pemberian intervensi musik. Data diukur dengan menggunakan uji Chi-square, uji Fisher-exact, uji t-independen, dan uji t-berpasangan.Hasil: Hasil menunjukkan bahwa subyek yang menerima intervensi musik secara signifikan menurunkan respon simpatetik fisiologis (p<0,05). Secara spesifik, ada perbedaan yang bermakna dalam tekanan darah sistolik, tetapi tidak ada perbedaan yang signifikan dalam tekanan darah diastolik, denyut jantung, dan frekuensi pernafasan diantara kedua grup. Pada kelompok kontrol, hanya tekanan darah diastolik yang menunjukkan menurunkan skor rerata dari pretes ke postes dalam grup eksperimen dan grup kontrol.Simpulan: Intervensi gamelan memberi dampak positif pada pasien dengan ventilator
MEDIA MEDIKA INDONESIANA
2013-03-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4574
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012; 168-177
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4574/4166
oai:ojs.ejournal.undip.ac.id:article/21826
2019-01-25T14:21:01Z
mmi:ART
Suplementasi Seng dan Probiotik pada Diare Akut Cair Anak
Karuniawati, Fenty
Santosa, Budi
Purwaningsih, Endang
Hariyana, Bambang
Zinc; probiotic; acute watery diarrhea; children
Backgrounds: Clinical trials have demonstrated that zinc supplement during diarrhea episodes reduces the duration and severity of illness. Studies have shown that probiotic may be useful in treating acute diarrhea. Study that evaluated diet enriched with zinc and probiotic showed significant reduction on the duration of diarrhea. Whether this combination is better than either supplementation of zinc or probiotic alone is unknown. The objective of the study was to compare the duration of diarrhea among children with acute watery diarrhea given zinc, probiotic and combined zinc - probiotic supplementation.Methods: Consecutive sampling from 6-24 months old hospitalized children with acute watery diarrhea in Kariadi hospital was done. There were 77 subjects randomized into 4 study groups. Three groups were supplemented daily with zinc, probiotic, or zinc and probiotic and one group as control. Each group had received standard therapy including rehydration and dietetic. Data were analyzed with Chi-square test, t test and one way ANOVA.Results: There were no differences in age, breastfeeding history, nutritional and social economic status, day before admission, and level of zinc serum among groups. Supplemented group showed significant reduction on the duration of diarrhea compared with control (p=0.02). There was no significant difference on the duration of diarrhea between zinc-probiotic and zinc or probiotic groups (p=0.15). Zinc-probiotic supplemented group had the lowest duration of diarrhea among groups.Conclusions: Zinc and probiotic are able to reduce the duration of acute watery diarrhea.ABSTRAKLatar belakang: Berbagai uji klinis menunjukkan suplementasi seng menurunkan durasi dan beratnya diare. Suplementasi probiotik juga menunjukkan manfaat pada terapi diare akut. Penelitian tentang diet yang difortifikasi seng dan probiotik menunjukkan penurunan durasi diare secara bermakna. Belum diketahui apakah suplementasi seng dan probiotik secara kombinasi lebih baik dari pada suplementasi seng dan probiotik secara terpisah. Penelitian ini bertujuan membandingkan durasi diare pada anak yang dirawat dengan diare akut cair yang diberikan suplementasi seng, probiotik, kombinasi seng dan probiotik serta kontrol.Metoda: Subjek diambil secara konsekutif dari anak usia 6-24 bulan yang dirawat dengan diare akut cair di RSUP Dr. Kariadi Semarang. Didapatkan 77 subjek dan diacak menjadi 4 kelompok. Tiga kelompok diberi perlakuan berupa suplementasi seng saja, suplementasi probiotik saja atau kombinasi seng dan probiotik serta satu kelompok sebagai kontrol. Setiap kelompok mendapat terapi standar berupa rehidrasi dan dietetik. Data dianalisis dengan menggunakan uji Chi-square, t test dan one way ANOVA.Hasil: Tidak terdapat perbedaan bermakna pada umur, riwayat pemberian ASI, status gizi dan sosial ekonomi, lama sakit sebelum dirawat, dan kadar seng serum diantara keempat kelompok. Kelompok suplementasi mempunyai penurunan durasi diare yang bermakna dibandingkan kontrol (68,6 vs 83,8 jam, p=0,02). Tidak didapatkan perbedaan bermakna antara kelompok kombinasi seng dan probiotik dibandingkan kelompok seng atau probiotik saja (p=0,15). Kelompok seng dan probiotik mempunyai durasi diare paling pendek dibandingkan kelompok lain.
MEDIA MEDIKA INDONESIANA
2010-04-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21826
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010; 7-12
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21826/14582
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3233
2012-04-18T11:17:19Z
mmi:ART
Persalinan Pervaginam dan Menyusui sebagai Faktor Risiko Kejadian HIV pada Bayi
Purnaningtyas, Dewi Astri
Dewantiningrum, Julian
Vertical transmission HIV, CD4 concentration, mode of delivery, breastfeeding, ARV
ABSTRACTVaginal delivery and breastfeeding as risk factors of HIV in infantsBackground: HIV incidence is increasing among housewives, leading to increasing HIV in infants. The aim of this study was to identify risk factors of HIV in infants.Method: A case control study was carried out among women who visited VCT (voluntary counselling and testing) clinic RSUP Dr. Kariadi during 2003-2011 that fulfill the inclusion criteria of term delivery and babies infection confirmed by VCT or PCRDNA/RNA. Risk factors were assessed by interview about ARV consumption during pregnancy, mode of delivery, prophylactic ARV for neonates and breastfeeding. CD4 concentration before delivery was defined from medical report. All subject divided into two group based on HIV infected children status, HIV and non HIV. Analysis used bivariate analysis using Chi square and odd ratio.Result: From 28 women: 16 women in HIV group and 12 women in non HIV group. Breast feeding (OR 13.00; 95% CI 2.12-79.59, p=0.006) and vaginal delivery (OR 6.07; 95% CI 1.11-3.24, p=0.050) were the most important risk factors for HIV infection in infants. ARV consumption during pregnancy (OR 0.13; 95% CI 0.01-1.40), ARV prophylactic in neonates (OR 0.20; 95% CI 0.02- 2.23), CD4 >400 sel/mm3 before delivery (OR 0.33; 95% CI 0.03-4.019) were not risk factors. Conclusion: Vaginal delivery and breastfeeding were risk factor for the incidence of HIV-infected infants.Keywords: Vertical transmission HIV, CD4 concentration, mode of delivery, breastfeeding, ARVABSTRAKLatar belakang: Insiden penderita HIV meningkat pada ibu rumah tangga, yang akan mempengaruhi peningkatan insiden penderita HIV baru pada masa perinatal. Penelitian ini bertujuan ingin mengetahui berbagai faktor risiko yang berpengaruh terhadap kejadian HIV pada bayi.Metode: Desain penelitian adalah studi kasus kontrol. Subyek penelitian adalah ibu dengan HIV yang datang ke klinik VCT RSUP Dr. Kariadi tahun 2002-2011, dengan kriteria inklusi cukup bulan serta bayi telah dilakukan pemeriksaan PCR DNA/RNA. Data diperoleh lewat wawancara langsung maupun per telepon dengan kuesioner terbuka dan pemeriksaan CD4 menjelang persalinan. Wawancara untuk mencari faktor risiko pemberian ARV selama kehamilan meliputi cara persalinan, pemberian ARV profilaksispada bayi dan pemberian ASI. Data dianalisis dengan Chi square.Hasil: Sebanyak 28 subyek penelitian terbagi dalam kelompok HIV 16 subyek dan non HIV 12 subyek. Analisis berbagai faktor risiko menunjukkan bahwa pemberian ASI (OR 13,00, 95% CI 2,12-79,59) dan persalinan pervaginam (OR 6,07, 95% CI 1,11-3,24) merupakan faktor risiko yang berpengaruh terhadap kejadian HIV pada bayi. Nilai CD4 serum ibu >400 sel/mm3 menjelang persalinan (OR 0,33; 95% CI 0,03-4,019), pemberian ARV profilaksis neonatus (OR 0,20; 95% CI 0,02-2,23) dan pemberian ARVpada ibu hamil (OR 0,13, 95% CI 0,01-1,40), tidak merupakan determinan terhadap penularan HIV dari ibu ke janin.Kesimpulan: Persalinan pervaginam dan pemberian ASI merupakan faktor risiko kejadian HIV pada bayi.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3233
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 139-143
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3233/2905
oai:ojs.ejournal.undip.ac.id:article/21903
2019-01-29T12:46:17Z
mmi:ART
Peran Nefroprotektif Pentoxifylline Terhadap Ekspresi TGF-β1, Kolagen Tipe-4, MMP-9, Glomerulosklerosis serta Albuminuria pada Mencit Galur Swiss Setelah Diinduksi Doksorubisin
Purwanto, Bambang
PTX; nephroprotector; TGF-β1; type-4 collagen; MMP-9; glomerulosclerosis; albuminuria
Nephroprotective effect of pentoxifylline through improvement in the expression of TGF-β1, type-IV collagen, MMP-9, glomerulosclerosis and albuminuria in swiss strain mice after inducing by doxorubicinBackground: Nephrotoxic effects of doxorubicin (DXR) as a cancer drug is still a problem. Pentoxifylline (PTX) has the nephrotoxic effects. The combination of DXR and PTX might reduce the nephrotoxic effects of DXR. The aim of study was to prove the nephroprotective effect of PTX on DXR nephrotoxicity through the improvement of TGF-β1, type-4 collagen, MMP-9, as well as the levels of glomerulosclerosis and albuminuria.Method: Fourty-four males Swiss strain mice, divided into three groups as control group (C) injected with NaCl 0.9%; DXR induced nephrotoxicity (D); and effect of PTX on D (P/D) by intraperitoneally, respectivelly, each group consisted of 8 mice. Injections done once a week for three consecutive weeks. At the 4th and 8th weeks post-treatment, all eight mice of each group were sacrificed. Examination of TGF-β1, type-4 collagen, and MMP-9 expression was done by immunohistochemistry with monoclonal antibody. Glomerulosclerosis examination was done by a histopathologist, using VvG staining. While albuminuria examination was done by Elisa. The statistic was investigated using one-way ANOVA.Result: In the fourth week proteins expression was increased from C to D and subsequently decreased in P/D for TGF-β1, collagen type-IV, glomerulosclerosis and albuminuria. Otherwise MMP-9 expression was increased from C to D and in P/D. While in the eighth week proteins expression was increased from C to D and subsequently decreased in P/D for TGF-β1, collagen type-IV, glomerulosclerosis, and albuminuria. Otherwise MMP-9 expression was decreased from C to D and subsequently increased in P/D.Conclusion: The combination of PTX and DXR can reduce the nephrotoxic effects of DXR. PTX was proved to be nephroprotector inducing by DXR.ABSTRAKLatar belakang: Efek nefrotoksik doxorubicin (DXR) sebagai obat kanker masih menjadi masalah. Pentoxifylline (PTX) memiliki efek nefroprotektif. Kombinasi DXR dan PTX diharapkan untuk mengurangi efek nefrotoksik DXR. Tujuan penelitian ini adalah menjelaskan perbedaan ekspresi TGF-β1, kolagen tipe-IV, MMP-9, serta tingkat glomerulosklerosis dan albuminuria dalam keadaan normal, nefrotoksik dan nefroprotektif.Metode: Mencit strain Swiss jantan 48 ekor, secara acak dibagi tiga kelompok dengan setiap kelompok 16 ekor. Masing-masing kelompok diberikan intraperitoneal sekali seminggu selama tiga minggu berturut-turut 0,2 ml NaCl 0,9% pada kelompok kontrol (C); 0,038 mg DXR/20 g berat badan untuk kelompok nefrotoksik (D); serta dosis kombinasi 0,038 mg DXR/20 g berat badan dan 1,6 mg PTX/20 g berat badan untuk kelompok terapi (P/D). Pada minggu ke-4 dan 8 setelah pengobatan, 8 mencit masing-masing kelompok dikorbankan untuk pengumpulan sampel. Ekspresi TGF-β1, kolagen tipe-IV dan MMP-9 dinilai dengan immunohistokimia. Glomerulosklerosis dinilai secara histopatologis, menggunakan pewarnaan VvG. Sementara albuminuria dinilai dengan teknik Elisa. Statistik dianalisis menggunakan one-way ANOVA. Hasil: Pada minggu keempat terlihat ekspresi meningkat dari C ke D dan kemudian menurun pada P/D untuk TGF-β1, kolagen type-IV, glomerulosklerosis dan albuminuria. Sebaliknya ekspresi MMP-9 meningkat dari C ke D dan pada P/D. Pada minggu ke delapan terlihat ekspresi meningkat dari C ke D dan kemudian menurun pada P/D untuk TGF-β1, kolagen type-IV, glomerulosklerosis, dan albuminuria. Sebaliknya ekspresi MMP-9 menurun dari C ke D dan selanjutnya meningkat pada P/D.Simpulan: Penggunaan kombinasi PTX dan DXR dapat mengurangi efek nefrotoksik dari DXR.
MEDIA MEDIKA INDONESIANA
2010-12-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21903
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 3 YEAR 2010; 107-117
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21903/14639
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3023
2012-04-05T12:34:59Z
mmi:ART
Ekstrak Herbal (Daun Salam, Jintan Hitam, Daun Seledri) dan Kadar IL-6 Plasma Penderita Hiperurisemia
Ngestiningsih, Dwi
Hadi, Suyanto
IL-6, Eugenia polyantha, Apium graveolens, Nigella sativa
ABSTRACTHerbal extract (Eugenia polyantha, Nigella sativa, Apium graveolens) and IL-6 plasma level of hyperuricaemic patientsBackground: Hyperuricaemia stimulates pro-inflammatory cytokines like TNF-α, IL-1 and IL-6. They also will stimulate leucocyte adhesion molecule. Suplementation of bay-leaf (Eugenia polyantha), celery herb (Apium graveolens) and blackseed (Nigella sativa) had known to decrease inflammatory cytokines response including IL-6 blood level. These herbal are common in Indonesia but have not clinically studied correlation with IL-6 pro inflammatory cytokine in human. The aim study was to determine the effect of herbal extract on IL-6 blood level of hyperuricaemic patients.Methods: This study was an experimental study with double blind randomised clinical trial, held on 2007 March–2008 February. Samples were hyperuricaemic patiens in clinic and wards of internal medicine and geriatric RSUP Dr. Kariadi Semarang. They were divided into 2 groups: (1) Extract herbal and (2) placebo group. IL-6 blood level were tested before and 4 weeks after treatment using ELISA methode.Results: Subjects were 43 hyperuricaemic patients (22 in herbal treatment group compare with 21 in placebo group). The mean of basic IL-6 level in herbal group was 214.58 pg/dl whereas in placebo was 182.89 pg/dl. The mean of outcome IL-6 level in herbal group was 192.15 pg/dl whereas in placebo group was 254,00 pg/dl. The mean of IL-6 delta level in herbal group was -22.43 pg/dl whereas in placebo was 71.11 pg/dl (p:0.045). The mean of IL-6 ratio in herbal group was 1142.16% whereas in placebo was 754.45% (p:0.052).Conclusion: The herbal extract being used uric acid lowering agent decreases IL-6 level.Keywords: IL-6, Eugenia polyantha, Apium graveolens, Nigella sativaABSTRAKLatar belakang: Hiperurisemia akan memacu produksi sitokin proinflamasi TNF-α, IL-1 dan IL-6. Ketiga sitokin tadi akan memacu penarikan lekosit ke daerah deposit kristal monosodium urat dan melipatgandakan respon inflamasi. Daun salam (Eugenia polyantha), seledri (Apium graveolens), dan biji jinten hitam (Nigella sativa) pada percobaan terdahulu dapat menurunkan respon inflamasi termasuk kadar IL-6 pada respon inflamasi. Ketiga tanaman ini sangat banyak digunakan di Indonesia namun sampai saat ini belum dilakukan uji klinik pada manusia. Tujuan penelitian ini untuk mengetahui efek pemberian formula ekstrak herbal terhadap kadar IL-6 serum penderita hiperurisemia.Metoda: Penelitian ini adalah eksperimental yaitu double blind randomised clinical trial (RCT), dilaksanakan Maret 2007–Februari 2008. Subyek penelitian adalah penderita hiperurisemia usia 18 tahun yang berobat di Poliklinik/Rawat Inap Penyakit Dalam dan Geriatri RSUP Dr. Kariadi Semarang. Sampel dibagi menjadi kelompok perlakuan dan kelompok kelola. Dilakukan pemeriksaan kadar IL-6 darah sebelum dan setelah 4 minggu perlakuan. IL-6 diperiksa dengan cara ELISA.Hasil: Sampel sebanyak 43 orang (22 orang kelompok herbal dan 21 orang kelompok plasebo). Rerata kadar IL-6 awal kelompok herbal 214,58 pg/dl sedangkan kelompok plasebo 182,89 pg/dl. Rerata kadar IL-6 akhir kelompok herbal 192,15 pg/dl sedangkan kelompok plasebo 254,00 pg/dl. Rerata delta kadar IL-6 kelompok ekstrak herbal -22,43 pg/dl dan kelompok plasebo 71,11 pg/dl (p:0,045). Rerata rasio IL-6 pada kelompok herbal 1142,16% sedangkan pada kelompok plasebo 754,45% (p:0,052).Simpulan: Ekstrak herbal penurun asam urat dapat menurunkan kadar IL-6 serum penderita hiperurisemia.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3023
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 113-117
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3023/2706
oai:ojs.ejournal.undip.ac.id:article/3825
2012-07-19T12:14:38Z
mmi:ART
Penanganan Stres dan Kesejahteraan Psikologis Pasien Kanker Payudara yang Menjalani Radioterapi di RSUD Dr. Moewardi Surakarta
Karyono,, Karyono
Dewi, Kartika Sari
TA, Lela
Stress management strategy, psychological well-being, breast cancer patient and radiotherapy.
Stress management and psychological well-being in breast cancer patient undergoing radiotherapyBackground: Many breast cancer patients suffer low psychological well-being because the disease and radiotherapy. To improve the patient’s psychological well-being, should be good stress management strategy.Objective: The research aimed to examine correlations between stress management strategy and psychological well-being among breast cancer patients, and the effectivity of stress coping to psychological well-being.Method: This study was an correlational study between stress management strategy and the psychological well-being. The subjects consist of 30 breast cancer patients undergoing radiotherapy in Moewardi Hospital of Surakarta. Data were measured using Stress Management Strategy Scale and Psychological Well-being scale. Statistical analysis was simple regression analysis.Result: There was significant correlations between stress coping and psychological well-being on breast cancer patients (r=0.778 and p=0.00). The (R2) was 0.606, which means 60.6% psychological well-being were influenced by stress management strategy.Conclusion: Stress management determines psychological well-being in breast cancer patient undergoing radiotherapy.Keyword: Stress management strategy, psychological well-being, breast cancer patient and radiotherapy.ABSTRAKLatar Belakang: Banyak penderita kanker payudara mengalami penurunan kesejahteraan psikologis karena penyakit dan radioterapi yang dijalani. Untuk memperbaiki kesejahteraan psikologis, dibutuhkan strategi penanganan stres.Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan strategi penanganan stres dengan kesejahteraan psikologis pada pasien kanker payudara, dan sumbangan efektif variabel stress coping terhadap kesejahteraan psikologis.Metode: Penelitian korelasional dilakukan dengan variabel prediktor strategi penanganan stres dan kesejahteraan psikologis. Subyek penelitian terdiri dari 30 pasien kanker payudara di RSUD Dr. Moewardi Surakarta yang menjalani radioterapi. Data penelitian diambil dengan Skala Strategi Penanganan Stres (koefisien reliabilitas 0,931) dan Skala Kesejahteraan Psikologis (koefisien reliabilitas 0,941). Analisis regresi sederhana digunakan terhadap data yang ada.Hasil: Ada hubungan antara strategi penanganan stres dengan kesejahteraan psikologis (r=0,778, p=0,00), dengan nilai R2=0,606 yang berarti 60,6% kesejahteraan psikologis ditentukan oleh strategi penanganan stres.Simpulan: Strategi penanganan stres sangat menentukan kesejahteraan psikologis pasien kanker payudara yang menjalani radioterapi.
MEDIA MEDIKA INDONESIANA
2012-07-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3825
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 2 Year 2008; 102-105
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3825/3509
oai:ojs.ejournal.undip.ac.id:article/4217
2012-12-05T12:46:14Z
mmi:ART
Aspartat Amino Transferase-Platelet Ratio Index (APRI), Kadar Bilirubin dan Venektasi Penderita Kolestasis Anak di RSUP Dr. Kariadi Semarang
Kusumawati, Ninung Rose Diana
Hartantyo, I.
Rosalina, Vina
Nurhayati, Indah
Cholestasis, children, APRI, venectation
Aspartat amino transferase (AST)-platelet ratio index (APRI), bilirubin level and venectation of the pediatric cholestatic patient in Kariadi Hospital SemarangBackground: Cholestasis occurs when there is obstruction in the secretion of various substances, causing substances retention in the liver and cause damage to liver cells. The number of patients with cholestasis in infants and children is increasing, but diagnosis is still problematic. The purpose of this study is to describe cholestatic patients in Dr. Kariadi Hospital Semarang and to define correlation between APRI, bilirubin level, and venectation.Method: A retrospective study was conducted in Dr. Kariadi Hospital, Semarang from December 2010 until January 2012. Discriptive analysis was used to analyse data and Spearman Brown correlation was used to analyse correlation between APRI, bilirubin level, and venectation.Result: From December 2010 to January 2012 there were 29 patients with cholestasis. For 10 patient (34%) the cause of cholestatic problem could not be found. From 19 patient that were diagnosed, the most common cause of cholestasis in this group is cytomegalovirus (CMV) infection, followed by billiary atresia and cholelithiasis. In this study the AST-Platelet Ratio Index (APRI) of the subjects were between 0.26 and 11.09, with mean of 3.23. There was no correlation between the degree of liver fibrosis as measured using the APRI with high levels of bilirubin (r=0.36; p=0.58) and venectation in the subject (r=0.47; p=0.14).Conclusion: Patients with cholestasis in Dr. Kariadi Hospital were mostly under 2 years old and the most common cause are CMV infection. There was no correlation between the degree of liver fibrosis with bilirubin, which is one of parameter in determining the prognosis of patients with end stage liver disease, and venectation. Although APRI is sensitive to detect liver fibrosis but it is not sensitive to determine the degree of liver damage.Keywords: Cholestasis, children, APRI, venectationABSTRAKLatar belakang: Kolestasis terjadi bila didapatkan hambatan sekresi berbagai substansi ke dalam duodenum, sehingga menyebabkan tertahannya bahan-bahan tersebut di dalam hati dan menimbulkan kerusakan sel-sel hati. Dari tahun ke tahun jumlah penderita kolestasis pada bayi dan anak semakin bertambah, dan sebagian penderita dengan kolestasis tersebut belum bisa ditegakkan diagnosisnya secara pasti. Penelitian ini bertujuan untuk mendapatkan data dan gambaran klinik penderita kolestasis anak di RSUPDr. Kariadi Semarang dan untuk mengetahui hubungan antara APRI dengan kadar bilirubin dan venektasi.Metode: Penelitian ini merupakan penelitian retrospektif di RSUP Dr. Kariadi Semarang dari Desember 2010 sampai dengan Januari 2012. Data dianalisis secara diskriptif dan hubungan antara APRI, bilirubin direk, dan venektasi dianalisis dengan tes Spearman Brown.Hasil: Dari bulan Desember 2010 sampai Januari 2012 didapat 29 penderita kolestasis. Sepuluh orang (34%) diantaranya belum dapat didiagnosis penyebab kolestasisnya. Dari 19 orang yang terdiagnosis didapatkan penyebab terbanyak adalah infeksi Cytomegalovirus (CMV) sebanyak 7 orang diikuti oleh atresia bilier dan kholelithiasis. Pada penelitian ini dihitung nilai ASTPlatelet Ratio Index (APRI). Nilai APRI terendah 0,26 dan nilai tertinggi 11,09 dengan nilai rata-rata 3,23. Nilai APRI dalam penelitian ini tidak berkorelasi dengan nilai bilirubin direk pada subyek (r=0,36; p=0,58) ataupun venektasi pada subyek (r=0,47; p=0,14).Simpulan: Penderita kolestasis yang datang di RSUP Dr.Kariadi Semarang sebagian besar berusia di bawah 2 tahundengan penyebab terbanyak adalah infeksi CMV. Tidakdidapatkan hubungan antara derajat fibrosis hati yangdengan APRI dengan kadar bilirubin yang merupakan salah satu parameter dalam menentukan prognosis penderitadengan end stage liver disease dan dengan venektasi.Meskipun APRI cukup sensitif untuk menentukan derajatfibrosis hati akan tetapi tidak sensitif untuk menentukantingkat kerusakan fungsi hati.
MEDIA MEDIKA INDONESIANA
2012-11-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4217
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012; 57-61
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4217/3843
oai:ojs.ejournal.undip.ac.id:article/4280
2012-12-15T12:21:14Z
mmi:ART
Pengaruh Polifenol Teh Hijau Terhadap Sistem Imun Penderita Karsinoma Nasofaring yang Mendapat Radioterapi Kajian jumlah monosit, limfosit serta produksi TNF-α, IFN-γ dan IL-2 ex vivo
Wiratno, Wiratno
Nasopharyngeal carcinoma, radiotherapy, green tea polyphenols, monocyte, lymphocyte, TNF-α, IFN-γ, IL-2
The effect of green tea polyphenols on the immunity of nasopharyngeal carcinoma patients treated with radiotherapy: A study on the number of monocytes and lymphocytes, and production of TNF-α, IFN-γ and IL-2 ex vivoBackground: Radiotherapy in patients with nasopharyngeal carcinoma gives side effects, among other is the suppression of immunity system. Green tea polyphenols (GTP) has been proven to modulate immune system. The study aimed to analyze the capacity of antioxidant GTP in inhibiting the suppression effect of radiotherapy to the immune system using monocytes, lymphocytes, TNF-α, IFN-γ and IL-2 parameters.Methods: An experiment study using pre-post test control group design was conducted to 50 NPC patients in II, III and IV stages, received 200 cGy/day 33 times. The treatment group was 25 patients consumed GTP (2900 mg of decaffeinated extract of green tea, containing 986 mg EGCG and 1711 mg of other polyphenols) 2 hours before and 10 hours after RT. The 10 ml blood of cubiti vein was taken 5 to 7 days prior and 3-5 hours after the whole RT. Monocytes and lymphocytes were cultured with autologous whole blood and TNF-α secretion of monocytes having been induced with LPS, IFN-γ and IL-2 by lymphocytes having been induced with PHA and LPS respectively, were measured using ELISA.Results: In the post RT, the control group, monocyte, lymphocyte, TNF-α, IFN-γ and IL-2 had decreased, and the treatment group, monocyte, lymphocyte, and TNF-α decrease, while IFN-γ and IL-2 increase. The t-test transformation logarithm data of monocyte, lymphocyte, and TNF-α comparing the two groups, the result of monocyte and lymphocyte was significantly different (p<0.05), except TNF-α. The Mann-Whitney test the delta data of the IFN-γ and IL-2 were significantly different (p<0.05).Conclusions: GTP significantly inhibit the decrease of the number of monocyte and lymphocyte as well as the production of IFN-γ and IL-2, except TNF-α.Keywords: Nasopharyngeal carcinoma, radiotherapy, green tea polyphenols, monocyte, lymphocyte, TNF-α, IFN-γ, IL-2ABSTRAK Latar belakang: Terapi radiasi pada karsinoma nasofaring (KNF) menimbulkan efek samping berupa supresi sistem imun. Polifenol teh hijau (PFTH) ditengarai dapat meningkatkan sistem imun. Dilakukan suatu penelitian untuk mengetahui kapasitas antioksidan polifenol teh hijau dalam menghambat efek supresi radioterapi (RT) terhadap monosit dan limfosit serta fungsinya ex vivo dalam memproduksi TNF-α, IFN-γ dan IL-2 pada penderita KNF.Metode: Penelitian dengan design pre-post test dengan kelompok kontrol dilakukan pada 50 penderita KNF stadium II, III dan IV yang mendapat radioterapi 200cGy/hari sampai 33 kali. Kelompok perlakuan 25 penderita mendapat PFTH (2900 mg ekstrak teh hijau non-kafein mengandung 986 mg EGCG dan 1711 mg polifenol yang lain) dikonsumsi 2 jam sebelum dan 10 jam setelah RT. 10 ml darah vena kubiti diambil 5-7 hari sebelum dan 3-5 jam setelah seluruh radioterapi. Monosit dan limfosit dikultur dalam darah lengkap penderita dan TNF-α sekresi dari monosit setelah diinduksi dengan LPS, IFN-γ dan IL-2 sekresi dari limfosit setelah diinduksi masing-masing dengan PHA dan LPS. Diperiksa dengan metode ELISA .Hasil: Pasca RT, kelompok kontrol didapatkan monosit, limfosit, TNF-α, IFN-γ dan IL-2 semuanya menurun, sedangkan pada kelompok perlakuan yang menurun monosit, limfosit dan TNF-α, sedangkan IFN-γ dan IL-2 keduanya meningkat. Uji t tes terhadap data logaritma monosit, limfosit dan TNF-αantara kelompok perlakuan dan kelompok kontrol, hasilnya hanya monosit dan limfosit yang berbeda bermakna (p<0,05), sedangkan TNF-α tidak. Uji dengan Mann-Whitney terhadap data delta IFN-γ dan IL-2 antara kedua kelompok didapatkan berbeda bermakna (p<0,05).Simpulan: PFTH menghambat secara bermakna penurunan jumlah monosit dan limfosit serta produksi IFN-γ dan IL-2, sedangkan TNF-α tidak
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4280
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009; 175-181
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4280/3900
oai:ojs.ejournal.undip.ac.id:article/4307
2013-01-03T11:37:16Z
mmi:ART
Pemberian Diet Tambahan pada Anak dengan Penyakit Jantung Bawaan Asianotik
Wishnuwardhana, M.
Mexitalia, M.
Susanto, JC.
ood supplementation, growth, acyanotic CHD
Food supplementation for children with acyanotic congenital heart diseaseBackground: Children with Congenital Heart Disease (CHD) have a high risk for growth faltering. The prevalence of undernutrition in children with acyanotic CHD on the Pediatric Cardiology Clinic Dr. Kariadi Hospital Semarang is 80.4%. The purpose of the study is to define the benefit of food supplementation to children with acyanotic CHD to improve their growth.Methods: Clinical trial with one group pre and post test design study were conducted in children with CHD in the Pediatric Cardiology Clinic Dr. Kariadi Hospital Semarang during 2005-2006. Twenty-two children aged 6-57 months were involved in this study. Besides their daily intake, they had been given biscuit as food supplementation for 3 months, 20% above their Requirement Daily Allowance (RDA). Their weight and length/height were measured every months. The data was analyzed using Wilcoxon test.Results: The mean of Weight of Age z score (WAZ), Height of Age z score (HAZ), and Weight of Height z score (WHZ) before the supplementation were -1.570.9; -0.751.97; and -0.891.7 respectively. After 3 months there were an increased on WAZ 0.16 and HAZ 0.33 significantly but the improvement of WHZ is 0.01 (not significant). During the supplementation the calorie and protein intake were increased 14.6% and 8.4% respectively.Conclusion: Food supplementation with biscuit 14.6% above the RDA for 3 months improve the growth of children with acyanotic CHD.Keywords: Food supplementation, growth, acyanotic CHDABSTRAKLatar belakang: Anak dengan penyakit jantung bawaan (PJB) merupakan anak yang rawan mengalami gangguan pertumbuhan. Di Klinik Kardiologi Anak RSUP Dr. Kariadi Semarang, didapatkan 80,4% anak dengan PJB asianotik mengalami gizi kurang. Pemberian diet tambahan diharapkan memperbaiki status gizi dan pertumbuhan. Tujuan penelitian ini untuk mengetahui manfaat diet tambahan pada anak dengan PJB asianotik terhadap pertumbuhan.Metode: Uji klinis one group dengan pre and post test design, dilakukan pada anak dengan PJB asianotik di Klinik Kardiologi Anak RSUP Dr. Kariadi Semarang tahun 2005-2006. Dua puluh dua anak berumur 6-57 bulan diberikan perlakuan dengan pemberian biskuit sampai dengan 20% di atas Angka Kecukupan Gizi (AKG) selama 3 bulan selain tetap diberikan diet sehari-hari. Setiap bulan berat badan, panjang/tinggi badan diukur. Data dianalisis dengan uji Wilcoxon dengan batas kemaknaan p<0,05.Hasil: Sebelum perlakuan rerata z skor BB/U (WAZ) -1,570,9, z skor TB/U (HAZ) -0,751,97, z skor BB/TB (WHZ) rerata -0,891,7 dan sesudah perlakuan WAZ BB/U -1,411, HAZ -0,421,8, WHZ -0,881,6. Peningkatan rerata pertumbuhan sebelum dan sesudah perlakuan WAZ 0,16, HAZ 0,33 dan WHZ 0,01. Didapatkan perbedaan bermakna pada WAZ dan HAZ sedangkan WHZ tidak bermakna. Akseptabilitas meningkat setiap bulan dan terjadi peningkatan bermakna rerata asupan energi dan protein yang bersumber dari biskuit masing-masing sebesar 14,6% dan 8,4% dalam waktu 3 bulan.Simpulan: Pemberian biskuit minimal 14,6% di atas AKG selama 3 bulan pada anak PJB asianotik meningkatkan pertumbuhan.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4307
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 6 YEAR 2009; 282-288
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4307/3928
oai:ojs.ejournal.undip.ac.id:article/11374
2016-07-01T13:25:43Z
mmi:ART
Perbandingan Kadar Estrogen Serum dan TGF β-1 Plasma pada Penderita BPH-Non BPH di Atas 50 Tahun dan Usia Muda
Nugroho, Eriawan Agung
Budijitno, Selamat
ABSTRACT Comparison of estrogen serum and TGF β-1 plasma levels in benign prostate hyperplasia (BPH) and non BPH patients, among 50-years old and young patients.Background: Benign prostatic hyperplasia (BPH) is often found in older men. This disease affects an estimated 70% of men over 60 years, increased by 90% in men over 80 years age. Many scientists tried explores the hypothesis of the mechanism of occurrence of BPH. The purpose of study compared the levels of estrogen and transforming growth factor (TGF) ß-1 in plasma related to the development of BPH, in BPH patients and non-BPH over 50 years and young age.Methods: A clinical analysis study was carried out on subjects who were divided into 3 groups: patients with BPH >50 years, non-BPH >50 years and younger non-BPH aged 30-40 years. T-test was used to analyze the data. Serum estrogen and plasma TGF β-1 were assessed using ELISA method.Results: There was no significant difference (p=0.129) between the level of estrogen in BPH patients >50 years (140.091±43.649) and non BPH patients >50 years (63.69±18.757) but there was a significant difference (p=0.015) between level of plasma TGF ß-1 BPH patients >50 years (10.47±4.507) and non BPH patients >50 years of age (25.8±16.1103). No significant differences (p=0.348) were found between serum estrogen level of non-BPH >50 years (63.69±18.757) and the young age (57.17±10.2748), and between plasma TGF ß-1 non-BPH group >50 years (25.80±16.1103) and the younger age group (31.4±17,576)(p=0.496).Conclusion: There is difference in the level of TGF ß-1 between younger and older age groups. Elderly men are recommended for early prostate examination, because at the age of 50 years there is already a tendency of enlarged prostate gland. Levels of transforming growth factor β-1 can predict prostate enlargement.Keywords: Estrogen, TGF ß-1, benign prostate hyperplasia (BPH)ABSTRAKLatar belakang: Benign prostate hyperplasia (BPH) sering ditemukan pada pria usia lanjut. Penyakit ini terjadi pada 70% pria di atas 60 tahun, dan meningkat hingga 90% pada pria di atas 80 tahun. Banyak ilmuwan mencoba mengetengahkan hipotesis faktor yang berpengaruh terjadinya BPH. Tujuan penelitian ini membandingkan tingkat estrogen dan transforming growth factor (TGF) ß-1 dalam plasma terkait pembentukan BPH.Metode: Penelitian klinik analitik dilakukan pada subyek yang dibagi 3 kelompok, pasien dengan BPH >50 tahun, pasien non-BPH berusia >50 tahun dan muda non-BPH berusia 30-40 tahun. Analisis data dengan uji beda kadar estrogen serum dan TGF β-1 plasma ketiga kelompok. Kadar TGF ß-1 dan estrogen diukur dengan metoda ELISA.Hasil: Serum estrogen pasien BPH usia >50 tahun (140,091±43,649) lebih tinggi tetapi tidak berbeda bermakna (p=0,129) dibandingkan non BPH usia >50 tahun (63,69±18,757). Estrogen serum non-BPH usia >50 tahun (63,69±18,757) dibandingkan usia muda (57,17±10,2748) tidak berbeda bermakna (p=0,348). TGF ß-1 plasma pasien BPH usia >50 tahun (10,47±4,507) lebih rendah (p=0,015) dibandingkan pasien non BPH usia >50 tahun (25,8±16,1103). TGF ß-1 plasma kelompok non-BPH >50 tahun (25,80±16,1103) dibandingkan kelompok usia muda (31.04±17,576) tidak berbeda bermakna (p=0,496).Simpulan: Ada perbedaan antara tingkat TGF β-1 pada kelompok yang lebih tua. Laki-laki usia tua disarankan lebih dini melakukan pemeriksaan prostat, usia >50 tahun cenderung didapatkan pembesaran kelenjar prostat. Pemeriksaan kadar TGF -1 dapat memprediksi risiko pembesaran kelenjar prostat.
MEDIA MEDIKA INDONESIANA
2016-07-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/11374
MEDIA MEDIKA INDONESIANA; 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013; 37-43
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/11374/8860
oai:ojs.ejournal.undip.ac.id:article/21897
2019-01-29T11:32:20Z
mmi:ART
Massa Otot dan Senam Sehat Indonesia pada Wanita Usia Lanjut
Cayami, Ferdy Kurniawan
Susanto, Hardhono
Senam Sehat Indonesia; muscle mass; elderly; anthropometry; skinfold
Muscle mass and senam sehat Indonesia in elderly womenBackground: Health problem in elderly has become main concern because of the population increase. One of the problems is the decrease of musculoskeletal function influenced by the decrease of muscle mass. Activity like exercise can maintain muscle mass. Senam Sehat Indonesia (SSI) is one of well known, easy and right exercise for elderly. The aim of this study was to compare muscle mass between elderly women who exercise SSI regularly and who didn’t in relation with age and Body Mass Index (BMI).Method: An observational study was done with subjects taken from 2 different nursing home based on inclusion criteria. To get the total of muscle mass, we measured the Mid Upper Arm Circumference (MUAC), Triceps Skinfold (TSF) and height followed by calculation with muscle mass formula. Body weight was measured to calculate the muscle mass percentage and BMI. Data were analyzed with ANCOVA test with age and BMI as covariates.Result: A total of 54 subjects with 31 of them (57,41%) had regular exercise. They have better muscle mass (28.96%) of body weight and BMI 21,78 compared to the inactive subjects (28.86% and 24,47; p for muscle mass=0.007).Conclusion: Elderly who had regular exercise had better muscle mass than those who are inactive.ABSTRAKLatar belakang: Kesehatan pada orang lanjut menjadi perhatian saat ini karena jumlah populasinya yang semakin meningkat. Salah satu masalah adalah penurunan fungsi musculoskeletal yang dipengaruhi oleh penurunan massa otot. Aktivitas gerak seperti olahraga berguna untuk mempertahankan massa otot. Senam Sehat Indonesia (SSI) merupakan salah satu olahraga yang mudah dilakukan dan cocok bagi usia lanjut. Tujuan dari penelitian ini adalah membandingkan massa otot antara wanita usia lanjut yang melakukan SSI dengan yang tidak dengan memperhatikan usia dan Indeks Massa Tubuh (IMT).Metode: Penelitian belah lintang analitik ini dilakukan dengan mengambil subjek dari dua panti wredha yang berbeda dan memenuhi kriteria inklusi. Dilakukan pengukuran lingkar lengan atas, lipatan kulit triceps dan tinggi badan untuk perhitungan dengan rumus untuk massa otot. Berat badan juga diukur untuk menghitung persentase massa otot dan IMT. Hasil yang diperoleh dianalisis dengan uji statistik ANCOVA (Analysis of Covariate) dengan kovarian usia dan IMT. Hasil: Dari total 31 subjek yang melakukan SSI dan 23 subjek yang tidak melakukan SSI diperoleh perbedaan sangat bermakna (p=0,007) dengan massa otot yang lebih baik pada yang melakukan SSI. Pada 31 subjek yang melakukan SSI dengan IMT 21,78% memiliki persentase massa otot 28,96% terhadap massa tubuh. Dari 23 subjek yang tidak melakukan SSI dengan IMT 24,77 memiliki persentase massa otot 28,86% terhadap massa tubuh. Simpulan: Massa otot orang usia lanjut yang melakukan Senam Sehat Indonesia secara bermakna berbeda lebih baik daripada yang tidak melakukan Senam Sehat Indonesia.
MEDIA MEDIKA INDONESIANA
2010-08-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21897
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 2 YEAR 2010; 70-75
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21897/14631
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3018
2012-04-05T11:31:14Z
mmi:ART
Clinical Skills Training in the Community: Lesson Learned from Diponegoro and Gadjah Mada University
Kristina, Tri Nur
Widyandana, Widyandana
Clerkships, clinical skills, medical students, CBE, communit
ABSTRACTBackground: Community-based education (CBE) clerkship in Faculty of Medicine Diponegoro University (FMDU) is implemented after finishing clinical rotation in tertiary hospital, whereas in Gadjah Mada University (FMGMU), is a part of clinical rotation. To have insight information of this difference method, the CBE clerkship in FMDU and FMGMU were compared.Methods: Close and open-ended students’ questionnaires were administered in the end of CBE clerkship.Results: Response rate to the questionnaire was 97.8% (n=286). FMDU students reported the most unprepared skills for CBE clerkship was blood smear of malaria, whereas FMGMU’s students reported management of PHC centre. Both students perceived that they are well prepared in communication skills, management of communicable diseases, and several clinical skills, and also reported that they have frequent experience in outpatient department. FMDU’ students perceived that CBE clerkship gave opportunity to work independently, and they felt more prepared to work as a doctor in the community. On the other hand, FMGMU students felt not so confident in patient management, and reported that supervisor did not give enough assistance. They suggested that CBE clerkship should be done at least after clinical rotation in two Departments, i.e.: Internal Medicine or Paediatric andSurgery or Ob-gyn.Conclusions: CBE clinical clerkship required students’ confidence and independency. Preparation should be done properly not only for the students but also supervisor in the community. Tertiary hospital, which has enough skillful supervisors, is important to train basic clinical skills to students before sending them to the community.Keywords: Clerkships, clinical skills, medical students, CBE, communityABSTRAKKepaniteraan klinik di masyarakat: pembelajaran di Universitas Diponegoro dan Gadjah MadaLatar belakang: Kepaniteraan klinik di masyarakat di Fakultas Kedokteran Universitas Diponegoro diimplementasikan setelah mahasiswa kedokteran tingkat akhir menyelesaikan rotasi klinik di rumah sakit pendidikan tersier, sedangkan di Universitas Gadjah Mada kepaniteraan klinik di masyarakat menjadi bagian dari rotasi klinik. Dalam rangka mendapatkan informasi yang mendalam mengenai perbedaan metode tersebut, kepaniteraan klinik di masyarakat pada ke-2 institusi tersebut dievaluasi dan dibandingkan.Metode: Penelitian kuesioner dengan pertanyaan tertutup dan terbuka, diberikan pada mahasiswa di akhir dari kepaniteraan klinik di masyarakat.Hasil: Kuesioner yang dikembalikan sebesar 97,8% (n=286). Mahasiswa FK Undip melaporkan bahwa yang paling kurang dipersiapkan untuk kepaniteraan kinik di masyarakat adalah keterampilan dalam melakukan pemeriksaan darah hapus malaria, sedangkan mahasiswa FK UGM melaporkan bahwa mereka kurang dipersiapkan dalam hal manajemen puskesmas. Mahasiswa dari ke-2 institusi sama-sama merasa bahwa mereka cukup dipersiapkan dalam hal keterampilan komunikasi, manajemen penyakit infeksi, dan beberapa keterampilan klinik. Mereka juga sama-sama melaporkan pengalaman yang cukup sering di poliklinik. Mahasiswa FK Undip merasa bahwa kepaniteraan klinik di masyarakat memberi kesempatan pada mereka untuk bekerja secara independen, dan merasa lebih siap untuk bekerja sebagai dokter di masyarakat. Di lain pihak, mahasiswa FK UGM merasa kurang percaya diri dalam mengelola pasien dan melaporkan bahwa supervisor di puskesmas kurang memberikan supervisi. Mereka menyarankan agar kepaniteraan klinik di masyarakat dilakukan setelah minimal menjalani rotasi klinik di 2 departemen, misalnya:interna/pediatrik dan bedah/kebidanan.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3018
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 69-73
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3018/2701
oai:ojs.ejournal.undip.ac.id:article/3252
2012-04-20T08:19:35Z
mmi:ART
Acceptability and Nutrient Content of Wet Noodles Fortified with Inorganic or Organic Iron and Provitamin A from Pumpkin (Cucurbita moschata)
Rustanti, Ninik
Murwani, Retno
Anwar, Syaiful
Fortification, organic iron, inorganic iron, provitamin A pumpkin, wet noodles
ABSTRACTBackground: Iron fortification of wet noodles is a choice among many others, to reduce iron deficiency anemia. Organic andinorganic iron interact with provitamin A. An experiment was conducted to fortify wet noodles with organic and inorganic iron and provitamin A from pumpkin, and to study its effect on acceptance and its iron and provitamin A content.Methods: Six groups were used in this experiment to test optimal level of iron fortification (100 ppm, 150 ppm, 200 ppm of FeSO4 or organic iron). As for pumpkin, 10%, 15% and 20% were used. To test iron and provitamin A content, 5 groups were employed: wet noodle alone, wet noodle + (FeSO4), + (organic Fe), + (FeSO4 & pumpkin), and + (organic Fe & pumpkin) respectively. Data were evaluated by one-way ANOVA and continued by Duncan’s test with 95% CI.Result: Noodle fortified with 200 ppm iron was acceptable in term color, taste and texture. Adding 15% pumpkin improved texture optimally compared to 10% and 20%. In term color and taste, 10%, 15% and 20% pumpkin addition gave similar acceptance. Fortification of iron and provitamin A from pumpkin didn’t affect the moisture, protein, fat, fiber, and carbohydrate content but increased iron, ash and betacarotene content. Highest content of iron and provitamin A were found in noodles + (FeSO4 + pumpkin) and noodles + (organic Fe + pumpkin).Conclusion: Iron and provitamin A fortified wet noodles can serve as a choice for eliminating iron deficiency anemia in Indonesia. Further studies to see the bioavailability and effectiveness of fortified wet noodles to reduce anemia are needed.Keywords: Fortification, organic iron, inorganic iron, provitamin A pumpkin, wet noodlesABSTRAKDaya terima dan kandungan gizi mie basah yang difortifikasi zat besi anorganik dan organik serta provitamin A labu kuning (Cucurbita moschata)Latar belakang: Fortifikasi mie basah merupakan salah satu pilihan untuk menanggulangi permasalahan anemia gizi besi. Besi organik dan anorganik dapat berinteraksi dengan provitamin A. Penelitian ini bertujuan untuk memfortifikasi mie basah dengan besi organik dan anorganik serta provitamin A labu kuning, dan untuk mengetahui pengaruhnya terhadap daya terima, kadar besi dan provitamin A pada mie basah.Metode: Enam perlakuan digunakan dalam penelitian untuk optimasi kadar besi fortifikan (100 ppm, 150 ppm, dan 200 ppm FeSO4 atau Fe organik). Labu kuning yang digunakan 10%, 15%, dan 20%. Untuk mengetahui kadar besi dan provitamin A digunakan 5 perlakuan: mie basah, mie basah + (FeSO4), + (Fe organik), + (FeSO4 & labu kuning), dan + (Fe organik & labu kuning). Data dianalisis dengan one-way ANOVA dan dilanjutkan dengan uji Duncan dengan 95% CI.Hasil: Mie yang difortifikasi dengan 200 ppm zat besi dapat diterima dari sisi warna, rasa dan tekstur. Penambahan labu kuning 15% memberikan tekstur yang lebih baik dibandingkan 10% dan 20%. Dari sisi warna dan rasa, penambahan labu kuning 10%, 15% dan 20% mempunyai daya terima yang sama. Fortifikasi besi dan provitamin A labu kuning tidak mempengaruhi kadar air, protein, lemak, serat dan karbohidrat tetapi meningkatkan kadar besi, abu dan betakaroten. Kadar besi dan provitamin A tertinggi terdapat pada mie + (FeSO4 +labu) dan mie + (Fe organik + labu).Simpulan: Mie basah yang difortifikasi besi dan provitamin Aberupa labu kuning dapat menjadi alternatif untuk mengatasianemia gizi besi di Indonesia. Diperlukan penelitian lanjutanuntuk mengetahui bioavailabilitas dan keefektifan mie yangdifortifkasi untuk mengurangi anemia.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3252
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 194-199
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3252/2920
oai:ojs.ejournal.undip.ac.id:article/3813
2012-07-18T13:20:17Z
mmi:ART
Metformin Dosis Rendah Jangka Pendek dan Risiko Timbulnya Aterosklerosis pada Prediabetes Non Obes
Hardiman, Djoko
etformin, non-obese prediabetic, hsCRP, PAI-1, Fibrinogen, VCAM-1
ABSTRACTLow-dose short-term metformin and the risk of atherosclerosis in non obese prediabetic.Background: The establishment of macrovascular (cardiovascular) event is initiated in the period of prediabetic. Metformin plays role in the carbohydrate and lipid metabolism as well as vascular protection. The mechanism of the cardiovascular event risk increase in the prediabetic individual has not been clearly established. The study was to determine if insulin resistance control by low-dose short-term metformin administration in the non-obese prediabetic individual might decrease the atherosclerosis risk.Method: The present study was a prospective, experimental study with pretest-posttest control group design. It was conducted on the first degree relative of type-2 DM patient who met the criteria of non-obese prediabetic individual. Subjects were randomly classified into treatment group (designed for metformin administration), and the control group (designed for placebo administration). The prediction of atherosclerosis risk was based on the hsCRP, PAI-1, VCAM-1 and fibrinogen levels.Results: The margin between pre and post metformin administration term were 1.89 vs 0.06 mg/L (p=0.001), 1.42 vs 0.84 IU/mL (p=0.015), 180.85 vs 03.81 mg/L (p=0.061) and 80.15 vs 31.42 mg/dL (p=0.001) for hsCRP, PAI-1, VCAM-1 and Fibrinogen in the treatment and control group, respectively.Conclusion: Low-dose short-term metformin administration might decrease the atherosclerosis risk factor in the non-obese prediabetic individuals.Keywords: Metformin, non-obese prediabetic, hsCRP, PAI-1, Fibrinogen, VCAM-1ABSTRAKLatar belakang: Awal terjadinya penyakit makrovaskuler (kardiovaskuler) terjadi pada periode prediabetes. Metformin mempunyai efek terhadap metabolisme karbohidrat, lipid dan proteksi terhadap vaskuler. Mekanisme timbulnya peningkatan resiko penyakit kardiovaskuler terjadi pada individu dengan prediabetes. Penelitian ini bertujuan untuk membuktikan bahwa pengendalian resistensi insulin pada individu prediabetes non obes dengan metformin dosis rendah jangka pendek, dapat menurunkan resiko timbulnyaaterosklerosis.Metode: Penelitian ini adalah suatu penelitian eksperimental yang bersifat prospektif dengan pretest-posttest control group design. Sampel dalam penelitian ini adalah turunan dari penderita DM tipe 2 yang tergolong ke dalam kriteria prediabetes. Subjek penelitian dikelompokkan atas dua kelompok, yaitu kelompok perlakuan yang mendapatkan kapsul yang berisi metformin, dan kelompok kontrol yang mendapatkan kapsul yang berisi kontrol. Pemilihan kelompok yang mendapat kontrol atau metformin dilakukan secara acak. Penentuan risiko aterosklerosis dengan menggunakan kadar hs-CRP, PAI-1, VCAM-1 dan fibrinogen.Hasil: Hasil penelitian ini menunjukkan rerata selisih kadar hs-CRP, PAI-1, VCAM-1 dan fibrinogen pre dan post pemberian metformin antara kelompok perlakuan dan kontrol adalah kadar hs-CRP 1,89 dan -0,06 mg/L (p=0,001), PAI-1 1,42 dan -0,84 IU/mL (p=0,015), VCAM-180,85 dan -3,81 ng/mL (p=0,061) dan fibrinogen 80,15 dan -31,42 mg/dL (p=0,001).Simpulan: Pemberian metformin dosis rendah jangka pendek menurunkan risiko terjadinya aterosklerosis pada prediabetes non obes.
MEDIA MEDIKA INDONESIANA
2012-07-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3813
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 2 Year 2008; 68-74
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3813/3497
oai:ojs.ejournal.undip.ac.id:article/4201
2012-11-29T12:25:59Z
mmi:ART
Uji Diagnostik Pemeriksaan Tulang Osteolitik Berbasis Intensitas Citra Digital
Susilo, Susilo
Nagoro, Maesadji Tjokro
Kusminarto, Kusminarto
Budi, Wahyu Setia
Digital image, bone metastases, osteolytic, optimum cut off point
Diagnostic test of osteolytic bone examination based on digital image intensityBackground: The visual examination of bone radiographs using digital computed radiography (CR) is an examination for the diagnosis of bone-metastatic cancer. The subjectivity of interpretation of bone radiographs may lead to doctor’s doubt in making decision to treatment patients with bone-metastatic cancer. Software Matlab-based computer application program makes a standard method to organize the results of bone radiographs. The objective of this study is to develop a software based on Matlab to analyze the diagnostic values, and to determine the optimal of cut off point to diagnose of osteolytic bone.Method: The researches data are collected from Department of Radiology of three hospitals i.e. Dr. Kariadi Hospital Semarang, Dr. Sardjito Hospital and Bethesda Hospital Yogyakarta. This research was carried out during four month from April to August 2009. Radiographs of osteolytic bone interpreted by radiologist were compared with PA examination result of the osteolytic bone which were viewed as the gold standard. The steps in this study i.e. patients are classified as a normal or osteolytic bone patients based on the cut off point that had been determined, calculate the value of the diagnostic test using 2x2 tables, determined the area under the curve (AUC) by the procedure of receiver operating characteristic (ROC), and determined the optimal of cut off point.Result: The results of study show that the diagnostic test for osteolytic bone by using Matlab-based software has sensitivity of 0.88, specificity of 0.891, positive expected value of 0.897, negative expected value of 0.950 and the cut off point at 0.93, while, the value of area under the curve (AUC) is 94% (95% CI: 89.7%-98.3%), and the accuracy is 0.881 for the case of osteolytic bone.Conclusion: Matlab-based software being used for diagnosing osteolytic bone has relatively high sensitivity and specificity.Keywords: Digital image, bone metastases, osteolytic, optimum cut off point ABSTRAKLatar belakang: Pemeriksaan radiograf tulang secara visual menggunakan sistem radiografi digital CR (computed radiography) merupakan pemeriksaan untuk diagnosis kanker metastasis tulang. Subyektivitas interpretasi radiograf tulang dapat menyebabkan keraguan dokter dalam mengambil keputusan untuk pengobatan pasien dengan kanker tulang metastatik. Software berbasis program aplikasi computer Matlab membuat suatu metode standard untuk mengorganisasikan hasil radiograf tulang. Tujuan penelitianadalah mengembangkan software berbasis Matlab untuk menganalisis nilai-nilai diagnostik, cut off point optimal dan akurasi pemeriksaan pada diagnosis tulang osteolitik.Metode: Data penelitian diambil di bagian radiologi dari tiga rumah sakit, yaitu RSUP Dr. Kariadi Semarang, RSUP Dr. Sardjito dan Rumah Sakit Bethesda Yogyakarta. Penelitian dilakukan selama empat bulan dari April sampai Agustus 2009. Radiograf tulang osteolitik yang diinterpretasikan oleh radiolog ini dibandingkan dengan hasil pemeriksaan PA tulang osteolitik yang dianggap sebagai gold standard. Langkah yang dilakukan dalam penelitian ini adalah pasien diklasifikasikan sebagai pasien tulang normal dan pasien osteolitik berdasar cut off point yang telah ditetapkan, menghitung nilai uji diagnostik menggunakan tabel 2x2, menghitung luasan di bawah kurva (AUC) dengan cara receiver operating characteristic (ROC), serta menetapkan cut off point optimal.Hasil: Hasil penelitian menunjukkan bahwa uji diagnostik tulang osteolitik menggunakan software berbasis Matlab memiliki sensitivitas 0,875, spesifisitas 0,891, nilai dugapositif 0,897, nilai duga negatif 0,950 dan cut off point 0,93. Nilai luasan di bawah kurva (AUC) ROC adalah sebesar 94%
MEDIA MEDIKA INDONESIANA
2012-11-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4201
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012; 19-25
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4201/3829
oai:ojs.ejournal.undip.ac.id:article/4274
2013-06-26T12:59:31Z
mmi:ART
Phytoestrogen Genistein and Black Cohosh and Marker of BMD in Menopausal Women
Amran, Rizani
Abadi, Adenan
Theodorus, Theodorus
Widiastuti, Elvi
Phytoestrogens, BMD, T-score, menopause
Background: In Indonesia, phytoestrogens can be found in the market as supplement to resolve climacteric complaint and osteoporosis. This phytoestrogens has not been proven scientifically to have benefit in overcoming the climacteric complaints and osteoporosis in menopausal women. Therefore, it is important to have clinical test searching data for knowing the increase of bone mineral density (BMD).Methods: The design was comparison clinical test in the form of “add on” with double blind in Hospital of Mohammad Hoesin Palembang started in August 2010 until February 2011 putting subjects into fitoestrogen and placebo groups randomly. T-score of spine and femur were measured using done densitometry before and after 6 months supplementation.Results: In the beginning of study, it was found that the average of spine T-score in the group of phytoestrogens was -1.455±0.264 after 6 months it increased to -1.295±0.223 with change 0.160±0.153 (p=0.001).Whereas in placebo group the average of spine T-score at the beginning of the study was -1.295±0.223 becoming -1.560±0.414 with decrease of -0.100±0.273 (p=0.118). Femur T-score level, of phytoestrogens group at the beginning of the study was -1.415±0.215, after 6 months it became -1.270±0.141 with change of 0.145±0.170 (p=0.001). In placebo group, the average of femur T-score was -1.475±0.202 becoming -1.595±0.421 with of decrease -0.120±0.33 (p=0.124). The status of spine and femur T-score BMD both in, phytoestrogens and placebo group was osteopenia at the beginning of the study. After 6 months, spine T-score in phytoestrogens group did not change, and in placebo group, 2 subject showed osteoporosis with spine T-score and femur T-score -2.7 and -2.75(±0.212).Conclusions: The administration of phytoestrogens is able to maintain bone mineral density and prevent the occurrence of osteoporosis.Keywords: Phytoestrogens, BMD, T-score, menopauseABSTRAK Fitoestrogen genistein dan black cohosh dan penanda BMD pada perempuan menopauseLatar belakang: Di Indonesia, fitoestrogen beredar di pasaran sebagai suplemen untuk mengatasi keluhan klimakterik dan osteoporosis. Fitoestrogen ini belum terbukti secara ilmiah bermanfaat untuk mengatasi keluhan klimakterik maupun osteoporosis pada perempuan menopause. Oleh karena itu uji klinik ini dilakukan untuk mencari data guna mengetahui meningkatnya gambaran BMD.Metode: Desain adalah uji klinik berpembanding dalam bentuk add on, secara tersamar ganda di RS Dr. Mohammad Hoesin Palembang bulan Agustus 2010 sampai dengan Februari 2011 pada subyek yang dibagi dalam kelompok fitoestrogen dan placebo secara acak. Variabel yang diukur adalah skor T tulang vertebra dan femur menggunakan bone densitometer sebelum dan setelah 6 bulan mendapat suplemen.Hasil: Pada awal penelitian rerata T-skor tulang belakang kelompok fitoestrogen -1,455±0,264 setelah 6 bulan menjadi -1,295±0,223 dengan perubahan 0,160 ± 0,153 (p=0,001). Sedangkan kelompok plasebo rerata T-skor tulang belakang pada awal penelitian -1,295±0,223 menjadi -1,560±0,414 dengan penurunan -0,100±0,273 (p=0,118). Pada kadar T-skor femur, di awal penelitian kelompok fitoestrogen -1,415±0,215 setelah 6 bulan menjadi -1,270±0,141 dengan besaran perubahan 0,145±0,170 (p=0,001). Pada kelompok plasebo rerata T-skor femur pada awal penelitian -1,475±0,202 menjadi -1,595±0,421 dengan perubahan -0,120±0,33 (p=0,124). Status BMD T-skor tulang belakang dan femur di awal penelitian, kelompok fitoestrogen dan kelompok plasebo adalah osteopeni. Setelah 6 bulan kemudian, pada kelompok fitoestrogen tidak terdapat perubahan status BMD sedangkan pada kelompok plasebo terdapat 2 orang yang densitas mineral tulangnya mengalami perubahan menjadi osteoporosis dengan rerata T-skor tulang belakang -2,70 dan T-skor femur -2,750 ± 0,212.Simpulan: Pemberian fitoestrogen dapat mempertahankan densitas mineral tulang dan mencegah terjadinya osteoporosis.
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4274
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 132-137
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4274/3895
oai:ojs.ejournal.undip.ac.id:article/4300
2013-01-02T11:34:34Z
mmi:ART
Estimating The Annual Cost of Smoking-Related Diseases in Indonesia
Sutrisna, Bambang
Surtidewi, Lujna
Jusuf, Anwar
Hudoyo, Ahmad
Kusmana, Dede
Setianto, Budhi
Purwaningsih, Endang
Smoking-related diseases, Annual cost, Indonesia.
Background: Smoking plays a role in the development of chronic diseases and causes substantial negative economic consequences. This study was carried out to estimate the annual cost of smoking-related cardio-cerebrovascular and pulmonary diseases in the population by taking into account the direct costs associated with such co-morbid conditions in Indonesia.Methods: Meta-analysis using the Mix-Programme Software of the data of patients from university medical centers who were active smokers for more than a year and more than 20-pack years or passive smokers for more than a year and diagnosed with Coronary Heart Disease, Myocardial Infarction, Stroke, COPD, Chronic bronchitis, or Lung Cancer had been conducted. Annual direct cost was taken into account using the Decision Analysis Tree Age Pro (=DATA) software; cost data related to health care expenditure were derived from secondary data sources in Jakarta. In addition, Population Attributable Risk (PAR) for each comorbid conditions was calculated based on published epidemiological data from local and international journals.Results: One-hundred and eighty-seven patients (96% male) satisfying the inclusion criteria, were analyzed, of whom confirmed diagnosis of Stroke was amongst 29% of the patients, CHD 16%, Myocardial Infarction 16%, Lung Cancer 15%, COPD 17%, and Chronic Bronchitis 7%. Mean direct annual cost was highest for Lung Cancer (Rp 51.6 million) followed by Myocardial infarction (Rp 38.5 million) and CHD (Rp 37.8 million); PAR for various co-morbid conditions (based on variations in relative risk and smoking prevalence estimates) were: Stroke ~16%-26%, CHD ~17%-27%, MCI ~ 22%-33%, Lung Cancer ~ 17%-26%, COPD ~ 13%-21%, Chronic Bronchitis ~ 42%-59%.Conclusions: Annual cost of smoking-related diseases in Indonesia has been estimated. The highest cost is for Lung Cancer. The highest PAR is for Chronic Bronchitis.Keywords: Smoking-related diseases, Annual cost, Indonesia. ABSTRAKEstimasi pembiayaan per tahun penyakit terkait merokok di IndonesiaLatar belakang: Merokok berkaitan dengan kejadian berbagai penyakit kronis dengan konsekuensi ekonomi berupa biaya yang sangat banyak. Penelitian ini bertujuan untuk mengestimasi biaya dampak merokok pada berbagai kondisi ko-morbid terkait penyakit jantung, otak dan paru di masyarakat Indonesia.Metode: Meta-analisis dengan Mix-Programme software pada data sekunder penderita penyakit jantung iskemik, infark miokard, stroke, COPD, bronkitis kronis atau kanker paru dari Rumah Sakit Pendidikan Jakarta dengan kriteria : perokok aktif lebih 1 tahun dan merokok lebih 20 pak/tahun atau perokok pasif lebih 1 tahun. Cost-analysis dengan Tree Age Pro (=DATA) software dilakukan untuk membandingkan pengeluaran/biaya pengobatan per tahun menurut berbagai ko-morbid. Population Attributable Risk (PAR) untuk kondisi ko-morbid merujuk perhitungan yang ada pada jurnal epidemiologi lokal maupun internasional.Hasil: Seratus delapan puluh tujuh=187 pasien (96% laki-laki) memenuhi kriteria inklusi; diantaranya 29% pasien menderita stroke, 16% penyakit jantung iskemik, 16% infark miokard, 15% kanker paru, 17% COPD, dan bronkitis kronis 7%. Rerata pengeluaran biaya per tahun tertinggi adalah kanker paru (Rp 51,6 juta), diikuti penyakit jantung iskemik (Rp 37,8 juta); dan infark miokard (Rp 38,5 juta). PAR untuk masing-masing kondisi komorbid sebagai berikut: stroke 16-26%, penyakit jantung iskemik 17-27%, infark miokard 22-33%, kanker paru 17- 26%, COPD 13-21%, dan bronkitis kronis 42-59%.Simpulan: Pengeluaran biaya per tahun tertinggi untuk penyakit terkait dampak merokok adalah kanker paru-paru dan bila PAR terbesar pada bronkitis kronis.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4300
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009; 247-253
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4300/3922
oai:ojs.ejournal.undip.ac.id:article/11369
2016-07-01T11:39:54Z
mmi:ART
Pengaruh Pemberian Ekstrak Phyllanthus niruri Linn Terhadap Infiltrasi Limfosit dan Ekspresi Perforin pada Kanker Kolon Tikus Sprague-Dawley
Sawitri, Endang
Riwanto, Ign.
Tjahjono, Tjahjono
Dharmana, Edi
ABSTRACTThe effect of Phyllanthus niruri Linn extract on lymphocytes infiltration and perforin expression in colon cancer of Sprague-Dawley RatBackground: Colon cancer treatment currently involves immunotherapy that aims to improve the quality of life and survival of patients. Phyllanthus niruri Linn (P. niruri L) may act as an immunomodulator, but its potency in antitumor immune responses has not been revealed. The study was conducted to evaluate the differences between the immunological status of rats suffering colon cancer which were not given to those given the extract of P. niruri L.Methods: The study was randomized posttest-only control group design. Samples were 30 Sprague-Dawley male rats, bodyweight 170-220 gr which induced by 1.2 DMH 30 mg/kgBW subcutaneously. On the weeks 9, 11 and 13, four induced rats each week were sacrified to detect the development of colon cancer. On the weeks of 13th all of 4 rats were developed colon cancer, so the induction were stopped. The rest of 18 induced rats were randomly into two groups: without P. niruri L or positive control (K+)=9 rats and given P. niruri L extract 13.5 mg/kg orally or X group=9 rats. After 19th week all of rats were then terminated and tumor lesion of colon were processed hystophatologically. The tissues of colon cancer were stained by H&E for evaluate the lymphocytes infiltration and immunohistochemistry monoclonal antibody anti-perforin for perforin expression. Non pairs t-test was used with considered significant if p<0.05.Results: The mean of lymphocytes infiltration of the group X was 401.89±70.19, it was higher compared to K+ 191.89±50.68 (p=0.000). The mean percentage of perforin expression of group X was 39.00±1.80%, it was higher compared to K+ 23.00± 3.00% (p=0.000). Conclusion: The extract of P. niruri L increases immunologic status through mechanism of lymphocytes infiltration and perforin expression elevation of colon cancer in animal mode.Keywords : Phyllanthus niruri Linn, colon cancer, lymphocytes infiltration, perforinABSTRAKLatar belakang: Penanganan kanker kolon saat ini melibatkan imunoterapi yang bertujuan untuk meningkatkan kualitas hidup dan survival penderitanya. Phyllanthus niruri Linn bekerja sebagai imunomodulator, tetapi potensinya dalam respons imun antitumor belum banyak diungkap. Penelitian bertujuan untuk mengevaluasi perbedaan status imunologis antara tikus coba yang menderita kanker kolon yang tidak diberi dengan yang diberi ekstrak P. niruri L.Metode: Penelitian ini merupakan randomized posttest-only control group design. Sampel berupa 30 ekor tikus Sprague-Dawley jantan, yang diinduksi 1,2 DMH 30 mg/kgBB subkutan sekali setiap minggu. Pada minggu ke-9, 11 dan 13 masing-masing empat ekor tikus dimatikan untuk melihat perkembangan tumor. Minggu ke-13 pada kolon empat tikus telah tumbuh kanker kolon, sehingga induksi dihentikan dan sisa 18 tikus dirandom alokasi menjadi 2 kelompok. Kelompok kontrol positif (K+) tanpa pemberian P. niruri L (9 tikus) dan kelompok diberi P. niruri L. 13,5 mg/kg per hari melalui sonde (9 tikus). Minggu ke-19 semua tikus diterminasi, lesi tumor pada kolon diproses menjadi sediaan histopatologik, kemudian dipulas dengan H&E untuk memeriksa infiltrasi limfosit dan pulasan imunohistokimia menggunakan antibodi monoklonal anti-perforin untuk melihat ekspresi perforin. Analisis data menggunakan uji t tidak berpasangan dengan derajat signifikansi p<0,05.Hasil: Rerata jumlah infiltrasi limfosit kelompok X adalah 401,89±70,19 lebih tinggi dibanding kelompok K+ yaitu191,89±50,68 (p=0,000). Persentase rerata ekspresi perforin kelompok X sebesar 39,00±1,80%, lebih tinggi dibandingkan dengan K+ yakni 23,00±3,00% (p=0,000).Simpulan: Ekstrak P. niruri L meningkatkan status imunologi melalui mekanisme peningkatan infiltrasi limfosit dan ekspresi perforin untuk melawan kanker kolon pada tikus coba
MEDIA MEDIKA INDONESIANA
2016-07-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/11369
MEDIA MEDIKA INDONESIANA; 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/11369/8855
oai:ojs.ejournal.undip.ac.id:article/21832
2019-01-25T14:21:02Z
mmi:ART
Kadar IFN-γ (fungsi TH-1 CD4+) dan IL-4 (Fungsi TH-2 CD4+) pada Penderita Artritis Lepra
Hadi, Suyanto
Triyuliati, Triyuliati
TH-1 CD4+ and TH-2 CD4+ lymphocyte; IFN-γ, IL-4; and leprosy arthritis
The correlation between IFN-γ (TH-1 CD4+ function) and IL-4 level (TH-2 CD4+ function) in leprosy arthritisBackground: It was hypothesized by some expertise that there is a negative correlation between TH-1 CD4+ function (IFN- level) and TH-2 CD4+ function (IL-4 level) in rheumatoid arthritis and lupus pathogenesis (Leader). The correlation between IFN-γ level and IL-4 level in the leprosy arthritis has never been reported. The objective of the study is to evaluate the correlate between IFN- and IL-4 level in leprosy arthritis. Method: The correlation between IFN- level (pg/ml) and IL-4 level (pg/ml) were analysed after stimulated with several M. leprae Ag. (10 kDa, 35 kDa, and MLSA 2 ug/ml) on the peripheral blood lymphocyte culture of leprosy arthritis patients (n=22) (RPMI 1640 sigma). The study was carried out at Hayati Laboratory Gajah Mada University. The Spearman correlation test was used in analysis.Result: There were no significant correlations between IFN- and IL-4 level given 3 different numbers of M. leprae with r1=-0.32, r2=0.262, and r3=0.324 with p1=0.888, p2=0.238, and p3=0.747 respectively of Spearman test on arthritis leprosy group. Conclusion: There is no correlation between IFN- and IL-4 level in leprosy arthritis patients.ABSTRAKLatar belakang: Dihipotesiskan oleh para ahli adanya korelasi negatif antara fungsi limfosit TH1CD4+ (kadar IFN- pg/ml) dan limfosit TH-2 CD4+ (kadar IL-4 pg/ml) pada artritis reumatoid dan lupus eritematosus sistemik (Leader). Korelasi kadar IFN-γ (pg/ml) dan kadar IL-4 (pg/ml) pada artritis lepra belum pernah dilaporkan. Penelitian ini bertujuan untuk mengevaluasi korelasi antara kadar IFN- dan IL-4 pada penderita artritis lepra.Metode: Metode penelitian yang dipergunakan adalah belah lintang. Dilakukan analisis hubungan kadar IFN- (pg/ml) dan IL-4 (pg/ml) pada kultur limfosit darah perifer (RPMI 1640 sigma) penderita artritis lepra pasca stimulasi beberapa Ag M. leprae (10 kDa, 35 kDa, dan MLSA 2 ug/ml). Kultur limfosit darah dilakukan di Laboratorium Hayati FK UGM Yogyakarta. Dilakukan uji korelasi dengan Spearman. Hasil: Tidak terdapat korelasi antara kadar IFN- (pg/ml) dengan kadar IL-4 (pg/ml) setelah distimulasi dengan dosis berbeda, dengan nilai r1=-0,32, r2=0,262, dan r3=0,324 berturut-turut disertai nilai p1=0,888, p2=0,238, dan p3=0,747 dengan uji korelasi Spearman. Simpulan: Tidak terdapat korelasi antara kadar IFN-γ dengan IL-4 pada kultur limfosit darah perifer penderita artritis lepra
MEDIA MEDIKA INDONESIANA
2010-04-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21832
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010; 44-48
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21832/14588
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3250
2012-04-20T08:04:04Z
mmi:ART
Kadar Merkuri pada Rambut Masyarakat di Sekitar Penambangan Emas Tanpa Ijin
DH, Andri
Anies, Anies
H, Suharyo
Illegal gold mining, length of stay, fish consumption, mercury concentration
ABSTRACTHair mercury concentration in community living sourrounding the illegal gold miningBackground: Higher mercury concentration in the hair surrounding of illegal gold mining communities occurred due to mercury exposed continuously in a long time. The purpose of this research was to identify the risk factors affecting the mercury concentration of the community hair living in the illegal gold mining activity.Methods: The study was a case control study. Subject were people living around the Mandor’s river consisting of 68 families (34 cases and 34 controls). Data collection was done through structured interviews, observation, depth interviews, and examination of the rate of mercury in the laboratory for hair samples. Data were analyzed by chi-square test and logistic regression.Results: There were significant relationship between length of stay when (p=0.003), house distance (p=0.002), employment(p=0.004), a water source (p=0.004), habit of bathing in river (p=0.015) and consumption of local fish (p=0.007) with mercury level in the hair. Variable local vegetable consumption and nutritional status do not have a significant influence on the rate of mercury in hair with (p=0.330) and (p=0.500). The risk for mercury level in the hair above the thresholds were the length of stay ≥15 years (OR=7.07; 95% CI=2.12-23.57) and consumption of local fish >3 times/weeks (OR=6.14; 95% CI=1.86-20.30), with a probability of 89.3%.Conclusion: Risk factors for the occurrence of mercury in the hair above the threshold is the length of stay ≥15 years andconsumption of local fish >3 times/weeks. Therefore it recommended to relocate house away from the river and decrease the consumption of Mandor’s river fish.Keywords: Illegal gold mining, length of stay, fish consumption, mercury concentrationABSTRAKLatar belakang: Aktivitas penambangan emas tanpa ijin (PETI) yang menggunakan merkuri untuk proses amalgamasi akanberakibat meningkatnya kadar merkuri pada perairan. Meningkatnya kadar merkuri pada rambut masyarakat di sekitar aktivitas PETI terjadi karena paparan merkuri yang berlangsung terus menerus dalam waktu yang lama. Penelitian ini bertujuan untuk memperoleh informasi tentang faktor risiko yang berpengaruh terhadap kadar merkuri pada rambut masyarakat yang tinggal di sekitar aktivitas PETI.Metoda: Penelitian ini merupakan penelitian observasional dengan rancangan case control. Sampel penelitian adalah masyarakat yang tinggal di sekitar aliran sungai Mandor dengan sampel 68 kepala keluarga (34 kasus dan 34 kontrol) di wilayah kecamatan Mandor. Pengumpulan data dilakukan dengan wawancara terstruktur, observasi, wawancara mendalam, dan pemeriksaan kadar merkuri di laboratorium untuk sampel rambut. Data dianalisis dengan uji chi-square dan regresi logistik.Hasil: Terdapat hubungan yang signifikan antara lama tinggal (p=0,003), jarak tempat tinggal (p=0,002), jenis pekerjaan(p=0,004), sumber air bersih (p=0,004), kebiasaan mandi (p=0,015) dan konsumsi ikan hasil setempat (p=0,007) dengan kadar merkuri pada rambut. Variabel konsumsi sayuran setempat dan status gizi tidak memiliki hubungan yang signifikan dengan kadar merkuri pada rambut masing-masing dengan (p=0,330) dan (p=0,500). Variabel yang berisiko terjadinya kadar merkuri pada rambut melebihi ambang batas adalah lama tinggal ≥15 tahun (OR=7,07; 95%CI=2,12–23,57) dan konsumsi ikan hasil setempat >3 kali per minggu (OR=6,14; 95% CI=1,86-20,30), dengan nilai probabilitas sebesar 89,3%.Simpulan: Berdasar hasil tersebut disimpulkan bahwa yangmerupakan faktor risiko terjadinya kadar merkuri pada rambut melebihi ambang batas adalah lama tinggal ≥15 tahun dan mengkonsumsi ikan hasil setempat >3 kali per minggu. Oleh karena ini disarankan untuk mengurangi konsumsi ikan yang berasal dari sungai Mandor dan merelokasi rumah jauh dari sungai Mandor
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3250
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 181-187
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3250/2918
oai:ojs.ejournal.undip.ac.id:article/3235
2012-04-18T11:17:19Z
mmi:ART
Senyawa Aktif Sayuran Cruciferae dan Perubahan Kadar Kolesterol serta Vitamin C pada Tikus Hiperkholesterolemia
Sunarsih, Endang Sri
Hakim, Lukman
Sugiyanto, Sugiyanto
Sumantri, Sumantri
Cruciferae, indole, TLC, cholesterol, vitamine C
ABSTRACTActive compounds of cruciferae family and the change of total cholesterol level and vitamine C in hipercholesterolaemic ratsBackground: Cauli flower is a member of the Cruciferae family. One of the active compound content of indole-3-carbinol, is used to prevent and treat cancer. Vitamine C in the cauli flower as an antioxidant is able to avert free radicals that are formed in aerobic organisms and hipercholesterolaemic condition. The study aimed to determine the active compounds contained in the of cauli flower and its role in changing of the lipid profile and vitamine C levels in hipercholesterolaemic rats.Methods: To identify up the active compounds of cauli flower by maceration repeately, with alcohol: ammoniak (19:1). The results were determinated by thin layer chromatography (TLC). Spotting results obtained were compared with standard spots in its color reaction and Rf spots with Rf standard samples. Twenty rats were divided into 4 groups, and made hipercholesterolaemic, group I as a negative control, group II as a positive control were given green tea 0.605 g/kgBW, group III-IV were given cauli flower juice for 14 days dose of 10 and 15 ml/kgBW, the blood were analyzed for total cholesterol level and vitamine C plasma.Results: Cauli flower active compounds are indole-3-carbinol, indole-1-3-carbinol, indole-3-carboxylic acid and sulforafan they were capable of decreasing total cholesterol levels to 45%, and increasing plasma vitamine C level by 55% compared to before treatment.Conclusion: Cauli flower contains 4 indoles, and is able to decrease total cholesterol and increase vitamine C plasma in hipercholesterolaemic rats.Keywords: Cruciferae, indole, TLC, cholesterol, vitamine CABSTRAKLatar belakang: Bunga kubis, termasuk keluarga Cruciferae. Salah satu kandungan senyawa aktifnya indol-3-karbinol, mampu mencegah dan mengobati penyakit kanker. Vitamin C yang terdapat di dalam bunga kubis sebagai antioksidan mampu menangkal radikal bebas yang terbentuk pada organisme aerobik, kondisi hiperkolesterolemia. Penelitian ini bertujuan untuk mengetahui senyawa aktif yang terkandung dalam bunga kubis (Brassica Oleracea var Botrytis L) dan perannya dalam mengubah profil lipid dankadar vitamin C pada tikus hiperkolesterolemia.Metode: Untuk menyari senyawa aktif bunga kubis dilakukan macerasi berulang, dengan alkohol: ammoniak (19:1). Hasil penyarian dilakukan penetapan senyawa aktif secara kromatografi lapis tipis (KLT). Hasil bercak yang diperoleh dibandingkan dengan bercak standar dengan membandingkan reaksi warna dan Rf bercak sampel dengan Rf standar.Untuk mengamati efek farmakologi, 20 ekor tikus dibagi menjadi 4 kelompok, dibuat hiperkolesterolemia, kelompok I sebagai kontrol negatif, kelompok II sebagai kontrol positif diberi teh hijau 0,605 g/kgBB, kelompok III-IV diberi jus bunga kubis bunga selama 14 hari dosis 10 ml/kgBB dan 15 ml/kgBB, data darah dianalisis kadar kholesterol total serum dan vitamin C plasma.Hasil: Bunga kubis (Brassica Oleracea var Botrytis L) mengandung senyawa aktif: indol-3-karbinol, indol-1-3-karbinol, indol-3- asam karboksilat dan sulforafan yang mampu menurunkan kadar kolesterol total serum sampai 45% dan meningkatkan kadar vitamin C plasma sampai 55% dibanding sebelum perlakuan.Simpulan: Bunga kubis mengandung 4 senyawa indol dan mampu menurunkan kolesterol total serum dan meningkatkan vitamin C plasma pada tikus hiperkolesterolemia
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3235
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 151-157
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3235/2907
oai:ojs.ejournal.undip.ac.id:article/3808
2012-07-18T11:01:43Z
mmi:ART
Penentuan Kadar Spesi Yodium dalam Garam Beryodium yang Beredar di Pasar dan Bahan Makanan Selama Pemasakan dengan Metode Kromatografi Cair Kinerja Tinggi-Pasangan Ion
Cahyadi, Wisnu
iodized salt, foodstuffs, iodine species, iodine stability and HPLC-Ion Pair
ABSTRACTDetermination of Iodine Species Content in Commercials Iodized Salt and Foodstuffs During Cooking By Ion Pair HPLC MethodBackground: Iodine deficiency disorders (IDD) is still a major public health problem in several areas of the world, especially in developing countries. The stability of iodine will be influenced by food type, water content and temperature during cooking. The objectivse of the study was to determine iodine species in iodized salt and food. The benefit of the study was expected to answer the controversy problem about iodine losses in iodized salt and foodstuff.Methods: The study method used descriptive design (survey and intake samples, sample preparation and condition of appliance, making of standards solution, and analysis of iodine species), sampling method (purposif), and the analyse design (linear regression equation) , while analysis method was used by ion pair-HPLC.Results: The study revealed that iodine and iodate of iodized salt products fulfilled the requirement containing 30-80 mg kg-1. There different ways of adding iodized salt which were before, during and after cooking resulting highest reduction of iodine content in the first method (68,2%-61,9%) and the lowest in the last method (19,5%).Conclusion: Addition or used of iodized salt into foodstuffs should be after cooking or before serving.Key Words : iodized salt, foodstuffs, iodine species, iodine stability and HPLC-Ion PairABSTRAKLatar belakang: Kekurangan yodium masih menjadi masalah besar di beberapa negara di dunia, khususnya negara-negara berkembang. Kestabilan yodium akan dipengaruhi oleh jenis makanan, kandungan air dan suhu pemanasan pada saat pemasakan. Tujuan penelitian adalah menentukan kadar spesi yodium dalam garam beryodium yang beredar di pasar dan bahan makanan selama pemasakan. Manfaat Penelitian ini diharapkan dapat menjawab masalah perbedaan pendapat tentang hilangnya yodiumdalam garam beryodium dan bahan makanan.Metode: Metode penelitian yang digunakan adalah rancangan deskripsi (survei pasar dan pengambilan sampel, preparasi sampel dan pengkondisian alat, pembuatan larutan standar, dan pengujian kandungan spesi yodium dalam berbagai sampel), metode sampling (purposif), dan rancangan analisis (persaman regresi linier), sedangkan metode analisis yang digunakan adalah kromatografi cair kinerja tinggi-pasangan ion.Hasil: Hasil penelitian menunjukkan kadar spesi yodium (iodida dan iodat) dari 15 produk garam beryodium (dengan merk yang berbeda) yang beredar di pasar telah memenuhi persyaratan yaitu sebesar 30-80 mg kg-1. Tiga cara penambahan garam beryodium ke dalam sediaan makanan yaitu sebelum pemasakan, pada saat pemasakan dan siap saji, menunjukkan hasil persentase penurunan iodat tertinggi dengan cara penambahan sebelum pemasakan yakni sebesar 68,20% s/d 61,90% dan yang terkecil dengan carapenambahannya saat siap saji yaitu 19,5%.Simpulan: Cara penambahan atau penggunaan garam beryodium ke dalam makanan sebaiknya dilakukan setelah pemasakan atausiap saji.
MEDIA MEDIKA INDONESIANA
2012-07-16
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3808
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 1 Year 2008; 22-29
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3808/3492
oai:ojs.ejournal.undip.ac.id:article/4036
2012-09-20T12:11:18Z
mmi:ART
Pengaruh Media Kontras Iopamidol Dosis Tinggi Intravaskuler Terhadap Kadar Kreatinin Serum dan Gambaran Histopatologi Tubulus Ginjal pada Tikus Sprague-Dawley: Upaya Proteksi dengan L-arginin
Sukmaningtyas, Hermina
Trihadi, Djoko Untung
Iopamidol, serum creatinine, acute tubular necrosis, L-arginine
High dose intravascular iopamidol influence on serum creatinine level and histopatologic feature of kidney tubules in Sprague-Dawley rats: using L-arginine as protectionBackground: Iopamidol, a Low Osmolar Contrast Media (LOCM), has relatively less nephrotoxicity, but contrast media (CM) volume has role to develop acute renal failure even in healthy person. L-arginine as a natural precursor of nitric oxide might prevent contrast nephropathy. Objectives: To investigate effects of iopamidol on acute renal damage by observing serum creatinine level and acute renal necrosis and to assses the role of L-arginine to protect acute renal failure.Methods: This was a post test only control group design experimental study using 35 male, twelve weeks old Sprague-Dawley rats, weighing 200-350 g, allocated into seven groups. The control group (K), P1, P2, P3 were group given 1.8 ml iopamidol and P4, P5, P6 groups were given 8.4% (W/V) L-arginine personde twice a day, 5 ml each for 7 days before 1.8 ml iopamidol injection. Serum creatinine and histological examination were done to assess acute tubular necrosis with H&E staining observed on 24, 48, and 72 hour accordingly. Dose of iopamidol used was equal to 100 ml human dose. The difference of serum creatinine and acute tubular necrosis were analyzed by using ANOVA test.Results: There were no significant differences among groups on serum creatinine level (p=0.261). Acute tubular necrosis increased following iopamidol administration in 72 hour (P3) p=0.007, and pretreatment with L-arginin reduced necrosis in group P6 (p=0.008).Conclusions: Serum creatinine level was not different after administration of iopamidol and L-arginine. Iopamidol induce acute tubular necrosis, while L-arginine can prevent CM-induced nephropathy. Keywords: Iopamidol, serum creatinine, acute tubular necrosis, L-arginine ABSTRAK Latar belakang: Iopamidol, media kontras osmolalitas rendah mempunyai efek nefrotoksik relatif rendah, tetapi pemakaian dosis tinggi merupakan faktor resiko nekrosis tubuler akut. L-arginin, asam amino prekursor NO dan sebagai antioksidan dapat mencegah contrast-induced nephropaty.Tujuan: Mengetahui pengaruh iopamidol terhadap perubahan kadar kreatinin serum dan gambaran nekrosis tubuler akut, serta melihat pengaruh L-arginin terhadap penurunan kejadian contrast-induced nephropaty.Metode: Penelitian eksperimental sesungguhnya dengan rancangan post test only control group design pada tikus Sprague-Dawley jantan, sehat, umur 12 minggu, berat badan 200-350 g. Sebanyak 35 ekor tikus dibagi secara acak menjadi 7 kelompok. Kelompok K, tidak mendapatkan perlakuan, P1, P2, P3 diberi iopamidol 1,8 cc intravena. Kelompok P4, P5, P6 diberi L-arginin 8,4 w/v 2x sehari masing-masing 5 ml selama 7 hari, sebelum disuntik iopamidol 1,8 ml intravena. Kadar kreatinin serum dan pemeriksaan nekrosis tubuler akut diperiksa secara histopatologi dengan pengecatan H&E pada jam ke-24, jam ke-48, jam ke-72 sesuai dengan kelompok perlakuan. Dosis iopamidol setara dengan 100 ml pada dosis manusia. Perubahan kadar kreatinin serum dan nekrosis tubuler akut diuji dengan uji ANOVA.Hasil: Kadar kreatinin serum tidak berbeda di antara kelompok (p=0,261). Pemberian iopamidol menyebabkan nekrosis tubuler akut pada jam ke-72 (p=0,007), dan pemberian L-arginin menurunkan nekrosis tubuler akut pada jam ke-72 (p=0,008). Simpulan: Iopamidol dosis tinggi dapat menginduksi nekrosis tubuler akut pada keadaan tanpa resiko, dan pemberian L-arginin dapat mencegah contrast-induced nephropathy. Kadar kreatinin serum tidak berbeda setelah pemberian iopamidol maupun L-arginin.
MEDIA MEDIKA INDONESIANA
2012-07-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4036
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 3 Year 2008; 138-147
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4036/3708
oai:ojs.ejournal.undip.ac.id:article/4269
2013-06-26T12:59:31Z
mmi:ART
Pajanan Pestisida Sebagai Faktor Risiko Hipotiroidisme pada Wanita Usia Subur di Daerah Pertanian
Suhartono, Suhartono
Djokomoeljanto, RRJ. Sri
Hadisaputro, Suharyo
Subagio, Hertanto Wahyu
Kartini, Apoina
Suratman, Suratman
Pesticide exposure, risk factor, hypothyroidism, women at childbearing age, agricultural area
Pesticide exposure as a risk factor for hypothyroidism in women at childbearing age in agricultural areasBackground: Hypothyroidism in women at childbearing age (WCA) will cause reproduction disorder, i.e. infertility, spontaneous abortion, impaired growth and development of foetus, placental abruption, and preterm delivery. Pesticide exposure is suspected to cause hypothyroidism. The research objective is to prove that pesticide exposure is a risk factor for hypothyroidism among WCA in agricultural areas.Methods: Case-control studies were used as study designs. Study subjects were 44 WCA as cases and 45 WCA as controls. Pesticide exposure was measured by asking WCA’s involvement in agricultural activities using structured questionnaire and by checking their levels of cholinesterase. Hypothyroidism was determined based on the results of TSH, FT4, and T3 level. Confounding variables were also measured. These variables were age, body mass index (BMI), participation in hormonal contraception, liver function, urinaryiodine excretion, urinary thiocyanate level and blood lead level. Chi-square test, OR (95% CI), and multivariate logistic regression were implemented to test the hypothesis.Results: Pesticides exposure is a risk factor for hypothyroidism (crude-OR=3.04; 95% CI=1.20-7.81; nilai p=0.033 and adjusted OR=3.31, 95% CI=1.25 to 8.78, p=0.016). The higher the degree of exposure, the greater the risk of having hypothyroidism.Conclusion: Pesticides exposure is a risk factor for hypothyroidism among WCA in agricultural areas.Keywords: Pesticide exposure, risk factor, hypothyroidism, women at childbearing age, agricultural areaABSTRAKLatar belakang: Hipotiroidisme pada kelompok wanita usia subur (WUS) dapat menyebabkan gangguan reproduksi, seperti infertilitas, abortus spontan, gangguan tumbuh-kembang janin, dan kelahiran prematur. Pajanan pestisida dapat mengganggu fungsi tiroid. Tujuan penelitian adalah membuktikan bahwa pajanan pestisida merupakan faktor risiko hipotiroidisme pada WUS di daerah pertanian.Metode: Desain penelitian yang digunakan adalah kasus-kontrol. Subyek penelitian adalah 44 WUS sebagai kasus dan 45 sebagai kontrol. Pajanan pestisida diukur menggunakan kuesioner dan pemeriksaan kadar kolinesterase. Kejadian hipotiroidisme diukur menggunakan parameter kadar TSH, FT4 dan T3. Variabel perancu yang diukur meliputi umur, indeks massa tubuh (IMT), penggunaan KB hormonal, fungsi hati, ekskresi yodium urin, kadar tiosianat urin, dan kadar Pb darah. Uji hipotesis yang digunakanadalah uji Chi-square, uji OR (95%CI), dan regresi logistik multivariat.Hasil: Pajanan pestisida merupakan faktor risiko hipotiroidisme pada WUS di daerah pertanian (crude-OR=3,04; 95%CI=1,20- 7,81; nilai p=0,033 dan adjusted OR=3,31; 95%CI=1,25-8,78; p=0,016). Semakin tinggi derajat pajanan pestisida, semakin besar risiko terjadinya hipotiroidisme.Simpulan: Pajanan pestisida merupakan faktor risiko kejadian hipotiroidisme pada WUS di daerah pertanian.
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4269
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 91-99
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4269/3890
oai:ojs.ejournal.undip.ac.id:article/4294
2012-12-29T12:08:17Z
mmi:ART
Gambaran IgG dan IgM Anti Phenolic Glycolipid–1 Mycobacterium leprae pada Siswa Pesantren Desa Wringin Jajar Kecamatan Mranggen Kabupaten Demak
Indrayanti, ES
Utama, Yuanita Dian
IgG, IgM Phenolic glycolipid, sub clinical of leprosy
IgG and IgM anti phenolic glycolipid–I mycobacterium leprae in pesantren students of Wringin Jajar village, Mranggen, DemakBackground: Sub clinical leprosy can be detected by IgM sera of anti phenolic glycolipid–I (PGL-1) value more than 600 u/ml. The prevalence data study of IgG and IgM sera anti PGL-I value in Indonesia are limited. Two leprosy patients have been reported on pesantren students of Wringin Jajar village, Mranggen District, Demak Regency.Methods: Enzyme linked immunosorbent assay (ELISA) was done to examine the IgG and IgM anti PGL-1 sera of the 44 pesantren students which have been contact which leprosy patients on Wringin Jajar, Mranggen Distric, Demak Regency.Results: The IgM anti PGL-1 sera value more than 600 u/ml (positive results) were on 33 of 41 students (80.5%), and the IgG anti PGL-1 sera value more than 150 u/ml were positive on 15 students (31.7%).Conclusions: The prevalence of sub clinic leprosy in pesantren students which have been contact with leprosy patients were high. Further studies are needed to preacut clinical leprosy outbreak.Keywords: IgG, IgM Phenolic glycolipid, sub clinical of leprosyABSTRAKLatar belakang: Lepra sub klinik dapat dideteksi dengan nilai IgM serum anti PGL-1 >600 iu/ml. Studi prevalensi serum antiPGL-1 di Indonesia masih terbatas. Dua penderita lepra telah dilaporkan pada siswa pesantren di Desa Wringin Jajar, Kecamatan Mranggen, Kabupaten Demak.Metode: Pemeriksaan nilai serum IgG dan IgM anti PGL-I dengan teknik enzyme linked immunosorbent assay (ELISA) dilakukan terhadap 44 siswa yang telah mengalami kontak dengan penderita lepra di desa Wringin Jajar, Mranggen Kabupaten Demak.Hasil: Hasil nilai IgM serum anti PGL-1 >600 u/ml terdapat pada 33 dari 41 (80,5%) siswa pesantren Desa Wringin Jajar, Kecamatan Mranggen, Kabupaten Demak. Sebaliknya IgG positif >150 u/ml positif pada 15 siswa (31,7%).Simpulan: Prevalensi lepra sub klinik siswa kontak penderita lepra positif di Pesantren Desa Wringin Jajar, Kecamatan Mranggen, Kabupaten Demak cukup tinggi. Studi lebih lanjut amat diperlukan untuk mencegah munculnya lepra secara klinis.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4294
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009; 220-223
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4294/3912
oai:ojs.ejournal.undip.ac.id:article/4577
2013-06-26T12:57:43Z
mmi:ART
Efek Ekstrak Etanol Morinda Citrifolia L (Mengkudu) Terhadap Kadar Gula Darah, Jumlah Neutrofil, dan Fibronektin Glomerulus Tikus Diabetes Mellitus
Kustarini, Indranilla
Dewi, Sri Sinto
M, Ika Pawitra
Morinda citrifolia, blood glucose, neutrophyl count, glomerular fibronektin
Ethanol extract of Morinda citrifolia L (mengkudu), blood glucose, neutrophyl count, and glomerulus fibronectin in diabetes mellitus ratBackground: Diabetes mellitus is a metabolic disease which caused by the present of insulin abnormality. Diabetes is shown by hyperglycemia to release free radical, superoxide, that induce oxidative stress. This stress will increase mesangial matrix production in glomerulus such as fibronectin. Ethanol extract Morinda citrifolia contain fenolat and flavonoid which have antioxidant system toblock the oxidative stress. This research purpose was to analyze the effect of ethanol extract Morinda citrifolia to blood glucose, neutrophyl count, glomerulus fibronectin of diabetes mellitus rats.Method: Using the post test only control group design, diabetic Sprague Dawley rats induced streptozotocin dose 40mg/kgBW, were divided into 4 groups of grading doses (10, 20, 40, 80mg/dl) of ethanol extract Morinda group and 1 control group. Each group used 6 male rat. Blood glucose, neutrophyl count and glomerular fibronectin were examined. Data analyze with Kruskall Wallis and ANOVA using SPSS ver 15.0Result: The mean of blood glucose before and after treating with extract ethanol Morinda were 553.04mg/dl and 408.81mg/dl respectively. Different score of neutrophyl count was p=0.0574 and fibronectin expression was p=0.000. Ethanol extract Morinda citrifolia can reduce blood glucose, and the fibronectin expression in glomerulus of diabetic rats significantly, but not for neutrophyl count. The lowest fibronectin expression occurred on dose 20 mg/dl.Conclusion: Extract ethanol Morinda citrifolia L (Mengkudu) improve diabetic nephtopathy through reducing blood glucose, netrophyl count, and fibronectin.Keyword: Morinda citrifolia, blood glucose, neutrophyl count, glomerular fibronektin ABSTRAKLatar belakang: Diabetes mellitus merupakan penyakit metabolik yang disebabkan karena adanya kelainan sekresi atau kerja insulin. Diabetes mellitus ditandai dengan adanya hiperglikemi, dimana pada kondisi ini akan melepaskan radikal bebas, superoksid, yang akan menyebabkan stres oksidatif, dengan akibat kerusakan sel baik sel neutrofil, sel mesangial ginjal yang akan mengeluarkan matrik ekstra sel berupa fibronektin. Ekstrak etanol Morinda citrifolia L memiliki kandungan fenolat dan flavonoid, dapat membantu sistem antioksidan dalam tubuh yang dapat mengatasi stres oksidatif. Penelitian ini bertujuan untuk menganalisis efek ekstrak etanol Morinda citrifolia L terhadap kadar gula darah, jumlah neutrofil, dan ekspresi fibronektin glomerulus tikus diabetes mellitus.Metode: Penelitian ini menggunakan pendekatan post test only control group design pada tikus Sprague Dawley yang diinduksi Streptozotozin (dosis 40mg/kgBB) sehingga menjadi DM, kemudian dikelompokkan menjadi 4 kelompok perlakuan ekstrak etanol Morinda citrifolia L (Mengkudu) dengan dosis 10, 20, 40, 80mg/dl dan 1 kelompok kontrol DM. Data dianalisis menggunakan uji Kruskal Wallis dan ANOVA dengan SPSS ver 15.0.Hasil: Rerata kadar gula darah sebelum 553,04 mg/dl dan sesudah diberi Morinda 408,81 mg/dl. Hasil menunjukkan perubahan jumlah neutrofil diperoleh nilai p=0,0574, dan ekspresi fibronektin glomerulus diperoleh nilai p=0,000. Ekstrak etanol Morinda citrifolia L menurunkan kadar gula darah dan ekspresi fibronektin secara bermakna, namun tidak bermakna pada jumlah neutrofil. Dosis 20 mg/dl merupakan dosis yang paling baik menurunkan ekspresi fibronektin glomerulus.Simpulan: Ekstrak etanol Morinda citrifolia L (Mengkudu) memperbaiki fungsi ginjal diabetes nefropati melalui penurunan gula darah, jumlah neutrofil dan fibronektin.
MEDIA MEDIKA INDONESIANA
2013-03-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4577
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012; 178-183
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4577/4169
oai:ojs.ejournal.undip.ac.id:article/21827
2019-01-25T14:21:01Z
mmi:ART
Hipotiroidisme pada Wanita Usia Subur (WUS) di Daerah Pertanian: Penelitian di Kecamatan Kersana Kabupaten Brebes
Suhartono, Suhartono
Djokomoeljanto, Sri
Hadisaputro, Suharyo
Subagio, Hertanto Wahyu
Kartini, Apoina
Hypothyroidism; women of childbearing age; agricultural areas
Background: Hypothyroidism can cause infertility, spontaneous abortion, fetal growth-development disorders, placental abruption and prematurity. Exposure to pesticides, both of organochlorines and organophosphate, can cause hypothyroidism. The aim of the study was to examine the prevalence of hypothyroidism in WCA in agricultural areas.Methods: A cross-sectional study was conducted in two hundred and eight women of WCA who were randomly selected from four villages and TSH levels were examined. The TSH cut-off point for the diagnosis of hypothyroidism was 4.5 μIU/mL. In a sub-sample, fT4 levels, UEI and thiocyanate in urine, were also examined. Result: The mean level of TSH was 3.66 (±5.330) μIU/mL, the lowest value was 0.05, and the highest was 60 µIU/mL; the median was 2.38 μIU/mL; the mean FT 4 (n=89) was 16.207±3.0438 pmol/L; UEI median value (n=41) was 288.0 mcg/L; while the mean of urinary thiocyanate levels (n=41) was 1.468±1.25 mcg/mL. There were 47 WCA (22,6%) with hypothyroidism, 46 of which (97.9%) are sub-clinical hypothyroidism.Conclusion: The prevalence of hypothyroidism in WCA was 22.6% and almost all women had sub-clinical hypothyroidism. Pesticide exposure is suspected as a risk factor for hypothyroidism in this population.ABSTRAKLatar belakang: Hipotiroidisme merupakan keadaan, di mana kelenjar tiroid tidak dapat memproduksi hormon cukup untuk memenuhi kebutuhan tubuh. Pada WUS, hipotiroidisme dapat menyebabkan infertilitas, abortus spontan, gangguan tumbuh-kembang janin, placental abruption dan bayi lahir sebelum waktunya. Pajanan pestisida, baik dari golongan organoklorin maupun organofosfat, dapat menyebabkan hipotiroidisme. Penelitian ini bertujuan mengkaji berapa besar prevalensi hipotiroidisme pada WUS yang bertempat tinggal di daerah pertanian.Metode: Penelitian ini menggunakan desain cross-sectional. 208 WUS dipilih secara acak dari empat desa dan dilakukan pemeriksaan kadar TSH. Diagnosis hipotiroidisme ditegakkan berdasarkan kadar TSH 4,5 µIU/mL. Pada sebagian WUS (sub-sampel) dilakukan pemeriksaan kadar fT4, UEI dan kandungan tiosianat dalam urin. Hasil: Rerata kadar TSH adalah 3,66 (±5,330) µIU/mL, nilai terendah 0,05, nilai tertinggi 60 µIU/mL sedangkan median TSH 2,38 µIU/mL; rerata fT 4 (n=89) adalah 16,207±3,0438 pmol/L; nilai median UEI (n=41) adalah 288,0 µg/L; rerata kadar tiosianat urin (n=41) adalah 1,25±1,468 µg/mL. Didapatkan 47 WUS (22,6%) dengan hipotiroidisme, 46 di antaranya (97,9%) adalah hipotiroidisme sub-klinik.Simpulan: Prevalensi hipotiroidisme pada WUS sebesar 22,6%, hampir semuanya hipotiroidisme sub-klinik. Pajanan pestisida patut dicurigai sebagai faktor risiko pada WUS di daerah pertanian yang diteliti ini.
MEDIA MEDIKA INDONESIANA
2010-04-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21827
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010; 13-19
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21827/14583
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3247
2012-04-20T07:45:52Z
mmi:ART
Penilaian Fungsi Pribadi dan Sosial Sebelum dan Sesudah Mendapat Pengobatan pada Penderita Gangguan Jiwa Korban Pemasungan
Fitrikasari, Alifiati
Hediati, Titis
Shackled, stocks, schizophrenia, PSP scale
ABSTRACTAssessment of personal and social function in shackled mentally disorders patients before and after treatmentBackground: The deprivation of people suspected of suffering from psychiatric disorders is an act contrary to human rights. Action deprivation is a common practice in developing countries, including Indonesia. The absence of regulations, low levels of education, lack of understanding of the symptoms of psychiatric disorders, as well as economic limitations are factors determining the emergence of shackled events. The objective of this study is to know the differences in the level of personal ability and social function in persons being deprived of their life before and after treatment at the Mental Hospital (RSJ).Method: The study was an observational study conducted in Pekalongan, Pati, Jepara, Salatiga, and Blora, Central Java, which aimed to find out the level of social and personal values in patients with mental disorders being deprived. The method used was done to 27 shackled cases with the scale of the personal and social performance (PSP scale).Results: There were 21 men (77.7%) and 6 women (22.3%), and almost all were diagnosed as schizophrenia. All of them are from poor families. The period of restraint ranged from 8 months to 27 years. Based on PSP scale, 19 cases (70.4%) had a low value and as many as 8 cases (29.6%) were categorized as having better value. There was improvement in PSP scale of every case after being treated.Conclusion: Medical treatment improve the value of the PSP. Thus deprivation, bedside inhumane is also depriving mentally ill persons for having better quality of life.Keywords: Shackled, stocks, schizophrenia, PSP scaleABSTRAKLatar belakang: Pemasungan terhadap orang yang diduga mengidap gangguan kejiwaan merupakan tindakan yang bertentangan dengan HAM. Tindakan pemasungan merupakan gejala yang umum ditemukan di negara berkembang, termasuk di Indonesia. Ketiadaan aturan hukum, rendahnya tingkat pendidikan, keterbatasan pemahaman terhadap gejala gangguan kejiwaan, serta keterbatasan ekonomi merupakan faktor yang mendeterminasi munculnya kejadian pasung. Penelitian ini merupakan studi observasi awal yang dilaksanakan di Kabupaten Pekalongan, Pati, Jepara, Salatiga, Rembang, dan Blora Jawa Tengah yang bertujuan untuk mengetahui tingkat kemampuan nilai sosial dan pribadi pada penderita gangguan jiwa yang mengalami pemasungan. Tujuan dari penelitian ini untuk mengetahui perbedaan tingkat kemampuan fungsi pribadi dan sosial pada penderita jiwa yang mengalami pemasungan sebelum dan setelah dirawat di rumah sakit jiwa (RSJ) pada penderita yang dipasung dalamwilayah Provinsi Jawa Tengah.Metode: Metode yang digunakan adalah pemeriksaan fungsi pribadi dan sosial yang dilakukan terhadap 27 orang penderitagangguan jiwa yang di pasung dengan skala personal and social performance (PSP). Data disajikan secara deskriptif dan uji beda pada skala PSP sebelum dan sesudah pengobatan.Hasil: Didapatkan 21 pria (77,7%) dan 6 wanita (22,3%) dan hampir semua terdiagnosis sebagai skizofrenia. Semuanya berasal dari keluarga miskin. Masa pengekangan berkisar dari 8 bulan sampai 27 tahun. Didapatkan sebanyak 19 kasus (70,4%) yang mempunyai nilai PSP yang buruk dan sebanyak 8 kasus (29,6%) yang mempunyai nilai PSP sedang. Didapatkan perbedaan yang bermakna pada nilai PSP saat pasung dan setelah dirawat di RSJ.Simpulan: Pengobatan dapat memperbaiki nilai PSP, dengan demikian pemasungan selain merendahkan martabat manusia, menghilangkan kesempatan penderita gangguan jiwa untuk memiliki kualitas hidup yang lebih baik.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3247
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 1 Year 2011; 49-52
0126-1762
en
oai:ojs.ejournal.undip.ac.id:article/21904
2019-01-29T12:51:02Z
mmi:ART
Masalah Mental Remaja di Kota Semarang
Hartanto, Fitri
Selina, Hendriani
Emotional; behavioral; mental; adolescent; the strength and difficulties questionnaire (SDQ)
Adolescent mental problems in the city of Semarang Background: The gap between the child's physical, social and psychological in adolescence can cause mental problems in the form of emotional disturbance, behavior, resistant and depression. No data on the distribution of mental problems among adolescents in Semarang.Methods: Descriptive study with cross sectional approach conducted on 578 Junior High School Students who are spread in 5 Junior High School in Semarang. SDQ (the strength and difficulties questionnaire) measure tool were used in assessing their mental status, which is presented in a descriptive narrative.Results: In the domain of prosocial are 8.0% abnormal and 14.5% borderline, hyperactive domain are 4.9% abnormal and 5.9% borderline, emotional domain are 18.5% abnormal and 9.1% borderline, the domain of behavior are 13.9% abnormal and 15.7% borderline, and the domain of peer group are 3.8% abnormal and 20.6% borderline.Conclusion: The result of the assessment of mental problems adolescents in Semarang got emotional problems 18.5%, behavior 13.9%, the total difficulties 9.1%, 8.1% prosocial, hyperactivity 4.9%, and peer group 3.8%.ABSTRAKLatar belakang: Kesenjangan yang terjadi antara perkembangan fisik, sosial dan psikologik pada masa remaja dapat menyebabkan masalah mental berupa gangguan emosi, perilaku, serta depresi. Belum ada data tentang distribusi masalah mental pada remaja di Kota Semarang.Metode: Penelitian deskriptif dengan pendekatan belah lintang dilakukan terhadap 578 pelajar SLTP yang tersebar pada 5 SLTP di wilayah Semarang. Alat ukur SDQ (the strength and difficulties questionnaire) dipakai dalam menilai status mental mereka yang disajikan dalam narasi deskriptif. Hasil: Pada ranah prososial didapatkan 8,0% abnormal dan 14,5% borderline, ranah hiperaktif 4,9% abnormal dan 5,9% borderline, ranah emosi 18,5% abnormal dan 9,1% borderline, ranah perilaku 13,9% abnormal dan 15,7% borderline, dan ranah peer group 3,8% abnormal dan 20,6% borderline. Simpulan: Hasil penilaian masalah mental remaja di Kota Semarang didapatkan masalah emosi 18,5%, perilaku 13,9%, total difficulties 9,1%, prososial 8,1%, hiperaktif 4,9%, dan peer group 3,8%.
MEDIA MEDIKA INDONESIANA
2010-12-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21904
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 3 YEAR 2010; 118-124
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21904/14640
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3025
2012-04-05T13:44:38Z
mmi:ART
Risiko Konsumsi Western Fast Food dan Kebiasaan Tidak Makan Pagi Terhadap Obesitas Remaja Studi di SMAN 1 Cirebon
Banowati, Lilis
Nugraheni, Nugraheni
Puruhita, Niken
Western fast food consumption, skipping breakfast, obesity, adolescent
ABSTRACTRisks of western fast food consumption and skipping breakfast to adolescents’obesity: Study at SMAN 1 CirebonBackground: Obesity prevalence in adolescents remains high. Western fast food consumption and skipping breakfast were identified as sub-culture among adolescents.The objective of this study was aimed to determine the risk of western fast food consumption in term of frequency of consumption, energy intake and energy contribution to adolescents’ obesity. It was also aimed to determine therisk of skipping breakfast for adolescents’ obesity.Method: It was an observational study using a case-control approach. Stratified random sampling was used to select participants from population. Seventy six secondary students from SMA Negeri 1 Cirebon were involved, divided into two groups; 38 students as case (BMI>95 persentile) and the rest 38 as controls (BMI 5-85 persentile). Chi-square and multiple logistic regression were employed in data analysis.Results: This study found obese students consumed western fast food more than their counterparts (263 kkal versus 140 kkal) (p=0.001). They were less frequent breakfast having (4.5 times per week) than those who were not obese (5,8 times per week) (p=0.019). Energy intake gained from western fast food consumption ≥244 kkal per day was found as the risk factor for obesity among adolescents (p=0,004) whilst frequency of consumption >9.2 times per month, energy contribution to total calorie intake >7.3% and skipping breakfast were failed to predict adolescents’ obesity (p>0.05). The result of multiple logistic regression test showed that the variable which is the most influential to the incident of obesity is energy intake gained from western fast food consumption (OR=6.26).Conclusion: Western fast food consumption ≥244 kkal per day is a risk factor for obesity.Keywords: Western fast food consumption, skipping breakfast, obesity, adolescentABSTRAKLatar belakang: Prevalensi obesitas remaja cukup tinggi. Hal ini disebabkan oleh konsumsi western fast food dan kebiasaan tidak makan pagi yang sudah merupakan kecenderungan di kalangan remaja. Tujuan penelitian ini untuk mengetahui besar risiko frekuensi konsumsi western fast food, asupan energi konsumsi western fast food, kontribusi energi western fast food dan kebiasaantidak makan pagi terhadap kejadian obesitas remaja SMAN 1 Cirebon.Metode: Jenis penelitian observasional dengan rancangan kasus kontrol. Pengambilan sampel dengan teknik stratified random sampling. Besar sampel 76 orang, terdiri dari 38 orang kasus (IMT >95 persentil) dan 38 orang kontrol (IMT persentil ke-5 -85). Penelitian menggunakan analisis bivariat dengan uji chi square dan analisis multivariat dengan uji regresi logistik ganda.Hasil: Pada remaja obesitas asupan energi konsumsi western fast food (263 kkal) lebih tinggi daripada yang tidak obes (140 kkal) (p=0,001). Sedangkan frekuensi makan pagi lebih rendah (4,5 kali/minggu) daripada yang tidak obes (5,8 kali/minggu) (p=0,019). Hasil analisis menunjukkan asupan energi konsumsi western fast food ≥244 kkal per hari merupakan faktor risiko terjadinyaobesitas (p=0,004). Sedangkan frekuensi konsumsi western fast food >9,2 kali per bulan, kontribusi energi western fast food terhadap total kalori >7,3% dan kebiasaan tidak makan pagi bukan faktor risiko obesitas (p>0,05). Hasil uji regresi logistik ganda menunjukkan bahwa variabel yang paling berpengaruh terhadap obesitas remaja adalah asupan energi konsumsi western fast food(OR=6,26).Simpulan: Konsumsi western fast food ≥244 kkal per hari berisiko untuk terjadinya obesitas.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3025
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 118-124
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3025/2708
oai:ojs.ejournal.undip.ac.id:article/3826
2012-07-20T10:16:28Z
mmi:ART
Dislipidemia dan Oval Fat Bodies Dalam Urin
Indranila, Indranila
Dyslipidemia, oval fat bodies
Dyslipidemia and oval fat bodies in urineBackground: Lipid profiles such as cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol screening are expensive. Oval fat bodies (OFB) an epithelial tubulus cell within lipid degenerated/macrophag contains fat granule, is a marker of lipiduria will be expected as a feature of serum lipids and may be performed as a simple non invasive, inexpensive laboratory test. The aim of the study was to analyze the correlation between dyslipidemia and OFB.Methods: This study was performed in 66 male and female subjects of hypercholesterolemia and hypertriglyceridemia of 20-83 years old, which come to a private laboratory in Semarang within 3 months. Sample were taken purposively. The method used in detecting lipids serum was enzymatics (CHOD-PAP for cholesterol and GPO enzymatic for triglyceride) and OFB examination in urine using Sternheimer–Malbin staining.Results: Triglyceride and cholesterol mean value were 210.8 mg/dl (±131.74) and 230.6 mg/dl (±36.4). OFB were found in the urine of on 15 subjects (75%) with hyperlipidemia, 26 subjects (72.2%) with hypercholesterolemia and 6 subjects (70%) with hypertriglyceridemia. There were corellations between hypercholesterolemia and hypertriglyceridemia and OFB (r1=0.82, p1=0.01; r2=0.84, p2=0.05; r3=0.75, p3=0.05).Conclusions: There are positive correlation between dyslipidemia and the presence of OFB in urine.Keywords: Dyslipidemia, oval fat bodies.ABSTRAKLatar belakang: Profil lipid sebagai uji saring umumnya adalah kolesterol, trigliserid, kolesterol-HDL, kolesterol-LDL dimana biaya pemeriksaan ini masih cukup mahal, sementara pola makan cenderung tinggi lemak. Oval fat bodies (OFB) merupakan salah satu petanda lipiduria diharapkan dapat menggambarkan keadaan lemak darah pada uji saring laboratorium secara sederhana, non invasif dan murah. Penelitian ini bertujuan untuk mengetahui hubungan antara dislipidemi dengan OFB.Metode: Pengamatan dilakukan pada 66 subyek usia dewasa baik laki-laki dan wanita dengan hiperkolesterolemia dan atau hipertrigliseridemia yang memeriksakan diri di laboratorium klinik swasta di Semarang selama kurun waktu 3 bulan secara purposivesampling. Metode pemeriksaan yang digunakan adalah ensimatik (CHOD–PAP untuk kolesterol dan GPO ensimatik untuk trigliserida) dan mikroskopik sedimen urin menggunakan pengecatan Sternheimer-Malbin untuk OFB.Hasil: Didapatkan rerata trigliserid dan kolesterol 210,8 mg/dl (±131,7) dan 230,6 mg/dl (±36,4) OFB ditemukan dalam urin 15 subyek (75%) dengan hiperlipidemia, 26 subyek (72,2%) dengan hiperkolesterolemia dan 6 subyek (70%) dengan hipertrigliseridemia. Ada korelasi antara hiperlipidemia, hiperkolesterolemia dan hipertrigliseridemia dengan keberadaan OFB di urin (r1=0,82, p1=0,01; r2=0,84, p2=0,05; r3=0,75, p3=0,05).Simpulan: Ada korelasi positif antara dislipidemia dengan ditemukannya OFB di urin.
MEDIA MEDIKA INDONESIANA
2012-07-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3826
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 3 Year 2008; 103-107
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3826/3510
oai:ojs.ejournal.undip.ac.id:article/4218
2012-12-05T12:57:59Z
mmi:ART
Peningkatan Pengetahuan dan Keterampilan Kader Posbindu dalam Pengukuran Tinggi Badan Prediksi Lansia, Penyuluhan Gizi Seimbang dan Hipertensi Studi di Kecamatan Grogol Petamburan, Jakarta Barat
Fatmah, Fatmah
Nasution, Yusran
Training, posbindu cadres, knowledge, antropometric skills, balanced nutrition education
Increased Posbindu cadres knowledge and skills on elderly predicted height measurement, balanced nutrition and hypertension education among elderly in Grogol Petamburan Subdistrict, West JakartaBackground: One strategy to increase the coverage of the elders’ visit to elders integrated service post (Posbindu) by conducting a training on improving the skills of cadres. They have tasks to measure height, weight and provide nutritional counseling for elderly. Many elderly can not be measured in standing height due to paralysis, disability and stooped due to kyphosis and osteoporosis. The results of the nutritional status assessment of elderly should be followed up by balanced nutrition and hypertension education. Theaim of study was to test the effect of training on the knowledge and skills of Posbindu cadres in predicted height and balanced nutrition counseling of elderly.Method: Study design was quasi-experimental one group pretest posttest towards 41 respondents (36 Posbindu cadres and 5 staffs of community health center) at Grogol Petamburan Subdictrict who have been trained previously. Knowledge were measured with a pre-post test questionnaire and the skills of cadres were observed for 3 months post-training using the checklist form.Result: Mean score of knowledge had significant difference between before and after training (p=0.000) and its increased by 22 points. There was significant difference between cadres skills before and after training in predicted height and balanced nutrition education (p=0.000). The level of cadres’ skills on moderate and high had significant difference after training.Conclusion: Cadres training improves performance of Posbindu cadres.Keywords: Training, posbindu cadres, knowledge, antropometric skills, balanced nutrition educationABSTRAKLatar belakang: Salah satu strategi upaya peningkatan cakupan kunjungan lanjut usia (lansia) ke posyandu lansia (Posbindu) adalah membekali keterampilan kader melalui pelatihan. Tugas kader antara lain melakukan pengukuran tinggi badan dan berat badan serta memberikan penyuluhan gizi bagi lansia. Namun kegiatan pengukuran antropometri dan penyuluhan gizi belum dilakukan secara tepat di Posbindu. Tujuan penelitian adalah untuk meningkatkan pengetahuan dan keterampilan kader Posbindumelalui pelatihan keterampilan antropometri tinggi badan prediksi (TB) dan penyuluhan gizi seimbang serta hipertensi lansia.Metode: Disain penelitian menggunakan metode quasi eksperimental dengan rancangan one group pretest-posttest design pada 41 responden (36 kader Posbindu dan 5 petugas puskesmas) di Kecamatan Grogol Petamburan. Peningkatan pengetahuan diukur dengan angket pre-post test dan keterampilan kader diamati selama 3 bulan pasca pelatihan menggunakan form checklist.Hasil: Rerata skor pre dan post-test pengetahuan pengukuran antropometri lansia berbeda makna dan meningkat sebesar 22 butir. Perbedaan rerata keterampilan kader sebelum dan setelah pelatihan pada antropometri tinggi badan prediksi dan penyuluhan gizi seimbang lansia. Ada perbedaan keterampilan responden dengan tingkat cukup dan baik bila dibandingkan sebelum dan setelah pelatihan.Simpulan: Pelatihan kader meningkatkan pengetahuan dan kinerja kader Posbindu.
MEDIA MEDIKA INDONESIANA
2012-11-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4218
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012; 61-68
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4218/3844
oai:ojs.ejournal.undip.ac.id:article/4281
2012-12-15T12:26:32Z
mmi:ART
Profil Kromatogram dan Aktivitas Antibakteri Ekstrak Etanol Rimpang Bengle (Zingiber cassumunar Roxb) Terhadap Bakteri Escherichia coli In Vitro
Raharjoyo, Lanjar
Gunardi, Gunardi
Ethanol extract of Bengle rhizome, Escherichia coli, anti-bacteria activity in vitro
Chromatogram profile and antibacterial activity of ethanol extract from bengle rhizome (Zingiber cassumunar Roxb.) to Escherichia coli in vitroBackground: Bengle (Zingiber cassumunar roxb.) was a plant which had been used by society since long time ago as a traditional medicine. It was predicted that there were anti-bacteria substances in bengle, so it might substitutes the utilization of conventional antibiotics. The aims of this research was to explore the chromatogram and antibacterial activity etanol extract of Bengle Rhizome against Escherichia coli.Methods: The method of these research were descriptive and experimental study using the post test only control group design. Ethanol extract of Bengle rhizome was made by maceration method with ethanol as solvent. Chromatogram profile was using thin layer chromatography and antibacterial activity against escherichia coli was done using dilution method and than cultured in Mac Conkey agar media.Results: The results showed thad, thin layer chromatography shown 4 spot under UV light 254 nm wave leng with colour, blue violet, blue violet, brown yellow, brown yellow and Rf value 0.21; 0.34; 0.45; 0.55. No bacterial growth at etanol extract of Bengle rhizome 12.5% on Mueller Hinton Broth media, nor at consentration of 25% on Mac Conkey media.Conclusions: The were 4 compounds predictly included of flavonoid, steroid, volatile oil and terpenoid group. Etanol extract of Bengle rhizome had minimum consentration inhibitory 12.5% and minimum bactericide consentration 25% against Escherichia coli.Keywords: Ethanol extract of Bengle rhizome, Escherichia coli, anti-bacteria activity in vitroABSTRAKLatar belakang: Bengle (Zingiber cassumunar Roxb.) adalah tanaman yang sudah lama digunakan di masyarakat sebagai obat tradisional. Dalam tanaman ini diduga terdapat zat anti bakteri sehingga dimungkinkan untuk digunakan sebagai pengganti antibiotika konvensional. Tujuan penelitian ini untuk mengetahui profil kromatogram ekstrak rimpang etanol rimpang Bengle dan aktivitasnya terhadap Escherichia coli.Metode: Metode penelitian yang dilakukan adalah penelitian deskriptif dan penelitian eksperimental dengan rancangan post test only control group design. Ekstraksi rimpang Bengle dilakukan dengan metode maserasi menggunakan pelarut etanol. Untuk mengetahui profil kromatogram dilakukan pemisahan secara kromatografi lapis tipis dan aktivitas terhadap Escherichia coli dilakukan dengan metode pengenceran yang dilanjutkan dengan metode penanaman pada media Mac Conkey.Hasil: Profil kromatogram di bawah UV 254 nm didapatkan 4 bercak berwarna ungu biru, ungu biru, kuning coklat, kuning coklat dengan Rf 0,21; 0,34; 0,45; dan 0,55. Dalam media cair Mueller Hinton Broth pertumbuhan bakteri tidak terlihat pada kadar ekstrak rimpang Bengle 12,5% dan dalam media Mc Conkey pada kadar 25%.Simpulan: Terdapat 4 komponen senyawa dalam ekstrak rimpang bengle yang dapat teramati, diperkirakan golongan flavonoid, steroid, minyak atsiri dan terpenoid. Ekstrak rimpang Bengle mempunyai aktivitas terhadap Escherichia coli dengan kadar hambat minimum 12,5% dan kadar bunuh minimum 25%.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4281
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009; 182-188
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4281/3901
oai:ojs.ejournal.undip.ac.id:article/4570
2013-06-26T12:57:43Z
mmi:ART
Pemberian Stimulasi Selama Satu Jam pada Perkembangan Anak Usia 12-24 Bulan
Irmawati, Mira
Ardani, I Gusti Ayu Indah Ardani Ayu Indah
Astasari, Dewi
Irwanto, Irwanto
Suryawan, Ahmad
Narendra, Moersintowarti B
Children, aged 12-24 months, early stimulation, Denver II
The influence of one hour stimulation in children aged 12-24 monthsIntroduction: Early stimulation plays an important role to reach optimal growth and development in children, especially cognitive, affective, and psychomotor developments. Stimulation has to be done continuously because this is important to maintain the connection between brain cells (synapse). Lack of stimulation can influence loss of brain cells functions. The aim of this study is to determine the influence of one hour stimulation on the development of children aged 12-24 months.Methods: An experimental analytic study with cohort prospective was conducted on children aged 12-24 months in Gubeng district, Surabaya, from September 2008-February 2009. Seventy healthy children were randomly divided into two groups, stimulation group and control group. Denver II was used to evaluate children’s developmental status, conducted before and after stimulation. Data analysis using McNemar and Chi Square test.Result: There were improvement on development in both groups, from 85.7% become to 94.3% in the stimulation group and 68.6% to 77.1% in the control group. There was a significant influence on children development, only 10% children did not have any development delay anymore in the stimulation group, but in the control group still 30% (p=0.042). After 3 months, there was an improvement of development in the stimulation group from suspect to normal in 80%, and 63.6% in the control group, but notsignificant (p=0.375 vs p=0.549).Conclusion: Early stimulation improves the development of children aged 12-24 months.Keywords: Children, aged 12-24 months, early stimulation, Denver II ABSTRAKPendahuluan: Stimulasi mempunyai peran penting untuk meningkatkan pertumbuhan dan perkembangan anak, terutama fungsi kognitif, afektif dan psikomotor. Stimulasi yang terus menerus mengakibatkan hubungan antar sel otak (sinapsis) bisa berjalan dengan baik. Kurangnya stimulasi akan mengakibatkan hilangnya fungsi sel-sel otak ini. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian stimulasi selama 1 jam pada perkembangan anak usia 12-24 bulan.Metode: Penelitian dilakukan secara analitik prospektif kohort pada anak usia 12-24 bulan di Kecamatan Gubeng, Surabaya, mulai bulan September 2008 hingga Februari 2009. Tujuh puluh anak sehat secara acak dibagi dalam 2 kelompok, kelompok stimulasi dan kelompok kontrol. Denver II digunakan untuk menilai status perkembangan anak, sebelum dan sesudah perlakuan. Analisis data menggunakan uji McNemar dan Chi Square.Hasil: Didapatkan perbaikan perkembangan pada kedua kelompok, dari 85,7% menjadi 94,3% pada kelompok stimulasi, dan 68,6% menjadi 77,1% pada kelompok kontrol. Terdapat perbedaan bermakna pada kemampuan perkembangan, hanya 10% tidak mengalami keterlambatan pada kelompok stimulasi, sedangkan kelompok kontrol 30% (p=0,042). Setelah 3 bulan, terjadi peningkatan perkembangan pada kelompok stimulasi dari subyek yang suspek menjadi normal sebesar 80%, dan kelompok kontrolsebesar 63,6%, tetapi tidak bermakna (p=0,375 vs p=0,549).Simpulan: Pemberian stimulasi satu jam meningkatkan kemampuan perkembangan anak usia 12-24 bulan.
MEDIA MEDIKA INDONESIANA
2013-03-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4570
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012; 147-150
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4570/4162
oai:ojs.ejournal.undip.ac.id:article/11375
2016-07-01T13:35:06Z
mmi:ART
Pengaruh Polifenol Mahkota Dewa Terhadap Proliferasi Sel dan Apoptosis pada Mencit Strain Balb/C yang Diinduksi Benzo(a) Pyrene (BaP)
Watuguly, Theopilus W.
KS, Indranila
Papilaya, Pamela Mercy
Dharmana, Edi
ABSTRACT The effect of mahkota dewa polyphenol in the cell proliferation and apoptosis in BaP induced Balb/c ratsBackground: The polyphenol of mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl) has the potency as antioxidant and anticancer which can handle free radicals, but there has not been extensive research on this. This research is aimed to prove the role of mahkota dewa polyphenol in the cell proliferation inhibition and induct lung carcinogenesis apoptosis in strain Balb/c mice which inducted with benzo(a)pyrene (BaP).Methods: Posttest control group design was carried out among 40 strain Balb/c mice sample, aged 1-2 weeks, weighed 20-30 grams, healthy mice condition. All mice were inducted with BaP and then randomized into 2 groups, as control group and the treatment group. The development of the lung tumor was observed by tissue surgery in the 8th, 17th and 26th week. The data collected were AgNORs, and IHC-TUNEL-apoptosis index dying. The data analysis was conducted using Kruskal-Wallis, Mann-Whitney, One-way ANOVA, and Post hoc test LSD with significance degree of p<α (0.05).Results: The oral administration of mahkota dewa polyphenol showed significantly decreasing cell proliferation, increasing apoptosis index in treatment group in week 8, 17 and 26 (p=0.000). Carcinogenesis incidence for the treatment group week 8 and 26 were 2.32±0.26 and 3.93±0.46, while for the treatment group were 1.88±0.38 and 0.88±0.22 (p=0.000). The cell proliferations for control group week 8 and 26 were 1.57±0.12 and 2.29±0.15, while for the treatment group were 1.53±0.11 and 1.60±0.04 (p=0.000). Apoptosis index for the control group for week 8 was 0.00±0.00 and 0.92±0.22 in week 26, while the treatment group was 1.12±0.71 and 2.02±1.05 (p=0.000).Conclusion: The administration of mahkota dewa polyphenol effectively inhibited the cell proliferation activity and increased apoptosis measured by apoptosis index. Therefore polyphenol has anticancer and antioxidant activities which can inhibit lung carcinogenesis in Balb/c mice.Keywords: Polyphenol, mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl), apoptosis index, strain Balb/c mice, benzo(a)pyrene (BaP).ABSTRAKLatar belakang: Polifenol mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl) berpotensi sebagai antioksidan dan antikanker yang mampu menangkap radikal bebas, namun belum banyak diteliti. Penelitian ini bertujuan membuktikan peran polifenol mahkota dewa dalam menginhibisi proliferasi sel dan menginduksi apoptosis pada mencit strain Balb/c hasil induksi Benzo(a)pyrene (BaP).Metode: Posttest control group design dengan sampel 40 mencit strain Balb/c, umur 1-2 minggu, berat 20-30 g, kondisi mencit sehat. Semua mencit diinduksi BaP kemudian hewan dirandomisasi menjadi 2 kelompok yaitu kelompok kontrol dan kelompok perlakuan polifenol 50 mg. Perkembangan tumor paru diamati dengan pembedahan jaringan pada minggu ke-8, 17 dan 26. Data dikumpulkan meliputi AgNORs, pengecatan IHC-TUNEL-indeks apoptosis. Analisis data dengan Kruskal-Wallis, Mann-Whitney, One-way ANOVA, post hoc test LSD dengan derajat kemaknaan p<α (0,05).Hasil: Pemberian oral polifenol mahkota dewa sebesar 50 mg secara bermakna memperlihatkan penurunan insidens karsinogenesis paru, proliferasi sel, protein Bax dan peningkatan indeks apoptosis, protein p53, Bcl-2, ekspresi caspase 3, 8, 9 pada kelompok perlakuan pada minggu ke-8, 17 dan 26 (p=0,000). Insidens karsinogenesis untuk kelompok kontrol minggu ke-8, dan 26 sebesar 2,32±0,26 dan 3,93±0,46, sedangkan kelompok perlakuan sebesar 1,88±0,38 dan 0,88±0,22 (p=0,000). Proliferasi sel untuk kelompok kontrol minggu ke-8 dan 26 sebesar 1,57±0,12 dan 2,29±0,15, sedangkan kelompok perlakuan sebesar 1,53±0,11 dan 1,60±0,04 (p=0,000). Indeks apoptosis pada kelompok kontrol minggu ke-8 sebesar 0,00±0,00 dan 0,92±0,22 minggu ke-26, sedangkan kelompok perlakuan sebesar 1,12±0,71 dan 2,02±1,05 (p=0,000).Simpulan: Pemberian polifenol mahkota dewa efektif meng-inhibisi proliferasi sel dan menginduksi apoptosis melalui peningkatan indeks apoptosis. Jadi polifenol mahkota dewa memiliki aktivitas antikanker dan antioksidan mampu menghambat karsinogenesis paru mencit Balb/c.
MEDIA MEDIKA INDONESIANA
2016-07-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/11375
MEDIA MEDIKA INDONESIANA; 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013; 44-55
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/11375/8861
oai:ojs.ejournal.undip.ac.id:article/21899
2019-01-29T11:39:15Z
mmi:ART
Perilaku Kadarzi Ibu Balita Ditinjau dari Sudut Pengetahuan dan Prakteknya: Studi Kuantitatif di Suatu Wilayah Urban
Fatma, Fatma
Nasution, Yusran
Kadarzi behavior; knowledge; practice
The behavior of underfives mothers on kadarzi from their knowledge and practice: a quantitative study in an urban area Background: Poor families at urban area have a high risk to get undernutrition due to low purchasing power for buying nutritious foods. To overcome it, The Indonesian government have been declared Kadarzi (Nutrition Awareness Family) movement since 1998 which aimed to establish nutrition awareness family for achievement an optimal nutritional status of family. However, until now the behavior’s of underfives mothers on Kadarzi at Jakarta City almost unknown because of the limited study on Kadarzi. Actually, role of mothers in family is very important as primary target to determine nutritional status quality of their underfives. Objective: The study aimed to identify the behavior of underfives mothers on Kadarzi from knowledge and practice sites at Penjaringan Village, Penjaringan Sub-district, North Jakarta. Methods: The study design was cross sectional using structured interview to 105 of mothers aged 18-45 years who are still have underfives children. Results: The study revealed that the majority of mothers had low knowledge and practice of Kadarzi due to lack of socialization from local community health centers. They were unfamiliar with the terminology of Kadarzi and considered that Kadarzi was identical with the terms of four healthy and five perfect for toddlers and pregnant women to improve their nutrition and health status. Conclusion: Lack of knowledge and practice on Kadarzi had role on the poor of mothers’ behavior on Kadarzi. Key words: Kadarzi behavior, knowledge, practiceABSTRAKLatar belakang: Keluarga miskin di wilayah perkotaan adalah kelompok paling berisiko terpapar masalah gizi kurang akibat rendahnya daya beli makanan bergizi. Untuk mengatasinya, pemerintah telah meluncurkan Gerakan Kadarzi (Keluarga Sadar Gizi) sejak tahun 1998 dengan tujuan untuk mewujudkan keluarga mandiri sadar gizi guna mencapai status gizi keluarga yang optimal. Namun hingga sekarang, perilaku Kadarzi ibu balita di wilayah miskin (kumuh) di Kota Jakarta hampir tidak diketahui akibat terbatasnya studi. Padahal peran ibu dalam keluarga sangat penting sebagai sasaran primer dalam menentukan kualitas gizi balitanya. Studi ini dilaksanakan dengan tujuan untuk melakukan identifikasi perilaku Kadarzi dari sudut pengetahuan dan praktek ibu balita di Kelurahan Penjaringan, Kecamatan Penjaringan, Jakarta Utara. Metode: Desain studi adalah cross sectional dengan metode wawancara terstruktur pada 105 ibu usia 19-45 tahun yang masih memiliki anak balita. Hasil: Mayoritas ibu balita memiliki pengetahuan dan praktek Kadarzi yang rendah karena kurangnya sosialisasi dari puskesmas setempat. Mereka kurang mengenal istilah Kadarzi dan menganggapnya identik dengan terminologi empat sehat lima sempurna bagi anak balita dan ibu hamil untuk meningkatkan status gizi dan kesehatan. Simpulan: Rendahnya pengetahuan dan praktek ibu balita terhadap Kadarzi berperan terhadap minimnya perilaku Kadarzi ibu balita.
MEDIA MEDIKA INDONESIANA
2010-08-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21899
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 2 YEAR 2010; 76-82
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21899/14632
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3019
2012-04-05T11:41:30Z
mmi:ART
Beberapa Faktor yang Berperan Terhadap Keaktifan Kunjungan Lansia ke Posyandu Studi Kasus di Desa Tamantirto Kecamatan Kasihan Kabupaten Bantul Propinsi DIY
Lestari, Puji
Hadisaputro, Soeharyo
Pranarka, Kris
Elderly community health care, actively visit, influencing factors
ABSTRACTFactors influencing elderly visit to elderly community health care (posyandu lansia): Case study in Tamantirto Village, Kasihan, Bantul, DIYBackground: Elderly community health care (ECHC) is the base of holistic-continuous care for the elderly. The number of elderly at Tamantirto Village is 11.3% of the total residents, which has not been accompanied by a high scope of ECHC visit, where 6 of 9 the ECHCs still have the coverage lower than 50%. Purpose of this study is to prove that age, education, occupation, socio economic status, knowledge, attitude, facilities, access, cadre and health workers services, social role and family role can affect elderly people’s visitations to the ECHC.Methods: Study design: observational analytic, case-control approach. The case: elderly as the ECHC members who actively visited, the control: elderly as ECHC members were who did not actively visit ECHC. The sample’s are 52 cases and 52 controls. The quantitative data were gathered by interviews, while the qualitative data by using focus group disscussion.Results: The factors influencing elderly people’s visitations to the ECHC are age of 71 years old (OR:4.6), not working (OR:8.1), good attitude (OR:3), good facilities (OR:5.4), good service of cadres and health workers (OR:6.5) and a good family role (OR:3.2). The factors that do not affect elderly people’s visitations are educational level, socio economic, knowledge, access, and social role ofthe elderly.Conclusion: Characteristics of elderly activity visit ECHC are age of 71 years old, not working, good attitude, good facilities, good service of cadres and health workers and a good family role.Keywords: Elderly community health care, actively visit, influencing factorsABSTRAKLatar belakang: Posyandu lansia merupakan dasar pelayanan yang holistik dan berkesinambungan pada lansia. Jumlah lansia yang cukup banyak di Desa Tamantirto yaitu sebanyak 11,3% dari jumlah penduduk, belum diiringi dengan cakupan kunjungan yang tinggi, dimana 6 dari 9 posyandu masih mempunyai cakupan di bawah 50%. Tujuan penelitian adalah membuktikan bahwa umur, pendidikan, pekerjaan, kondisi sosial ekonomi, pengetahuan, sikap, fasilitas posyandu, akses terhadap posyandu, pelayanan kader dan petugas kesehatan, peran sosial lansia, serta peran keluarga berpengaruh terhadap kunjungan lansia ke posyandu.Metode: Desain penelitian: analitik observasional, pendekatan kasus kontrol. Kasus adalah lansia anggota posyandu (umur 60 tahun) yang aktif melakukan kunjungan ke posyandu. Kontrol adalah lansia anggota posyandu (umur 60 tahun) yang tidak aktifmelakukan kunjungan ke posyandu. Sampel penelitian 52 kasus dan 52 kontrol. Data kuantitatif diperoleh dengan wawancara, data kualitatif dengan diskusi kelompok terarah.Hasil: Faktor yang berpengaruh terhadap keaktifan kunjungan lansia ke posyandu yaitu umur 71 tahun (OR:4,6), tidak bekerja (OR:8,1), sikap yang baik (OR:3), fasilitas yang baik (OR:5,4), pelayanan kader dan petugas kesehatan yang baik (OR:6,5), peran
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3019
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 74-82
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3019/2702
oai:ojs.ejournal.undip.ac.id:article/3253
2012-04-20T08:26:09Z
mmi:ART
Pemberian Fenitoin Oral dan Timbulnya Hiperplasia Ginggiva pada Pasien Epilepsi
Utomo, Tranggono Yudo
Husni, Amin
Hanum, Farichah
Dosage and duration of phenytoin administration, ginggival hyperplasia
ABSTRACTPhenytoin oral treatment and the development of ginggival hyperplasia in epileptic patientsBackground: Phenytoin is commonly used as a first line drug therapy for epilepsy because of its potency and low cost. Dosage and duration of oral phenytoin administration have been considered as important factors in the development of ginggival hyperplasia.Objective: To investigate whether dosage and duration of oral phenytoin usage were risk factors of ginggival hyperplasia in epileptic patients.Method: Twenty epileptic patiens with phenytoin monotherapy who developed ginggival hyperplasia, and 20 epileptic patients with phenytoin monotherapy without ginggival hyperplasia as a control group were studied. The history of illness, physical examination, fasting and post prandial blood glucose level, funduscopy, oral hygiene, index of hyperplasia scoring from Saymor were taken. Blood sample 3-5 cc were also taken to examine the level of phenytoin. Oral dose, serum dose and duration of administration were noted. Odd ratio was calculated by multiple regression statistic (95% confidence interval).Result: High dose of oral phenytoin was a significant risk factor of ginggival hyperplasia, (p<0.05), while duration of administration >6 months was not a risk factor (p=0.522). Adjusted by duration of oral phenytoin usage, high dose of oral phenytoin usage was still a significant risk factor for gingival hyperplasia, OR=29.14 (95%CI 3.8-291.9).Conclusion: High dose of phenytoin was a significant risk factor for ginggival hyperplasia.Keywords: Dosage and duration of phenytoin administration, ginggival hyperplasiaABSTRAKLatar belakang: Fenitoin sering digunakan sebagai lini pertama pengobatan epilepsi karena potensial dan ekonomis. Dosis dan lama pemberian fenitoin, dianggap sebagai faktor yang berperan dalam timbulnya hiperplasia ginggiva. Tujuan penelitian ini mengetahui apakah dosis fenitoin yang tinggi dan durasi pemberian fenitoin yang panjang merupakan faktor risiko terhadap timbulnya hiperplasia ginggiva pada penderita epilepsi.Metode: Dua puluh pasien epilepsi dengan monoterapi fenitoin yang mengalami hiperplasia ginggiva dan dua puluh pasien epilepsi dengan monoterapi fenitoin yang tidak hiperplasia ginggiva diambil sebagai studi kasus kontrol. Dilakukan anamnesa, pemeriksaan fisik, gula darah puasa dan postprandial, funduskopi, higine mulut, skoring hiperplasia Indek Saymor, pengambilan sampel darah serum fenitoin 3-5cc. Selanjutnya mendata dosis oral, dosis serum dan lama pemberian. Rasio odds (95% interval kepercayaan) dihitung dengan statistik multiple regresi.Hasil: Dosis tinggi fenitoin merupakan faktor risiko yang signifikan terhadap risiko hiperplasia ginggiva (p<0,05), sementara lama pemberian obat >6 bulan tidak terbukti sebagai faktor risiko (p=0,522). Bila dikendalikan oleh faktor durasi, maka besar dosis fenitoin oral tetap merupakan faktor risiko hiperplasia ginggiva yang signifikan OR=29,14 (95%CI, 38-291,9) sedang lama pemberian fenitoin tetap bukan merupakan faktor risiko yang signifikan.Simpulan: Dosis tinggi fenitoin merupakan faktor risiko yang signifikan terhadap hiperplasia ginggiva.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3253
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 200-205
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3253/2921
oai:ojs.ejournal.undip.ac.id:article/3821
2012-07-19T10:27:50Z
mmi:ART
Perbedaan Pengaruh Latihan Gerak Terhadap Kekuatan Otot pada Pasien Stroke Non-Hemoragik Hemiparese Kanan Dibandingkan dengan Hemiparese Kiri
Irdawati, Irdawati
Movement Exercise, Stroke, Non-Hemoragik.
The different effect of exercise on the muscle strength of patients with right and left non hemorrhagic hemipareses.Background: The stroke patients experienced difficulty in walking since they have disorder on their muscle strength, balance andmovement coordination, therefore they are difficult to do daily activities. Exercise make stroke patients improvement faster, because they will influence the movement sensation in the brain. The Objective of this study to prove the difference of movement exercise effect toward muscle strength on the right hemiparese of non-haemoragic stroke patients compared to those ones of the lefthemiparese.Method: An experimental research with two group designs; pretest and posttest groups. The research uses two groups of patients. The observed groups consist of 20 patiens for the group of stroke patients of the right hemiparese of non-haemoragic and 20 other patiens for the left hemiparese. They are given movement exercise according to physiotherapy program of Dr. Moewardi Hospital Surakarta. The data analysis was conducted using descriptive statistic and variable comparative hypothesis test which wereprocessed using SPSS version 13.0.Result: On the right and left hemiparese, an average increasing of muscle strength were 18.25 and 21.70 respectively. The result from Mann-Whitney test showed that there was no significant difference on the increasing value of muscle strength among the patient of right hemiparese (p=0.828). The average increasing of muscle strength as much as 57.10% on the right hemiparese and 71.92% on the left hemiparese.Conclusion: There was no significant difference on the increasing value of muscle strength among the patient of right and left hemiparese.Keyword : Movement Exercise, Stroke, Non-Hemoragik.ABSTRAKLatar Belakang: Penderita stroke mengalami kesulitan saat berjalan karena gangguan pada kekuatan otot, keseimbangan dan koordinasi gerak, sehingga kesulitan dalam melakukan aktivitas sehari-hari. Latihan gerak mempercepat penyembuhan pasien stroke, karena akan mempengaruhi sensasi gerak di otak. Tujuan penelitian ini untuk membuktikan perbedaan pengaruh latihan gerak terhadap kekuatan otot pada pasien stroke non-hemoragik hemiparese kanan dibandingkan dengan hemiparese kiri.Metode: Jenis penelitian ini adalah penelitian eksperimental dengan rancangan two group pretest dan posttest. Penelitian ini menggunakan dua kelompok pasien. Kelompok yang yang diteliti adalah pasien stroke non-hemoragik hemiparese kanan 20 pasien dan hemiparese kiri 20 pasien, yang diberi latihan gerak sesuai program fisioterapi Rumah Sakit Dr. Moewardi Surakarta. Analisis data dilakukan dengan statistik deskriptif dan uji hipotesis komparatif variabel dengan program SPSS versi 13.0.Hasil: Pada hemiparese kanan terjadi kenaikan rerata kekuatan otot sebesar 18,25 dan pada hemiparese kiri sebesar 21,70. Hasil uji statistik Mann-Whitney menyimpulkan tidak ada perbedaan yang bermakna pada kenaikan nilai kekuatan otot antara pasien hemiparese kanan dan hemiparese kiri (p=0,828). Rerata kenaikan nilai kekuatan otot 57,10% pada pasien stroke hemiparese kanan dan 71,92% pada pasien stroke hemiparese kiri.Simpulan: Tidak terdapat perbedaan kenaikan nilai kekuatan otot antara pasien stroke hemiparese kanan dibandingkan dengan hemiparese kiri setelah diberikan latihan gerak.
MEDIA MEDIKA INDONESIANA
2012-07-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3821
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 2 Year 2008; 75-82
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3821/3505
oai:ojs.ejournal.undip.ac.id:article/4202
2012-11-29T12:58:44Z
mmi:ART
Ekstrak Phyllanthus niruri Linn, Pertumbuhan Tumor dan Proliferasi Sel Kanker Kolorektal: Studi Eksperimental pada Tikus Sprague-Dawley yang Diinduksi 1,2 DMH
Sawitri, Endang
Riwanto, Ign.
Tjahjono, Tjahjono
Dharmana, Edi
Phyllanthus niruri Linn, colorectal cancer, tumor growth, proliferation
Effect of Phyllanthus niruri Linn extract on tumor growth and cell proliferation of colorectal cancer: experimental study in 1.2 DMH-induced Sprague-Dawley ratsBackground: The development of chemotherapy for colorectal cancer (CRC) is so very advanced, however, the survival of patients has not been satisfactory, therefore, the current therapy also involve immunotherapy. Phyllanthus niruri Linn (P. niruri L) may act as an immunomodulator and anticancer, but its potency has not been revealed. Study was conducted to confirm the effects of P. niruri L extract in the treatment of CRC.Method: The study was randomized posttest-only control group design. Samples were Sprague-Dawley male rats, bodyweight 170- 220 gr, were divided into two groups: non induced or negative control (K-) consisted of 9 normal rats, and induced by 1.2 DMH 30 mg/kgBW subcutaneously group consisted 30 rats. On the weeks 9, 11 and 13, four induced rats each week were sacrified to detect the development of CRC. On the weeks of 13th all of 4 rats were developed CRC, so the induction were stopped. The rest of 18 induced rats were randomly into two groups: without P. niruri L or positive control (K+)=9 rats and given P. niruri L extract 13.5 mg/kg orally or X group=9 rats. After 19th week all of rats were then terminated and tumor lesion of colon were examined macroscopically and hystophatologic tissues were stained with AgNORs for evaluate the cells proliferation. Oneway Anova and Post Hoc LSD test for the growth of colon tumor and non pairs t-test for cell proliferation were used. Considered significant if p was <0.05. Result: There was no tumor growth on K- group, while for K+ was 83.33±14.34% and on X was 40.44±13.23% (p=0.000). The mean of AgNORs on K+ was 4.60±0.55 while on X was 2.25±0.39 (p=0.000).Conclusion: The extract of P. niruri L suppress the tumor growth and cell proliferation of CRC.Keywords: Phyllanthus niruri Linn, colorectal cancer, tumor growth, proliferationABSTRAKLatar belakang: Perkembangan kemoterapi untuk kanker kolorektal (KKR) sangat maju, tetapi kelangsungan hidup penderitanya belum memuaskan, sehingga penanganan multimodalitas juga melibatkan imunoterapi yang bertujuan untuk meningkatkan kualitas hidup. Phyllanthus niruri Linn dapat bekerja sebagai imunomodulator sekaligus antikanker, tetapi potensinya belum banyak diungkap. Penelitian bertujuan untuk menganalisis pengaruh pemberian ekstrak P. niruri L terhadap pertumbuhan tumor danproliferasi sel KKR.Metode: Penelitian ini merupakan randomized posttest-only control group design. Sampel berupa tikus Sprague-Dawley jantan, dibagi 2: kelompok tanpa induksi 1,2 DMH dan tanpa P. niruri L (K-: kelompok kontrol negatif) sebanyak 9 ekor dan kelompok induksi 1,2 DMH 30 mg/kgBB subkutan setiap minggu sebanyak 30 ekor. Pada minggu ke-9, 11 dan 13 masing-masing empat ekor tikus dibunuh untuk melihat perkembangan tumor. Pada minggu ke-13 keempat tikus telah berkembang menjadi KKR, induksidihentikan dan sisa 18 tikus dirandom alokasi menjadi 2 kelompok. Kelompok kontrol positif (K+) tanpa pemberian P. niruri L (9 tikus) dan kelompok diberi P. niruri L. 13.5 mg/kg per hari melalui sonde (9 tikus). Minggu ke-19 semua tikus diterminasi, diperiksa lesi tumor makroskopik pada kolon. Jaringan histopatologik diwarnai AgNORs untuk memeriksa proliferasi sel. Analisis data meliputi analisis deskriptif dan uji Oneway Anova, dilanjutkan dengan post hoc test LSD untuk pertumbuhan tumor kolon dan uji ttidak berpasangan untuk proliferasi sel. Derajat signifikansi yang dipilih adalah p<0,05. Hasil: Tidak ditemukan pertumbuhan tumor pada kelompok K-. Persentase rerata pertumbuhan tumor kelompok X sebesar40,44±13,23%berbeda sangat signifikan (p=0,000) dibanding K+ sebesar 33±14,34%. Rerata bercak AgNORs kelompok K+sebesar 4,60±0,55 dan menurun pada kelompok X (2,25±0,39), terdapat perbedaan yang sangat signifikan pada kedua kelompok (p=0,000). Simpulan: Ekstrak P. niruri L menekan pertumbuhan tumor dan proliferasi sel kanker kolorektal.
MEDIA MEDIKA INDONESIANA
2012-11-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4202
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012; 25-33
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4202/3830
oai:ojs.ejournal.undip.ac.id:article/4275
2013-06-26T12:59:31Z
mmi:ART
Tingkat Ketahanan Hidup Penderita Kanker Nasofaring pada Berbagai Modalitas Terapi Studi Kasus yang Menjalani Terapi Konvensional dan Pengobatan Komplementer Alternatif
Christanti, Jessica
Prasetyo, Awal
NPC, CAM, survival rate
Survival rate of patients with nasopharyngeal cancer on various modalitie: Case study of patients on conventional therapy and Indonesian complementary and alternative medicineBackground: There are no data on survival rate of patients with nasopharyngeal cancer (NPC) on complementary alternative medicine in Indonesia. The aim of this study was to analyze the survival rate of patients with nasopharyngeal cancer (NPC) on conventional (modern) and complementary and alternative medicine (CAM) treatments.Methods: A cross-sectional observational study of 33 NPC patients from each conventional (modern) treatment and CAM group was performed. The guided intervews were conducted to describe CAM treatment in NPC patients by using a validated questionnaire based CAM therapies of California Health Interview Survey 2001. Survival analysis was conducted by the Kaplan-Meir method.Results: Most patients (52.3%) used CAM treatments.Multivitamin and herbal medicines were among the commonly used CAM (52.8%). Kaplan-Meier analysis showed no significant results (p=0.444) between groups. The first and second year of survival rate was comparable between groups (66.6% vs. 54.5%; 45.5% vs 33.3%). Furthermore, the median overall survival (OS) was shown (16; 95% CI: 1.58-8.90) in CAM treatment patients and conventional (modern) treatment (12; 95% CI: 8.477-0.00). The prevalenceratio (PR) obtained in this study was 1.2 (95% CI: 0.79-1.69).Conclusion: CAM treatment on NPC patients had no effect on survival rate compared with conventional (modern) treatment.Keywords: NPC, CAM, survival rateABSTRAKLatar belakang: Saat ini, belum ada data tingkat ketahanan hidup penderita kanker nasofaring (KNF) yang menjalani pengobatan komplementer alternatif di Indonesia. Fakta menunjukkan bahwa pengobatan komplementer alternatif di Indonesia merupakan bagian aktivitas sosial budaya. Penelitian ini menganalisis tingkat ketahanan hidup penderita KNF yang memperoleh pengobatan modern konvensional disertai pengobatan komplementer dan alternatif (PKA).Metode: Penelitian cross sectional dilakukan pada 33 penderita KNF di tiap kelompok yang menjalani PKA dan kelompok yang menggunakan pengobatan modern konvensional di wilayah Semarang dan sekitarnya. Wawancara terpimpin untuk terapi PKA dengan menggunakan California Health Interview Survey 2001 yang telah divalidasi. Tingkat ketahanan hidup dianalisis dengan uji Kaplan Meier.Hasil: Sebanyak (52,3%) penderita menjalani PKA, dimana yang tersering adalah dengan multivitamin dan jamu (52,8%). Tingkat ketahanan hidup kelompok PKA di tahun pertama (66,6%) dan tahun ke-2 (45,4%). Tingkat ketahanan hidup tahun pertama dan kedua kelompok obat konvensional 54,5% dan 33,3%. Analisis Kaplan Meier menunjukkan hasil yang tidak bermakna (p=0,444). Analisis median tingkat ketahanan hidup, penderita kelompok PKA didapatkan nilai 16 (CI 95%:1,581-8,900), dan pada kelompok pengobatan modern konvensional didapatkan nilai 12 (CI 95%: 8,477-0,00). Nilai PR didapatkan 1,158 (CI 95%: 0,792-1,692).Simpulan: Penggunaan PKA dan terapi modern konvensional tidak mempengaruhi tingkat ketahanan hidup penderita KNF.
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4275
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 138-148
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4275/3896
oai:ojs.ejournal.undip.ac.id:article/4302
2013-01-03T10:17:27Z
mmi:ART
Metode RPTLC dan Optimasi Fase Gerak Dalam Penetapan Harga Rm Sebagai Salah Satu Parameter Lipofilisitas Dalam Rancangan Obat
Gunardi, Gunardi
Asmah S., Ratna
Purwanto, Bambang Tri
Sulistyowati, Edy
Musinah, Siti
RPTLC, mobile phase, Rm value
RPTLC and optimizing mobile phase methods in Rm value determination as one of lipophylicity parameters in drug designBackground: The early process to successfully achieve its target is drug penetration or absorption. Of the three physicochemical parameters i.e, lipophyllicity, electronic and steric parameters, the lipophyllicity parameter is the most reponsible in drug absorption process. The research was aimed to determine retention modified (Rm) value of barbituric acid compound derivatives using RPTLC metod and mobile phase optimizing.Methods: This study was conducted on barbituric acid compound derivatives by using reverse phase thin layer chromatography (RPTLC). Silica Gel GF 254 that had been submerget in the mixture of liquid paraffin and petroleum eter (95:5) was used as a stationary phase. The mixture of polar to non polar solvent was used as mobile phase.Results: Research showed that in this method the most optimum of mobile phase was indicated by methanol and acetic acid mixture in the ratio of (1:9). The resulted Rm values of 5,5-diethylbarbituric acid, 5,5-diallylbarbituric acid, 5-allyl-5-isopropylbarbituric acid, 5-allyl-5-isobuthylbarbituric acid, 5-etil-5-(1-methylbutyl) barbituric acid, 5-(1-cyclohexene-1-yl)-1,5-dimethylbarbituric acid and 5-ethyl-5-phenylbarbituric acid were as follow 0.116; 0.144; 0.162; 0.221; 0.262; 0.187 and 0.199.Conclusions: The most optimum mobile phase in this method was the mixed solvents that had lower polarity, i.e, the mix of methanol and acetic acid in the ratio of (1:9). The H1 , H2 and H3 substituens in barbituric acid nuclei showed, the longer carbon chain, the higher the Rm values, howover the existing of double bond in such substituents will decrease the Rm value.Keywords: RPTLC, mobile phase, Rm value ABSTRAK Latar belakang: Proses awal keberhasilan obat dalam mencapai target adalah penetrasi atau absorpsi. Parameter lipofilisitas paling bertanggung jawab terhadap proses absorpsi obat dibanding parameter elektronik dan stearik. Tujuan penelitian ini adalah penggunaan metode RPTLC dan optimasi fase gerak dalam penentuan harga retention modified (Rm) senyawa turunan asam barbiturat.Metode: Penelitian dilakukan terhadap senyawa turunan asam barbiturat, dengan metoda kromatografi lapis tipis fase terbalik. Digunakan fase diam silika gel GF 254 yang telah dibacem dengan campuran parafin cair dan petroleum eter dengan perbandingan (95:5). Fase gerak yang digunakan dipilih campuran pelarut dari yang sangat polar sampai yang kurang polar.Hasil: Fase gerak yang paling optimum digunakan dalam metode ini adalah campuran metanol dan asam asetat dengan perbandingan (1:9). Harga Rm yang diperoleh secara berturutan, asam 5,5-dietilbarbiturat, asam 5,5-dialilbarbiturat, asam 5-alil-5- isopropilbarbiturat, asam 5-alil-5-isobutilbarbiturat, asam 5-etil-5-(1-metilbutil) barbiturat, asam 5-(1-sikloheksen-1-il) 1,5- dimetilbarbiturat dan asam 5-etil-5-fenilbarbiturat adalah: 0,116; 0,144; 0,162; 0,221; 0,262; 0,187 dan 0,199.Simpulan: Fase gerak yang paling optimum dalam metoda ini adalah bukan fase berair, tetapi berupa campuran pelarut yang mempunyai polaritas rendah, yakni campuran metanol dan asam asetat dengan perbandingan (1:9). Substituen atom H1 , H2 dan H3 pada inti asam barbiturat, menunjukkan makin panjang rantai karbon, makin tinggi harga Rm-nya. Adanya ikatan rangkap pada substituen menurunkan harga Rmnya.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4302
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009; 254-259
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4302/3923
oai:ojs.ejournal.undip.ac.id:article/11370
2016-07-01T12:48:50Z
mmi:ART
Pengaruh Asap Rokok Terhadap Histopatologi Koklea: Studi pada Tikus Putih (Rattus norvegicus)
Rianto, Bambang Udji Djoko
ABSTRACT The effect of cigarette smoke on histopathology of cochleaBackground: Clinical studies have suggested that cigarette smoking associate with hearing loss. Smoke exposure is a risk factor to endothelial disfunction and developing atherosclerosis. Cochlea is a auditory organ that is sensitive to hipoxia condition. Objective this study was to determine the effect of cigarette smoke exposure to histological cochlear integrity.Methods: This was post test only design experimental study, using twenty male rats (Rattus norvegicus) were divided into 2 groups. The control group (10 rats) was kept in room free from cigarette smoke, while the experimental group (10 rats) was exposed to tobacco smoke, two cigarette per 1 hour exposure, twice a day, every work day, for 6 months from July 2004-February 2005. The cochlea rats were examined in Patologi Anatomi Laboratory Gadjah Mada University for histopathological examination.Results: There was 1 rat died in each group, and 18 rats (9 control group and 9 experimental group) were still alive. Based on histopathological result, there were abnormality in 7 rats (77.7%) of experimental group while all of control group were normal. This difference is significant statistically with Relatif Risk (RR) was 3.5 (95% CI: 0.66-34.53). The histopathological abnormality were of congestion of capilare, vacuolar degeneration, foam cell and necrosis of hair cells.Conclusion: Tobacco smoke causes histopatological abnormality in cochlear integrity. The relatif risk (RR) of histopathological abnormality on experimental group was 3.5.Keywords: Tobacco smoke, cochlea, stria vascularis, hair cells ABSTRAKLatar belakang: Beberapa studi klinik membuktikan bahwa kebiasaan merokok berhubungan dengan penurunan pendengaran. Paparan asap rokok merupakan faktor risiko terhadap disfungsi endotel yang dapat berkembang menjadi aterosklerosis. Koklea merupakan organ pendengaran yang sensitif terhadap keadaan hipoksia. Penelitian ini membuktikan pengaruh paparan asap rokok terhadap integritas histologis koklea.Metode: Rancang penelitian eksperimental yang digunakan adalah post test only design, dengan sampel sebanyak 20 ekor tikus putih jantan (Rattus norvegicus) dibagi menjadi 2 kelompok. Kelompok kontrol (10 ekor) disimpan di dalam ruangan bebas asap rokok. Kelompok eksperimental (10 ekor) diberi pajanan asap rokok 2 batang rokok per pajanan selama 1 jam, 2 kali sehari, setiap hari kerja selama 6 bulan dari bulan Juli 2004-Februari 2005. Koklea tikus diperiksa secara histopatologi di Laboratorium Patologi Anatomi Fakulatas Kedokteran Hewan Universitas Gadjah Mada.Hasil: Dari seluruh sampel didapatkan pada masing-masing kelompok 1 sampel mati, sedangkan 18 ekor tikus yang berhasil hidup sampai akhir masa pajanan (masing-masing kelompok 9 ekor) terdapat kelainan histologi pada 7 (77,7%) ekor tikus kelompok pajanan dengan RR 3,5 (95% CI: 0,66-34,53). Perubahan histopatolgi yang terjadi berupa kongesti pembuluh darah, degenerasi vakuoler, foam cell dan nekrosis sel rambut getar.Simpulan: Asap rokok berpengaruh pada kerusakan integritas histologis koklea. Kerusakan koklea pada kelompok pajanan asap rokok lebih besar dibanding kelompok kontrol dengan risiko relatif/RR sebesar 3,5.
MEDIA MEDIKA INDONESIANA
2016-07-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/11370
MEDIA MEDIKA INDONESIANA; 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013; 11-17
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/11370/8856
oai:ojs.ejournal.undip.ac.id:article/21833
2019-01-25T14:21:02Z
mmi:ART
Berbagai Konsentrasi Ekstrak Daun Serai Wangi dan Daun Mimba Terhadap Kematian Larva Aedes aegypti
Utomo, Margo
Budiarti, Umi
Serai wangi extract; mimba leaf extract; aedes aegypti larvae
Several concentration of serai wangi leaf extract (Cymbopongan nardus L) and mimba (Azadiracta indica a juss L) and the death of Aedes aegypti larvaeBackground: Infection diseases spread through Aedes aegypti is still high in Indonesia. Herbal larvacide was essentially developed to kill Aedes aegypti larva. Serai wangit leaf extract contains aldehid, geroniol and citronelol. Mimba leaf extract contains azadirachitin. The aim of the study is to analyze the influenced several concentration of extract to kill the larvae.Method: A randomized post test only control group design was done, on 900 tails, 25 per tube of Aedes aegypti B2P2VRP Salatiga isolated, which was taken by random sampling. Extract of serai wangi and mimba leaf with any concentration, were taken from Balai Penelitian Tanaman Obat (BPTO) Tawangmangu. Result: One hundred percent larvae died in serai wangi extract at 60% level concentration with LC50 in 25.82% concentration and LC90 in 39.52% while for mimba extract 100% larvae died in 80% concentration with LC50 in 37.20% concentration and LC90 in 55.27%. There was significant difference in the death of Aedes aegypti larvae in various concentrations. Conclusion: Serai fragrant extract has better killing effect than mimba extract.ABSTRAKLatar belakang: Penyakit yang ditularkan lewat Aedes aegypti masih cukup tinggi di Indonesia. Larvasida alami sangat penting dikembangkan untuk membunuh larva Aedes aegypti. Ekstrak daun serai wangi mengandung aldehid, geroniol dan sitronelol. Ekstrak daun mimba mengandung azadirachitin. Tujuan penelitian ini adalah untuk mengetahui pengaruh berbagai konsentrasi ekstrak serai wangi (Cymbopongan nardus L) dan mimba (Azadiracta indica A juss L) terhadap kematian larva Aedes aegypti. Metode: Desain penelitian adalah randomized post test only control group menggunakan 900 ekor larva isolat laboratorium B2P2VRP Salatiga, dibagi tiap tabung 25 ekor, dengan acak sederhana, dengan kontrol dan 3 kali ulangan. Ekstrak daun serai wangi dan daun mimba dari Balai Penelitian Tanaman Obat Tawangmangu.Hasil: Kematian larva 100% terjadi pada konsentrasi ekstrak serai wangi 60%, LC50 pada konsentrasi 25,82% dan LC90 pada konsentrasi 39,52%. Kematian larva 100% terjadi pada konsentrasi ekstrak daun mimba 80%, LC50 pada konsentrasi 37,20% dan LC90 pada konsentrasi 55,27%.Simpulan: Ekstrak daun serai wangi lebih baik daya bunuhnya daripada ekstrak daun mimba.
MEDIA MEDIKA INDONESIANA
2010-04-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21833
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010; 49-55
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21833/14589
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/2985
2012-04-04T12:55:03Z
mmi:ART
Hiperglikemia dan Aterosklerosis Arteri Karotis Interna pada Penderita Pasca Stroke Iskemik
Darmawan, Agus
Tugasworo, Dodik
Dalem Pemayun, Tjokorda Gde
ABSTRACTHyperglycemia and atherosclerosis of internal carotid artery in post ischemic stroke patientBackground: Atherosclerosis is the primary cause of death in stroke. Marker of atherosclerosis in carotid artery is intima media thickness (IMT) of artery walls. One of trigger atherosclerosis is hyperglycemia. The objective of the study is to investigate the association between hyperglycemia to atherosclerosis of internal carotid artery in post ischemic stroke patient.Methods: A cross sectional design study, patients post ischemic stroke admitted outpatient clinic of neurology department at Dr. Kariadi General Hospital Semarang, start at May 2010 until July 2010. Analysis of atherosclerosis using carotid duplex ultrasound, analysis of hyperglycemia with fasting blood glucose levels, two-hour postprandial glucose levels and also HbA1c levels using bloodvenous in the laboratory of clinical pathology department at Dr. Kariadi General Hospital. Descriptive statistic and logistic regression test were performed to analyze the data.Result: The mean of fasting blood glucose (FBG) levels were 113.93 (SD 42.2) mg/dL, two-hours postprandial glucose (2hPPG) levels were 182.4 (SD 76.5) mg/dL, HbA1c levels were 6.4 (SD 1.5)%. The mean of intima media thickness of internal carotid artery was 1.2 (SD 1.9) mm. No significance difference between FBG, 2hPPG and A1c (95% CI, p>0.05) to atherosclerosis of internalcarotid artery in post ischemic stroke patient.Conclusion: There are no significant association between hyperglycemia and atherosclerosis of internal carotid artery in post ischemic stroke patient.Keywords: Hyperglycemia, atherosclerosis, post ischemic stroke ABSTRAKLatar belakang: Aterosklerosis merupakan penyebab kematian utama pada stroke. Petanda aterosklerosis di arteri karotis adalah ketebalan tunika intima media intima media thickness (IMT) di arteri tersebut. Salah satu pemicu aterosklerosis adalah hiperglikemia. Tujuan penelitian ini adalah membuktikan pengaruh hiperglikemia terhadap aterosklerosis arteri karotis interna pada penderita pasca stroke iskemik.Metode: Desain penelitian adalah cross sectional, pada penderita pasca stroke iskemik yang kontrol di Poliklinik Saraf RSUP Dr. Kariadi Semarang mulai Mei 2010 sampai Juli 2010. Analisis aterosklerosis menggunakan USG Karotis Duplex, analisis hiperglikemia dengan menganalisis kadar glukosa darah puasa, kadar glukosa darah 2 jam postprandial dan kadar HbA1c menggunakan darah vena di Laboratorium Patologi Klinik RSUP Dr. Kariadi. Data dianalisis dengan statistik deskriptif dan uji regresi logistik.Hasil: Rerata kadar glukosa darah puasa (GDP) 113,9 (SB 42,2) mg/dL, kadar glukosa darah 2 jam postprandial (GD2PP) 182,4 (SB 76,5) mg/dL dan kadar HbA1c 6,4 (SB 1,5)%. Rerata ketebalan tunika intima media arteri karotis interna 1,2 (SB 1,9) mm. Tidak ada hubungan bermakna antara GDP, GD2PP dan HbA1c (95% CI, p>0,05) terhadap aterosklerosis arteri karotis interna pada penderita pasca stroke iskemik.Simpulan: Tidak ada hubungan hiperglikemia dengan aterosklerosis arteri karotis interna pada penderita pasca stroke iskemik.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/2985
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 1 Year 2011; 1-7
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/2985/2669
oai:ojs.ejournal.undip.ac.id:article/3236
2012-04-18T11:17:19Z
mmi:ART
Faktor Risiko Kejadian Kurang Pendengaran Tipe Sensorik pada Bayi Baru Lahir
Muyassaroh, Muyassaroh
Kosim, M. Sholeh
Suprihati, Suprihati
Hearing loss, risk factors, newborn baby
ABSTRACTThe risk factors of sensory type of hearing loss in newborn babyBackground: The influence of risk factors (RF) of hearing loss (HL) varies from birth until many years of live. This study aimed to analyze whether the risk factors asphyxia, indirect bilirubin levels, prematurity, birth weight and sepsis in the newborn influenced to the incidence of HL.Method: The cohort prospective study in newborn baby with or without RF at Kariadi Hospital Juli 2010-Desember 2010. Basic data and RF were taken from medical records. Hearing examination with DPOAE and tympanometer were done when discharge from the hospital and 3-month-old baby. Sensory HL is refer DPOAE and type A of tympanogram. Data analysis was using the chisquare test and relative risk.Result: There were 112 babies with RF and 117 babies without RF. The incidence of HL after 3 month, were 9 babies (3.9%) at-risk group and 3 (1.3%) in the group without RF. The risk to sensory HL in the babies with many RF was 4 times greater than one RF. Prematurity and VLBW influenced the incidence of sensory HL. Multivariate logistic regression analysis found that VLBW independency influenced the incidence of sensory HL (RR=9.500 CI=1.091-82.725; p=0.041). Aspyxia, hiperbilirubinemia and sepsis not influenced the incidence of sensory HL.Conclusion: Prematurity and VLBW influenced the incidence of sensory HL. VLBW independently influenced the incidence of sensory HL.Keywords: Hearing loss, risk factors, newborn babyABSTRAKLatar belakang: Manifestasi klinik kurang pendengaran (KP) dari beberapa faktor risiko (FR) bervariasi dari sejak lahir sampai bayi umur beberapa bulan atau setelah beberapa tahun. FR yang dapat menyebabkan KP adalah asfiksia, berat badan lahir, prematuritas, kadar bilirubin indirek, dan sepsis. Penelitian ini bertujuan untuk membuktikan bahwa FR asfiksia, berat lahir, prematuritas, kadar bilirubin indirek dan sepsis pada bayi baru lahir secara sendiri atau bersama-sama berpengaruh terhadapkejadian KP tipe sensorik.Metode: Dilakukan penelitian kohort prospektif pada 229 bayi baru lahir dengan atau tanpa FR yang dirawat di RSUP Dr. Kariadi Semarang Juli 2010-Desember 2010. Data dasar dan FR diambil dari rekam medik. Pemeriksaan pendengaran dengan distortion product otoacustic emission (DPOAE) dan timpanometri sesaat sebelum pulang dan dievaluasi setelah 3 bulan. KP tipe sensorik bila hasil pemeriksaan DPOAE merujuk pada “refer” dan timpanogram menghasilkan tipe A. Analisis statistik digunakan uji Chi-squaredan risiko relatif.Hasil: Didapatkan 112 bayi dengan FR dan 117 bayi tanpa FR. Kejadian KP tipe sensorik pada 9 bayi dengan FR (3,9%) dan 3 bayi tanpa FR (1,3%). Bayi dengan beberapa FR mempunyai risiko 4 kali lebih besar terjadi KP tipe sensorik dibandingkan dengan bayi satu FR. Prematur dan BBLSR berpengaruh terhadap kejadian KP tipe sensorik. Analisis regresi logistik multivariat didapatkan BBLSR secara independen berpengaruh terhadap kejadian KP tipe sensorik (RR=9,500 CI=1,091-82,725; p=0,041). Asfiksia, hiperbilirubinemia dan sepsis tidak berpengaruh terhadap kejadian KP tipe sensorik. Asfiksia, hiperbilirubinemia dan sepsis tidak berpengaruh terhadap kejadian KP tipe sensorik.Simpulan: Prematur dan BBLSR berpengaruh terhadap kejadian KP tipe sensorik. BBLSR secara independen berpengaruh terhadap kejadian KP tipe sensorik.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3236
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 158-162
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3236/2908
oai:ojs.ejournal.undip.ac.id:article/3809
2012-07-18T11:06:11Z
mmi:ART
Antenatal, Place of Birth and Post-natal Related to Breastfeeding Practice among Women in Peri-urban Area, Semarang
Margawati, Ani
Breast-feeding practice, lack of knowledge, antenatal care, birth place.
ABSTRACTBackground: Key health issues for women of reproductive age include problems concerning sexuality and reproduction. Sexuality is not merely about sex, but about the right of women to make choices and decisions related to sexual behaviour and practices, relationships, breastfeeding, contraception and abortion. This paper will examines the various health facilities, the services and treatments which are available, in particular those which influence breastfeeding practices.Methods: A combination of qualitative and quantitative data collection methods were used in this research. In the quantitative method, a questionnaire survey was conducted following preliminary analysis of the data collected through focus group discussions (FGDs). The methods employed for qualitative data collection included focus group discussions, informal and in-depth interviews and participant observation. The sample group in the peri-urban area included pregnant women, mothers with babies less than 2years old, a few husbands and a small number of women of reproductive age.Results: This research found that there were many factors influencing the choice of birth place such as location, costs and the quality of the services provided by nurses, doctors, etc. The women in this area still preferred the services of the dukun bayi for the postnatal treatment.Conclusion: The place where the mother delivers the baby influences their motivation to breastfeed. Although the respondents mentioned that breastfeeding is a good practice for feeding baby, however, they lack of knowledge about breastfeeding. This condition is closely related to poor counselling about breastfeeding.Key Words: Breast-feeding practice, lack of knowledge, antenatal care, birth place.ABSTRAKTempat persalinan, pemeriksaan pre dan pasca melahirkan terhadap pengetahuan dan praktek menyusui di pinggiran Semarang.Latar belakang: Beberapa permasalahan utama pada perempuan usia reproduksi adalah seksualitas dan reproduksi. Seksualitas tidak hanya meliputi masalah tentang seks, akan tetapi juga hak perempuan untuk memilih dan menentukan terhadap perilaku seksual, praktek, menyusui, pemilihan alat kontrasepsi dan juga aborsi. Artikel ini akan menganalisis berbagai fasilitas kesehatan, pelayanan dan perlakuan terhadap ibu hamil dan melahirkan dalam kaitannya dengan perilaku menyusui.Metode: Metode penelitian yang dipergunakan dalam penelitian ini adalah gabungan antara metode kuantitatif dan kualitatif. Teknik survei adalah metode yang diaplikasikan dalam metode kuantitatif dan disajikan secara deskriptif; sedangkan metode kualitatif dilakukan dengan diskusi kelompok terarah, wawancara mendalam dan observasi partisipasi. Sampel dalam penelitian adalah ibu yang tinggal di lokasi penelitian dan mempunyai anak di bawah 2 tahun dan beberapa wanita usia reproduksi.Hasil: Hasil penelitian menunjukkan bahwa terdapat berbagai faktor yang membuat keputusan terhadap pemilihan lokasi pemeriksaan kehamilan, tempat persalinan, dan perawatan pasca persalinan, seperti lokasi, biaya dan mutu pelayanan. Ibu-ibu di daerah penelitian masih lebih memilih dukun bayi sebagai orang yang melakukan perawatan pasca persalinan.Simpulan: Tempat persalinan memberi pengaruh dan motivasi ibu-ibu di daerah penelitian untuk menyusui. Meskipun responden menyatakan bahwa menyusui merupakan perilaku yang baik sebagai pemberian makanan kepada bayi, akan tetapi mereka masih terbatas pengetahuannya terhadap menyusui. Hasil penelitian menunjukkan bahwa rendahnya pengetahuan disebabkan karena terbatasnya penyuluhan yang diberikan oleh petugas pada masa pemeriksaan kehamilan, dan juga pasca persalinan.
MEDIA MEDIKA INDONESIANA
2012-07-16
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3809
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 1 Year 2008; 29-36
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3809/3493
oai:ojs.ejournal.undip.ac.id:article/4037
2012-09-20T12:10:19Z
mmi:ART
Penyuluhan Model Pendampingan dan Perubahan Status Gizi Anak Usia 6 – 24 Bulan
Amir, Aswita
Muis, S. Fatimah
Suyatno, Suyatno
Outreached counseling, nutritional status, 6–24 months old children.
The outreach counseling model and nutritional status change in 6–24 months old childrenBackground: Insufficient knowledge on food and health of mothers will lead to inadequate food intake and high infection risk, especially diarrhea and acute respiratory tract infection (ARTI). Improvement of knowledge can be achieved by counseling. There are several model of counseling, one of them is the outreach model. This study aimed was to analyze the influence of outreach counseling model toward the change of nutritional status of 6–24 months old children. Methods: Research design was a quasi experiment with non randomized pre post test control group. Intervention group recieved outreach counseling model by outreach nutritionists (Tenaga Gizi Pendamping) and control group recieved conventional counseling from nutritionists of primary health care center (Tenaga Gizi Puskesmas). The study was done in Makassar City, South Sulawesi Province with the working area of Sudiang Raya’s Primary Health Care chosen as intervention area and Bira’s Primary Health Care as control site. Subjects were children aged 6–24 months with WAZ between -3 until 0 SD. The number of subjects in intervention group were 32 and control were 37 children. The observation variables were changes of mother’s knowledge, energy adequacy level, protein adequacy level, diarrhea and ARTI duration and nutritional status (WAZ, HAZ and WHZ) of the children. Data were analyzed using t-test and multivariate analysis by linear regression.Results: After 3 months of intervention, there were increase in mother’s knowledge, energy adequacy level, and the decrease of duration diarrhea was higher in the outreach counseling group than the control group. The WAZ and HAZ in outreach counseling group were better than control group, and there was an increase in WHZ in outreach counseling group with a decrease in the control group.Conclusions: Outreach counseling model is more effective than conventional counseling in lowering the decrease of nutritional status on 6–24 months old children.Key words: Outreached counseling, nutritional status, 6–24 months old children. ABSTRAK Latar Belakang: Pengetahuan ibu yang kurang tentang gizi dan kesehatan akan menyebabkan asupan makanan yang tidak cukup serta meningkatnya risiko penyakit infeksi diantaranya diare dan ISPA pada anak. Peningkatan pengetahuan dapat dilakukan dengan penyuluhan. Penyuluhan terdiri dari beberapa model, salah satu diantaranya adalah model pendampingan. Penelitian ini bertujuan untuk menganalisis pengaruh penyuluhan model pendampingan terhadap ibu selama 3 bulan terhadap perubahan status gizi anak usia 6-24 bulan.Metode: Desain penelitian adalah quasi experiment berupa non randomized pre post test control group. Kelompok intervensi mendapat penyuluhan model pendampingan oleh Tenaga Gizi Pendamping (TGP) dan kelompok kontrol mendapat penyuluhan konvensional oleh Tenaga Gizi Puskesmas. Penelitian dilakukan di wilayah kerja Puskesmas Sudiang Raya Kota Makassar sebagai lokasi intervensi dan Puskesmas Bira sebagai lokasi kontrol. Subyek penelitian adalah anak usia 6–24 bulan dengan skor Z BB/U -3 s.d. 0 SB. Jumlah subyek untuk kelompok intervensi 32 dan kontrol 37 anak. Variabel yang diamati meliputi perubahan pengetahuan ibu, Tingkat Kecukupan Energi (TKE), Tingkat Kecukupan Protein (TKP), hari sakit (Diare dan ISPA) dan status gizi (skor Z BB/U, PB/U dan BB/PB). Analisis data dilakukan dengan menggunakan uji beda dan analisis multivariat dengan regresi linier.Hasil: Setelah 3 bulan intervensi, terjadi peningkatan rerata skor pengetahuan ibu dan TKE, dan penurunan jumlah hari sakit diare lebih tinggi pada kelompok intervensi dibandingkan kontrol. Status gizi (skor Z BB/U dan PB/U) pada kelompok intervensi lebih baik dibandingkan kontrol (p<0,05), terjadi peningkatan skor Z BB/PB pada kelompok intervensi dan penurunan skor tersebut pada kelompok kontrol (p<0,05).Simpulan: Penyuluhan model pendampingan lebih efektif daripada penyuluhan konvensional dalam menekan penurunan status gizi anak usia 6–24 bulan.
MEDIA MEDIKA INDONESIANA
2012-07-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4037
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 3 Year 2008; 148-155
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4037/3709
oai:ojs.ejournal.undip.ac.id:article/4270
2013-06-26T12:59:31Z
mmi:ART
Suplementasi Folate, Kadar Homocysteine, Nitric Oxide dan Petanda Retinopati Diabetik Studi pada Tikus Sprague Dawley Diabetes
Rachmawati, Banundari
Folic acid supplementation of 8 ppm gives benefits to diabetic rats.
Folate supplementation homocysteine, nitric oxide levels and marker for diabetic retinopathy: Study on Sprague Dawley diabetic ratsIntroduction: Diabetic retinopathy (DR) is the leading cause of blindness among diabetes mellitus (DM) patients. Hyperhomocysteinemia (HHcy) is reported to increase the risk for DM complications, however, the underlying mechanism is still unclear. Retina is particularly vulnerable to oxidative stress due to a high demand for oxygen. Hyperglycemia stimulates retinal oxidative stress and increases Nitric Oxide (NO). NO contributes to the regulation of retinal blood vessel function and the occurrence of retinopathy. The administration of folic acid (FA) 0.65 mg/day on HHcy subject, decrease serum Hcy by 42%. This study was aimed to analyze the effect of folate administration on Hcy, NO levels and markers of DR (VEGF serum).Methods: An experimental study using a randomized controlled group pretest posttest design was conducted in UGM Yogyakarta. The total of 40 male Sprague Dawley rats were divided into 5 groups: negative control and the other four group were induced with Streptozotocin 40 mg/kgBW intraperitoneal. Intervention group were given FA 2, 4, 8 ppm through a nasogastric tube for 30 days. Before and after intervention, serum Hcy, NO and VEGF were assessed, and Wilcoxon tests were used to measure the difference ofit.Result: Administration of 8 ppm FA significantly decreased serum Hcy (p=0.043), NO levels (p=0.043) but not for markers of DR.Conclusion: Folic acid supplementation of 8 ppm gives benefits to diabetic rats.Keywords: Diabetic retinopathy, homocysteine, NO, VEGFABSTRAKPendahuluan: Retinopati diabetik (RD) merupakan komplikasi diabetes mellitus yang dapat menjadi salah satu penyebab kebutaan. Hyperhomocysteinemia (HHcy) meningkatkan risiko komplikasi diabetes, namun bagaimana interaksinya masih belum jelas. Retina sangat peka terhadap stres oksidatif karena kebutuhan O2 yang tinggi sedangkan hiperglikemi akan memacu retinal oxidative stres dan peningkatan nitric oxide (NO). NO berperan pada regulasi fungsi pembuluh darah retina dan terjadinya retinopati. Pemberian folic acid (FA) 0,65 mg/hr pada subyek HHcy menurunkan Hcy serum 42%. Tujuan penelitian ini adalah menganalisis pengaruh pemberian folate terhadap kadar Hcy, NO dan petanda RD (VEGF serum)Metode: Penelitian ini bersifat eksperimental dengan rancangan randomized controlled group pretest posttest design. Penelitian dilakukan di LPPT unit IV UGM Yogyakarta. Sampel 40 tikus Sprague Dawley jantan, umur 2-3 bulan, BB 190-275 g dibagi 5 kelompok: kelompok kontrol negatif dan 4 kelompok lain diinduksi dengan STZ 40mg/kgBB intra peritoneal. Kelompok intervensi diberi FA 2, 4, 8 ppm (sonde) selama 30 hari. Kemudian diperiksa kadar Hcy, VEGF, NO serum. Perbedaan parameter sebelum dan sesudah intervensi dianalisis dengan uji Wilcoxon.Hasil: Pemberian FA 8 ppm menurunkan secara bermakna kadar Hcy (p=0,043), NO serum (p=0,043) dan tidak menurunkan petanda RD (VEGF serum) secara bermakna.Simpulan: Pemberian FA 8 ppm bermanfaat pada tikus diabetes.
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4270
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 100-107
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4270/3891
oai:ojs.ejournal.undip.ac.id:article/4295
2012-12-29T12:12:01Z
mmi:ART
Pengaruh Kalsium dan Vitamin D3 Terhadap Stabilitas Tulang Alveolar - Studi pada Tikus Jantan Putih (Rattus Norvegicus)
Anwar, Saifuddin Ali
Calcium, vitamin D3, alveolar bone weight.
The effect of calcium and vitamin D3 on alveolar bone stability - The study in white male Rattus Norvegicus rats.Background: Calsium and vitamin D3 play important roles in the development and stability of alveolar bone that hold teeth. Alveolar bone stability is very important for successful outcome of orthodontic and prostodontic treatment.Objective: This study aimed to analyze the effect of calcium and vitamin D3 supplementation on different dosages on the alveolar bone stability.Methods: A post test-only control group design experiment was carried out on white rats (Rattus norvegicus Wistar strain). The treatments were 20% calcium reduction in the diet (P1) and supplentation of 20% (P2); 40% (P3) and 60% (P4) calsium to the standar diet given to control group. Alveolar bone stability was assessed by calcium contents, the number of osteocytes and weight of alveolar bone which were measured by AAS methode, histologic examination using hematoxylin and eosin staining on two microscopic fields of lamella Haversi region of alveolar bone and weighing of upper incisivus region of alveolar bone respectively. Data were analysed using t.test, Anova and LSD. Results: There were no difference on the calcium content of the alveolar bone among the 5 experimental groups (F=0.290, p=0.881). The number of osteocytes were different among as well as between the groups (F=9.685; p=0.000). There were differences of alveolar bone weight among the groups (F=10.901; p=0.000) while the weight were only significantly increase in the groups which given 40% (P3) and 60% (P4) calcium supplements this difference was not occured in the group which given 20% calcium supplements compare to the control group. There was no difference of alveolar weight between P3 and P4 groups.Conclusions: Supplementation of calsium and vitamin D3 20%, 40% and 60% above the standard diet give different result in 2 parameters of bone stability.Keywords: Calcium, vitamin D3, alveolar bone weight.ABSTRAK Latar belakang: Kalsium dan vitamin D3 berperan dalam pembentukan dan stabilitas tulang alveolar yang berfungsi sebagai penyangga gigi. Stabilitas tulang alveolar berperan dalam keberhasilan perawatan ortodontik dan prostodontik. Penelitian ini bertujuan untuk mengkaji perbedaan pengaruh suplementasi kalsium dan vitamin D3 pada berbagai takaran terhadap stabilitas tulang alveolar pada hewan coba.Metode: Dilakukan suatu penelitian eksperimental dengan rancangan the post test-only control group, menggunakan hewan coba tikus putih jantan (Rattus norvegicus galur Wistar). Perlakuan yang diberikan berupa pengurangan kalsium 20% (P1) dan penambahan 20% (P2), 40% (P3) dan 60% (P4) kalsium dalam pakan. Stabilitas tulang alveolar dinilai dengan parameter kadar kalsium, jumlah osteosit dan berat tulang alveolar, yang secara berurutan diukur dengan metoda SSA, dihitung secara histologik dengan pengecatan hematoksilin dan eosin pada dua lapang pandang lamela Haversi regio insisivus atas dan penimbangan tulang alveolar regio incicivus atas. Data di analisis menggunakan uji t, Anova dan LSD.Hasil: Tidak ada perbedaan yang bermakna pada kadar kalsium tulang alveolar di antara 5 kelompok penelitian (F=0,290; p=0,881). Jumlah osteosit berbeda bermakna di antara kelompok dan antara kelompok perlakuan (F=9,685, p=0,000).
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4295
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009; 224-228
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4295/3913
oai:ojs.ejournal.undip.ac.id:article/4578
2013-06-26T12:57:43Z
mmi:ART
Citra Tubuh, Pendidikan Ibu, Pendapatan Keluarga, Pengetahuan Gizi, Perilaku Makan dan Asupan Zat Besi pada Siswi SMA
Rahayu, Santi Dwi
Dieny, Fillah Fithra
Body image, eating behavior, iron intake
The body image, mother’s education, family income, nutritional knowledge, eating behavior and iron intake among senior high school female studentsBackground: The concept of ideal body shape in female adolescent is tall and slim that oftenly to lead restriction of the food intake especially the food sources of iron that are considered as foods with high fat. This study aimed to identify factors association between body image, mother’s education, family income, nutritional knowledge, and eating behavior with iron intake among senior high school female students.Method: This study used cross sectional design, and it was conducted on female students at SMA Negeri 1 Tangerang Selatan. The selection of 80 subjects was performed by stratified random sampling technique. Data on body image was obtained by body shape questionnaire, family income, mother’s education, nutritional knowledge and eating behavior were collected by questionnaire, and iron intake was obtained by 24-hour food recall. Data were analyzed by Rank Spearman.Result: Subjects aged in 15-17 years old. The subjects had a dissatisfaction of their body image were 41.25% subjects and 40% subjects had deficit iron intake. Subjects had inappropriate eating behavior 47.5% and 66.3% were classified as intermediate level of family income. The level of mother’s education at SMA/MA were 53.8% subjects and only 7.5% subjects had good nutritional knowledge. The subjects had a dissatisfaction of their body image would be had inappropriate eating behavior so they had lower iron intake too. The good mother’s education of subjects would be had good iron intake, moreover the higher family income that increased food expenditure so subjects had adequate iron intake. The nutritional knowledge was not correlated with iron intake.Conclusion: Body image was associated with eating behavior. Eating behavior, mother’s education, and family income were correlated with iron intake.Keywords: Body image, eating behavior, iron intake ABSTRAKLatar belakang: Konsep tubuh ideal tinggi langsing menimbulkan remaja putri melakukan pembatasan asupan makanan terhadap sumber zat besi yang dianggap sebagai makanan dengan lemak tinggi. Tujuan penelitian untuk mengidentifikasi hubungan antara citra tubuh, pendidikan ibu, pendapatan keluarga, pengetahuan gizi dan perilaku makan dengan asupan zat besi pada siswi SMA.Metode: Rancangan penelitian cross sectional. Populasi adalah siswi SMA Negeri 1 Tangerang Selatan. Pemilihan 80 subyek dilakukan secara stratified random sampling. Data citra tubuh dengan body shape questionnaire, pendapatan keluarga dengan angket, pendidikan ibu, pengetahuan gizi dan perilaku makan dengan kuesioner serta asupan zat besi dengan kuesioner food recall 24 jam. Data dianalisis dengan korelasi Rank Spearman.Hasil: Subyek berusia 15-17 tahun. Subyek dengan ketidakpuasan citra tubuh sebanyak 41,25% dan 40% subyek mempunyai tingkat asupan zat besi defisit. Subyek dengan perilaku makan tidak sesuai sebanyak 47,5% dan 66,3% subyek mempunyai tingkat pendapatan keluarga ekonomi menengah. Tingkat pendidikan ibu subyek tamat SMA/MA sebanyak 53,8% dan hanya 7,5% yang mempunyai tingkat pengetahuan gizi baik. Subyek dengan citra tubuh yang tidak puas cenderung mempunyai perilaku makan yang tidak sesuai sehingga asupan zat besinya rendah. Subyek dengan ibu berlatar belakang pendidikan tinggi cenderung mempunyai asupan zat besi baik, selain itu makin tinggi pendapatan keluarga, maka pengeluaran belanja pangan makin meningkat sehingga asupan zat besi pada subyek terpenuhi. Namun pengetahuan gizi tidak berhubungan dengan perilaku makan.Simpulan: Citra tubuh berhubungan dengan perilaku makan. Perilaku makan, pendidikan ibu, dan pendapatan keluarga berhubungan dengan asupan zat besi
MEDIA MEDIKA INDONESIANA
2013-03-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4578
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012; 184-194
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4578/4170
oai:ojs.ejournal.undip.ac.id:article/21828
2019-01-25T14:21:01Z
mmi:ART
Efek Pemberian Ekstrak Eurycoma Longifolia dan Pimpinella Alpina pada Spermatogenesis Tikus Spraque Dawly
Juniarto, Achmad Zulfa
Eurycoma longifolia; pimpinella alpina; spermatogenesis
The effect of eurycoma longifolia and pimpinella alpina on spermatogenesis in male Spraque Dawly Background: Alternative medicine used to overcome infertility among others is using traditional herbs. Crops which often used are pasak bumi (Eurycoma longifolia) and purwaceng (Pimpinella alpina). Several studies reported that pasak bumi and purwaceng could improve testosterone, luteinizing hormone and follicle stimulating hormone level in animal. The aim of the study was to analyze whether the extract of Eurycoma longifolia and Pimpinella alpina had effect on motility and spermatogenesis in white male Spraque Dawly mouse.Material and Method: Thirty white male mice, aged 40 days, with mean body weight of 200 grams were divided into 10 groups randomly. Each mouse was placed into individual cage and was given 25 mg Pimpinella alpina, 25 mg Eurycoma longifolia Jack and plain water in control group. Food was given ad libitum. All the treatment was given every morning for 53 days successively then the testis and epididymis were taken for analysis. Result: Administration of Eurycoma longifolia and Pimpinella alpina increased the number and motility of sperms as well as the spermatogenesis. However, there was no difference between the effect of Eurycoma longifolia and Pimpinella alpine.Conclusion: Extract of Eurycoma longifolia and Pimpinella alpina can improve spermatogenesis.ABSTRAKLatar belakang: Pengobatan alternatif untuk mengatasi infertilitas antara lain adalah dengan menggunakan pasak bumi (Eurycoma longifolia Jack) dan purwaceng (Pimpinella alpina). Pada beberapa penelitian keduanya terbukti meningkatkan kadar hormon testosteron, luteinizing hormone dan follicle stimulating hormone. Tujuan dari penelitian ini adalah untuk mempelajari apakah pemberian ekstrak pasak bumi dan purwaceng berpengaruh terhadap peningkatan derajat spermatogenesis serta jumlah dan motilitas sperma pada tikus putih jantan Spraque Dawly.Metode: Tiga puluh ekor tikus putih jantan, umur 40 hari dengan berat badan rata-rata 200 gram dibagi menjadi 10 kelompok secara acak. Tiap-tiap kelompok terdiri dari 3 ekor tikus. Setiap tikus ditempatkan dalam kandang individual. Makanan yang diberikan secara ad libitum. Masing-masing kelompok diberi perlakuan ekstrak akar pasak bumi sebanyak 25 mg, purwaceng sebanyak 25 mg dan akuades sebagai kontrol. Semua perlakuan tersebut diberikan tiap pagi selama 53 hari berturut-turut, kemudian diperiksa testis untuk derajat spermatogenesisnya dan epididimisnya. Untuk pemeriksaan jumlah dan motilitasnyaHasil: Pemberian ekstrak pasak bumi maupun purwaceng meningkatkan jumlah, motilitas spermatozoa serta derajat spermato-genesis tikus bila dibandingkan dengan kontrol (p<0,01). Efek pemberian pasak bumi tidak berbeda dengan pemberian purwaceng (p>0,01).Simpulan: Ekstrak Eurycoma longifolia dan Pimpinella alpine meningkatkan derajat spermatogenesis.
MEDIA MEDIKA INDONESIANA
2010-04-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21828
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010; 20-26
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21828/14584
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3248
2012-04-20T07:51:41Z
mmi:ART
Emping Garut (Maranta arundinacea Linn) sebagai Makanan Ringan dan Kadar Glukosa Darah, Angiotensin II Plasma serta Tekanan Darah pada Penderita Diabetes Mellitus Tipe 2 (DMT2)
Novitasari, Dwi
Sunarti, Sunarti
Farmawati, Arta
Crispy arrowroot, blood glucose, angiotensin II, hypertension
ABSTRACTConsumption of crispy arrowroot (Maranta arundinacea Linn), blood glucose and angiotensin II level, and blood pressure in type 2 diabetesBackground: The mortality of DM caused by cardiovascular complication is about 75% can be reduce by using food with lowglycemic index. The level of fiber consumption on DM sufferers is low (12.08±3.80 gr/day). Crispy arrowroot has 14 glycemic index. The purpose of this study is to know the influence of crispy arrowroot giving to the fasting plasma glucose, angiotensin II rate and blood pressure and also to study the correlation between angiotensin II and blood pressure before and after the giving of crispy arrowroot.Method: This research used quasi-experimental design of pre and post test one group design, the subjects were 14 DMT2 female sufferers (35 to 60 years old), the length of suffering from DM was 1 year, and used insulin therapy. The giving of crispy arrowroot was 20 gr/day for four weeks. The determination of fasting blood glucose rate used colorimetry, angiotensin II rate used ELISA sandwich method and blood pressure used spignomanometer. The data analysis used paired t test and regression test.Results: Consumption of crispy arrowroot does not increase fasting blood sugar (p=0.551), or decrease angiotensin II (p=0.550), and systolic-diastolic blood pressure (psystolic=0.518; pdiastolic=0.216). Conclusion: Crispy arrowroot of 20 g/day for 4 weeks does not give any benefit to DM type 2 patients.Keywords: Crispy arrowroot, blood glucose, angiotensin II, hypertensionABSTRAKLatar belakang: Angka kematian penderita DM karena komplikasi kardiovaskular sekitar 75%. Upaya mengurangi komplikasi tersebut dapat menggunakan makanan dengan indeks glikemik rendah. Tingkat konsumsi serat penderita DM relatif rendah yaitu sekitar 12,08±3,80 gr/hari. Umbi garut mempunyai indeks glikemik 14 sehingga dapat digunakan sebagai makanan fungsional penderita DM. Tujuan penelitian untuk mengkaji pengaruh pemberian makanan ringan emping garut terhadap kadar glukosa darah puasa (GDP), angiotensin II dan tekanan darah serta mengkaji hubungan antara angiotensin II dan tekanan darah sebelum dan setelah pemberian emping garut pada penderita DMT2.Metode: Penelitian menggunakan desain kuasi eksperimental pre and post test one group design, subyek penelitian 14 wanita (35-60 tahun) penderita DMT2, lama DM 1 tahun dan menggunakan insulin. Emping garut sangrai 20 gr/hari diberikan pagi dan sore hari selama 4 minggu. Pengukuran GDP menggunakan metode kolorimetri, angiotensin II ditentukan menggunakan metode ELISA sandwich dan tekanan darah menggunakan spignomanometer. Analisis data menggunakan uji paired t test dan uji regresi.Hasil: Pemberian emping garut tidak meningkatkan GDP (p=0,551) dan tidak menurunkan kadar angiotensin II (p=0,550), serta tekanan sistolik dan diastolik (psistolik=0,518; pdiastolik=0,216).Simpulan: Pemberian emping garut sangrai 20 gr/hari selama 4 minggu pada penderita DM tidak menunjukkan manfaat.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3248
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 1 Year 2011; 53-58
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3248/2916
oai:ojs.ejournal.undip.ac.id:article/21905
2019-01-29T13:11:27Z
mmi:ART
Skor Diskriminan Manifestasi Klinis dan Laboratorik sebagai Prediktor Syok pada Demam Berdarah Dengue
Supriatna, Mohamad
Hapsari, MMDEAH
Mexitalia, Maria
Istanti, Yusrina
Predictor of shock; discriminant score; dengue hemorrhagic fever (DHF); DSS
Discriminant score of clinical and laboratory manifestations as a predictor of shock in dengue hemorrhagic fever Background: Case fatality rate of dengue shock syndrome (DSS) is still high. In Dr. Kariadi Hospital Semarang (RSDK) was 5.7 to 10.8% during 2000 to 2004. This is due to clinical course of dengue hemorrhagic fever (DHF) are unpredictable whether patients will develop to shock or not. We aimed to formulate discriminant score of clinical and laboratory manifestations that can be used as a predictor of shock in DHF.Methods: An observational analytic study was done. Consecutive sample were taken from DHF patients aged 3–14 years who were treated at RSDK in February 2001–March 2003. Diagnosis was established based on WHO 1997 criteria and serologic indirect-ELISA. Septic children were excluded. Clinical and laboratory manifestations were examined at admission or when diagnosed as DHF. Chi-square, Mann-Whitney, and discriminant analysis were done to formulate discriminant score.Results: There were 152 DHF patients enrolled, consist of 61 non-DSS and 91 DSS. Discriminant score formulation was obtained as: D=–1.103 + (0.013 x bleeding type) + (1.229 x vomiting) + (0.478 x abdominal pain) + (0.922 x hepatomegaly) – (0.039 x haemoglobin) + (0.014 x haematocryt) – (0.404 x albumin) – (0.046 x total protein) + (0.043 x pleural effusion index). Discriminant score mean for DSS is +0.739 and non-DSS –1.103 with cut-off point of –0.182. If the score <–0.182 patients become non-SSD and ≥–0.182 DSS. Conclusion: Discriminant score of clinical and laboratory manifestations can be used as a predictor of shock in DHF with prediction accuracy of 80.3%.ABSTRAKLatar belakang: Angka kematian sindrom syok dengue (SSD) masih tinggi. Di RSUP Dr. Kariadi (RSDK) Semarang 5,7–10,8% pada tahun 2000–2004. Hal ini disebabkan perjalanan klinis demam berdarah dengue (DBD) sulit diprediksi apakah penderita akan mengalami syok atau tidak. Tujuan penelitian adalah merumuskan skor diskriminan manifestasi klinis dan laboratoris yang dapat dijadikan sebagai prediktor syok pada DBD. Metoda: Dilakukan penelitian observasional analitik dengan sampel secara consecutive dari penderita DBD umur 3–14 tahun yang dirawat di RSDK pada Februari 2001–Maret 2003. Diagnosis ditegakkan berdasar kriteria WHO 1997 dan serologis indirect-ELISA. Anak dengan sepsis dieksklusi dari penelitian. Manifestasi klinis dan laboratoris diperiksa saat masuk rumah sakit atau saat diagnosis ditegakkan. Uji Chi-square, Mann-Whitney, dan analisis diskriminan dilakukan untuk merumuskan skor diskriminan.Hasil: Didapatkan 152 penderita DBD yang terdiri dari 61 non-SSD dan 91 SSD. Rumus skor diskriminan yang didapat sebagai berikut: D=–1,103 + (0,013 x jenis perdarahan) + (1,229 x muntah) + (0,478 x nyeri perut) + (0,922 x hepatomegali) – (0,039 x hemoglobin) + (0,014 x hematokrit) – (0,404 x albumin) – (0,046 x protein total) + (0,043 x indeks efusi pleura).Rerata skor diskriminan SSD +0,739 dan non-SSD –1,103 dengan cut off point –0,182. Bila skor <–0,182 penderita akan menjadi non-SSD dan ≥–0,182 akan menjadi SSD. Simpulan: Skor diskriminan manifestasi klinis dan laboratoris dapat dijadikan sebagai prediktor syok pada DBD dengan 80,3% ketepatan prediksi.
MEDIA MEDIKA INDONESIANA
2010-12-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21905
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 3 YEAR 2010; 125-132
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21905/14641
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3026
2012-04-05T13:51:50Z
mmi:ART
Kadar Apolipoprotein B dan Aterosklerosis Arteri Karotis Interna pada Pasien Pasca Stroke Iskemik
Teguh, Haryo
Retnaningsih, Retnaningsih
Widiastuti, MI
Apolipoprotein B level, internal carotid artery atherosclerosis, ischemic stroke
ABSTRACTRelations between apolipoprotein B level with internal carotid artery atherosclerosis in post ischemic stroke patientBackground: Ischemic stroke is caused by brain artery obstruction or brain artery narrowing called atherosclerosis. Its marker is the thickness of tunica intima-media (intima-media thickness/IMT) of the artery. Apolipoprotein B is one of the indicator of atherosclerosis diseases. Most of the previous studies investigate association between apolipoprotein B level and cardiovascular disease, while the association between apolipoprotein B and atherosclerosis in post ischemic stroke patients has not been studied yet.Objective: To investigate association between apolipoprotein B level and internal carotid artery atherosclerosis based on thickness of intima-media in patients post ischemic stroke.Method: This cross-sectional study was done in post ischemic stroke (first attack) subjects in outpatient clinic of Neurology Department Kariadi Hospital Semarang, during December until February 2011. Apolipoprotein B level was measured with Integra method, during 1 month after the onset. The thickness of tunica intima-media of the internal carotid artery was measured by Ultrasonography Duplex.Result: Fourty four patients post ischemic stroke that met the inclusion and exclusion criteria, comprise of 22 male (50%) and 22 female (50%). Atherosclerosis which was defined as tunica intima-media thickness >0.9 mm, was found in 24 subjects (54.6%). Apolipoprotein B level, which designated as high if apoB >105 mg/dl, was found in 25 subjects (56.8%). Multivariate logistics regression test controlling lipid factor as confounding factors resulted in OR 142.1 (p=0.0001).Conclusion: Apolipoprotein B level significantly correlate with atherosclerosis of internal carotid artery represented by thickness of intima-media in patients post ischemic stroke.Keywords: Apolipoprotein B level, internal carotid artery atherosclerosis, ischemic strokeABSTRAKLatar belakang: Stroke iskemik disebabkan obstruksi atau penyempitan pembuluh darah arteri otak yang disebut aterosklerosis. Marker aterosklerosis adalah ketebalan tunika intima-media (intima-media thickness/IMT) di pembuluh darah tersebut. Kadar apolipoprotein B merupakan indikator penyakit yang disebabkan aterosklerosis. Penelitian yang ada kebanyakan menghubungkan pengaruh apoB dengan penyakit kardiovaskuler, pengaruh apoB dengan aterosklerosis pada pasien pasca stroke iskemik belum pernah dilakukan.Tujuan: Membuktikan adanya hubungan antara kadar apolipoprotein B dengan aterosklerosis arteri karotis interna yang dilihat dari ketebalan tunika intima-media pada pasien pasca stroke iskemik.Metode: Penelitian cross sectional, dilaksanakan di Poli Saraf RSUP Dr. Kariadi Semarang, periode Desember 2010-Februari 2011. Subyek penelitian adalah pasien pasca stroke iskemik pertama kali yang diambil secara consecutive sampling. Kadar apolipoprotein B diukur dengan menggunakan metode Integra, pemeriksaan ketebalan tunika intima-media arteri karotis internamenggunakan Ultrasonografi Duplek.Hasil: Empat puluh empat pasien pasca stroke iskemik yang memenuhi kriteria inklusi dan eksklusi, terdiri dari pria 22 (50,0%) dan wanita 22 (50,0%). Dikategorikan aterosklerosis bila ketebalan tunika intima-media >0,9 mm dan terjadi pada 24 subyek (54,6%). Kadar apolipoprotein B tinggi (apoB>105 mg/dl) terdapat sebanyak 25 subyek (56,8%). Hasil analisis uji regresi logistik multivariat yang mengendalikan faktor lipid (kolesterol, LDL, trigliserid) menunjukkan OR 142,1 (p=0,0001).
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3026
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 125-132
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3026/2709
oai:ojs.ejournal.undip.ac.id:article/3254
2012-04-20T08:30:41Z
mmi:ART
Risk Factors of Stunting among 1-2 Years Old Children in Semarang City
Candra, Aryu
Puruhita, Niken
Susanto, JC
Stunting, malnutrition, children, growth, risk factors
ABSTRACTBackground: Prevalence of stunting in children under five years in Central Java is high, more than 33%. Semarang City has high prevalence of malnutrition therefore there is a need to identify risk factors of stunting in Semarang city.Method: This was a case control study, completed with qualitative study about risk factors of stunting. Samples were 58 cases and 58 controls. Data were analyzed by univariate analysis, bivariate analysis with chi square test, and multivariate analysis with multiple logistic regression. Qualitative study was done by using indepth interview, and presented in narration.Results: The multivariate analysis result showed that risk factors of stunting in children 1-2 years old were short stature father (<162 cm) (p=0.016; OR=2.7; CI=1.2-6), children had history of low birth weight (p=0.028; OR=11.2; CI=1.3-96.3), and children had history of underweight (p=0.006; OR=3.3; CI=1.4-7). Risk factors which were not proven to influence the incidence of stunting were maternal height, history of exclusively breastfed, complementary feeding history; sex, history of infection, and immunization history.Conclusions: Risk factors that influence the incidence of stunting in children 1-2 years olds are having father’s height <162 cm, and positive history of low birth weight, and of underweight.Keywords: Stunting, malnutrition, children, growth, risk factorsABSTRAKFaktor risiko dari stunting pada anak usia 1-2 tahun di kota SemarangLatar belakang: Stunting adalah perawakan pendek yang timbul akibat malnutrisi yang lama. Prevalensi stunting pada balita di Jawa Tengah tinggi, yaitu lebih dari 33%. Kota Semarang merupakan ibukota Jawa Tengah yang memiliki prevalensi malnutrisi cukup tinggi sehingga diperlukan studi untuk mengetahui faktor risiko stunting di Kota Semarang.Metode: Penelitian ini merupakan studi kasus kontrol, dilengkapi kajian kualitatif mengenai stunting pada status ekonomi kurang dan status ekonomi cukup. Jumlah sampel 58 kasus dan 58 kontrol. Analisis data dilakukan secara univariat, bivariat dengan chi square test, multivariat dengan metode regresi logistik ganda. Kajian kualitatif denganmetode indepth interview dan disajikan dalam bentuk narasi.Hasil: Hasil analisis multivariat menunjukkan faktor risiko yang berpengaruh terhadap kejadian stunting pada anak 1-2 tahun di kota Semarang adalah tinggi badan ayah <162 cm (p=0,016; OR=2,7; CI:1,2-6), anak yang mempunyai riwayat BBLR (p=0,028; OR=11,2; CI=1,3-96,3), dan anak mempunyai riwayat underweight (p=0,006; OR=3,3; CI=1,4-7). Faktor risiko yang tidak terbukti mempengaruhi kejadian stunting adalah jenis kelamin, tinggi badan ibu, riwayat ASI eksklusif, riwayat infeksi, riwayat imunisasi, dan riwayat makanan pendamping ASI.Simpulan: Faktor risiko yang mempengaruhi kejadian stunting pada anak 1-2 tahun adalah yang mempunyai ayah dengan tinggi badan <162 cm dan mempunyai riwayat BBLR, serta berat badan kurang.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3254
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 206-212
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3254/2922
oai:ojs.ejournal.undip.ac.id:article/3827
2012-07-20T10:16:56Z
mmi:ART
Nyeri Yang Diprovokasi Electric Foot Shock, Daya Bunuh Makrofag dan Penggunaan Imunomodulator BCG pada Mencit Balb/C
Pudjonarko, Dwi
Jenie, M. Naharuddin
Dharmana, Edi
Pain, macrophages, NO, bacterial count
Provocated pain by electric foot shock, macrophage killing ability and the use of BCG as immunomodulator in Balb/C miceBackground: Pain affects immune system through Hypothalamic-Pituitary-Adrenal (HPA) and Symphatetic-adrenal-medullary (SAM) axis. Immunostimulator BCG increase immune system via type I response. The aim of this study is to prove that the decrease of immune response due to pain can be improved by introducing BCG vaccine assessed by macrophage activity.Methods: The study adapts Laboratory Experimental and Post-Test Only Control Group Design. Samples were 24 female Balb/C mice average weight 21.88(SD=1.75) grams and divided into four groups. The control group (C) received no other additional treatment. The BCG group (B) received intra-peritoneal injection of 0.1 ml BCG at day 1st and 11th. The EFS (E) received Electric foot shock 1-3 mA at day 12th to 21st and the BCG+ EFS group (BE) received BCG and EFS as mentioned before. All groups wereintravenously injected with 104 live L. monocytogenes at day 21st and sacrificed at day 26th by chloroform anaesthesia. Then, Macrophages Nitrit Oxyde (NO) concentration and liver bacterial count were measured. Data were analyzed by One Way ANOVA, Post Hoc Test Bonferroni and Pearson’s product moment supported by computer software SPSS 13.0 (significant if p<0.05).Results: There were significant differences in the macrophages NO production and the liver bacterial count (p<0.05) among the groups. The highest number of bacterial count and the lowest number of NO production was found in the E group. In contrast, there were significant differences on the number of bacterial count and NO production between BE group and E group (p>0.05).Conclusions: Pain provocation causes low NO concentration in macrophages and the introduction of BCG could improve the condition.Keywords: Pain, macrophages, NO, bacterial count ABSTRAKLatar belakang: Nyeri dapat mempengaruhi imunitas tubuh melalui aksis Hypothalamic-Pituitary-Adrenal (HPA) dan Symphateticadrenal- medullary (SAM) dengan menurunkan produksi sitokin tipe 1. Penggunaan imunostimulator BCG terbukti dapat meningkatkan respon imunitas seluler melalui respon tipe I. Penelitian ini bertujuan untuk membuktikan penurunan imunitas seluler yang diakibatkan nyeri dapat diperbaiki dengan pemberian vaksin BCG dengan melihat aktivitas makrofag.Metode: Penelitian ini merupakan penelitian eksperimental laboratorik, dengan pendekatan The Post Test – Only Control Group Design yang menggunakan 24 ekor mencit betina strain Balb/C, umur 6-8 minggu. Sampel dibagi menjadi 4 kelompok dan mendapatkan makanan standar. Pada Kelompok Kontrol (K), mencit tidak mendapatkan perlakuan, sedangkan kelompok BCG (B) divaksinasi secara intra peritoneal dengan 0,1cc BCG pada hari ke-1 dan ke-11. Kelompok Nyeri (N), mendapat sensasi nyerimenggunakan Electric Foot Shock mulai hari ke-12 sampai 21 dan kelompok Nyeri + BCG (NB) mendapat kombinasi perlakuan N+B. Pada hari ke-21, semua mencit disuntik 104 Listeria monocytogenes hidup secara intravena. Dilakukan terminasi mencit pada hari ke-26 untuk dilakukan pemeriksaan konsentrasi produksi NO makrofag serta hitung kuman organ hepar. Dilakukan uji beda dengan Oneway ANOVA dan korelasi Pearson’s product moment dengan menggunakan software SPSS 13.0.Hasil: Didapatkan adanya perbedaan yang bermakna pada produksi NO makrofag dan hasil hitung kuman organ hepar antar kelompok perlakuan (p<0,05). Pada kelompok Nyeri (N) didapatkan produksi NO makrofag terendah dan jumlah hitung kuman tertinggi. Pada kelompok Nyeri yang mendapat BCG (NB) didapatkan hasil yang berlawanan dan perbedaannya bermakna dalam variabel yang diteliti dibandingkan dengan kelompok Nyeri yang tidak mendapat BCG (N) (p<0,05).Simpulan: Provokasi nyeri menyebabkan rendahnya konsentrasi NO makrofag dan penggunaan BCG dapat memperbaiki keadaan tersebut.
MEDIA MEDIKA INDONESIANA
2012-07-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3827
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 3 Year 2008; 107-117
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3827/3511
oai:ojs.ejournal.undip.ac.id:article/4265
2013-06-26T12:59:31Z
mmi:ART
Are GSTM1 Null and GSTT1 Null Risk Factor of Autism Spectrum Disorder? A Preliminary Study
Hermawati, Donna
Then, Sue-Mian
Winarni, Tri Indah
Jamal, Rahman
Faradz, Sultana MH
GSTM1 null, GSTT1 null, risk factor, autism spectrum disorder
Background: Low plasma total glutathione (tGSH) levels, elevated levels of oxidized glutathione (GSSG) and low ratios of tGSH to GSSG in autism were reported. Glutathione S-transferases (GST) are antioxidant enzymes that play important role in cellular detoxification and the excretion of environmental pollutants including heavy metals. Glutathione S-transferase mu (GSTM1) and Glutathione S-transferase theta (GSTT1) are known to be highly polymorphic. Homozygous deletions of these genes result in lack ofenzyme activity and impaired the ability to excrete metals including mercury. Combined effects of mercury (Hg) accumulation coupled with decreased levels of antioxidants (low glutathione and antioxidant enzymes) contribute to the phenotypic presentation of autism spectrum disorder (ASD). Association of GSTM1 null genotype with autism has been reported. Therefore the preliminary study was performed to investigate the role of GSTM1 null and GSTT1 null as risk factor of ASD associated with phenotype expression.Method: Fifty one ASD patients were recruited from special need & autism school and 45 controls from Semarang & Solo. Blood veins samples were collected and genomic DNA was extracted by salting-out method in CEBIOR Semarang. Genotyping for GSTM1 and GSTT1 gene was done in UMBI Malaysia. Multiplex PCR was performed and PCR products were separated on 1.2 % agarose gel, stained with ethidium bromide and visualized on UV transiluminator. GSTM1 & GSTT1 gene product is about 625 bp and 459 bp. Absence of GSTM1 and GSTT1 gene band was interpreted as GSTM1 null & GSTT1 null.Results: The frequency of GSTM1 null and GSTT1 null in ASD higher compared with control group but the difference is not statistically significant (p=0.357, OR=0.504; 95% CI 0.117-2.168 and p=0.364, OR=0.674; 95% CI 0.287-1.580). There is also no statistically different in the distribution of GSTM1 null and GSTT1 null between mild to moderately autistic and severely autistic (p=0.983, OR=0.980; 95% CI 0.158-6.095 and p=0.439, OR=1.633; 95% CI 0.471-5.656).Conclusion: GSTM1 null and GSTT1 null are not risk factor of ASD. Further investigations are needed with a bigger sample size, analyzing multiple GST genes and GST activity determination to find out the gene susceptibility of ASD and factors that contribute to the phenotype expression of ASD.Keywords: GSTM1 null, GSTT1 null, risk factor, autism spectrum disorder ABSTRAKApakah GSTM1 Null dan GSTT1 Null merupakan faktor risiko autism spectrum disorder? Studi pendahuluanLatar belakang: Pada autism ditemukan bahwa glutathion total plasma (tGSH) rendah, oxidized glutathione (GSSG) meningkat dan rasio tGSH terhadap GSSG rendah. Glutathione s-transferase (GST) merupakan enzim antioksidan yang berperan penting dalam proses detoksifikasi seluler dan ekskresi polutan lingkungan termasuk diantaranya logam berat. Polimorfisme gen GST mu (GSTM1) dan GST theta (GSTT1) cukup tinggi. Delesi homozigot gen GSTM1 dan GSTT1 yang menyebabkan berkurang sampai tidak adanya aktivitas enzim GST serta menurunnya level antioksidan berkontribusi terhadap risiko ASD. Oleh karena itu dilakukan penelitian pendahuluan untuk mengetahui hubungan antara gen GSTM1 null dan GSTT1 null sebagai faktor risiko ASD dengan ekspresi fenotip.Metode: Lima puluh satu pasien ASD dari SLB dan sekolah autis serta 45 kontrol dari Semarang dan Solo diambil darah vena, kemudian diekstraksi dengan metode salting-out diCEBIOR Semarang. Pemeriksaan genotip gen GSTM1 & GSTT1 dilakukan di UMBI Malaysia. Metode yang digunakan adalah PCR multipleks, setelah itu produk PCR dipisahkanpada 1,2% gel agarosa kemudian dicat dengan ethidium bromida dan hasilnya dilihat menggunakan transiluminator UV. Besar produk untuk GSTM1 & GSTT1 adalah 625 bp &459 bp. Tidak adanya band untuk gen GSTM1 & GSTT1 diinterpretasikan sebagai GSTM1 null & GSTT1 null.Hasil: Frekuensi gen GSTM1 null dan GSTT1 null pada ASD lebih tinggi dibandingkan kontrol tetapi tidak ditemukan perbedaan yang signifikan (p=0,357, OR=0,504; 95% CI0,117-2,168 and p=0,364, OR=0,674; 95% CI 0,287-1,580). Distribusi gen GSTM1 null dan GSTT1 null pada autis ringan sedang dan autis berat juga tidak ditemukan perbedaan yang signifikan secara statistik (p=0,983, OR=0,980; 95% CI 0,158-6,095 and p=0,439, OR=1,633; 95% CI 0,471-5,656).Simpulan: GSTM1 null dan GSTT1 null bukan merupakan faktor risiko ASD. Penelitian lebih lanjut sangat diperlukan dengan jumlah sampel yang lebih besar, analisis gen GSTmultipel dan pemeriksaan aktivitas GST untuk mendapatkan gen faktor risiko ASD dan faktor-faktor yang mempengaruhi ekspresi fenotip ASD.
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4265
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 69-74
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4265/3886
oai:ojs.ejournal.undip.ac.id:article/4282
2012-12-15T12:30:21Z
mmi:ART
Pengaruh Pemberian Jus Jambu Biji (Psidium Guajava L) Terhadap Volume Kaki dan Kadar Ion Nitrit Adjuvant Induced Arthritis Tikus Wistar
Wiralis, Wiralis
Purwaningsih, Endang
Adjuvant arthritis, guajava, NO
The effect of Psidium Guajava L juice on nitric ion level and swelling of the joint in adjuvant induced arthritis ratsBackgraund: Nitric oxide increases in adjuvant induced arthritis. It has been associated with the activities of nitrite oxide mediates inflammation and axidant, it is a progressive joint disease. Characterized by swelling of the joint associated with an destruction of bone and cartilage. Jambu biji (Psidium Guajava L) is known to be the source of antioxidant and antiinflamation.Aim: To find out the difference volume joint and nitrite ion in adjuvant induced arthritis rats after administration of jambu biji (Psidium Guajava L) juice.Methods: An experimental study had been done using a randomized post test only control group. Twenty five Wistar rats were divided into 5 group. 2 control groups (K- and K+) and 3 treated groups (jambu biji juice 1 g/day, 2 g/day and 3 g/day). Volume joint to assay mercury placement pletismography Griess was used to assay nitrite ion (activity NO) serum. One Way Anova test and mann Withney test were applied for data analysis.Results: A significant difference in volume joint between the treated groups. A significant different nitrite ion was found among the treated groups (p<0.05), but not between the K+ group and 2 g/day in 3 cc treated group.Conclusions: Jambu biji (Psidium Guajava L) juice shows an effect for volume joint and nitrite ion in consentration in adjuvant induced arthritis.Keyword: Adjuvant arthritis, guajava, NOABSTRAK Latar belakang: Pada adjuvant induced arthritis NO meningkat, aktivitas NO dihubungkan dengan inflamasi dan oksidasi serta perkembangan penyakit. Karakteristik AIA berupa pembengkakan sendi, hingga menyebabkan destruksi tulang dan kartilago. Jambu biji (Psidium Guajava L) mengandung fitonutrien sebagai sumber antioksidan dan antiinflamasi.Tujuan: Mengetahui pengaruh pemberian jus jambu biji terhadap volume kaki dan kadar ion nitrit serum adjuvant induced arthritis tikus wistar.Metode: Studi eksperimen laboratorik menggunakan desain randomized post test only control group pada 25 ekor tikus strain wistar. Sampel terbagi 5 kelompok yaitu kelompok K- (non terapi); kelompok K+ (aspirin); P1 (jus jambu biji 1 gram/hari); P2 (jus jambu biji 2 gram/hari) dan P3 (jus jambu biji 3 gram/hari). Dilakukan pemeriksaan volume kaki dengan mercury placement pletismography dan ion nitrit serum sebagai aktivitas NO dengan metode Griess. One Way Anova test dan Kruskal-Wallis Test denganderajat kemaknaan p<0,05.Hasil: Ada perbedaan kadar volume kaki pada kelompok perlakuan. Ion nitrit pada kelompok perlakuan (p=0,00<0,05), hasil uji LSD diketahui kelompok kontrol (K+) tidak berbeda dengan perlakuan jus jambu biji 2 gram/hari. Ada perbedaan gambaran histopatologik panus pada kelompok perlakuan terhadap kelompok perlakuan aspirin (K+), perlakuan jus jambu biji 1 gram/hari, jus jambu biji 2 gram/hari dan jus jambu biji 3 gram/hari, dibuktikan dengan nilai p=0,011<0,05. Hasil uji Mann-Whitney diketahui tidak ada perbedaan gambaran histopatologik panus terdapat pada kelompok perlakuan terhadap kontrol.Simpulan: Pemberian jus jambu biji berpengaruh terhadap kadar ion nitrit dan gambaran histopatologik panus sendi tikus yang diinduksi dengan CFA.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4282
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009; 188-196
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4282/3902
oai:ojs.ejournal.undip.ac.id:article/4571
2013-06-26T12:57:43Z
mmi:ART
Kecemasan pada Penderita Penyakit Ginjal Kronik yang Menjalani Hemodialisis di RS Universitas Kristen Indonesia
NA, Luana
Panggabean, Sahala
Lengkong, Joyce VM
Christine, Ika
Hemodialysis, anxiety, HARS
Anxiety in chronic renal failure patients underwent hemodialysis at Christian University of Indonesia HospitalBackground: Anxiety is a pathological condition, characterized by fear and somatic signs. Anxiety is also a response to unidentified, internal, vague threads and conflicts. One of the etiologies of anxiety is biological disorder, such as chronic renal failure (CRF) which needs hemodialysis. Hemodialysis patients experience anxiety, which probably due to its chronicity. The aim of this study is to identify the difference of frequency and period of hemodialysis in various level of anxiety in CRF patients underwent hemodialysis atChristian University of Indonesia Hospital.Methods: This is an observational study with cross-sectional design, conducted during October-December 2011. Anxiety level was measured using the Hamilton Rating Scale for Anxiety (HRSA). Kruskall Wallis test was used to analyze the difference of frequency and period of hemodialysis in three levels of anxiety (mild, moderate, and severe).Results: Twenty eight (51.9%) men and 26 (48.1%) women with CRF who underwent hemodialysis at Christian University of Indonesia Hospital were included in this research. There were 42 (77.78%) among them who experienced anxiety. Patients with the longest mean of period and frequency of hemodialysis experienced mild anxiety, whereas patients with the shortest mean of period and frequency of hemodialysis experience moderate anxiety. There are significant differences found between period and frequency of hemodialysis and levels of anxiety (p=0.002 and p=0.003, respectively).Conclusion: There are significant differences found between period and frequency of hemodialysis and levels of anxiety.Keywords: Hemodialysis, anxiety, HARS ABSTRAKLatar belakang: Cemas (ansietas) adalah suatu keadaan patologik yang ditandai oleh perasaan ketakutan diikuti dan disertai tanda somatik. Kecemasan juga merupakan respon terhadap suatu ancaman yang sumbernya tidak diketahui, internal, samar-samar, atau konfliktual. Kecemasan salah satunya disebabkan oleh gangguan biologik, seperti penyakit ginjal kronik (PGK) yang membutuhkan hemodialisis. Penderita hemodialisis mengalami kecemasan, salah satunya dapat diakibatkan oleh kronisitas penyakit. Penelitian ini bertujuan untuk mengetahui perbedaan frekuensi dan periode menjalani hemodialisis pada berbagai derajat kecemasan pada penderita penyakit ginjal kronik yang menjalani hemodialisis di RS Universitas Kristen Indonesia.Metode: Penelitian ini adalah penelitian observasional dengan rancangan cross-sectional, dilakukan selama bulan Oktober- November 2011. Pengukuran derajat cemas menggunakan instrument Hamilton Rating Scale for Anxiety (HRSA). Dilakukan analisis uji beda Kruskall Wallis untuk menganalisis perbedaan frekuensi dan periode hemodialisis pada tiga derajat kecemasan (ringan, sedang, dan berat).Hasil: Dua puluh delapan (51,9%) laki-laki dan 26 (48,1%) perempuan penderita PGK yang menjalani hemodialisis di Universitas Kristen Indonesia ikut serta dalam penelitian ini. Terdapat 42 (77,78%) di antaranya yang mengalami kecemasan. Penderita dengan rerata periode dan frekuensi hemodialisis terpanjang mengalami kecemasan ringan, sedangkan penderita rerata periode dan frekuensi hemodialisis terpendek mengalami kecemasan sedang. Terdapat perbedaan yang bermakna antara frekuensi dan periodehemodialisis dan derajat kecemasan pada penderita hemodialisis (p=0,002 dan p=0,003, secara berurutan).Simpulan: Terdapat perbedaan yang bermakna antara frekuensi dan periode hemodialisis dan derajat kecemasan pada penderita hemodialisis.
MEDIA MEDIKA INDONESIANA
2013-03-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4571
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012; 151-156
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4571/4163
oai:ojs.ejournal.undip.ac.id:article/11376
2016-07-01T13:39:49Z
mmi:ART
Manajemen Sumber Daya Manusia Dalam Perspektif Kemandirian Fakultas Kedokteran Swasta: Studi Kasus pada Medical Educational Unit (MEU)
Affandi, Affandi
ABSTRACT The management of human resource in relation to private medical school independency: case study of medical educational unitsBackground: Most of the weaknesses of private medical schools in Indonesia are due to inappropriateness in the management of human resources. Medical Educational Unit (MEU) can be used to evaluate its role in the management of human resource. There is no information about what aspects of management in human resources have been implemented by MEU.Objection: To analyze the implementation of aspects contributed to the management of human resources by MEU.Method: This is a qualitative study to assess the implementation of the management of human resources in MEU. Data collected by in depth interview, observations, and document analysis in 4 (four) private medical schools in West Java. Data analysis was done by using koding, categorization and description.Results: The compensations for human resources in private Medical Schools in West Java is still inappropriate. Based on observations in the perspective of self-directing, self-motivating, self-regulating, self-supporting, self-assessing, and self-decision, this study showed the weaknesses in self-motivating, which can be seen in low level of achievement drive, commitment, inisiative, and optimism. Besides, there was no optimalization in the usefulness of information system technology.Conclusions and Suggestions: The perspective of to be autonomous in private medical schools in the aspects of MEU is still inappropriate. Therefore, the management of human resources in MEU is still to be increased.Keywords: MEU, Fakultas Kedokteran, ManajemenABSTRAKLatar belakang: Lemahnya kemandirian Fakultas Kedokteran (FK) Swasta di Indonesia umumnya berkaitan dengan lemahnya manajemen sumber daya manusia (SDM) dalam menyelenggarakan pendidikan. Salah satu aspek dalam manajemen pendidikan yang dapat dijadikan tolok ukur adalah peran Unit Pendidikan Kedokteran (Medical Education Unit/MEU) yang sudah dimiliki oleh setiap FK di Indonesia. Belum diketahui bagaimana manajemen SDM diimplementasikan oleh MEU.Tujuan: Menganalisis implementasi aspek-aspek yang berkontribusi terhadap manajemen SDM di MEU.Metode: Merupakan penelitian kualitatif dengan melakukan wawancara mendalam, observasi, dan analisis dokumen pada MEU di 4 FK Swasta di Jawa barat. Data dianalisis secara deskriptif.Hasil: Aspek kompensasi pada manajemen sumber daya manusia di FK Swasta di Jawa Barat masih kurang dari memadai. Ditinjau dari perspektif kemandirian perguruan tinggi swasta, yaitu dari aspek self-directing, self-motivating, self-regulating, self-supporting, self-assessing, dan self-decision, maka hasil pengamatan yang diperoleh adalah aspek self-motivating masih kurang memadai, hal ini terlihat dari tingkat achievement drive, komitmen, inisiatif dan tingkat optimisme yang dapat dikategorikan belum memuaskan. Penggunaan teknologi sistem informasi untuk mendukung proses pendidikan juga belum dilaksanakan secara optimal.Simpulan dan Saran: Perspektif kemandirian FK swasta dilihat dari aspek MEU masih sangat kurang, hal ini terlihat dari rendahnya tingkat achievement drive, komitmen, inisiatif maupun tingkat optimisme. Oleh karena itu, kemandirian FK swasta
MEDIA MEDIKA INDONESIANA
2016-07-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/11376
MEDIA MEDIKA INDONESIANA; 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013; 56-60
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/11376/8862
oai:ojs.ejournal.undip.ac.id:article/21900
2019-01-29T12:21:14Z
mmi:ART
Kadar Imunoglobulin M Anti Phenolic Glycolipid-I Mycobacterium Leprae dan Tumor Necrosis Factor-α pada Penderita Lepra Subklinis
Utama, Yuanita Dian
Soejoto, Soejoto
Susanto, Sri Djoko
Indrayanti, ES
Subakir, Subakir
Ernawati, Dhiana
IgM anti PGL-I; TNF-α; subclinical leprosy
Immunoglobulin M anti phenolic glycolipid-I mycobacterium leprae level and tumor necrosis factor-α level in subclinical leprosyBackground: In subclinical leprosy, patients have no clinical lesion but seropositive to anti PGL-I antibody specific to M. leprae. On the other hand, TNF-α is produced in majority during innate immunity, inhibits mycobacterial growth and mediates granuloma formation. Mutant allele of TNF2308A has protective role against the development of severe form of leprosy. This study analyzed the correlation between IgM anti PGL-I and TNF-α levels in subclinical leprosy. Method: Study was done at an orphanage, using observational study with cross-sectional approach. Three mililiter peripheral blood were centrifuged and divided into 2 cryotubes. Immunoglobulin M anti PGL-I Mycobacterium leprae levels were measured by quantitative indirect ELISA. Tumor necrosis factor-α levels of subclinical leprosy patients (IgM anti PGL-I M. leprae level ≥600 U/mL) were measured using Human TNF-α ELISA Bender Medsystems for sandwich ELISA. Analysis of distribution normality using Shapiro-Wilk, continued with Rank Spearman correlation test.Result: Immunoglobulin M anti PGL-I levels were ranged between 616.85-1753.8 U/mL. Tumor necrosis factor-α levels were ranged between 2.72-50.13 pg/mL. There was significant positive correlation between IgM anti PGL-I level 600-1000 U/mL and TNF-α level (p=0.714; p=0.006), and insignificant negative correlation between IgM anti PGL-I level ≥1000 U/mL and TNF-α level (p=-0.172; p=0.557). Conclusion: There were significant positive correlation between IgM anti PGL-I level 600-1000 U/mL and TNF-α level, and insignificant negative correlation between IgM anti PGL-I level ≥1000 U/mL and TNF-α level. ABSTRAKLatar belakang: Pada lepra subklinis tidak dijumpai lesi, namun ditemukan antibodi anti PGL-I yang spesifik terhadap M. leprae. Di sisi lain, TNF-α dihasilkan terutama pada imunitas alami, dapat menghambat pertumbuhan mikobakteria dan memperantarai pembentukan granuloma. Alel mutan TNF2308A diketahui protektif mencegah berkembangnya bentuk lepra yang lebih berat. Penelitian ini menganalisis hubungan antara kadar IgM anti PGL-I dan TNF-α lepra subklinis.Metode: Penelitian dilakukan di sebuah panti asuhan secara observasional dengan pendekatan cross-sectional. Tiga mililiter darah perifer, disentrifus, kemudian dibagi dalam 2 cryotube. Pemeriksaan kadar IgM anti PGL-I M. leprae menggunakan ELISA indirek kuantitatif. Pada penderita lepra subklinis (kadar IgM anti PGL-I M. leprae ≥600 U/mL) diperiksa kadar TNF-α menggunakan ELISA sandwich dengan Human TNF-α ELISA Bender Medsystems. Analisis uji normalitas distribusi dengan Shapiro-Wilk, dilanjutkan uji korelasi Rank Spearman.Hasil: Kadar IgM anti PGL-I berkisar antara 616,85-1753,8 U/mL. Kadar TNF-α berkisar antara 2,72-50,13 pg/mL. Terdapat hubungan positif bermakna (p=0,714; p=0,006) antara kadar IgM anti PGL-I 600-1000 U/mL dan kadar TNF-α, dan hubungan negatif tidak bermakna (p=-0,172; p=0,557) antara kadar IgM anti PGL-I ≥1000 U/mL dan kadar TNF-α. Simpulan: Pada kadar IgM anti PGL-I 600-1000 U/mL, semakin tinggi kadar IgM anti PGL-I, semakin tinggi pula kadar TNF-α; sedangkan pada kadar IgM anti PGL-I ≥1000 U/mL terdapat kecenderungan hubungan terbalik yang tidak bermakna.
MEDIA MEDIKA INDONESIANA
2010-08-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21900
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 2 YEAR 2010; 83-91
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21900/14636
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3020
2012-04-05T11:53:37Z
mmi:ART
General Reaction Score and CD56+CD16+CD3- Cells Distributions Among Women with Aircraft Noise Stress
Hartono, Hartono
Aircraft noise, CD56+CD16+CD3-, women, Adi Sumarmo Airport
ABSTRACTBackground: One of the noise impacts is stress. The NK cells (CD56+CD16+CD3-) are also one of the leukocyte subsets, which are responsive to the physiological stress and psychological stress. The aims of the research is to find out the correlation of the general reaction score with CD56+CD16+CD3- cells distributions among women with aircraft noise stress in the area of Adi Sumarmo Airport of Solo, Indonesia.Methods: The research design was an analytical survey with a cross sectional approach, taking location at the Dibal and Gagak Sipat Village, Boyolali District. The respondents who fulfilled the exclusive and inclusive criteria were selected by means of simple random sampling. The number of respondens was 39 and divided into 3 groups; Group 1 was exposed 92.29 dB of noise level (13 respondents); Group 2 was exposed 71.79 dB of noise level (13 respondents); and Group 3 was exposed 52.17 dB of noise level (13 respondents). The data were analyzed by Anova followed by post hoc test using LSD test completed with homogenous subsets and Pearson Correlation test.Results: The Pearson Correlation test was showed that there was significant association between general reaction score with CD56+CD16+CD3- cells distributions (r=0.589; p=0.000).Conclusion: There is correlation of the general reaction score with CD56+CD16+CD3- cells distributions among women with aircraft noise stress in the area of Adi Sumarmo Airport of Solo, Indonesia.Keywords: Aircraft noise, CD56+CD16+CD3-, women, Adi Sumarmo AirportABSTRAKGeneral Reaction Score dan CD56+CD16+CD3- pada wanita yang mengalami stres bising pesawat udaraLatar belakang: Salah satu dampak bising adalah stres. Natural killer cells (CD56+CD16+CD3-) adalah salah satu subset leukosit yang sangat respon terhadap stres fisiologis maupun stres psikologis. Tujuan penelitian adalah untuk mengetahui hubungan antara general reaction score dengan jumlah sel NK (CD56+CD16+CD3-) pada wanita yang memperoleh stres bising pesawat udara disekitar Bandara Adi Sumarmo Solo, Indonesia.Metode: Rancangan penelitian adalah survai analitik dengan pendekatan cross sectional. Lokasi di Desa Dibal dan Gagak Sipat, Kabupaten Boyolali. Responden yang memenuhi kriteria eksklusif dan inklusif diambil sejumlah 39 sebagai sampel dengan cara simple random sampling. Responden selanjutnya dibagi menjadi 3 kelompok; Kelompok 1 responden yang terpapar bising denganintensitas 92,29 dB (13 responden); Kelompok 2 responden yang terpapar bising dengan intensitas 71.79 dB (13 responden); dan Kelompok 3 responden yang terpapar bising dengan intensitas 52.17 dB (13 responden). Data dianalisis dengan uji Anova dilanjutkan dengan post hoc test menggunakan LSD test completed with homogenous subsets dan Pearson Correlation test.Hasil: Pearson Correlation test menunjukkan adanya hubungan yang signifikan antara general reaction score dengan jumlah sel NK (CD56+CD16+CD3-) (r=0.589: p=0.000).Simpulan: Penelitian ini menunjukkan bahwa ada hubungan antara general reaction score dengan jumlah sel NK(CD56+CD16+CD3-) pada wanita yang mengalami stres bising pesawat udara di sekitar Bandara Adi Sumarmo Solo, Indonesia.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3020
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 83-89
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3020/2703
oai:ojs.ejournal.undip.ac.id:article/3822
2012-07-19T11:07:49Z
mmi:ART
Vaginal Acidity and Whiff Test for Screening Bacterial Vaginosis in Pregnant Women Tri Nur
Kristina, Tri Nur
Bacterial Vaginosis, sensitivity, specificity
Keasaman vagina dan tes whiff untuk penapisan bacterial vaginosis pada ibu hamil.Background: It has been acknowledged that bacterial vaginosis (BV) in pregnant women is associated with miscarriage and premature delivery. Microscopic examination of vaginal secretion should be used in the diagnosis of BV. Nevertheless, usually microscope does not exist in antenatal care facility in the community based setting. Therefore, screening tool of BV among pregnant women attending antenatal care that is simple, cheap, and fast is needed.Methods: Diagnostic study was conducted among pregnant women attending antenatal care in the Community Health Centre. Vaginal acidity combines with whiff test were used as a screening tool, and compared blindly with Gram stain of vaginal smear as a gold standard to diagnose BV.Results: This study showed that the sensitivity and specificity of the vaginal acidity combine with whiff test to diagnose BV were 93.1% and 69% respectively. It means that false negative and false positive were 6.9% and 31% respectively. In the screening method, high sensitivity or less false negative is needed. Therefore, only few people who really have the disease (the false negative) can’t be reached by the gold standard of diagnostic test.Conclusions: It could be concluded that the combination of vaginal acidity and whiff test is a useful tool for screening BV in pregnant women especially in the community-based health facility.Keywords: Bacterial Vaginosis, sensitivity, specificity ABSTRAKLatar belakang: Vaginosis Bakterial (VB) pada ibu hamil diketahui secara luas sebagai faktor risiko terjadinya abortus dan kelahiran prematur. Diagnosis VB harus ditegakkan dengan pemeriksaan sekret vagina menggunakan pemeriksaan mikroskopik, yang pada umumnya tidak tersedia di tempat pemeriksaan kehamilan primer. Oleh karena itu dibutuhkan alat pemeriksaan (penapisan) VB pada ibu hamil yang mudah, murah dan cepat.Metode: Penelitian ini merupakan studi diagnostik pada ibu hamil yang memeriksakan kehamilannya di Puskesmas. Keasaman vagina dikombinasikan dengan tes whiff digunakan sebagai alat penapisan dan dibandingkan secara membuta dengan pengecatan Gram pada sekret vagina yang digunakan sebagai standar baku emas untuk mendiagnosis VB.Hasil: Hasil penelitian menunjukkan keasaman vagina dikombinasikan tes whiff memiliki sensitifitas 93,1% dan spesifisitas 69%. Hal ini berarti kemungkinan adanya negatif palsu hanya 6,9% sedangkan kemungkinan positif palsu 31%. Dalam metode penapisan dibutuhkan alat diagnostik yang memiliki sensitifitas tinggi atau hanya sedikit yang negatif palsu, sehingga hanya sedikit pula yang akan luput dari pemeriksaan Gram.Kesimpulan: Kombinasi keasaman vagina dengan tes whiff dapat dipergunakan untuk penapisan VB pada ibu hamil terutama di fasilitas kesehatan primer.Kata Kunci: Vaginosis Bakterial, sensitivitas, spesifisitas
MEDIA MEDIKA INDONESIANA
2012-07-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3822
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 2 Year 2008; 83-87
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3822/3506
oai:ojs.ejournal.undip.ac.id:article/4210
2012-12-04T10:31:26Z
mmi:ART
Induksi Polifenol Mahkota Dewa dan Apoptosis Sel Kanker Paru Mencit Strain Balb/C: Analisis pada Up-Regulation Bax dan Down-Regulation Bcl-2
Watuguly, Theopilus W
Tjahjono, Tjahjono
Kaihena, Martha
Wael, Syahran
Polyphenol, Mahkota Dewa (Phaleria macrocarpa [Scheff.] Boerl), protein Bax, protein Bcl-2, strain Balb/c mice, benzo(a)pyrene (BaP)
Mahkota Dewa polyphenol induction and apoptosis cell lung cancer in Balb/c strain mice analysis on up-regulation bax and downregulation Bcl-2Background: This research is aimed to prove the role of Mahkota Dewa polyphenol in the up-regulation Bax and down-regulation in strain Balb/c mice which inducted with benzo(a)pyrene (BaP).Method: Post test control group design with 30 strain Balb/c mice sample, aged 1-2 weeks, weighed 20-30 grams, healthy mice condition. All mice inducted with BaP and then randomized into 2 groups, which were the control group and the treatment group (polyphenol 50mg). The development of the lung carcinogenesis was observed by tissue surgery in the 8th, 17th and 26th week. The data collected include expression examination Bax and Bcl-2. The data analysis was conducted by Kruskal-Wallis, Mann-Whitneyand correlation test of Spearman's with significance degree of p<a (0.05).Result: The oral administration of Mahkota Dewa polyphenol of 50 mg were significantly decreased the occurance of lung carcinogenesis through decreasing of protein Bax and increasing Bcl-2 in treatment group in week 8, 17 and 26 (p=0.000). Protein Bax for the control group for week 8 were 4.04±0.22 and 1.92±0.10 in week 26, while the treatment group were 5.96±0.32 and 4.68±0.22 (p=0.000). Protein Bcl-2 for the control group for week 8 were 5.80±0.32 and 9.64±0.26 in week 26, while the treatmentgroup were 5.12±0.22 and 7.38±0.21 (p=0.000). The Spearman correlation for Bax and Bcl-2 with significancy value of (p=0.000).Conclusion: The administration of Mahkota Dewa polyphenol of 50 mg effectively increased Bax protein expression and decreased Bcl-2 protein expression in mice Balb/c.Keywords: Polyphenol, Mahkota Dewa (Phaleria macrocarpa [Scheff.] Boerl), protein Bax, protein Bcl-2, strain Balb/c mice, benzo(a)pyrene (BaP)ABSTRAKLatar belakang: Penelitian ini bertujuan membuktikan peran polifenol Mahkota Dewa dalam meningkatkan protein Bax dan menurunkan protein Bcl-2 pada mencit strain Balb/c hasil induksi Benzo(a)pyrene (BaP).Metode: Post test only control group design dengan sampel 30 mencit strain Balb/c, umur 1-2 minggu, berat 20-30 gram, kondisi mencit sehat. Semua mencit diinduksi BaP kemudian hewan dirandomisasi menjadi 2 kelompok yaitu kelompok kontrol dan kelompok perlakuan polifenol 50 mg. Perkembangan karsinogenesis paru diamati dengan pembedahan jaringan pada minggu ke-8, 17 dan 26. Data dikumpulkan meliputi pemeriksaan ekspresi Bax dan Bcl-2. Analisis data dengan Kruskal-Wallis dilanjutkan denganuji Mann-Whitney dan uji korelasi Spearman dengan derajat kemaknaan p<a (0,05).Hasil: Pemberian oral polifenol Mahkota Dewa sebesar 50 mg secara bermakna memperlihatkan peningkatan protein Bax dan penurunan protein Bcl-2 pada kelompok perlakuan pada minggu ke-8, 17 dan 26 (p=0,000). Protein Bax pada kelompok kontrol minggu ke-8 sebesar 4,04±0,22 dan 1,92±0,10 minggu ke-26, sedangkan kelompok perlakuan sebesar 5,96±0,32 dan 4,68±0,22 (p=0,000) sedangkan protein Bcl-2 pada kelompok kontrol minggu ke-8 sebesar 5,80±0,32 dan 9,64±0,26 minggu ke-26, sedangkan kelompok perlakuan sebesar 5,12±0,22 dan 7,38±0,21 (p=0,000). Hasil uji korelasi Spearman protein Bax dan protein Bcl-2 dengan nilai significancy (p=0,000).
MEDIA MEDIKA INDONESIANA
2012-11-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4210
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012; 33-43
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4210/3833
oai:ojs.ejournal.undip.ac.id:article/4277
2012-12-15T11:41:58Z
mmi:ART
Kadar C-Reaktif Protein Anak Kandung Penderita Dengan dan Tanpa Penyakit Jantung Koroner
Juwairiyah, Juwairiyah
BS, Lisyani
KS, Indranila
BW, Imam
Inflammation, CRP levels, parents with coronary heart disease, inherited
C-reactive protein levels in children of patients with and without coronary heart diseaseBackground: Coronary heart disease (CHD) has become the main cause of death worldwide, with atherosclerosis which is a chronic inflammation as the hiden background. CRP (C-reactive protein), a serum inflammation marker, appear in coronary heart disease. So for, the studies about the relation of CRP and CHD had been conducted, but the condition of the CRP serum level in children of CHD patients still rarely be evaluated. The aims to analyse the means CRP levels in children of patients with or without CHD, and to find the influence of CHD patients to the children’s CRP level after controlled by body mass index and lipid profile.Methods: A cross sectional approach to 20 blood specimens from each group, children of patients with and without CHD. The serum CRP levels means were measured twice in range of 2 weeks, using hs-CRP PETIA technique and analysed with Mann-Whitney test and logistic regression.Results: Median CRP levels in children of CHD parents was 2.15 mg/L, which was different from children without CHD parent (1.48 mg/L which was p=0.001). The proportion of parents with CHD to high CRP level in their own children 87%. Logistic regression analysis shows that parents with CHD was not a determinant to high CRP level (p=0.172; 95% CI=0.487-55.821).Conclusions: The CRP of level of children whose parents have CHD is higher than those with parents without CHD.Keywords: Inflammation, CRP levels, parents with coronary heart disease, inheritedABSTRAKLatar belakang: Penyakit jantung koroner (PJK), penyebab kematian utama di dunia dengan aterosklerosis sebagai penyebab tersembunyi merupakan inflamasi kronik. CRP (C-reactive protein), suatu petanda inflamasi akut didapatkan pada PJK. Penelitian yang menghubungkan CRP dan PJK sudah banyak, tetapi penelitian CRP anak dengan riwayat orang tua PJK masih terbatas. Tujuan penelitian ini untuk menganalisis perbedaan rerata kadar CRP anak kandung penderita dengan dan tanpa PJK serta pengaruh orang tua PJK terhadap kadar CRP anak kandung setelah dikontrol dengan IMT (indeks masa tubuh) dan profil lipid.Metode: Pendekatan belah lintang, masing-masing 20 spesimen darah anak kandung penderita PJK dan tanpa PJK. Diukur rerata kadar CRP pada dua kali pemeriksaan dengan interval dua minggu, menggunakan metoda hs-CRP teknik PETIA dan analisis statistik uji beda Mann-Whitney serta regresi logistik.Hasil: Median kadar CRP anak kandung penderita PJK berbeda dengan anak tanpa orang tua PJK (p=0,001). Proporsi orang tua PJK dengan kadar CRP yang tinggi pada anak kandung 87%. Hasil analisis regresi logistik menunjukkan bahwa orang tua PJK tidak merupakan determinan terhadap kadar CRP yang tinggi pada anak (p=0,172; 95% CI=0,487-55,821) .Simpulan: Kadar CRP anak dengan orang tua PJK lebih tinggi daripada mereka yang orang tua bukan penderita PJK.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4277
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009; 155-160
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4277/3897
oai:ojs.ejournal.undip.ac.id:article/4303
2013-01-03T10:30:11Z
mmi:ART
Prevalensi Kuman ESBL (Extended Spectrum Beta Lactamase) dari Material Darah di RSUP Dr. Kariadi Tahun 2004-2005
Winarto, Winarto
ESBL, intensive wards, meropenem
Prevalence of Extended-Spectrum -Lactamases (ESBL)-bacteria of Blood Isolates in Dr. Kariadi Hospital Semarang 2004–2005Background: Prevalence of ESBL bacteria varies among hospitals, which its resistance could be spread to other bacteria; causes infections with a high morbidity and mortality. There were no data of ESBL prevalence and its distribution within Dr. Kariadi hospital wards. Objective of the study were to determine the prevalence, distribution and antibiotic sensitivity pattern of ESBL bacteria in Dr. Kariadi hospital.Methods: Retrospective study was used on laboratory records of in-patients at Clinical Microbiology Laboratory during 2004–2005. Blood culture was inoculated into BACTEC bottle medium, incubated at 370C, isolated, identified and examined for antibiotic susceptibility by Kirby-Bauer method. Inclusion criteria were gram negative bacteria subjected to ESBL screening by cefotaxime, ceftazidime or ceftriaxone disc. Samples without clinical informations were excluded.Results: Four thousand three hundred and fifty blood samples were examined during 2 years periode with culture positive rate was 34.76% consist of gram negative bacteria 59.6% in which ESBL bacteria was 50.6%. ESBL bacteria significantly high recovered from intensive wards. Predominance bacteria were Ps. aeruginosa (50.9%), E. aerogenes (37.5%) and E. coli (8.7%). Sensitivity patterns to meropenem >82.2%, quinolone >65.6% except Ps. aeruginosa 52.5%, fosfomisin >74% except Ps. aeruginosa 15.5%,amikacin >82% except Ps. aeruginosa 20.6%.Conclusions: Bacterial culture positive rate was 34.76% with predominance bacteria was gram negative bacteria (59.6%), in which ESBL detected in 50.6%. The most predominance bacteria were Ps. aeruginosa, E. aerogenes and E. coli. Antibiotic sensitivity patterns mostly sensitive to meropenem, aminoglycocide and quinolone.Keywords: ESBL, intensive wards, meropenem ABSTRAKLatar belakang: Prevalensi kuman ESBL berbeda diberbagai rumah sakit, mempunyai gen penyandi di plasmid yang mudah dipindahkan ke kuman lain dengan morbiditas dan mortalitas tinggi. Di RSUP Dr. Kariadi belum ada data komprehensif tentang prevalensi dan distribusi kuman ESBL. Maksud penelitian untuk memberikan gambaran tentang prevalensi, distribusi dan pola kepekaan kuman ESBL.Metode: Penelitian bersifat retrospektif menggunakan catatan pemeriksaan darah pasien rawat inap yang dikultur menggunakan BACTEC di Laboratorium Mikrobiologi Klinik tahun 2004-2005. Tes kepekaan menggunakan metode Kirby-Bauer. Kriteria inklusi ialah kuman gram negatif yang resisten terhadap salah satu atau lebih dari disk antibiotika cefotaxim, ceftazidime dan cefipim, sedang kriteria eksklusi adalah keterangan klinik yang tidak lengkap.Hasil: Didapat 4.350 sampel, yang tumbuh kuman sebanyak 1.512 (34,76%) terdiri dari kuman gram positif 611 (40,4%) dan kuman gram negatif 901 (59,6%), diantaranya kuman ESBL sebanyak 456 (50,6%). Kuman ESBL di ruang perawatan intensif lebih banyak dibandingkan ruang non-intensif (p=0,00 chi square test). Prevalensinya adalah Ps. aeruginosa (50,9%), E. aerogenes (37,5%), E. coli (8,7%), K. pneumoniae (1,5%), A. baumini (1,1%) dan E. clocae (0,3%). Sensitifitas kuman terhadap antibiotika: meropenem >82,2%, kuinolon >65,6% kecuali Ps. aeruginosa 52,5%, fosfomisin >74% kecuali Ps. aeruginosa 15,5%, amikasin >82% kecuali Ps. aeruginosa 20,6%.Simpulan: Hasil kultur positif 34,76%, kuman ESBL didapatkan 50,9% dengan predominan Ps. aeruginosa, E. aerogenes dan E. coli. Kuman ESBL di ruang perawatan intensif lebih banyak, dengan sensitifitas antibiotika yang masih baik ialah meropenem, aminoglikosida dan kuinolon.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4303
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009; 260-268
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4303/3924
oai:ojs.ejournal.undip.ac.id:article/11371
2016-07-01T12:57:53Z
mmi:ART
Serum Serotonin Levels among Homosexual and Heterosexual Men
Santoso, Santoso
Batubara, Lusiana
ABSTRACT Background: Variations in sexual preferences and orientations have both proximate and ultimate causes. Serotonin (5-HT) system is a key in the regulation of reward-related behaviors, from eating, drinking to sexual activity. Recent study demonstrated that a serotonin level is involved in sexual preference in rodent as animal models. This study focuses on the profile of serotonin levels from blood among homosexual compared to heterosexual men.Methods: Eight adult (34.5±7.69) homosexual men were purposively collected from homosexual communities in Surabaya, as well thirteen adult (27.61±5.14) heterosexual men from Semarang. Complete psychological examinations were done, then serum serotonin levels were measured using ELISA. Furthermore age and Zung-self-rating depression scale were cross matched, then serum serotonin levels were tested using Mann-Whitney U Test to determine the difference of serotonin levels among two groups.Results: Our data demonstrated that 25% of homosexual men suffered from depression. There was no difference on serum serotonin levels among homosexual men compared to heterosexual men (p=0.41).Conclusion: There is no significant difference on serum serotonin levels among homosexual and to heterosexual men.Keywords: Sexual preferences, homosexual, heterosexual, serotonin, depressionABSTRAKKadar serum serotonin pada laki-laki homoseksual dan heteroseksualLatar belakang: Variasi dalam preferensi dan orientasi seksual memiliki beberapa faktor penyebab. Serotonin (5-HT) merupakan kunci dalam pengaturan perilaku mulai dari makan, minum sampai aktivitas seksual. Penelitian terdahulu menyebutkan bahwa kadar serotonin memiliki peran dalam penentuan preferensi seksual pada tikus. Penelitian ini bertujuan untuk menganalisis kadar serotonin darah pada laki-laki homoseksual dan heteroseksual.Metode: Delapan laki-laki homoseksual dewasa secara purposif (34,5±7,69 tahun) diambil dari komunitas homoseksual di Surabaya dan 13 laki-laki heteroseksual dari Semarang (27,61±5,14 tahun), kemudian dilakukan skrining tanda depresi dengan menggunakan Zung-self-rating depression scale. Kadar serotonin serum diperiksa dengan menggunakan metode ELISA. Data yang diperoleh kemudian dianalisis dengan menggunakan uji Mann-Whitney U untuk melihat perbedaan kadar serotonin serum pada kedua kelompok.Hasil: 25% laki-laki homoseksual mengalami depresi, dan tidak ada perbedaan kadar serotonin pada serum laki-laki homoseksual maupun heteroseksual (p=0.41).Simpulan: Tidak terdapat perbedaan antara kadar serotonin serum laki-laki homoseksual dengan heteroseksual.
MEDIA MEDIKA INDONESIANA
2016-07-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/11371
MEDIA MEDIKA INDONESIANA; 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013; 18-22
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/11371/8857
oai:ojs.ejournal.undip.ac.id:article/21834
2019-01-25T14:35:39Z
mmi:ART
The Role of SHOX Gene in Short Stature of Turner Syndrome and Its Variant
Winarni, Tri Indah
Mundhofir, Farmaditya EP
Faradz, Sultana MH
SHOX gene; short stature; and Turner syndrome
Background: SHOX gene is located on the edge of each short/p arm sex chromosome called the pseudoautosomal region-1 (PAR1) plays as a fundamental role on controlling chondrocyte differentiation and apoptosis in the growth plate. Longitudinal growth is determined by environmental, hormonal and genetic factors. Short stature is defined as a standing height below the third percentile according to Tanner et al. Short stature affects approximately 2% of children. Turner syndrome is the most common genetic disorder in female characterized by the absence of all or part of a normal second X chromosome, affecting 1:2500 live-born female babies. Short stature and ovarian failure is the main clinical feature. The objective of this study is to elucidate the implication of SHOX gene in short stature of Turner Syndrome and its variant.Method: Purposive sampling was performed to recruit female with short stature after informed consent agreement. Female with growth treatment history and chronic diseases was excluded from this study. Cytogenetics testing was done for all samples by G-banding method, in routine karyotyping. Result: We report 9 females with short stature which cytogenetically and clinically diagnosed as Turner Syndrome. Four cases is classic Turner syndrome with standing height is below third percentile, three cases are 45,X/46,X,i(Xq) with standing height is below third percentile, one case is 46,XX/45,X (80%) with standing height is below third percentile, and the rest is 46,XX/45,X (20%) with standing height is between 3rd–97th percentile or normal.Conclusion: SHOX gene haploinsufficiency is strongly indicated the cause of short stature in Turner Syndrome.ABSTRAKPeran gen SHOX pada perawakan pendek Sindrom Turner dan variannyaLatar belakang: Gen SHOX terdapat di ujung lengan pendek kromosom seks yang disebut pseudoautosomal regio-1 (PAR1) yang berperan penting pada pengaturan diferensiasi kondrosit and apoptosis di lempeng epifisis. Pertumbuhan memanjang ditentukan oleh faktor lingkungan, hormon, dan faktor genetik. Menurut Tanner dkk, perawakan pendek didefinisikan sebagai tinggi badan kurang dari tiga persentil dan diperkirakan terjadi pada 2% populasi anak-anak. Sindrom Turner merupakan kelainan genetik pada perempuan yang paling banyak ditemukan akibat hilangnya sebagian atau seluruh kromosom X normal yang kedua dengan gambaran klinik utama berupa short stature dan insufisiensi ovarium, dengan insidensi 1:2500 bayi lahir hidup. Tujuan penelitian ini untuk memahami peran gen SHOX pada perawakan pendek Sindrom Turner dan variannya.Metode: Subjek penelitian adalah wanita berperawakan pendek yang setuju mengikuti penelitian dengan menandatangani informed consent. Dilakukan eksklusi untuk wanita berperawakan pendek dengan riwayat pengobatan pemacu pertumbuhan dan penyakit kronik. Pemeriksaan sitogenetik dengan metode pengecatan Giemsa dilakukan pada semua preparat kromosom dilanjutkan dengan analisis kromosom rutin.Hasil: Dilaporkan sembilan (9) wanita berperawakan pendek yang secara sitogenetik dan klinis didiagnosis sebagai Sindrom Turner. Empat kasus didiagnosis sebagai Sindrom Turner klasik dengan tinggi badan di bawah tiga persentil, tiga kasus dengan 45,X/46,X,i(Xq) dengan tinggi badan di bawah tiga persentil, satu kasus dengan 46,XX/45,X (80%) dengan tinggi badan di bawah tiga persentil, dan sisanya adalah 46,XX/45,X (20%) dengan tinggi badan di bawah antara 3-97 persentil atau normal.Simpulan: Haploinsufficiency gen SHOX diduga kuat menyebabkan perawakan pendek pada Sindrom Turner.
MEDIA MEDIKA INDONESIANA
2010-08-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21834
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 2 YEAR 2010; 57-61
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21834/14590
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3015
2012-04-04T12:55:03Z
mmi:ART
Suplementasi Vitamin E dan Profil Lipid Penderita Dislipidemia: Studi pada Pegawai Rumah Sakit Profesor Dokter Margono Soekarjo Purwokerto
Krisnansari, Diah
Kartasurya, Martha Irene
Rahfiludin, M. Zen
ABSTRACT Vitamin E supplementation and lipid profile in patients with dislipidemia Background: The prevalence of dislipidemia in Indonesia increase lately. Vitamin E has important role in cholesterol metabolism and protecting low density lipoprotein cholesterol against oxidation. This study was to investigate the effect of vitamin E supplementation on lipid profile.Method: The study was a randomised controlled clinical trial. Subjects were the employees of Professor Doctor Margono Soekarjo hospital aged 30-50 years who suffered from dislipidemic. The supplementation groups received 400 IU vitamin E and the control group received placebo once a day for 30 days. Lipid profile was examined using vitros system chemistry analyser 250 dan 350. Nutritional intake were gathered using food recall method and processed with nutrisurvey. Analyses were conducted using T-test, Mann Whitney, Wilcoxon and Chi square tests. Result: There were no differences in total (p=0.910), LDL (p=0.457) and HDL cholesterol levels (p=0.809) as well as trigliseride level (p=0.687) between the two groups before suplementation. There were differences in total (p=0.004) and LDL (p=0.002), there were no differences in HDL cholesterol level (p=0.332) and trigliseride level (p=0.940) between the two groups after supplementation. There were differences on the changes in total cholesterol (p=0.001) and LDL cholesterol (p=0.000) and no differences on the changes in HDL cholesterol level (p=0.197) as well as trigliserida level (p=0.438). There was no difference in nutritional intake between the two groups. Conclusion: That supplementation of vitamin E 400 IU once daily for 30 days improve lipid profile. Keywords: Dislipidemia, vitamin E, total cholesterol, LDL cholesterol, HDL cholesterol, trigliseride ABSTRAK Latar belakang: Angka kejadian dislipidemia di Indonesia semakin meningkat. Vitamin E merupakan antioksidan penting dalam metabolisme kolesterol, melindungi kolesterol LDL terhadap oksidasi dan meningkatkan kolesterol HDL. Penelitian ini bertujuan mengetahui pengaruh suplementasi vitamin E terhadap profil lipid penderita dislipidemia. Metode: Desain studi adalah acak buta ganda terkontrol dengan subyek 42 orang karyawan RS Profesor Dokter Margono Soekarjo penderita dislipidemia yang berusia 30-50 tahun, dibagi menjadi dua kelompok yaitu 22 orang memperoleh vitamin E 400 IU dan 20 orang memperoleh placebo sekali sehari selama 30 hari. Karakteristik subyek diperoleh melalui wawancara, berat badan dan tinggi badan diperoleh melalui pengukuran. Profil lipid diukur sebelum dan sesudah suplementasi dengan vitros system chemistry analyser 250 dan 350. Asupan gizi diperoleh melalui food recall dan dianalisis dengan program nutrisurvey. Data dianalisis dengan uji T, Mann Whitney, Wilcoxon dan Chi square. Hasil: Tidak ada perbedaan kolesterol total (p=0,910), kolesterol LDL (p=0,457), kolesterol HDL (p=0,809) dan trigliserida (p=0,687) antara kedua kelompok sebelum suplementasi. Ada perbedaan kolesterol total (p=0,004) dan kolesterol LDL (p=0,002), tidak ada perbedaan kolesterol HDL (p=0,332) dan trigliserida (p=0,940) antara kedua kelompok sesudah suplementasi. Ada perbedaan perubahan kolesterol total (p=0,001) dan kolesterol LDL (p=0,000), tidak ada perbedaan perubahan kolesterol HDL (p=0,197) dan trigliserida (p=0,438) antara kedua kelompok. Tidak ada perbedaan asupan gizi antara kedua kelompok. Simpulan: Suplementasi vitamin E 400 IU sekali sehari 30 hari dapat memperbaiki kolesterol total dan kolesterol LDL penderita.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3015
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 1 Year 2011; 16-25
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3015/2699
oai:ojs.ejournal.undip.ac.id:article/3237
2012-04-18T11:21:37Z
mmi:ART
Preparat Anti Jamur Dalam Pencegahan Mukositis Oral Akibat Efek Samping Radioterapi pada Pasien Keganasan Kepala Leher
Kartikawati, Henny
Fluconazole, itraconazole, mucositis, radiotherapy
ABSTRACTEffect of anti fungal preparations as oral mucositis prevention from radiotherapy side effects in nasopharyngeal carcinoma patientsBackground: Oral mucositis may lessened food intake and delays the radiation schedule in patients with nasopharyngeal carcinoma. Antifungal treatment fluconazole is known to be effective for treating fungal infections of mucous membrane and systemic infections caused by Candida sp. Itraconazole is also effective in treating fungal infections of mucous membrane or systemic infections. This study proves the effectiveness of fluconazole and itraconazole in the prevention of moderate to severe mucositis.Methods: An experimental study design with pre and post test randomized-control trial. Group A1 received fluconazole as prophylactic treatment, group A2 received itraconazole as prophylactic treatment. Group B was as control or non-prophylaxis. The treatment was given from day 11 to day 26 of radiotherapy (for 3 weeks). The outcome of this study was the incidence of moderate to severe mucositis and the findings of Candida Sp. on moderate to severe mucositis using KOH examination.Results: Moderate to severe mucositis was found in 6 cases in the control group (75%), markedly more than the prophylactic fluconazole group with only 2 cases (25%). The incidence of moderate to severe mucositis was also fewer in the itraconazole group, with only 8 cases (36.36%) compared to control group with 15 cases (68.18%). Examination using KOH showed positive fungal infection was greater in the control group compared to fluconazole and itraconazole groups.Conclusion: Fluconazole and itraconazole are useful in preventing the occurrence of moderate to severe mucositis as the side effects of radiotherapy in nasopharyngeal carcinoma patients, with relative risk reduction (RRR) of 40% for fluconazole and 45.8% ofitraconazole.Keywords: Fluconazole, itraconazole, mucositis, radiotherapyABSTRAKLatar belakang: Mukositis oral dapat menurunkan intake makanan dan tertundanya jadwal radiasi pada pasien keganasan kepala leher. Fluconazole adalah obat anti fungal yang efektif untuk mengobati infeksi jamur pada mukosa dan infeksi sistemik yang disebabkan oleh Candida sp. Itraconazole juga efektif untuk menangani infeksi jamur pada mukosa atau sistemik. Penelitian ini membuktikan efektivitas fluconazole dan itraconazole dalam pencegahan mukositis sedang-berat.Metode: Studi eksperimental dengan desain pre and post test randomized control trial. Kelompok A1 mendapat fluconazole, kelompok A2 menerima itraconazole sebagai perlakuan profilaksis. Kelompok B adalah kontrol atau non profilaksis. Perlakuan diberikan hari ke-11 sampai -26 radioterapi (3 minggu). Outcome penelitian ini berupa jumlah kejadian mukositis sedang-berat dan ditemukannya Candida Sp pada mukositis sedang-berat dengan pemeriksaan KOH.Hasil: Mukositis sedang-berat didapat 6 kasus kontrol (75%), jauh lebih banyak dibanding profilaksis fluconazole (2 kasus/25%). Kelompok itraconazole 8 kasus (36,36%) kejadian mukositis sedang-berat, lebih sedikit dibanding kontrol (15 kasus/68,18%). Penilaian KOH positif jamur lebih banyak pada kelompok kontrol dibanding fluconazole dan itraconazole.Simpulan: Fluconazole dan itraconazole bermanfaat untuk mencegah kejadian mukositis sedang-berat akibat efek samping radioterapi pada penderita karsinoma nasofaring, dengan nilai RRR (relative risk reduction) 40% pada fluconazole dan 45,8% pada itraconazole.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3237
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 163-168
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3237/2909
oai:ojs.ejournal.undip.ac.id:article/3810
2012-07-18T11:20:54Z
mmi:ART
Kejadian dan Faktor Resiko Akne Vulgaris
Tjekyan, R.M. Suryadi
Prevalence, acne vulgaris, risk factors
ABSTRACTAcne vulgaris and its risk factors.Background: Acne vulgaris (AV) gives cosmetic as well as psychological problem among the young. There is no data on the community prevalence and risk factors on this problem. Objective of this study aimed to find the community prevalence and risk factors of AV.Methods: A cross sectional study was carried in the city of Palembang among 5024 subjects aged 14-21 years in March-July 2007. Data were collected using questionnaire distributed through hamlets (RT) and analyzed using SPSS 13Results: The prevalence of AV was 68.2% and specifically were 58.4% among women and 78.9% among men, who were mostly at the age of 15-16 years. Papulopustulair type was the highest (35.8%) followed by comedonal (30.1%) and nodulistic (2.2%) with the location mostly on the face (58.9%) with bilateral position (55.7%). Routine facial cleaning gave lower AV development. Using and changing cosmetics were associated with AV (p1=0.04, p2=0.000). Respondents with family history of AV has higher risk to developAV (OR=2.18).Conclusion: Acne vulgaris is common among 15-16 years old boys and girls.Key Words: Prevalence, acne vulgaris, risk factorsABSTRAKLatar belakang: Akne vulgaris menjadi masalah kosmetika dan psikologis umum yang terutama terjadi pada kalangan remaja. Belum ada data angka kejadian dan faktor resiko akne vulgaris di masyarakat. Penelitian ini bertujuan untuk meneliti angka prevalensi dan beberapa faktor resiko akne vulgaris penduduk kota Palembang.Metode: Studi potong lintang dilakukan pada 5204 sampel usia 14 sampai 21 tahun di Palembang, memakai kuesioner yang didistribusikan melalui rukun tetangga di setiap kecamatan di kota Palembang yang terpilih. Penelitian dilaksanakan pada bulan Maret sampai Juli tahun 2007. Data diolah dengan piranti lunak SPSS 13.Hasil: Prevalensi umum AV pada subjek penelitian 68,2% dan 58,4% pada wanita dan 78,9% pada laki-laki dengan umur terbanyak berusia 15-16. Tipe papulopustular adalah yang tertinggi (35,8%) diikuti dengan komedonaly (30,1%) dan noduler (2,2%) dengan lokasi terutama di wajah dan bilateral. Pembersihan wajah secara rutin memberikan kejadian AV yang rendah. Menggunakan kosmetik dan kebiasaan berganti-ganti kosmetik berhubungan dengan kejadian AV (p1=0,04, p2=0,000). Responden dengan riwayatkeluarga ber-AV memiliki resiko untuk mendapatkannya (0R=2,18).Simpulan: Akne vulgaris banyak menimpa laki-laki maupun perempuan usia 15-16 tahun.
MEDIA MEDIKA INDONESIANA
2012-07-16
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3810
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 1 Year 2008; 37-43
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3810/3494
oai:ojs.ejournal.undip.ac.id:article/4168
2012-11-21T11:52:16Z
mmi:ART
Tinggi Badan yang Diukur dan Berdasarkan Tinggi Lutut Menggunakan Rumus Chumlea pada Lansia
Murbawani, Etisa Adi
Puruhita, Niken
Yudomurti, Yudomurti
Elderly, height, knee height, nutritional assesment
Measured height and calculated height based on knee height using chumlea formula in elderlyBackground: Height is an important anthropometric measurement. Height calculation equation for elderly with dorsal deformity using knee height was developed by Chumlea. However, the equation is not appropriate for elderly in Asian population. The aim of this study was to compare measured height with calculated height based on knee height using Chumlea formula for elderly in Indonesia.Method: A cross sectional study was conducted in 86 elderly in geriatric outpatient clinic in Kariadi hospital, nursing home, and eldery integrated health service (posyandu lansia) in Semarang which were randomly selected in July-September 2009. The inclusion criteria were elderly without deformities and able to stand up straightly. Data collected were demography characteristics, height and knee height. Height was measured using microtoise, knee height was measured using knee calliper. Both microtoise and knee calliper had 0.1 cm accuracy. Data were analysed using Wilcoxon signed rank test.Result: Most samples were female, aged 59-88 years. The average age was 71±8.7 years. The average measured height in female and male subjects were 146.8±5.6 cm and 160.8±6.2 cm respectively. The average calculated height in female and male subjects were 154.3±7.03 cm and and 159.1±6.78 cm respectively. There was no different (p=0.077) in measured height and calculated height using Chumlea formula.Conclusion: There was no different in measured height and calculated height using Chumlea formula.Keywords: Elderly, height, knee height, nutritional assesmentABSTRAKLatar belakang: Tinggi badan merupakan salah satu indikator pengukuran antropometri yang penting. Persamaan perhitungan tinggi badan pada lansia (lanjut usia) dengan deformitas punggung telah dikembangkan oleh Chumlea. Persamaan yang ada saat ini tidak tepat untuk populasi Asia. Tujuan penelitian ini adalah mengetahui kesesuaian antara tinggi badan yang diukur dengan microtoise dengan perhitungan berdasarkan tinggi lutut menggunakan rumus Chumlea untuk lansia di Indonesia.Metode: Desain penelitian ini adalah belah lintang. Subyek penelitian adalah 86 (delapan puluh enam) lansia yang menjadi pasien rawat jalan Poliklinik Geriatri di RSUP Dr. Kariadi Semarang, lansia yang menjadi penghuni panti wredha dan lansia yang menjadi anggota posyandu lansia di Semarang pada bulan Juli-September 2009. Kriteria inklusi pasien adalah tidak ada deformitas pada struktur tubuh dan mampu berdiri tegak. Data yang dikumpulkan meliputi karakteristik demografi, tinggi badan dan tinggilutut. Tinggi badan diukur menggunakan microtoise, sedangkan tinggi lutut diukur menggunakan knee calliper dengan akurasi 0,1 cm. Analisis data menggunakan uji beda Wilcoxon signed rank test.Hasil: Sebagian besar subyek berjenis kelamin perempuan, dengan usia 59-88 tahun. Rerata umur subyek sebesar 71±8,7 tahun. Rerata tinggi badan perempuan dan laki-laki adalah 146,8±5,6 cm, dan 160,8±6,2 cm. Rerata tinggi badan perempuan dan laki-laki dengan rumus Chumlea, adalah 154,3±7,03 cm dan 159,1±6,78 cm, dengan perbedaan yang tidak bermakna (p=0,077).Simpulan: Tidak ada perbedaan pengukuran tinggi badan menggunakan microtoise dan rumus Chumlea.
MEDIA MEDIKA INDONESIANA
2012-11-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4168
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012; 1-6
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4168/3801
oai:ojs.ejournal.undip.ac.id:article/4271
2013-06-26T12:59:31Z
mmi:ART
Karakteristik Klinik dan Laboratorik Kolestasis Intrahepatal dan Ekstrahepatal di Bangsal Perawatan Anak RSU Dr. Saiful Anwar Malang
Wibowo, Satrio
Santoso, Nurtjahjo Budi
Acholic stool, leucocyte, ALT, cholesterol, triglyseride, potassium, cholestasis
Clinical and laboratory characteristics of intrahepatic and extrahepatic cholestasis in pediatric ward of Dr. Saiful Anwar General Hospital MalangIntroduction: Clinical examination in determining intrahepatic and extrahepatic cholestasis in children and infant remains invasive and difficult. There is a need of simple and aplicative method on clinical practice. The objective of this review is to find the cause of cholestasis based on clinical and laboratory examination. Subject and Methode: Sixty nine medical records from pediatric patients who suffered from prolonged conjugated jaundice between January 2008 and March 2011 in the Department of Pediatrics of Dr. Saiful Anwar General Hospital, Malang, Indonesia were reviewed with regard to the clinical examinations, laboratory parameters and ultrasound. Liver ultrasound was used to classify patients into two groups: intra or extrahepatic cholestasis. Unpaired t-test was performed to compare numerical data. P value less than 0.05 were considered as to indicate statistical significant.Results: Leucocytes count (mean 2.649/mm3, 95%CI 1.556 to 12.141/mm3, p=0.012), ALT (mean 155 IU/L, 95%CI 66.9 to 245 IU/L, p=0.043), cholesterol (mean 243 mg/dl, 95%CI 31 to 455 mg/dl, p=0.026) and triglyseride (mean 219 mg/dl, 95%CI 40 to 398 mg/dl, p=0.018) were significantly higher in patients with extrahepatic cholestasis than intrahepatic group, but potassium level (mean 1.18 mEq/L, 95%CI 0.22 to 2.14 mEq/L, p=0.017) were significantly lower in intrahepatic group. Pale stool color had 75%sensitivity and 80% spesificity in determining extrahepatic cholestasis.Conclusion: Elevated leucocyte count, increased ALT serum level, cholesterol, triglyseride and decreased of potassium and acholic stool can be used as determinant factors in classifying intra or extrahepatic cholestasis in children.Keywords: Acholic stool, leucocyte, ALT, cholesterol, triglyseride, potassium, cholestasisABSTRAKLatar belakang: Diagnosis pasti kolestasis intrahepatal dan ekstrahepatal pada bayi dan anak membutuhkan pemeriksaan yang invasif dan sulit. Dibutuhkan metode yang sederhana dan aplikatif untuk praktek klinis. Penelitian ini bertujuan untuk menentukan jenis kolestasis intrahepatal berdasarkan pemeriksaan klinis dan laboratoris.Metode: Enam puluh sembilan rekam medis pasien yang pernah dirawat di bangsal anak RSU Dr. Saiful Anwar Malang dengan kolestasis selama periode Januari 2008 sampai Maret 2011 dianalisis. USG digunakan untuk menentukan ada tidaknya sumbatan ekstrahepatal dan menentukan kelompok kolestasis intrahepatal atau ekstrahepatal. Identitas, keluhan, riwayat penyakit dan hasilhasil pemeriksaan laboratorium dibandingkan antara dua kelompok penelitian. Unpaired t-test digunakan untuk membandingkandata numerik dari dua kelompok yang diteliti.Hasil: Leukosit (rerata 2,649/mm3, 95%CI 1.556-12,141/mm3, p=0,012), ALT (rerata 155 IU/L, 95%CI 66,9-245 IU/L, p=0,043), kolesterol (rerata 243 mg/dl, 95%CI 31-455 mg/dl, p=0,026) dan trigliserida (rerata 219 mg/dl, 95%CI 40-398 mg/dl, p=0,018) lebih tinggi pada pasien dengan kolestasis ekstrahepatal dibandingkan dengan intrahepatal, namun kadar kalium (rerata 1,18 mEq/L, 95% CI 0,22-2,14 mEq/L, p=0,017) lebih rendah. Warna tinja pada kedua jenis kolestasis juga berbeda. Warna tinja yang pucat memiliki sensitivitas 75% and spesifisitas 80% dalam menentukan kolestasis ekstrahepatal.Simpulan: Peningkatan jumlah leukosit, ALT, kolesterol, trigliserida dan penurunan kadar kalium darah serta warna
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4271
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 108-114
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4271/3892
oai:ojs.ejournal.undip.ac.id:article/4296
2012-12-29T12:24:31Z
mmi:ART
Pola Makan dan Pertumbuhan Bobot Tubuh Tikus yang Diinokulasi Porphyromonas gingivalis Sebelum dan Sesudah Terjadinya Periodontitis
Praptiwi, Praptiwi
Sulistyowati, Enik
Kustiyono, Kustiyono
Periodontitis, food pattern, weight growth
Food pattern and body weight growth of rat inoculation by porphyromonas gingivalis before and after periodontitisBackground: The rat model of periodontitis induced by Porphyromonas gingivalis (P. gingivalis) were selected to prove that energy requirement is rising in periodontitis, as well as the body mass erosion that giving influence to growth. This study aimed to get food consumption pattern and the lowest growth of body weight which would give information about time period to deliver nutrients needed to increase body weight to fasten healing.Methods: Experimental study was done using 63 Wistar adult, healthy male rat in Laboratorium Penelitian dan Pengujian Terpadu Gadjah Mada University, Yogyakarta in 2007-2008. The subject study were induced periodontitis by bacterial innoculation using P. gingivalis. The objects of the study were food consumption pattern and growth of body weight. Food consumption pattern was percentage of subject finishing food devided by total subject, before and during periodontitis period. Growth of body weight is mean of increasing body weight of 2 adjacent periodontitis period devided by length of day between the 2 periods.Results: The beginning of subject finishing the food was the time when periodontitis identified by Pathology Anatomic examination. Amount of subject finishing the food was variable according to periodontitis process. The growth of body weight before and during periodontitis was inclining by age. The highest incremental of mean body weight per day was observed before periodontitis until the beginning of periodontitis. The lowest incremental of mean body weight was found between the beginning of periodontitis tochronical period 1, as long as 7 days.Conclusions: The subject study began to finish the food since the beginning of periodontitis. During 7 days period from the beginning of periodontitis to chronical period 1, there was the lowest incremental body weight.Keywords: Periodontitis, food pattern, weight growthABSTRAKLatar belakang: Model tikus yang mengalami periodontitis dengan inokulasi P. gingivalis dipilih untuk membuktikan bahwa kebutuhan energi pada periodontitis meningkat dan terjadi erosi massa tubuh yang mempengaruhi pertumbuhan. Tujuan penelitian adalah diperolehnya pola makan serta pertumbuhan bobot tubuh (BT) terendah, yang akan memberikan gambaran periode waktu pemberian zat-zat gizi untuk meningkatkan bobot tubuh guna mempercepat penyembuhan.Metode: Dilakukan studi eksperimental pada 63 ekor tikus Wistar jantan dewasa di Laboratorium Penelitian dan Pengujian Terpadu Universitas Gadjah Mada Yogyakarta tahun 2007-2008. Subyek studi diinokulasi dengan P. gingivalis hingga terjadi periodontitis. Penilaian periodontitis dengan pemeriksaan Patologi Anatomik dari sediaan jaringan periodontal. Pola makan yaitu persentase subyek dengan pakan habis terhadap keseluruhan subyek studi, sebelum dan selama periodontitis. Pertumbuhan BT adalah rerata bobot tubuh 2 periode periodontitis yang berurutan dibagi lama hari antara 2 periode tersebut.Hasil: Awal pakan habis dimulai dari teridentifikasinya periodontitis melalui pemeriksaan Patologi Anatomik. Besaran subyek dengan pakan habis bervariasi menurut proses periodontitis. Pertumbuhan BT sebelum dan selama periodontitis menunjukkan peningkatan dengan bertambahnya umur. Peningkatan rerata BT per hari menunjukkan nilai tertinggi pada periode sebelum periodontitis ke awal periodontitis. Nilai terendah peningkatan rerata BT terdapat pada awal periodontitis ke periode kronik 1, selama 7 hari.Simpulan: Subyek studi mulai menghabiskan pakan sejak dimulai periodontitis. Selama 7 hari dari awal periodontitis sampai periode kronik 1, terjadi peningkatan rerata BTterendah
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4296
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009; 229-234
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4296/3914
oai:ojs.ejournal.undip.ac.id:article/4579
2013-06-26T12:57:43Z
mmi:ART
Pola Kuman Pasien Pneumonia di Instalasi Rawat Intensif Anak (IRIA) RSUP Dr. Sardjito
Setyati, Amalia
Murni, Indah Kartika
Pneumonia, culture, antibiotics
Bacterial pattern of pneumonia patient admitted in pediatric intensive care unit (PICU) Dr. Sardjito General HospitalBackground: Pneumonia is an inflammation of the lung parenchyma. The causative agent of pneumonia is difficult to determinate. This study was to attemp the pattern of bacteria and antibiotic sensitivity of pneumonia, and to see the risk of pneumonia mortality by age and bacteria obtained from cultures.Methods: Data of tracheal aspirate and blood cultures and its sensitivity to antibiotics of pneumonia patients who admitted to PICU of Sardjito General Hospital Yogyakarta in January-June 2011 were collected retrospectively from medical records. Analyzed by using chi-square test and the relative risk is expressed by odds ratio.Results: Ninety-four isolates of bacteria were obtained. There are 63 of tracheal aspirate and 32 of blood specimens. Gram (+) were 39.36% and gram (-) were 60.64%. The most cultures of tracheal aspirate was Pseudomonas, which the sensitivity of imipenem, amikacin, fosfomisin, netilmisin were 81.25%, 80.95%, 76.19%, 68.42%. The sensitivity of Klebsiella pneumoniae to fosfomisin, imipenem, amikacin were 92.31%, 84.62%, 76.92%. All isolates of coagulase negative Staphylococcus (CONS) were resistant to cephalosporin, likely 100% were sensitive to vancomisin. The sensitivity of Pseudomonas aeruginosa in the blood to ciprofloxacin, chloramphenicol, amikacin, cefepime and ceftazidim, gentamicin netilmisin and imipenem were 93.75%, 87.50%, 81.25%, 75%, 68.75%. The odds ratio (OR) of pneumonia death of age <1 year was 1.6, as well as the OR of pseudomonas was 2.5.Conclusion: The bacteria found were Pseudomonas aeruginosa, Klebsiella pneumoniae and CONS. The sensitivity of imipenem, amikacin, fosfomisin and ciprofloxacin were good to the three kind of bacteria. Patient under 1 year old and Pseudomonas aeruginosa are risk factors for death in pneumonia.Keywords: Pneumonia, culture, antibiotics ABSTRAKLatar belakang: Pneumonia adalah peradangan pada parenkim paru-paru. Penentuan penyebab pneumonia adalah sulit, Tujuan penelitian ini adalah melakukan pemetaan pola kuman dan kepekaan antibiotik pada pneumoni, melihat risiko kematian pneumonia berdasarkan umur dan kuman yang didapatkan dari kultur.Metode: Data kultur aspirat trakeal dan darah beserta kepekaan terhadap antibiotik pasien pneumonia yang dirawat di Instalasi Rawat Intensif Anak (IRIA) RSUP Dr. Sardjito Yogyakarta Januari- Juni 2011 diambil secara retrospektif dari catatan medik. Data dianalisis menggunakan uji x 2, risiko relatif dinyatakan dengan rasio odd.Hasil: Didapatkan 94 isolat kuman. Aspirat trakeal ada 63, isolat spesimen darah 32 isolat. Bakteri gram (+) 39,36% dan gram (-) 60,64%. Dari kultur aspirat trakeal terbanyak Pseudomonas, kepekaan terhadap Imipenem 81,25%, amikasin 80,95%, fosfomisin 76,19%, netilmisin 68,42%. Kepekaan Klebsiella pneumonia terhadap fosfomisin 92,31%, imipenem 84,62%, amikasin 76,92%. Semua isolat Staphylococcus coagulase negative (CONS) resisten terhadap sefalosporin, namun 100% peka dengan vancomisin. Kepekaan Pseudomonas aeruginosa dalam darah: ciprofloxacin 93,75%, kloramfenikol 87,50% amikasin, cefepime, ceftazidim 81,25%, gentamisin dan netilmisin 75%, imipenem 68,75%. Rasio odd (RO) kematian pasien pneumonia umur <1 tahun 1,6, RO kematian karena kultur pseudomonas 2,5.Simpulan: Kuman utama adalah Pseudomonas aeruginosa, Klebsiella pneumonia dan CONS. Kepekaan imipenem, amikasin, ciprofloksasin dan fosfomisin baik terhadap ketiga kuman tersebut. Umur <1 tahun dan pseudomonas merupakan faktor risiko kematian pada pneumoni
MEDIA MEDIKA INDONESIANA
2013-03-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4579
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012; 195-200
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4579/4171
oai:ojs.ejournal.undip.ac.id:article/21829
2019-01-25T14:21:01Z
mmi:ART
Pain Stimulated by Electric Foot Shock to Liver and Spleen Microscopic Immunological Response Features (BALB/c Mice Experimental Study)
Pudjonarko, Dwi
Jenie, M Naharuddin
Sadhana, Udadi
Pain; electric foot shock; macrophages; microabscess; hepatocytes; spleen multinucleated giant cells
Background: Pain affects immune system by decreasing type I-immune response that might be seen on microscopic features of liver and spleen. The objective of the study is to prove the effect of pain to immune response that confirmed by liver microabscess formation, hepatocytes destruction and spleen multinucleated giant cells of Balb/c mice suffered from pain.Method: This study adapts Laboratory Experimental and Post-Test Only Control Group Design. The samples were 12 female BALB/c mice (average weight 21.88 (SD=1.75) grams and divided into two groups. The control group (C) received no other additional treatment. The Pain (P) group received pain stimulated by Electric Foot Shock (EFS) 1-3 mA at day 12th to 21st. All groups were intravenously injected with 104 live L. monocytogenes at day 21st and sacrificed at day 26th by chloroform anaesthesia. Then, liver microabscess formation, hepatocytes destruction and spleen multinucleated giant cells were counted. Data were analyzed by independent t-test (significant if p<0.05).Result: There were significant differences in the liver microabscess formation, hepatocytes destruction and spleen multinucleated giant cells (p<0.05) between the groups. The number of liver microabscess formation and hepatocytes destruction in the P group were higher than C group. The number of spleen multinucleated giant cells in the P group were lower than C group. Conclusion: Pain has an immunosuppressive effect not only on high liver microabscess formation and hepatocytes destruction, but also low spleen multinucleated giant cells.ABSTRAKPengaruh nyeri yang distimulasi electric foot shock terhadap gambaran mikroskopis respon imunologis di hepar dan lien. (Studi eksperimental pada mencit Balb/c).Latar belakang: Nyeri dapat mempengaruhi imunitas tubuh dengan menurunkan produksi sitokin tipe 1 yang kemungkinan akan mempengaruhi gambaran mikroskopis respon imunologis baik di hepar maupun lien. Penelitian ini bertujuan untuk membuktikan penurunan imunitas seluler yang dilihat dari mikroabses dan kerusakan hepatosit pada hepar serta sel datia lien mencit BALB/c yang mendapatkan stimulasi nyeri dengan electric foot shock (EFS).Metode: Penelitian ini merupakan penelitian eksperimental laboratorik, dengan pendekatan the post test–only control group design yang menggunakan 12 ekor mencit betina strain BALB/c, umur 6-8 minggu dan rerata barat badan 21,88 (SD=1,75) gram. Sampel dibagi dalam 2 kelompok dan mendapatkan makanan standar. Pada kelompok Kontrol (K), mencit tidak mendapatkan perlakuan, sedangkan kelompok Nyeri (N), mencit mendapat sensasi nyeri menggunakan EFS mulai hari ke-12 sampai 21. Pada hari ke-21, semua mencit disuntik 104 listeria monocytogenes hidup iv. Dilakukan terminasi mencit pada hari ke-26 untuk dilakukan penghitungan mikroabses dan kerusakan hepatosit pada hepar serta sel datia lien. Dilakukan uji beda antar kelompok perlakuan dengan independent t-test. Perbedaan dinyatakan bermakna bila didapatkan nilai p<0,05.Hasil: Terdapat perbedaan yang bermakna pada jumlah mikroabses dan kerusakan hepatosit pada hepar serta sel datia lien pada mencit yang distimulasi nyeri dengan EFS dibandingkan kontrol (p<0,05). Stimulasi nyeri dengan EFS menyebabkan mikroabses dan kerusakan hepatosit pada hepar lebih tinggi terhadap kontrol, sedangkan sel datia pada lien jumlahnya lebih rendah bila dibandingkan kontrol
MEDIA MEDIKA INDONESIANA
2010-04-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21829
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010; 27-32
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21829/14585
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3121
2012-04-09T13:40:58Z
mmi:ART
Pemberian Teh Rosela (Hibiscus sabdariffa Linn), Simvastatin dan Profil Lipid serta Serum ApoB pada Tikus Hiperkolesterolemi
Probosari, Enny
WS, Hertanto
Puruhita, Niken
Lipid profile, apoB, roselle, simvastatin
ABSTRACTConsumption of roselle tea and simvastatin, lipid profile and apoB serum in hypercholesterolemic ratsBackground: Roselle is commonly used as herbal beverages in Indonesian that is known have a hypocholesterolemic effect. The study was conducted to determine the efficacy of roselle tea compared to simvastatin on lipid profile and apo B of hypercholesterolemic rats.Methods: This study was an animal experimental with randomized pre test post test control design. Sixteen hypercholesterolemic male wistar rats of 15 week-aged were devided into 3 groups: control groups (K) received normal feeding and water adlibitum, group P1 received normal feeding, water adlibitum and roselle tea 4.5 ml twice a day, group P2 received normal feeding, water adlibitum and simvastatin 0.4 mg daily. Blood samples were collected at baseline and 30 days after administration of roselle tea or simvastatin for the measurement of serum lipids and apoB using ELISA.Results: Administration of roselle tea 1.37gram twice a day decreased trigliserid concentrations from 81.7mg/dl±43.13 to 26.5mg/dl±13.92 (p=0.038), but increased total cholesterol concentrations from 62.1mg/dl±4.25 to 91.9mg/dl±11.74 (p=0.001). Administration of 0.4mg simvastatin didn’t decreased triglicerid concentrations (50.9mg/dl±55.95 to 67.9mg/dl±3.07, p=0.207), total cholesterol concentrations (67.9mg/dl±3.07 to 74.2mg/dl±10.65, p=0.146), LDL cholesterol concentrations (156.8mg/dl±291.9 to 34.0mg/dl±30.06, p=0.686) nor increased HDL cholesterol concentration (58.1mg/dl±12.73 to 60.5mg/dl±8.61, p=0.674).Conclusion: Intake of 1.37 gram rosella tea twice a day decreases trigliserid more effective than simvastatin. Administration of roselle tea and simvastatin are not effective to reduce LDL cholesterol concentrations and apoB concentrations, nor increased HDL cholesterol concentrations.Keywords: Lipid profile, apoB, roselle, simvastatinABSTRAKLatar belakang: Teh rosela merupakan salah satu bahan minuman yang diketahui mempunyai efek menurunkan kadar kolesterol. Penelitian ini bertujuan untuk mengetahui efektifitas pemberian teh rosela dibandingkan simvastatin terhadap profil lipid dan apolipoprotein B pada tikus hiperkolesterolemi.Metode: Penelitian ini adalah penelitian eksperimental laboratorium dengan desain pre-post-test dengan kelompok kontrol. Enam belas tikus putih jantan galur wistar hiperkolesterolemi, usia 15 minggu, dibagi menjadi kelompok kontrol (K) hanya diberi pakan standar dan minum adlibitum, kelompok perlakuan 1 (P1) diberi pakan standar minum adlibitum, seduhan rosela 2x4,5ml per haridan kelompok perlakuan 2 (P2) diberi pakan standar minum adlibitum dan simvastatin 0,4mg per hari, selama 30 hari. Pada awal dan akhir perlakuan diambil serum darah untuk mengetahui kadar trigliserid, kolesterol total, kolesterol LDL, kolesterol HDL, sedangkan kadar apo B diukur pada akhir penelitian menggunakan metode ELISA.Hasil: Pemberian teh rosela (kelompok P1) menurunkan kadar trigliserid dari 81,7mg/dl±43,13 menjadi 26,5mg/dl±13,92 (p=0,038) setelah perlakuan, namun kadar kolesterol totalnya meningkat dari 62,1mg/dl±4,25 menjadi 91,9mg/dl±11,74 (p=0,001) setelah perlakuan. Pemberian 0,4mg simvastatin tidak menurunkan kadar trigliserid (50,9mg/dl±55,95 menjadi 67,9mg/dl±3,07, p=0,207), tidak menurunkan kadar kolesterol total (67,9mg/dl±3,07 menjadi 74,2mg/dl±10,65, p=0,146), tidak menurunkan kadar kolesterol LDL (156,8mg/dl±291,9 menjadi 34,0mg/dl±30,06, p=0,686) dan tidak meningkatkan kadar kolesterol HDL (58,1mg/dl±12,73 menjadi 60,5mg/dl±8,61, p=0,674).Simpulan: Pemberian teh rosela dengan berat rata-rata 1,37 gram yang dikonsumsi dua kali per hari lebih efektif dalam menurunkan kadar trigliserid serum tikus hiperkolesterolemi dibandingkan pemberian 0,4mg simvastatin. Pemberian teh rosela dosis lazim dan pemberian simvastatin dosis 0,4mg sama tidak efektifnya dalam menurunkan kadar kolesterol LDL, kadar apolipoprotein B dan meningkatkan kadar kolesterol HDL.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3121
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 1 Year 2011; 41-48
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3121/2801
oai:ojs.ejournal.undip.ac.id:article/21906
2019-01-29T13:20:45Z
mmi:ART
sTfR Sebagai Faktor Risiko Bangkitan Kejang Demam
Khanis, Abdul
Bahtera, Tjipta
Wijayahadi, Noor
Febrile seizures; iron deficiency; sTfR
sTfR parameter as a risk factor of febrile seizuresBackground: Febrile seizures is the most often neurologic disorder in children and 2%-5% children under 5 years old have experienced febrile seizures. Prognosis of febrile seizures is good, however the seizure brings serious worries to the parents. Iron deficiency as a risk factor of febrile seizures is still controversial.Objective: To analyze iron deficiency with serum transferrin receptor (sTfR) parameter as a risk factor of febrile seizures in children.Method: Study design was case control with subjects 72 children aged 3 months – 5 years in Dr. Kariadi hospital on August 2009 – January 2010, 36 children with febrile seizures as case group and 36 children with febrile with no seizure as control group. Clinical data and blood sampling were recorded from study subjects for sTfR level measurement. Risk factors were analyzed with odds ratio (95% confidence interval) and multivariate logistic regression.Results: Mean sTfR level was 6.2 μg/mL (2.6-6.8) in case group and 2.0 μg/mL (1.8-2.3) in control group. Multivariate analysis showed iron deficiency with sTfR parameter was significantly as a risk factor for febrile seizures (p<0.001; OR=25.1; 95%CI 5.1-122.6). sTfR level could be used as febrile seizures indicator with sTfR level cut-off point was 2.55 μg/ml. Conclusion: sTfR parameter can be used is a risk factor for febrile seizures. ABSTRAKLatar belakang: Kejang demam merupakan kelainan saraf tersering pada anak dan 2%-5% anak di bawah umur 5 tahun pernah mengalami kejang demam. Prognosis kejang demam baik, namun cukup mengkhawatirkan bagi orang tuanya. Defisiensi besi sebagai faktor risiko bangkitan kejang demam masih kontroversial. Tujuan penelitian ini menganalisis defisiensi besi dengan parameter serum transferrin receptor (sTfR) sebagai faktor risiko bangkitan kejang demam pada anak.Metode: Penelitian kasus kontrol ini dengan subyek penelitian 72 anak berumur 3 bulan sampai 5 tahun di RSUP Dr. Kariadi pada Agustus 2009 – Januari 2010, 36 anak kelompok kasus dengan bangkitan kejang demam dan 36 anak kelompok kontrol dengan demam tanpa kejang. Subyek penelitian dicatat data klinis dan pengambilan darah untuk diperiksa kadar sTfR. Faktor risiko dianalisis dengan rasio odds (95% interval kepercayaan) dan multivariat regresi logistik.Hasil: Rerata kadar sTfR pada kelompok kasus 6,2 μg/mL (2,6-6,8) dan kelompok kontrol 2,0 μg/mL (1,8-2,3). Analisis multivariat menunjukkan defisiensi besi dengan parameter sTfR secara bermakna merupakan faktor risiko bangkitan kejang demam (p<0,001; OR=25,1; 95%CI 5,1-122,6). Kadar sTfR dapat dipergunakan sebagai indikator bangkitan kejang demam dengan cut-off point kadar sTfR adalah 2,55 μg/mL.Simpulan: Parameter sTfR merupakan faktor risiko bangkitan kejang demam.
MEDIA MEDIKA INDONESIANA
2010-12-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21906
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 3 YEAR 2010; 133-140
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21906/14642
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3027
2012-04-05T13:57:59Z
mmi:ART
Korelasi Kadar TNF-α dan Skor Psoriasis Area and Severity Index (PASI) pada Pasien Psoriasis
Budiastuti, Asih
Psoriasis, TNF-α, PASI score
ABSTRACTCorrelation of serum TNF-α levels and psoriasis area and severity index (PASI) score in psoriatic patientsBackround: Psoriasis is a chronic inflammatory disease characterized by erythematous scaly patches. Psoriasis affects ±2.5% of world population, and 20-30% patients have moderate to severe psoriasis. Psoriatic patients have increased proinflammatory Th1 cytokines expression, including TNF-α, with relative deficiency of Th2 cytokines. Psoriasis area and severity index (PASI) is a subjective method which commonly used to measure disease severity. This study was aimed to determine the correlation betweenserum TNF-α level and PASI score, in order to obtain objective method for measuring disease severity.Method: This was an observational study performed psoriatic patients. Subjects underwent PASI score examination and serum TNF-α assay using ELISA.Result: Subjects were 16 patients (6 females and 10 males), with mean age of 51 years. Serum TNF-α levels ranged from 15,0-202,4 pg/mL. PASI score ranged from 0,3-55,8. The test showed no significant correlation between PASI score and serum TNF-α level. (ρ=-0,265; p=0,322)Conclusion: Serum TNF-α can not be used as clinical parameter of psoriasis severity.Keywords: Psoriasis, TNF-α, PASI scoreABSTRAKLatar belakang: Psoriasis adalah penyakit peradangan kronik dengan gambaran klinis berupa plakat bersisik berwarna merah terang. Penyakit ini mengenai ±2,5% dari populasi dunia, dimana 20-30% menderita psoriasis sedang sampai berat. Pada psoriasis terjadi peningkatan ekspresi sitokin pro inflamasi Th1, di antaranya TNF-α, dan defisiensi relatif sitokin Th2. Skor psoriasis area and severity index (PASI) adalah metode yang paling banyak digunakan untuk mengukur derajat keparahan psoriasis, namun metode ini bersifat subyektif. Penelitian ini bertujuan menentukan apakah terdapat korelasi antara kadar TNF-α serum dan skor PASI, guna mendapatkan parameter obyektif untuk mengukur derajat keparahan psoriasis.Metoda: Penelitian ini merupakan penelitian observasional pada pasien psoriasis. Subyek penelitian menjalani pemeriksaan skor PASI, lalu diperiksa kadar TNF-α serum menggunakan metode ELISA.Hasil: Subyek penelitian terdiri atas 16 penderita (6 wanita dan 10 laki-laki) dengan rerata usia 51 tahun. Rentang kadar TNF-α pada penderita 15,0 pg/mL -202,4 pg/mL. Rentang skor PASI penderita adalah 0,3-55,8. Uji korelasi menunjukkan bahwa tidak terdapat hubungan bermakna (ρ=-0,265; p=0,322) antara skor PASI dan kadar TNF-α, tanpa pengendalian berbagai faktor pengganggu.Simpulan: Kadar TNF-α serum belum dapat dipakai sebagai parameter keparahan psoriasis
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3027
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 133-137
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3027/2710
oai:ojs.ejournal.undip.ac.id:article/3794
2012-07-16T10:54:43Z
mmi:ART
Peran Gen Polimorfik δ Asam Amino Levulinat Dehidratase pada Intoksikasi Pb
Sunoko, Henna Rya
ALAD polymorphism gene, ALAD1, ALAD2, blood lead level
ABSTRACTThe role of δ amino levulinic acid dehydratase polymorphism gene in lead intoxication.Background: Three distinct isozymes, designated ALAD 1-1, 1-2, and 2-2 are resulted from the expression of two common alleles, designated ALAD1 and ALAD2. The existence of this polymorphism gene whose product was implicated in the pathogenesis of lead toxicity suggested the potential for a genetically determined differential susceptibility. This study was attempted to investigate the role of ALAD polymorphism gene in lead intoxication showed by children blood lead levels.Methods: The study involved 54 children with 5-10-year-old, coming from Gebang Sari, Sekaran and Moro Demak. Cross-sectional design was adopted in this research. Blood lead level was measured by atomic absorption spectrophotometer. The ALAD polymorphism in exon 4 was determined by polymerase chain reaction (PCR) with restriction fragment length polymorphism, according to the methods described by Schwartz et al. Data were not statistically analyzed due to only two samples were ALAD2.Results: Two samples were ALAD2 (1-2 isozymes) with blood lead levels (BLL) of 24.50 ppb and 91.70 ppb respectivelly. The mean of ALAD2 BLL was about 48.60 ppb higher compared to that of ALAD1BLL.Conclusion: Individuals with ALAD2genotype had blood lead levels higher than those of individuals with the ALAD1 genotype, therefore, ALAD2genotype was much more susceptible to lead .Key Words: ALAD polymorphism gene, ALAD1, ALAD2, blood lead levelABSTRAKLatar belakang: ALAD 1-1, 1-2, dan 2-2, adalah tiga isozym yang berasal dari dua macam alel yaitu ALAD1 dan ALAD2. Keberadaan gen ALAD polimorfik dengan produknya ini, dalam patogenesis toksisitas Pb telah mengimplikasikan bahwa secara genetik sangat potensial untuk menyebabkan terjadinya perbedaan suseptabilitas terhadap Pb. Penelitian ini ditujukan untuk mempelajari peran gen ALAD polimorfik pada intoksikasi Pb yang ditunjukkan oleh tingkat kadar Pb darah.Metode: Penelitian mengikutsertakan 54 anak, umur 5-10 tahun, berasal dari Gebang Sari, Sekaran dan Moro Demak. Penelitian didesain secara cross-sectional. Kadar Pb darah diukur dengan alat atomic absorption spectrophotometer. ALAD polimorfik pada exon 4 dideterminasi dengan polymerase chain reaction (PCR) dengan restriksi “fragmentlength polymorphism” sesuai dengan metoda Schwartz et al. Analisis statistik tidak dilakukan sebab hanya ada dua sampel dengan ALAD2.Hasil: Ditemukan dua sampel anak dengan ALAD2 (1-2 isozymes), kadar Pb darah masing-masing 24,50 ppb dan 91,70 ppb. Rerata kadar Pb darah dengan ALAD2 lebih tinggi sekitar 48,60 ppb dibanding rerata kadar Pb darah dengan ALAD1.Simpulan: Genotipe ALAD2 lebih suseptibel terhadap Pb.
MEDIA MEDIKA INDONESIANA
2012-07-16
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3794
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 1 Year 2008; 1-10
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3794/3478
oai:ojs.ejournal.undip.ac.id:article/3828
2012-07-20T10:32:48Z
mmi:ART
Inspeksi Visual Asam Asetat (IVA) untuk Deteksi Dini Lesi Prakanker Serviks
Wiyono, Sapto
Iskandar, T. Mirza
Suprijono, Suprijono
VIA, acetowhite, early detection, cervical precancer lesion.
Visual acetic acid inspection (IVA) for early cervix pre cancer lesion detectionBackground: In 1985 WHO and had recommended an alternative approach, the down staging concept of cervical malignancy with visual inspection with acetic acid (VIA) for developing countries. Displastic cervical epithelial cells will make an acethowhite appearance with VIA. It is important to know the sensitivity and specificity of VIA for early detection of cervical precancer lesion.Methods: A hundred and twenty subjects who fullfilled inclution criteria had Pap test, VIA and four quadrant biopsy. Fortyfive subjects came from Gynecology and fertility clinic at Dr. Kariadi hospital and seventy five subjects came from Indonesian Cancer Foundation Semarang. From all of these examination the sensitivity, specificity, positive predictive value and negative predictive value were calculated by 2x2 tabel. Biopsy result was considered as gold standard.Results: Based on biopsy result there were 32 cases (26.7%) with normal finding, 31 cases (25.81%) with chronic cervicitis, 50 cases (41.6%) with chronic cervicitis with mild dysplasia, 3 cases (2.5%) with chronic cervicitis and moderate dysplasia, 2 cases (1.7%) with non specific inflammation, 2 cases (1.7%) with chronic cervicitis and mild dysplasia, 1 cases (0.8%) with malignancy. The sensitivity of Pap test was 55%, specificity 90%, PPV 84% and NPV 69% whether VIA had sensitivity 84%, specificity 89%, PPV87% and NPV 86%.Conclusions: Visual inspection with acetic acid has high sensitivity for early detection of cervical precancer lesion.Keywords: VIA, acetowhite, early detection, cervical precancer lesion.ABSTRAKLatar belakang: Tahun 1985 WHO merekomendasikan suatu pendekatan alternatif bagi negara yang sedang berkembang dengan konsep down staging terhadap kanker serviks dengan pemeriksaan IVA. Epitel serviks yang mengalami displasia akan memberikan gambaran acethowhile dengan pemeriksaan IVA. Untuk itu perlu diketahui seberapa besar sensitivitas dan spesifisitas dari pemeriksaan VIA dalam mendeteksi dini lesi prakanker serviks.Metode: Seratus dua puluh peserta penelitian, 45 berasal dari poliklinik ginekologi dan FER RSUP Dr. Kariadi dan 75 berasal dari YKI Cabang Semarang yang memenuhi kriteria penerimaan sampel dilakukan pemeriksaan tes Pap, IVA dan biopsi empat kuadran. Terhadap hasil pemeriksaan ini dilakukan perhitungan sensitivitas, spesifisitas, nilai duga positif maupun nilai duga negatifHasil: Berdasarkan hasil pemeriksaan biopsi didapatkan 32 subyek (26,7%) dengan hasil normal, 31 (25,8%) dengan servisitis kronis, 50 (41,6%) dengan servisitis kronis dengan displasia ringan, 3 (2,5%) servisitis kronis dengan displasia sedang, 2 (1,7%) dengan radang tidak spesifik dengan displasia ringan, 2 (1,7%) dengan radang tidak spesifik dan 1 (0,8%) dengan keganasan serviks. Sensitivitas untuk tes Pap 55%, spesifisitas 90%, nilai duga positif 84%, nilai duga negatif 69%, sedang sensitivitaspemeriksaan IVA 84%, spesifisitas 89%, nilai duga positif 87% dan nilai duga negatif 86%.Simpulan: Pemeriksaan IVA mempunyai sensitivitas yang tinggi untuk deteksi dini lesi prakanker serviks.
MEDIA MEDIKA INDONESIANA
2012-07-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3828
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 3 Year 2008; 116-121
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3828/3512
oai:ojs.ejournal.undip.ac.id:article/4266
2013-06-26T12:59:31Z
mmi:ART
Faktor Risiko Kejang Demam Berulang pada Anak
Gunawan, Prastiya Indra
Saharso, Darto
Children, risk factors, recurrent febrile seizures
Risk factors of recurrent febrile seizures in childrenBackground: Febrile seizures (FS) are the most common seizure disorder in childhood. Recurrent febrile seizures (RFS) occur in one third of children who experience a first FS. About nine percent had three or more recurrence. Little is known about predictors of recurrence. The aim of this study is to determine the incidence and the risk factors of RFS in children with FS at Dr. Soetomo Hospital Surabaya.Method: This is a cohort prospective study. Data was taken from all children with first FS aged 6 month-old to 5 year-old who were admitted at pediatric ward Dr. Soetomo Hospital from August 2009 to November 2010. They were observed for one year period to ascertain wether FS recurred. Logistic regression statistic was used to analyze those variables including sex, age, body temperature during the fever episode, family history of seizures, diagnosis at the first onset, maternal illness, abnormal delivery and recurrence ofFS.Results: Recurrent FS occured in 65% of the 100 children at one year observation, and 26% of them had further attack. Male to female ratio was 2:1. Thirty-one (77.5%) of subjects were less than 12 months-old. Body temperature ≤38.5OC (OR=5.50, 95%CI, p=0.019) and complex FS (OR 5.03, 95%CI, p=0.025) were related to increase risk of reccurence.Conclusions: The risk of RFS increased with body temperature ≤38.5OC and diagnosed as complex FS at the first FS.Keywords: Children, risk factors, recurrent febrile seizures ABSTRAKLatar belakang: Kejang demam (KD) adalah kasus kejang yang sering dialami anak-anak. KD berulang terjadi pada sepertiga anak yang mengalami KD pertama. Sekitar 9% dari penderita KD mengalami tiga atau lebih kejadian berulang. Hanya sedikit yang diketahui tentang prediktor berulangnya KD. Tujuan penelitian untuk mengetahui angka kejadian KD berulang dan menentukan faktor risiko terjadinya KD berulang pada anak yang mengalami KD di RSUD Dr. Soetomo Surabaya.Metode: Studi kohort prospektif dilakukan pada bulan Agustus 2009 sampai November 2010. Subyek diambil dari anak usia 6 bulan sampai 5 tahun yang menderita KD pertama yang MRS di RSUD Dr. Soetomo. Subyek diamati selama 1 tahun untuk menentukan apakah KD terjadi berulang. Analisis antar variabel jenis kelamin, usia, suhu badan saat terjadi demam, riwayat kejang pada keluarga, diagnosis awal, penyakit ibu, kelahiran yang tidak normal dan kejadian KD berulang, dilakukan dengan regresi logistik.Hasil: KD berulang terjadi 65% pada 100 anak yang diobservasi selama 1 tahun pertama dan 26% mengalami KD lebih dari 2 kali. Rasio laki-laki dibanding perempuan adalah 2:1. Tiga puluh satu (77,5%) anak berusia kurang dari 12 bulan. Faktor risiko suhu badan ≤38,5OC (OR=5,50, 95%CI, p=0,019) dan KD komplikata (OR 5,03, 95%CI, p=0,025) bermakna secara signifikan untuk kejadian berulangnya KD.Simpulan: Risiko KD berulang pada anak meningkat pada suhu badan ≤38,5OC dan diagnosis KD komplikata pada saat KD pertama.
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4266
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 75-80
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4266/3887
oai:ojs.ejournal.undip.ac.id:article/4283
2012-12-15T12:37:45Z
mmi:ART
Studi Komparasi Pemeriksaan MRI 0,5 Tesla Terhadap EEG Skalp dan Evaluasi Hasil Operasi Berdasarkan Kriteria Engel pada Epilepsi Mesial Temporal Sclerosis
Baskoro, Nurdopo
Sukmaningtyas, Hermina
Abubakar, Abubakar
MTS, EEG, MRI 0.5 T, Engel’s criteria
Comparative study of MRI 0,5 Tesla result with scalp ECG and evaluation of surgery result based on Engel classification among patient with mesial temporal sclerosis epilepsy.Background: Accurate preoperative localization of the epileptic is important in the intraoperative localization of lesion which ultimately will control the postoperative seizures.Purpose: To investigate the association among routine scalp electroencephalographic (EEG), Magnetic Resonance Imaging (MRI) 0.5 Tesla and Surgical outcome using Engel’s criteria in Mesial Temporal Sclerosis (MTS).Methods: This study used is an analitical descriptive study with cross sectional design. Correlation between EEG and MRI was analized using the Kappa and MRI findings with operative outcome was analized using the Spearmann. Forty seven patients with intractable Epilepsy who underwent temporal lobe lobectomy between 2000 and 2007 were the subjects of the study.Results: Routine scalp EEG and MRI findings revealed that the focus were the mostly temporal lobe epileptiform in the right side. Comparing the EEG foci with MRI lesion, the study revealed same location of foci in the right side (42.6% vs 61.7%), in the left side (27.7% vs 27.7%), bilateral (14.9% vs 2.1%) and normal (14.9% vs 8.5%). The correlation of lateralization of foci between EEG findings and MRI lesion is significan. There was association between the MRI 0.5 Tesla findings and operative outcome (r=0.352, p=0.015). All patients after surgery showed I-III Engel’s classification.Conclusions: Result of MRI 0.5 Tesla gives slight agreement with scalp ECG result but is associated with the operation outcome based on Engel classification.Keyword: MTS, EEG, MRI 0.5 T, Engel’s criteriaABSTRAKLatar belakang: Menentukan lokalisasi fokus epilepsi secara akurat sangat membantu dalam melokalisasi lesi intraoperasi yang pada akhirnya dapat mengkontrol serangan kejang pasca operasi.Tujuan: Untuk mencari hubungan antara pemeriksaan rutin elektroensefalografi (EEG) skalp dan MRI 0,5 Tesla dan hasil operasi berdasarkan kriteria Engel pada Mesial Temporal Sclerosis.Metode: Jenis penelitian ini menggunakan studi deskriptif analitik dengan desain Cross Sectional. Hubungan antara EEG dan MRI dilakukan analisis dengan Kappa dan antara temuan MRI dan hasil operasi dilakukan analisis dengan Uji korelasi Spearman. Dievaluasi sebanyak 47 pasien dengan epilepsi intraktabel yang telah dilakukan operasi lobektomi temporal antara tahun 2000- 2007.Hasil: Dari pemeriksaan EEG scalp dan MRI didapatkan fokus epilepsi lobus temporalis lebih banyak di sisi kanan. Perbandingan lokasi fokus berdasarkan EEG dan MRI adalah lokasi yang sama pada sisi kanan (42,6% vs 61,7%), pada sisi kiri (27,7% vs 27,7%), bilateral (14,9% vs 2,1%) dan normal (14,9% vs 8,5%). Lateralisasi fokus antara pemeriksaan EEG dan MRI menunjukkan hubungan yang bermakna. Ada hubungan antara pemeriksaan MRI 0,5 Tesla dan hasil operasi (r=0,352, p=0,015). Pasca operasi,semua pasien termasuk dalam kriteria Engel I-III.Simpulan: MRI 0,5 Tesla menunjukkan kesesuaian yang rendah dengan hasil EEG, namun berkorelasi dengan temuan hasil operasi.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4283
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009; 197-201
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4283/3903
oai:ojs.ejournal.undip.ac.id:article/4572
2013-06-26T12:57:43Z
mmi:ART
Kadar Autoantibodi dan Manifestasi Klinis pada Pasien Nefritis Lupus Silent dan Nefritis Lupus Overt
Handono, Kusworini
Gunawan, Atma
Rosandi, Rulli
SLN, OLN, NL class, autoantibodies
Autoantibodies level and clinical manifestation differences between patients with silent nephritis lupus and overt nephritis lupusBackground: One of the serious clinical manifestations of SLE is the occurrence of lupus nephritis (LN). The pathogenesis of LN is still unclear. Glomerular inflammation has been associated with high levels of autoantibodies. The purpose of this study was to assess the difference of ANA, anti ds-DNA, anti-Sm antibodies and the clinical manifestations between silent lupus nephritis (SLN) and overt lupus nephritis (OLN).Subject and Methods: Subjects were forty SLE patients (diagnosed according to ARA criteria of 1997). Autoantibodies ANA was assayed with IFA, anti-dsDNA and anti-Sm levels were assayed with ELISA. The diagnosis of LN was established using clinical signs, urinary sediments pattern and kidney biopsy, and then patients classified as a silent lupus nephritis (SLN) or overt lupus nephritis (ONL). Classification of NL histopathologic pattern was established according to WHO criteria. Differences in clinical manifestations, presence of ANA, anti-dsDNA and anti-Sm levels in the SLN and OLN and NL classes were analyzed by Chi squaretest and T test. Statistical significance determined when p<0.05.Results: OLN patients showed a edema, hypertension, anemia and autoantibodies more higher than in SLN patients. The mean level of anti-dsDNA was significantly higher in patients with OLN than in SLN (285.75±41.85 vs 179.01±61.81, p<0.000). Renal biopsy on 20 OLN patients showed: 6 patients with NL grade I/II, 9 patients with NL class III/IV and 5 patients with NL class V. Moreover on 11 SLN patients there were 7 patients with NL class I/II, 3 patients with NL class III/IV and 1 patient with NL class V. The NL classIII/IV NL patients showed anti-dsDNA level higher than the class V NL (p<0.05).Conclusion: OLN patients had clinical manifestations more severe than SLN patients. NL patients with class III/IV showed the presence of anti-dsDNA more frequently and with higher levels than the class V NL. Diagnosing NL based solely on clinical signs and laboratory often is inappropriate.Keywords: SLN, OLN, NL class, autoantibodies ABSTRAKLatar belakang: Salah satu manifestasi serius LES adalah terjadinya nefritis lupus (NL). Patogenesis NL hingga saat ini masih belum jelas. Terjadinya inflamasi di glumerulus telah dikaitkan dengan tingginya kadar autoantibodi. Tujuan penelitian ini mengetahui perbedaan ANA, anti ds-DNA dan anti-Sm pada pasien dengan NL tenang (silent lupus nephritis/SLN) dan NL manifes (overt lupus nephritis/OLN).Metode: Sampel penelitian adalah empat puluh penderita LES (didiagnosis berdasarkan kriteria ARA 1997). ANA diperiksa dengan metoda IFA, anti-dsDNA dan anti-Sm menggunakan metoda ELISA. Diagnosis NL didasarkan adanya tanda klinis, sedimen urin dan biopsi ginjal dan dikelompokkan sebagai silent lupus nephritis (SLN) dan overt lupus nephritis (ONL). Klasifikasi histopatologi NL ditegakkan berdasarkan kriteria WHO. Perbedaan manifestasi klinis, adanya ANA, kadar anti-dsDNA dan anti-Sm pada SLN dan OLN serta kelas NL dianalisis dengan uji Chi square dan T tes. Signifikansi statistik ditentukan bila p<0,05.Hasil: Penderita OLN menunjukkan adanya edema, hipertensi, anemia dan autoantibodi yang lebih tinggi daripada penderita SLN. Rerata kadar anti-dsDNA nyata lebih tinggi pada penderita OLN daripada SLN (285.75±179.01 vs 41,85±61,81; p<0,000). Biopsi ginjal 20 penderita OLN menunjukkan 6 penderita dengan NL kelas I/II, 9 penderita dengan NL kelas III/IV dan 5 penderita dengan NL kelas V. Pada 11 penderita SLN terdapat 7 penderita NL kelas I/II, 3 penderita dengan NL kelas III/IV dan 1 penderita NL kelas V. Penderita dengan NL kelas III/IV menunjukkan kadar anti-dsDNA yang lebih tinggi daripada NL kelas V (p<0,05).Simpulan: Penderita OLN mempunyai manifestasi klinis yang lebih berat daripada penderita SLN. Penderita NL kelas III/IV menunjukkan adanya anti-dsDNA yang lebih sering dan dengan kadar yang lebih tinggi daripada NL kelas V. Diagnosis NL hanya berdasarkan tanda klinis dan laboratoris seringkali menimbulkan kesalahan.
MEDIA MEDIKA INDONESIANA
2013-03-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4572
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012; 157-162
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4572/4164
oai:ojs.ejournal.undip.ac.id:article/11377
2016-07-01T13:54:10Z
mmi:ART
Uji Validitas dan Reliabilitas Kwesioner Etiologi dan Faktor Risiko Kanker Nasofaring
Prasetyo, Awal
Hariwiyanto, Bambang
Hakimi, Mohammad
Sastrowijoto, Soenarto
ABSTRACT Validity and reliability tests on questionnaires designed for etiology and risk factors of nasopharynx cancerBackground: The etiology and risk factors of NPC is a combination of multi-risk factors of genetic history, lifestyle, environmental exposure, and EBV infection. Currently, there is no publication about NPC’s questionnaire. This study analyzed the reliability and validity of the questionnaire of NPC’s etiology and risk factors.Methods: The cross-sectional study of the questionnaires of NPC’s etiology and risk factors were filled by the used-tryout samples i.e NPC sufferers and their family members, in April to August 2012. The study were done at Anatomical Pathology Laboratory of Kariadi & St. Elisabeth Hospitals Semarang. There are three main constructs, namely; genetic, lifestyle, and environmental exposure. The 74 filled-questionnaires were tested by correlation analysis of product moment for the validity, and the reliability tests conducted with Cronbach's Alpha. The data were analyzed with SPSS for Windows version 17.0.Results: A test for risk family history constructs were valid (p>0.932) and reliabel (Cronbach's Alpha=0.864). A test for lifestyle with a Pearson Correlation were p>0.785 for smoking habit, eating salted fish p>0.793, eating grilled-fish p>0.862, eating pickled p>0.831, drinking alcohol p>0.760, instant noodle p>0.497, food preservation p>0.495, food contains MSG p>0.627, with Cronbach's Alpha>0.751. A test for environmental exposure risk were valid for the exposure to passive cigarette smoke (p>0.486) Cronbach's Alpha=0.789,the exposure of the home environment p>0.658 Cronbach's Alpha=0.832, exposure-related jobs p>0.373 Cronbach's Alpha=0.697, and chronic nasopharingitis are all valid (p>0.900) with Cronbach's Alpha=0851.Conclusions: The questionnaires designed as a tool of NPC’s etiology and risk factors are valid and reliable.Keywords: Validity, realibility, questionnaires, NPC’s etiology and risk factorsABSTRAKLatar belakang: Etiologi dan faktor risiko KNF merupakan kombinasi risiko riwayat genetik, gaya hidup, paparan lingkungan, dan infeksi EBV. Saat ini, belum ada publikasi tentang kwesioner KNF. Penelitian ini membuktikan validitas dan reliabilitas alat ukur kwesioner etiologi dan faktor risiko KNF.Metode: Penelitian cross-sectional terhadap hasil pengisian kwesioner etiologi dan faktor risiko KNF yang diisi oleh sampel tryout terpakai, yaitu penderita KNF dan anggota keluarganya, pada April - Agustus 2012, di Laboratorium Patologi Anatomi RSUP Dr. Kariadi Semarang dan RS St. Elisabeth Semarang. Kwesioner berdasar pada tiga konstruk utama, yaitu risiko genetik, risiko kebiasaan/gaya hidup, dan risiko paparan lingkungan. Sebanyak 74 kwesioner dilakukan uji validitas dengan analisis korelasi product moment, serta uji reliabilitas Cronbach's Alpha. Data dianalisis dengan SPSS for Windows version 17.0.Hasil: Uji konstruk risiko riwayat keluarga didapatkan valid (p>0,932) dan reliabel (Cronbach's Alpha=0,864). Uji konstruk risiko gaya hidup dengan Pearson Correlation didapatkan p>0,785 untuk subkonstruk kebiasaan merokok, kebiasaan makan ikan asin p>0,793, kebiasaan makan ikan/daging asap/bakar p>0,862, kebiasaan makan asinan p>0,831, kebiasaan minum alkohol p>0,760, kebiasaan makan mie instan p>0,497, kebiasaan makan makanan awetan p>0,495, kebiasaan makanan mengandung MSG p>0,627, Cronbach's Alpha=0,751. Uji konstruk risiko paparan lingkungan didapatkan valid untuk subkonstruk paparan pasif asap rokok (p>0,486), Cronbach's Alpha=0,789, paparan lingkungan rumah p>0,380, Cronbach's Alpha=0,713, paparan yang berhubungan dengan pekerjaan p>0,373 Cronbach's Alpha=0,697, infeksi nasofaringitis kronik semuanya valid (p>0,900), Cronbach's Alpha=0,851.Simpulan: Kwesioner yang diuji sebagai alat ukur untuk menggali etiologi dan faktor risiko KNF layak dipergunakan karena valid dan reliabel
MEDIA MEDIKA INDONESIANA
2016-07-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/11377
MEDIA MEDIKA INDONESIANA; 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013; 61-70
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/11377/8863
oai:ojs.ejournal.undip.ac.id:article/21901
2019-01-29T12:19:49Z
mmi:ART
Pengaruh Ekstrak Lengkuas Merah (Alpinia Galanga) Dosis Bertingkat Terhadap Ekspresi Caspase 3 dan Grading Kanker Payudara Mencit C3H
Karlowee, Vega
Tjahjono, Tjahjono
Wijayahadi, Noor
Alpinia galanga; caspase 3 expression; breast cancer grading
Effect of oral administered graded doses of alpinia galanga on the caspase 3 expression and histopathological grading of breast cancer in C3H miceBackground: 1’-Acetoxychavicol Acetate (ACA), in Alpinia galanga, known to have pro apoptotic and anticancer effects. The pro apoptotic effect is by elevating caspase 8 and 9 activity. ACA causes the cycle cell stops at G0/G1 phase. The aim of this study is to prove the effect on caspase 3 and histopathological grading of breast cancer.Method: It was an laboratory experimental with post test only control group design. Four groups of C3H mice, aged 2-3 months, had breast cancer inoculation. After the tumor mass were palpabled, K received no extract, P1, P2, P3 received Alpinia galanga extract at dose levels of 225, 450, 750 mg/kgBW/day, for 2 weeks. Immunohistochemistry examination of caspase 3 expression was scored with Allred criteria and cancer grading was scored with modified Scarff-Bloom-Richardson (MSBR) criteria. All data were analyzed by Kruskal-Wallis test, with level of significant α <0.05.Result: At P1, P2, P3 there were 1, 5, 7 mice dead in each group before termination, while in K all were survived. Pro protocol analysis showed no significance difference on caspase 3 expression (p=0.137) and grading score (p=0.399) between groups. Intention to treat analysis showed significance differences on caspase 3 expression between P1 with K (p=0.033) and P3 (p=0.005), and significance difference on grading score between P3 with K (p=0.002) and P1 (p=0.004). Histopathology examination showed damages on liver and kidney, especially in P3, which might be the mice’s cause of death.Conclusion: Caspase 3 expression is the highest at dose level of 225 mg/kgBW/day. Grading score is the lowest at dose level of 750 mg/kgBW/day.ABSTRAKLatar belakang: Senyawa 1’-Acetoxychavicol Acetate (ACA) dalam Alpinia galanga memiliki efek proapoptosis dan antikanker. Efek proapoptosis melalui aktivasi caspase 8 dan 9. ACA menyebabkan terhentinya siklus sel fase G0/G1. Tujuan penelititan ini adalah membuktikan adanya efek terhadap caspase 3 dan grading kanker payudara.Metode: Jenis penelitian eksperimental dengan desain post test only control group. Mencit C3H usia 2–3 bulan dibagi 4 kelompok, diinokulasi kanker payudara. Setelah tumbuh massa tumor, kontrol (K) tidak diberi perlakuan dan P1, P2, P3 diberi ekstrak Alpinia galanga dosis 225, 450, 750 mg/kgBB/hari selama 2 minggu. Penilaian ekspresi caspase 3 berdasarkan kriteria Allred dan grading kanker berdasarkan kriteria modified Scarff-Bloom-Richardson (MSBR). Dilakukan uji beda Kruskal-Wallis dengan tingkat kemaknaan α <0,05. Hasil: Pada P1, P2, P3, didapatkan kematian mencit sebanyak 1, 5, dan 7 ekor, sedangkan K tidak ada. Dalam pro protocol analysis, tidak ada perbedaan bermakna ekspresi caspase 3 (p=0,137) maupun grading kanker (p=0,399) antar kelompok. Pada intention to treat analysis ekspresi caspase 3, ada perbedaan bermakna antara P1 dengan K (p=0,033) dan P3 (p=0,005). Pada grading kanker payudara, ada perbedaan bermakna antara P3 dengan K (p=0,002) dan P1 (p=0,004). Pada histopatologis organ, ditemukan kerusakan hati dan ginjal, terutama pada P3, yang kemungkinan mengakibatkan kematian mencit.Kesimpulan: Skor ekspresi caspase 3 kanker payudara tertinggi didapatkan pada dosis 225 mg/kgBB/hari. Skor grading kanker payudara terendah didapatkan pada dosis 750 mg/kgBB/hari.
MEDIA MEDIKA INDONESIANA
2010-08-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21901
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 2 YEAR 2010; 92-100
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21901/14634
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3021
2012-04-05T12:00:39Z
mmi:ART
Ekstrak Keladi Tikus (Typhonium flagelliforme) Fraksi Diklorometanolik dan Ekspresi Caspase-3 dan p21 Cell-Line Kanker Payudara MCF-7
Putra, Agung
Tjahjono, Tjahjono
Winarto, Winarto
p21, caspase-3, MCF-7 cell-line, Typhonium flagelliforme
ABSTRACTThe dichloromethanolic fraction of keladi tikus (Typhonium flagelliforme) extract and the expression of p21 and caspase-3 of MCF-7 breast cancer cell-lineBackground: Breast cancer has a high degree of heterogeneity and problems in therapy, such as insensitive to antiproliferation signal and able to escape from apoptosis program. Typhonium flagelliforme (Lodd), Blume (Araceae) more commonly known as keladi tikus in Indonesia, often used as alternative in treating cancer, including breast cancer. The objective of study is proving the dichloromethanolic fraction of Typhonium flagelliforme tuber extracts influence on the expression of caspase-3 and p21 of MCF-7 cell-line that have deletion in CASP-3 gene.Methods: This study adapts laboratory experimental in-vitro in cells-line MCF-7, with “post test control group only design” and divided into two groups, were incubated in 5h, 10h and 20h. The control group received no other treatment. The treatment group received the dichloromethanolic fraction of Typhonium flagelliforme tuber extracts in IC50. Starting with cytotoxicity assay using MTT to determine the IC50, followed by Immunocytochemical analysis to observe the expression of p21 and caspase-3.Results: Paired sample T test shows a significant differences in treatment groups compared with the controls (p<0.05), namely an increase in the expression of nuclear p21 and caspase-3 on 20h incubation.Conclusion: There were increased in the expression of caspase-3 and nuclear p21, as well as depleted the cytoplasmic of p21 on MCF-7 cell-line that have deletion in CASP-3 in treatment by tuber extract of Typhonium flagelliforme dichloromethanolic fraction.Keywords: p21, caspase-3, MCF-7 cell-line, Typhonium flagelliformeABSTRAKLatar belakang: Kanker payudara mempunyai tingkat heterogenitas tinggi dan problem dalam terapi, diantaranya tidak sensitif terhadap signal antiproliferasi dan mampu menghindar dari program apoptosis. Typhonium flagelliforme (Lodd). Blume (Araceae) yang lebih dikenal sebagai keladi tikus di Indonesia, sering digunakan sebagai alternatif dalam mengobati penyakit kanker,termasuk kanker payudara. Tujuan penelitian ini untuk membuktikan pengaruh Typhonium flagelliforme terhadap ekspresi caspase- 3 dan p21 pada cell-line MCF-7 yang mengalami delesi gen CASP-3.Metode: Penelitian eksperimental laboratorik secara invitro pada cell-line MCF-7, dengan rancangan penelitian post test control group only design, yang dibagi dalam 2 kelompok dan diinkubasi dalam 5 jam, 10 jam dan 20 jam. Kelompok kontrol tidak mendapatkan perlakuan, sedangkan kelompok perlakuan mendapatkan ekstrak umbi Typhonium flagelliforme fraksi diklorometanolik kadar 62,08 μg/mL(IC50). Dimulai dengan uji sitotoksisitas menggunakan MTT untuk menentukan IC50, dilanjutkananalisis imunositokimia untuk melihat ekspresi p21 dan caspase-3.Hasil: Paired sample T test menunjukkan terdapat perbedaan bermakna pada kelompok perlakuan dibandingkan kontrol (p<0,05), dimana terjadi peningkatan ekspresi caspase-3 dan p21 nukleus serta deplesi p21 sitoplasmik pada inkubasi 20 jam.Simpulan: Ekstrak umbi Typhonium flagelliforme fraksi diklorometanolik mampu meningkatkan ekspresi caspase-3 dan p21 nukleus serta deplesi p21 sitoplasmik cell-line MCF-7 yang mengalami delesi gen CASP-3.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3021
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 95-104
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3021/2704
oai:ojs.ejournal.undip.ac.id:article/3823
2012-07-19T11:51:52Z
mmi:ART
Efek Misoprostol Sublingual pada Kasus Blighted Ovum dan Missed Abortion
Poerwoko, Agoes Oerip
Mochtar, Anantyo Binarso
Tjahjanto, Hary
Sublingual misoprostol, blighted ovum, missed abortion.
Sublingual misoprostol effect in blighted ovum and missed abortion casesBackground: Misoprostol, a prostaglandin E1 analog is widely used especially during first and second trimester as a cervical ripening before curretage as well as medical abortion without curretage. Misoprostol dosage and mode of administration are still an interesting study. Sublingual administration of misoprostol needs further study.Objective: To evaluate the effect and side effect of repeated dosage of 400 g misoprostol administered sublingually at four-hourly interval up to a maximum of two doses in total for the treatment of blighted ovum and missed abortion.Methods: A pseudo clinical trial was done to all patients diagnosed to have blighted ovum and missed abortion coming to Dr. Kariadi Hospital between March and July 2005. Patients were given sublingual 400 g misoprostol. Evaluation were done every 4 hours toward blood pressure, heart rate and body temperature and other major complaints. Descriptive analysis was carried to the available data.Results: Mean time interval between drug administration and uterine contraction achieved for 187.5 (115.4) minutes. Mean time interval of drug administration and the expulsion of product of conception achieved for 300.6 (118.5) minutes. Cervical dilatation in patient with no product of conception expulsion were 9.1 (1.3) mm and median 9.0 (range: 7-12) mm. Sublingual misoprostol found to dilate a cervix without expulsion of product of conception in 51.4% of subject and expulsion of product of conception in 48.6%with side effect of shivering in 11.4%, headache 8.6%, nausea 5.7% and vomiting 2.9%.Conclusion: Sublingual misoprostol dilates cervix with and without product of conception expulsion and gives mild side effect.Keywords: Sublingual misoprostol, blighted ovum, missed abortion.ABSTRAKLatar belakang: Misoprostol, suatu analog prostaglandin E1 telah dipakai secara luas di bidang obstetri ginekologi pada kehamilan trimester I dan II untuk pematangan serviks sebelum tindakan kuretase sampai tindakan aborsi medis tanpa kuretase. Jalur atau cara pemberian misoprostol serta dosis misoprostol sampai saat ini masih menarik untuk menjadi bahan penelitian. Salah satu diantaranya adalah pemberian misoprostol secara sublingual.Tujuan: Meneliti efek dan efek samping misoprostol sublingual 400 g dosis ulangan dengan interval 4 jam maksimal dua kali pemberian pada kasus blighted ovum dan missed abortion.Metode: Studi bersifat eksperimen klinik tanpa pembanding dengan subyek penelitian semua pasien dengan blighted ovum dan missed abortion pada bulan Maret sampai dengan Juli 2005 di RS Dr. Kariadi Semarang. Diberikan 400 g sublingual dengan evaluasi tiap 4 jam terhadap tekanan darah, frekuensi nadi, suhu tubuh dan keluhan lainnya. Uji statistik deskriptif dilakukan terhadap semua data yang ada.Hasil: Didapatkan rerata interval waktu antara saat pemberian obat sampai timbulnya kontraksi uterus 187,3 (115,4) menit, rerata interval waktu antara saat pemberian obat sampai timbulnya pengeluaran jaringan 300,6 (118,5) menit. Dilakukan pengukuran dilatasi serviks pada subyek yang tidak terjadi pengeluaran jaringan didapatkan rerata dilatasi serviks sebesar 9,1 (1,3) mm dan median 9,0 (range: 7–12 mm). Secara keseluruhan misoprostol sublingual menimbulkan dilatasi serviks tanpa pengeluaran jaringanhasil konsepsi pada 51,4% subyek dan terjadinya pengeluaran jaringan hasil konsepsi pada 48,6% subyek. Efek samping yang timbul adalah menggigil (11,4%), pusing (8,6%), mual (5,7%) dan muntah (2,9%).Simpulan: Misoprostol sublingual menimbulkan dilatasi serviks tanpa dan dengan pengeluaran jaringan hasil konsepsi serta menimbulkan efek samping ringan.
MEDIA MEDIKA INDONESIANA
2012-07-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3823
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 2 Year 2008; 88-95
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3823/3507
oai:ojs.ejournal.undip.ac.id:article/4211
2012-12-04T10:41:42Z
mmi:ART
Kajian Spektra Infra Merah dan UV Minyak Atsiri dari Umbi Teki (Cyperus Rotundus Linn.)
Murnah, Murnah
Tuber roots, essential oils, UV, infra-red, a-cyperone
Infra red and ultra violet spectra study of essential oils from tubber root (Cyperus Rotundus Linn.)Background: Tubber roots (Cyperus rotundus Linn.) has long been known as Indonesian original drug for centuries and used widely by the people of Indonesia. However, until now only few research has been done on tuber roots based on its function as a traditional medicine. The essential oils within tubber roots is suspected has potential role for traditional medicine. The purpose of this study is to determine the profile of infrared and ultra violet (UV) spectra of the tubber.Method: The research was a descriptive research. Extraction of essential oil from tubers puzzles using Soxhlet method with petroleum ether solvent. To get the best fraction analysis was carried out by column chromatography. All fractions were then separated by thin layer chromatography (TLC) and collected by extracting with chloroform. Chloroform extract was evaporated and dissolved in methanol and analyzed by infra red (IR) and UV spectrophotometer.Result: The infrared spectra indicate that there was a volatile oil absorption characteristics of aromatic compounds and functional groups C=O and CH3. In addition, there was an absorption which showed the C-C binding, C-H, and C-CH. UV spectra showed that there were two peaks at a wavelength of 204 nm and 249 nm.Conclusion: Infrared and UV spectra show that the structure of essential oils contained in the bulb puzzle has similarities with the structure of the compound a-cyperone.Keywords: Tuber roots, essential oils, UV, infra-red, a-cyperone ABSTRAKLatar belakang: Umbi teki (Cyperus Rotundus Linn.) telah lama dikenal sebagai obat asli Indonesia sejak berabad-abad lamanya dan digunakan secara luas oleh masyarakat Indonesia. Namun demikian, hingga kini tidak banyak dilakukan penelitian mengenai umbi teki berdasarkan fungsinya sebagai obat-obatan tradisional. Dalam umbi teki diduga terdapat minyak atsiri yang fungsinya dapat mendukung umbi teki sebagai obat-obatan tradisional. Tujuan penelitian ini untuk mengetahui profil spektra infra merah danUV dari umbi teki.Metode: Metode penelitian yang digunakan adalah penelitian deskriptif. Ekstraksi minyak atsiri dari umbi teki menggunakan metode Soxhlet dengan pelarut petroleum eter. Untuk mendapatkan fraksi terbaik dilakukan dengan kromatografi kolom. Semua fraksi yang diperoleh kemudian dipisahkan secara kromatografi lapis tipis (KLT) dan dikumpulkan dengan cara diektrasi dengan kloroform. Ekstrak kloroform ini diuapkan kemudian dilarutkan dalam metanol dan dianalisis dengan spektrofotometer IR dan UV.Hasil: Spektra inframerah minyak atsiri menunjukkan bahwa terdapat serapan karakteristik dari senyawa aromatik dan gugus fungsi C=O dan CH3. Selain itu, terdapat serapan yang menunjukkan ikatan C–C, C–H, dan C–CH. Spektra UV menunjukkan bahwa terdapat dua puncak pada panjang gelombang 204 nm dan 249 nm.Simpulan: Spektra infra merah dan UV menunjukkan bahwa struktur minyak atsiri yang terdapat dalam umbi teki memiliki kemiripan dengan struktur senyawa a-siperon.
MEDIA MEDIKA INDONESIANA
2012-11-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4211
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012; 44-50
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4211/3834
oai:ojs.ejournal.undip.ac.id:article/4278
2012-12-15T11:55:50Z
mmi:ART
Penentuan LD50 Penyakit Infeksi Toxoplasma gondii pada Mencit balb/c
Winarto, Winarto
LD50, Toxoplasma gondii, balb/c mice, infection
LD50 determination in toxoplasma gondii infection in balb/c miceBackground: LD50 is a marker of virulence which is reflects degree of microorganism pathogenicity. LD50 of every pathogens to be used should be determined in order to choose an appropiate infective dose of agent under the study. Toxoplasma gondii RH strain has been maintained in the laboratory by serial passage in mice for several years, in which the biologic and laboratory conditions might has an effect on its virulence. The objective of this study was to determine LD50 of Toxoplasma gondii RH strain used for research in Biotechnology Laboratory Gajah Mada University.Methods: The design of the study was true experiment consisting three goups of 10 female balb/c mice aged 8–10 weeks that were infected with 101, 103 and 106 of Toxoplasma gondii RH strain/mice respectively, and being followed up to day 18. Homogeneity of mice before infection were analyzed by Levence statistic, while the effects of infection was analyzed by Anova. The number of dead mice in each group were recorded and LD50 was calculated base on proportional distance.Results: There was no weight difference between groups of mice before infection. The weight increased up to day 6 in group I and II, while group III after day 3 there was weight decrease. LD50 of Toxoplasma gondii was 1.39x103 which belonged to genotype II of pathogenicity classification.Conclusions: LD50 of Toxoplasma gondii was 1.39x103 which is lower than the original RH strain, and belonged to group II of genotype, which is often reported as the major cause of human and animal infections.Keywords: LD50, Toxoplasma gondii, balb/c mice, infection. ABSTRAKLatar Belakang: Toxoplasma gondii di laboratorium dipelihara dengan cara pasase dari satu mencit ke mencit berikutnya, yang mungkin berpengaruh terhadap virulensinya. LD50 adalah ukuran virulensi suatu mikroorganisme penyebab infeksi, yang harus diketahui apabila akan melakukan penelitian tentang fenomena infeksi pada binatang coba. Tujuan penelitian ini untuk menentukan besar LD50 Toxoplasma gondii strain RH yang disimpan dan digunakan untuk penelitian di Laboratorium Bioteknologi UGM yang belum pernah ditentukan nilai LD50nya.Metode: Disain penelitian adalah eksperimental murni. Tiga kelompok mencit balb/c usia 6–8 minggu masing-masing kelompok terdiri dari 10 mencit, diinfeksi Toxoplasma gondii strain RH secara berturut-turut tiap kelompok diinfeksi dengan 101, 103 dan 106 toksoplasma/mencit, yang diamati sampai hari ke-18. Sebelum perlakuan ketiga kelompok dilakukan tes homogenitas berat badan mencit dengan statistik Levene. Efek infeksi toksoplasma dianalisis dengan Anova, sedangkan LD50 dihitung berdasarkan jarak proporsi.Hasil: Sebelum diinfeksi Toxoplasma gondii, tidak terdapat perbedaan berat badan mencit pada 3 kelompok. Setelah diinfeksi toksoplasma sampai hari ke-6, berat badan mencit pada kelompok I dan II naik, sedangkan kelompok III pada hari ke-1 sampai hari ke-3 beratnya naik, kemudian setelah hari ke-3 beratnya turun. LD50 Toxoplasma gondii strain RH di PAU Bioteknologi UGM didapatkan sebesar 1,39x103 yang sesuai dengan genotipe II.Simpulan: LD50 Toxoplasma gondii sebesar 1,39x103 lebih rendah dari strain RH yang sebenarnya dan termasuk genotipe II yaitu yang paling sering dilaporkan sebagai penyebab infeksi pada manusia dan binatang.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4278
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009; 160-166
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4278/3898
oai:ojs.ejournal.undip.ac.id:article/4304
2013-01-03T10:44:18Z
mmi:ART
Determination of L-Type Calcium Current in the Primary Hypertrophied Left Ventricular Cardiomyocytes of Hypertrophy Heart Rats/HHR
Danes, Vennetia R.
HHR rats, LV hypertrophy, cardiomyocyte, L-type calcium current
Background: The molecular mechanisms responsible for electromechanical derangements found in primary left ventricular (LV) hypertrophy have not been clearly elucidated. Of particular interest is the voltage gated L-type Ca current (ICa L) which plays crucial role in the EC-coupling. This study aimed to investigate cardiomyocyte ICa(L) in newly developed line of rats namely HHR (hypertrophy heart rat) and NHR (normal heart rat).Methods: A pure experimental study has been conducted using male HHR (n=7 rats) and NHR (n=9 rats), aged 19-25 week. Cardiomyocytes were isolated enzymatically. By using whole cell patch clamp techniques, ICa were measured and normalized (pA/pF) for cell size determined by capacitance (Cm). In Na-free superfusate, the ICa(L) of HHR (n=18 cells) and NHR (n=12 cells) obtained at holding potential (HP) -50 mV were analyzed using Student’s t-test and one-way ANOVA (repeated measures). p<0.05values were considered significance.Results: Myocyte mean Cm of HHR slightly increased but not significantly greater than that of NHR (364.3±22.33 pF vs 300.2±27.78 pF, p=0.08). In HHR, peak Ca current density was significantly increase, i.e, at HP -50 mV, the ICa(L) evoked at test potential (TP) -10 mV were -7.74±0.86 (HHR) vs -4.68±1.09 (NHR) pA/pF, p<0.02.Conclusions: Peak Ca current density of HHR increases approximately 1.6 times that of the NHR (-7.74±0.86 vs -4.68±1.09 pA/pF). This increase is attributed primarily to L-type Ca current, best known to peak at around TP -10 mV. The dramatic increase in sarcolemmal calcium influx in the HHR provides evidence of altered EC coupling processes in primary LV hypertrophy.Keywords: HHR rats, LV hypertrophy, cardiomyocyte, L-type calcium currentABSTRACT Penentuan arus kalsium tipe L pada kardiomiosit tikus yang mengalami hipertrofi primer ventrikel kiri (Hypertrophy Heart Rats/HHR)Latar belakang: Mekanisme molekuler yang bertanggung jawab pada munculnya kelainan elektro-mekanik pada hipertrofi primer ventrikel kiri masih belum jelas, khususnya arus kasium tipe L, ICa(L), yang berperan penting pada ‘EC-coupling’. Tujuan penelitian ini untuk mengukur dan menganalisis ICa(L) kardiomiosit dari tikus jenis baru bernama HHR (hypertrophy heart rat) dan NHR (normal heart rat).Metode: Eksperimen murni laboratorik dilakukan pada tikus jantan NHR (n=9) dan HHR (n=7) berusia 19-25 minggu. Kardiomiosit diisolasi menggunakan teknik enzimatika. Dengan teknik ‘whole cell patch clamp’; arus kalsium ICa(L) diukur dan dinormalisasi sesuai ukuran selnya (pA/pF), yang ditentukan melalui pengukuran kapasitans membran (Cm). Pada kondisi bebas Na, ICa(L) dari kedua kelompok sel HHR (n=18) dan NHR (n=12), yang didapat dari ‘holding potential’ (HP) -50mV dianalisis dengan Student’st-test dan one-way ANOVA (repeated measures). Nilai p<0,05 dianggap bermakna.Hasil: Rerata kapasitans membran (Cm) dari HHR dan NHR secara statistik tidak beda secara bermakna (364,3±22,33 pF vs 300,2±27,78 pF, p=0,08). Pada HP -50 mV, densitas arus kalsium ICa(L) yang dihasilkan dari ‘test potential’ (TP)-10 mV meningkat secara bermakna pada HHR dibanding NHR -7,74±0,86 vs -4,68±1,09 pA/pF (p<0,02).Simpulan: Terjadi peningkatan densitas arus kalsium pada HHR yaitu 1,6 kali NHR (-7,74±0,86 vs -4,68±1,09 pA/pF). Peningkatan ini seluruhnya disebabkan oleh ICa(L), karena tipe ini biasanya memuncak pada TP sekitar -10 mV. Peningkatan influx kalsium sarkolemma HHR yang sangat besar ini, merupakan bukti adanya perubahan proses ‘EC coupling’ pada ventrikel kiri yang mengalami hipertrofi primer.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4304
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 6 YEAR 2009; 269-277
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4304/3925
oai:ojs.ejournal.undip.ac.id:article/11372
2016-07-01T13:04:59Z
mmi:ART
Pengaruh Pemberian Jus Jambu Biji (Psidium Guajava L), Terhadap Parameter Histopatologi Radang Kronik dan Ekspresi Vascular Endothelial Growth Factor: Studi Eksperimental Laboratorik pada Adjuvant-Induced Arthritis pada Tikus Wistar
Herlina, Andika Eka
Wijaya, Indra
Wijayahadi, Noor
ABSTRACT The effect of Psidium guajava juice on the histopathologic chronic inflammation parameter and expression of vascular endothelial growth factorBackground: Poliphenol compound and vitamin C in Psidium guajava L has antioxidant, antiinflammation, and antiangiogenic effect. These effects work by inhibiting cytokine, MMP, and VEGF expression. Effects in chronic inflammation histopathological parameter and angiogenic component (VEGF) is not yet known. The objective of the study was to analyze the effect of Psidium guajava L juice on histopathological parameter of chronic inflammation (the depth of cartilage destruction, amount of mononuclear cell, amount of capillary vessel) and VEGF expression in adjuvant-induced arthritis Wistar rats.Methods: It was an laboratory experimental with post test only control group design. Two groups of male Wistar rat, aged 3-4 month, were induced with CFA 0,1 ml twice. After booster on the seventh day, control group was given aquadest, and another group was given Psidium guajava L juice 9 g/15 ml per day, divided into 3 doses for 14 days. Histopathological parameter evaluation and VEGF expression was done in 10 fields view. All data were analysed by T-Test, with level of significant p≤0.05.Result: The amount of mononuclear cell (p=0.000) and capillary vessel (p=0.000) in P group is significantly fewer than K group. The amount of capillary vessel with positive VEGF expression (p=0.138) and size of depth in cartilage destruction (p=0.120) shows no significance difference between two groups. Conclusion: Psidium guajava L juice shows a lowering effect on histopathological parameter of chronic inflammation and VEGF expression in adjuvant-induced arthritis Wistar rats.Keywords: Psidium guajava L, histopathology of chronic inflammation in arthritis, VEGF expressionABSTRAKLatar belakang: Senyawa polifenol dan vitamin C dalam buah Psidium guajava L memiliki efek antiinflamasi, antioksidan, dan antiangiogenik. Ketiga efek ini bekerja melalui penghambatan terhadap sitokin inflamasi, MMP, dan ekspresi VEGF. Efek terhadap parameter histopatologi radang kronik dan komponen angiogenesis (VEGF) pada arthritis belum diketahui. Tujuan: Menganalisis pengaruh jus Psidium guajava L terhadap parameter histopatologi radang kronik berdasarkan ukuran kedalaman destruksi tulang rawan oleh panus, jumlah sel radang mononuklear, jumlah pembuluh darah kapiler dan ekspresi VEGF jaringan sendi adjuvant-induced arthritis tikus Wistar.Metode: Jenis penelitian eksperimental laboratorik dengan desain post test only control group. Tikus Wistar jantan usia 3-4 bulan dibagi 2 kelompok, diinduksi CFA 0,1 ml 2 kali. Setelah hari ke-7 booster, kontrol diberi aquades, perlakuan diberi jus Psidium guajava L 9 g/15 ml per hari dibagi dalam 3 dosis selama 14 hari. Penilaian parameter histopatologi radang kronik dan ekspresi VEGF dilakukan manual dalam 10 lapangan pandang. Dilakukan uji beda T-Test dengan tingkat kemaknaan p≤0,05.Hasil: Pada ukuran kedalaman destruksi tulang rawan, tidak ada perbedaan bermakna antara K dengan P (p=0,120). Jumlah sel radang mononuklear P lebih sedikit secara bermakna dibandingkan K (p=0,000). Jumlah pembuluh darah kapiler P lebih sedikit secara bermakna dibandingkan K (p=0,000). Jumlah pembuluh darah dengan ekspresi VEGF positif tidak ada perbedaan bermakna antara K dengan P (p=0,138).Simpulan: Pemberian jus jambu biji (Psidium guajava L) berpengaruh memperbaiki beberapa parameter radang kronik pada tikus Wistar yang mengalami arthritis.
MEDIA MEDIKA INDONESIANA
2016-07-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/11372
MEDIA MEDIKA INDONESIANA; 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013; 23-29
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/11372/8858
oai:ojs.ejournal.undip.ac.id:article/21836
2019-01-25T14:47:03Z
mmi:ART
Kekuatan Genggam pada Lansia Wanita Aktif dan Tidak Aktif Berolahraga
S, Gheby Soraya
Murbawani, Etisa Adi
Handgrip strength; exercise activity; elderly woman.
Handgrip strength in active and inactive elderly womanBackgrounds: Exercise is one of the factors determining handgrip strength. Lower handgrip strength is an indicator for lower Body Mass Index (BMI). The aim of this study is to compared differences in handgrip strength between active and inactive elderly woman. Methods: This was a cross-sectional study of 26 elderly active woman (spent ≥30 minutes for five times or more a week for exercise) and 26 elderly inactive woman (spent <30 minutes and less than five times a week for exercise). Subject were chosen through purposive sampling. Handgrip strength was measured with handgrip dynamometer. Questionnaire was used for measuring exercise activity. BMI value were obtained from body weight was measurement with digital scale and height measurement with microtoise. Data on energy and protein intake were obtained from food frequency semi quantitative questionnaire (FFSQ). Data analysed were using Kolmogorov-Smirnov, independent t-test, and anacova. Result: Most of active elderly woman (69.2%) had handgrip strength in sufficient category. There were significant differences of handgrip strength between the active and inactive elderly woman (p=0.001) and after being controlled by BMI, energy and protein intake per day (p=0.005). Conclusion: Routine exercise should be recommended to elderly for better handgrip strength.. ABSTRAKLatar belakang: Lansia wanita mempunyai kekuatan genggam yang lebih rendah daripada pria. Kebiasaan olahraga merupakan salah satu faktor yang berpengaruh terhadap kekuatan genggam. Nilai kekuatan genggam merupakan indikator nilai Indeks Massa Tubuh (IMT). Tujuan dari penelitian ini adalah membandingkan kekuatan genggam pada lansia wanita yang aktif dan tidak aktif berolahraga. Metode: Studi cross-sectional pada 26 lansia wanita yang aktif (menghabiskan waktu ≥30 menit dan 5 kali atau lebih dalam seminggu untuk berolahraga) dan 26 lansia wanita yang tidak aktif (menghabiskan waktu <30 menit dan kurang dari 5 kali dalam seminggu untuk berolahraga). Sampel diperoleh dengan cara purposive sampling. Kekuatan genggam diukur menggunakan Handgrip Dynamometer. Kuesioner digunakan untuk mengetahui kebiasaan olahraga. IMT diperoleh dari data berat badan yang diukur dengan timbangan digital dan tinggi badan yang diukur dengan mikrotoa, sedangkan data asupan energi dan protein diperoleh dari Food Frequency Semi Quantitative Questionnaire (FFSQ). Analisis data dengan Kolmogorov-smirnov, Independent t-test dan Anacova. Hasil: Nilai kekuatan genggam sebagian besar lansia wanita yang aktif berolahraga (69,2%) dalam kategori cukup sedangkan sebagian lansia wanita yang tidak aktif berolahraga (53,8%) dalam kategori sangat kurang. Terdapat perbedaan kekuatan genggam sangat bermakna antara lansia wanita yang aktif dan tidak aktif berolahraga (p=0,001) dan setelah dikontrol dengan IMT, asupan energi dan protein (p=0,005).Simpulan: Latihan teratur perlu dilakukan para lansia agar memiliki kekuatan genggam yang baik.
MEDIA MEDIKA INDONESIANA
2010-08-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21836
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 62-69
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21836/14591
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3012
2012-04-04T12:55:03Z
mmi:ART
Homosistein Plasma dan Perubahan Skor Fungsi Kognitif pada Pasien Pasca Stroke Iskemik
Yudawijaya, Agus
Kustiowati, Endang
Pemayun, Tjokorda Gde Dalem
ABSTRACTPlasma homocysteine and cognitive function score change in post ischemic stroke patients Background: Increase of total homocysteine level is a strong risk factor for cerebrovascular disorder and is correlated with decrease of performance in sort of cognitive tests, including mini mental state examination (MMSE) and clock drawing test (CDT). The aim of this study was to prove the correlation between plasma homocysteine level and change in cognitive function score in postischemic stroke patients. Methods: The design was cross-sectional. The subjects were post-ischemic stroke patients, treated at B1-ward Dr. Kariadi Hospital Semarang from January-June 2010. Plasma homocysteine levels were measured on the first week post onset of ischemic stroke using venous blood at GAKI Laboratory Dr. Kariadi Hospital and cognitive function score was examined using MMSE and CDT on the first and 12th week post onset. Datas were analyzed using descriptive analysis and Spearman’s rho correlation test. Results: Of 30 patients, there were 13 patients with homocysteinemia (43.3%) and 17 with hyperhomocysteinemia (56.7%). There was significant difference of MMSE and CDT score decrease in the first and 12th post onset, with p=0.000 and p=0.001 respectively. Spearman’s rho showed correlation between plasma homocysteine level and cognitive function score based on MMSE with r=-0.837; p=0.000, and based on CDT with r=-0.655; p=0.000. Conclusions: There is strong negative correlation between plasma homocysteine level and change in cognitive function score on the first week post onset of ischemic stroke. Keywords: Homocysteine level, cognitive function score, post-ischemic stroke ABSTRAK Latar belakang: Peningkatan kadar homosistein plasma merupakan faktor risiko kuat terjadinya penyakit serebrovaskuler dan dihubungkan dengan penurunan performa sederet tes-tes kognitif, termasuk MMSE (mini mental state examination) dilengkapi oleh CDT (clock drawing test). Tujuan penelitian ini adalah membuktikan hubungan antara homosistein plasma dengan perubahan skor fungsi kognitif pada pasien pasca stroke iskemik. Metode: Desain penelitian adalah cross sectional, pasien pasca stroke iskemik dirawat di Bangsal B1 Saraf RSUP Dr. Kariadi Semarang mulai Januari 2010 sampai Juni 2010. Pemeriksaan homosistein plasma dilakukan pada I minggu pasca onset stroke iskemik menggunakan darah vena di Laboratorium GAKI RSUP Dr. Kariadi dan pemeriksaan skor fungsi kognitif dengan tes MMSE dan CDT dilakukan pada I dan XII minggu pasca onset stroke iskemik. Data di analisis dengan statistik deskriptif dan uji korelasi Spearman’s rho. Hasil: Didapatkan homosisteinemia pada 13 orang (43,3%) dan hiperhomosisteinemia pada 17 orang (56,7%). Terdapat perbedaan bermakna penurunan skor MMSE dan CDT pada I dan XII minggu pasca onset stroke iskemik dengan nilai p=0,000 dan p=0,001. Uji korelasi Spearman’s rho, menunjukkan koefisien korelasi homosistein plasma dengan skor fungsi kognitif berdasarkan MMSE adalah r=-0,837; p=0,000, sedangkan berdasarkan skor CDT adalah r=-0,655; p=0,000. Simpulan: Didapatkan adanya hubungan kuat dan negatif antara homosistein plasma dengan perubahan skor fungsi kognitif pada I minggu pasca onset stroke iskemik.
MEDIA MEDIKA INDONESIANA
2012-04-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3012
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 1 Year 2011; 8-15
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3012/2696
oai:ojs.ejournal.undip.ac.id:article/3238
2012-04-18T11:35:51Z
mmi:ART
Sumbangan All-Trans Asam Retinoat (ATRA) Bagi Penyembuhan Periodontitis
Praptiwi, Praptiwi
Muis, Siti Fatimah
Hadisaputro, Soeharyo
Suryono, Suryono
ATRA supplementation, collagen degradation, periodontitis
ABSTRACTAll-trans retinoic acid (ATRA) contribution to periodontitis healingBackground: In inflammation and infection of periodontal ligament i.e periodontitis, collagen fiber is damaged. All-trans retinoic acid (ATRA), metabolite of vitamin A, has potency to depress damage in inflammation. Indonesia with high vitamin A deficiency, facing to delayed recovery of periodontitis. The disease is vastly suffered by common people in this country. The study aimed to know the collagen status of periodontal ligament suffering periodontitis treated with tetracycline and ATRA supplementation.Method: The experimental study using post test only design in 12 adult male Wistar rat was done in 7 days. The animal study were induced periodontitis through Porphyromonas gingivalis inoculation. Tetracycline 90 mg/kg was given, beside ATRA supplementation of 10 mg/kg and 5 mg/kg. Four experimental groups were chosen randomly. Group of periodontitis + tetracycline was the control of the study. The independent variables were ATRA supplementation of those high and low dose. The dependent variable was collagen status. Collagen status consist of degradation and synthesis of collagen, indicated by mRNA MMP-2 and mRNA P1CP respectively. They were measured by reversed transcriptase polymerizing chain reaction and thin layer chromatography. All-trans retinoic acid concentration was measured using high performance liquid chromatography. The dataanalyzed using t-test, Oneway ANOVA, post hoc duncan and least significant differences.Result: In group receiving 10 mg ATRA/kgBB, the ATRA level was highest but the collagen degradation was lower although not significant compared to the low dose ATRA group. In both groups the degradation was significantly lower than the control group (p=0.007). The synthesis of collagen in the low dose ATRA group was higher than the high dose ATRA group and the control group.Conclusion: High dose of ATRA supplementation contribution to less degradation of collagen, but in term of collagen synthesis, low dose ATRA supplementation gives better result.Keywords: ATRA supplementation, collagen degradation, periodontitis ABSTRAKLatar belakang: Pada peradangan dan infeksi kronik ligamentum periodontal yaitu periodontitis, terjadi kerusakan serat kolagen. All-trans asam retinoat (ATRA), metabolit vitamin A, berpotensi menekan kerusakan pada peradangan. Tingginya defisiensi vitamin A di Indonesia, menghambat proses penyembuhan periodontitis yang banyak diderita masyarakat luas. Penelitian bertujuan mengetahui status kolagen ligamentum periodontal periodontitis yang mendapat pengobatan tetrasiklin dan suplementasi ATRA.Metode: Studi eksperimental dengan rancangan post test only pada 12 tikus Wistar jantan dewasa telah dilakukan selama 7 hari. Hewan coba diinduksi periodontitis melalui inokulasi bakteri Porphyromonas gingivalis. Diberikan tetrasiklin 90 mg/kg, juga suplementasi ATRA 10 mg/kg dan 5 mg/kg. Empat kelompok studi dipilih secara acak. Kontrol adalah kelompok sakit + tetrasiklin. Variabel bebas adalah suplementasi ATRA dosis tinggi dan dosis rendah, variabel tergantung adalah status kolagen. Status kolagenmencakup degradasi dan sintesis, berturut-turut dengan petanda mRNA MMP-2 dan mRNA P1CP, diukur menggunakan reverse transcriptase polymerizing chain reaction dan thin layer chromatography. Kadar ATRA diukur dengan high performance liquid chromatography. Data dianalisis dengan uji t, Oneway ANOVA, post hoc Duncan dan least significant differences.Hasil: Pada kelompok yang menerima suplementasi ATRA 10 mg/kgBB kadar ATRA tertinggi, tetapi degradasi kolagennya lebih rendah walau tidak bermakna. Kedua kelompok sumplementasi degradasi kolagennya lebih rendah secara bermakna dibanding kelompok kontrol (p=0,007), dalam sintesis kolagen,kelompok yang mendapat suplementasi ATRA 50 mg/kgBB sintesisnya lebih baik dibanding kelompok yang mendapat ATRA 10 mg/kgBB maupun kelompok kontrol.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3238
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 169-173
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3238/2910
oai:ojs.ejournal.undip.ac.id:article/3811
2012-07-18T12:33:24Z
mmi:ART
Peran Limfosit T Helper-1 (TH1) dan T Helper-2 (TH2) pada Patogenesis Artritis Lepra
Hadi, Suyanto
Sunarto, Sunarto
S, Hardyanto
Triyuliati, Triyuliati
J, Susanto
Hartono, F.X.
Leprosy arthritis, IFN-γ, IL-4, TH1 CD4+ and TH2 CD4+ lymphocyte, and M. leprae Ag
ABSTRACTThe role of lymphocyte T Helper-1 (TH1) and T Helper-2 (TH2) in the pathogenesis of leprosy arthritisBackground: The autoreactive of TH CD4+ cells is the thought to play an important role in arthritis leprosy pathogenesis. However, wheter of TH1 or TH2 predominant has never been studied.Methods: Various Ag M. leprae (Ag 35 kDa, 10 kDa, 45 kDa, 85 kDa, and MLSA 2 ug/ml) were stimulated to the peripheral blood (10cc) lymphocyte culture (PBMC) using 96 weels microplate and RPMI 1640 media of 22 leprosy arthritis cases, control-1 (n=12) (leprosy without arthritis) and control 2 (n=12) (healthy contact). The activity difference between TH1 and TH2 CD4+ lymphocyte was analysed using the difference delta levels of IFN-γ and IL-4 (ELISA) of the three group studies. Statistical analysis used wereANOVA, Kruskal Wallis or Mann Whitney, and Chi-square.Results: IFN-γ delta levels was significantly higher in the lymphocytes cultures in LA group (the median 132.234 pg/ml, 60.347 g/ml, 14.093 pg/ml, 16.619 pg/ml and 138.394 pg/ml) compared with IL-4 value level (median 0.317 pg/ml, 0.017 pg/ml, -0.206 pg/ml, -0.200 pg/ml and 0.492 pg/ml) after being stimulated with 35 kDa, 10 kDa MMP-1, 45 kDa LAM, 85 kDa and MLSA of 2 ug/ml dose consecutively (all p<0.001). The IFN-γ delta value in LA group also showed the significantly higher level in response toall M. leprae Ag compared to all control-groups, with all p value < 0.05.Conclusion: TH1 CD4+ lymphocyte activity is more dominant compared than TH2 CD4+ lymphocyte activity in leprosy arthritis group patients.Key Words: Leprosy arthritis, IFN-γ, IL-4, TH1 CD4+ and TH2 CD4+ lymphocyte, and M. leprae Ag ABSTRAKLatar belakang: TH CD4+ autoreactive diduga kuat pada patogenesis artritis lepra. Apakah autoimunitas akibat dominansi aktivasi limfosit TH1 atau TH2 pada penderita lepra belum pernah diteliti.Metode: Berbagai Ag M.leprae (35 kDa, 10 kDa, 45 kDa LAM, 85 kDa, dan MLSA dosis 2 ug/ml) distimulasikan pada kultur limfosit darah perifer (10 cc darah vena), menggunakan media RPMI 1640 dari 22 kasus artritis lepra, 12 kontrol-1 (lepra tanpa artritis), dan 12 kontrol-2 (tetangga sehat kontak positif). Nilai delta kadar IFN-γ dan IL-4 (ELISA) diukur untuk mengetahui peran aktivitas limfosit TH1 dan TH2. Statistik yang dipergunakan uji ANOVA, uji Kruskal-Wallis atau Mann Whitney, dan metode Chi-square.Hasil: Nilai delta IFN-γ kultur limfosit kasus artritis lepra (median 132,234 pg/ml, 60,347 pg/ml, 14,093 pg/ml, 16,619 pg/ml dan 138,394 pg/ml) kelompok LA lebih tinggi bermakna dibandingkan nilai delta IL-4 (median 0,317 pg/ml, 0,017 pg/ml, -0,206 pg/ml, - 0,200 pg/ml dan 0,492 pg/ml) pasca stimulasi dengan Ag M. leprae 35 kDa, 10 kDa MMP-1, 45 kDa LAM, 85 kDa dan MLSA dosis 2 ug/ml, (p<0,001). Nilai delta IFN-γ kelompok kasus juga lebih tinggi dibandingkan kedua kelompok kontrol (p< 0,05).Simpulan: Aktivitas limfosit TH1 CD4+ lebih dominan dibandingkan TH2CD4+ pada kelompok penderita artritis lepra.
MEDIA MEDIKA INDONESIANA
2012-07-16
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3811
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 1 Year 2008; 44-53
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3811/3495
oai:ojs.ejournal.undip.ac.id:article/4199
2012-11-29T11:39:43Z
mmi:ART
Pemberian Cairan Karbohidrat Elektrolit, Status Hidrasi dan Kelelahan pada Pekerja Wanita
Mardiana, Mardiana
Kartini, Apoina
Widjasena, Baju
Carbohydrate-electrolyte solution, hydration status, fatigue, women workers
Carbohydrate electrolyte solution improve hydration status and decrease fatigue among women workersBackground: Heat exposure cause dehydration and fatigue if water intake is insufficient. Carbohydrate electrolyte drinks consumption maintans workers hydration status and prevent fatigue. Women workers at ironing department in garment industry are at risk of dehydration and fatigue because of the heat exposure.Objective: To determine the effect of carbohydrate electrolyte solution on hydration and fatigue status among women workers.Method: This quasy experiment was conducted in pre post test control group design. Population of this study was women workersaged 18-35 years in ironing department of garment industry. Thirty-three subjects were selected by inclution criteria. Subjects were given three treatments, without intervention, drink water and carbohydrate electrolyte solution. Body weight and fatigue of the subjects were measured on the third, fourth, and fifth intervention days before and after each treatment. Body weight was measuredusing digital scales. Fatigue was measured by reaction timer to flash light. Data were analyzed using paired t test, Wilcoxon test, and Ancova.Result: Body weight decreased 0.1?0.2 kg after work without intervention and drinking water, while increased body weight of 0.1?0.1 kg after given carbohydrate electrolyte. Reaction timed to flash light decreased 12.2?49.0 milliseconds after given carbohydrate electrolyte solution increased 14.9?62.3 and 26.4?33.8 milliseconds after drinking water and without intervention respectively. Drinking carbohydrate electrolyte solution improved hydration status and decreased fatigue status before and aftercontrolled for energy and fluid intake, vitamin B1 and B6 intake.Conclusion: Carbohydrate-electrolyte solution improved the hydration status and decreased fatigue among women workers.Keywords: Carbohydrate-electrolyte solution, hydration status, fatigue, women workers ABSTRAKLatar belakang: Paparan panas selama bekerja dapat menyebabkan dehidrasi dan kelelahan jika asupan cairan tidak cukup. Penambahan cairan karbohidrat elektrolit selama bekerja diduga dapat mencegah dehidrasi dan kelelahan. Pekerja wanita di bagian ironing perusahaan garmen terpapar panas sehingga berisiko dehidrasi dan kelelahan. Tujuan penelitian ini untuk mengetahui pengaruh pemberian cairan karbohidrat elektrolit terhadap status hidrasi dan kelelahan pada pekerja wanita.Metode: Desain penelitian nonrandomized pre-post test control group design. Populasi adalah pekerja wanita perusahaan garmen berusia 18-35 tahun di bagian ironing. Subyek berjumlah 33 orang yang dipilih berdasarkan kriteria inklusi. Subyek mendapat tiga perlakuan, yaitu tanpa intervensi, pemberian air minum dan karbohidrat elektrolit. Subyek diukur berat badan dan kelelahan sebelum dan setelah bekerja selama tiga hari berturut-turut untuk setiap perlakuan. Pengukuran berat badan menggunakan timbangan injak digital. Kelelahan diukur melalui kecepatan dalam merespon cahaya dengan menggunakan alat reaction timer. Data dianalisis menggunakan paired t test, Wilcoxon, repeated measure, dan uji Ancova.Hasil: Pada kondisi tanpa intervensi dan pemberian air minum terjadi penurunan berat badan (0,1?0,1 kg) setelah bekerja, sedangkan pada pemberian karbohidrat elektrolit terjadi peningkatan berat badan sebesar 0,1?0,2 kg. Waktu reaksi rangsang cahaya menurun sebesar 12,2?49,0 millidetik setelah pemberian karbohidrat elektrolit dan meningkat sebesar 26,4?33,8 millidetik pada kondisi tanpa intervensi serta 14,9?62,3 millidetik pada pemberian air minum. Pemberian cairan karbohidrat elektrolit memperbaiki status hidrasi sebelum dan setelah dikontrol dengan asupan energi dan cairan serta menurunkan kelelahan sebelum dan setelah dikontrol dengan asupan energi, cairan, vitamin B1, dan vitamin B6. Simpulan: Pemberian cairan karbohidrat elektrolit dapat memperbaiki status hidrasi dan menurunkan kelelahan
MEDIA MEDIKA INDONESIANA
2012-11-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4199
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012; 6-11
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4199/3827
oai:ojs.ejournal.undip.ac.id:article/4272
2013-06-26T12:59:31Z
mmi:ART
Uji Banding Efektivitas Kalsipotriol Topikal, Suction Blister Grafting dan Kombinasi Keduanya pada Terapi Repigmentasi Lesi Vitiligo Stabil
Nurhayati, Diana
Stable vitiligo, suction-blister-grafting, calcipotriol, repigmentation.
Comparison study the efficacy of topical calcipotriol, suction blister grafting and combination of both therapies for repigmentationc of stable vitiligoBackground: Stable vitiligo is defined as non-progressive vitiligo for more than 6-month. A large variety of therapeutic agents are being tried, but an optimal treatment is not yet available. Topical calcipotriol is one of those agent that hypothetically can stimulate repigmentation of vitiliginous lesions. Suction-blister-grafting (SBG), is one of the surgical therapies for replenishment of melanocytes in stable vitiligo. The aim of this study was to compare the efficacy of topical calcipotriol, SBG and the combination of both therapies in the treatment of stable vitiligo.Methods: Twenty-one stable vitiligo (focal, segmental, and generalized) patients were selected for study. Patients were divided into three groups. First-groups were advised to apply topical calcipotriol (50ug/mg) twice-daily over the vitiliginous patches. Secondgroups were given with SBG, and third-groups were given with combination of both treatments. The main outcome measurement was the evaluation of the percentage of repigmentation in treated target lesions in 12-weeks.Results: After12-weeks periods, the combination therapies were found more effective than single therapy. The combination therapies-treated areas showed marked intense repigmentation improvement 19.1% compared to 15.1% on the SBG-only side (p<0.05). Calcipotriol was found to induce initiating repigmentation, but was not statistically significant.Conclusion: Combination therapy of SBG and topical calcipotriol is more effective than single therapy for stable vitiligo.Keywords: Stable vitiligo, suction-blister-grafting, calcipotriol, repigmentation.ABSTRAK Pendahuluan: Vitiligo stabil merupakan vitiligo yang tidak berkembang dalam jangka waktu minimal 6 bulan. Berbagai jenis terapi telah banyak dicoba, akan tetapi terapi yang optimal belum tersedia sampai saat ini. Kalsipotriol topikal merupakan salah satu bahan yang diduga mampu menstimulasi repigmentasi pada lesi vitiligo. Suction blister grafting (SBG) merupakan salah satu tindakan bedah yang dapat dipakai untuk mengganti melanosit pada vitiligo stabil. Tujuan penelitian adalah untuk membandingkan efektivitas kalsipotriol topikal, SBG dan kombinasi keduanya untuk terapi vitiligo stabil.Metode: Penelitian ini dilakukan pada dua puluh satu pasien vitiligo stabil (fokal, segmental dan generalisata). Pasien dibagi menjadi tiga kelompok. Kelompok pertama diberi kalsipotriol topikal (50ug/mg) dioleskan dua kali/hari, kelompok kedua dilakukan tindakan suction blister grafting, dan kelompok ketiga diberi keduanya. Hasil dinilai berdasarkan persentase repigmentasi pada area yang di terapi pada akhir minggu ke-12.Hasil: Pada akhir minggu ke-12, terapi kombinasi terbukti lebih efektif daripada terapi tunggal. Pada lesi yang diterapi kombinasi tampak adanya perbaikan repigmentasi 19,1% dibandingkan terapi SBG tunggal yang 15,1% (p<0,05). Kalsipotriol juga terbukti dapat memicu terjadinya repigmentasi awal, meskipun repigmentasinya secara statistik tidak signifikan.Simpulan: Kombinasi terapi SBG dan kalsipotriol topikal merupakan terapi yang lebih efektif dibandingkan dengan terapi tunggal pada terapi vitiligo stabil
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4272
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 114-121
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4272/3893
oai:ojs.ejournal.undip.ac.id:article/4297
2012-12-29T12:39:06Z
mmi:ART
Sindrom Stevens-Johnson dan Nekrolisis Epidermal Toksis di RSUP MH Palembang Periode 2006 - 2008
Thaha, M. Athuf
Stevens-Johnson syndrome, toxic epidermal necrolysis, drug-induced cutaneous reactions
Steven-Johnson syndrome and toxic epidermal necrolysis in RSUP MH Palembang in year 2006-2008Background: Stevens-Johnson syndrome (SSJ) and toxic epidermal necrolysis (TEN) are rare, life-threatening, drug-induced cutaneous reactions.Methods: We conducted a retrospective study by gathering 43 SJS, SJS/TEN, and TEN patients data from RSUP MH General Hospital Palembang from 2006-2008. Variable that were evaluated covered the age, gender, incidence, drug causes, and results of medical treatment.Results: The number of SSJ cases was higher than SJS/TEN and TEN cases, most of SSJ patients were in 26-36 year age group (11 patients or 25.5%), with male/female ratio of: 55.8%:44.2%. The use of paracetamol, amoxycilline, tetracycline, cotrimoxsazole, methampirone, ciprofloxacine, and carbamazepine was associated with large increases in the risk of SSJ or TEN. Hospital stays for SSJ was 8.91 ± 5.52 days, and 13.2 ± 3.89 days for SJS/TEN. This retrospective study expressed the high incidence of the SJS inRSUP MH in 2006-2008 period, compared with the incidence reported in the bibliography.Conclusions: Although there were still controvercies in systemic corticosteroid use, this study showed the use of steroid gave satisfactory results.Keywords: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug-induced cutaneous reactions ABSTRAKLatar belakang: Sindrom Stevens-Johnson (SSJ) dan nekrolisis epidermal toksis (NET) ialah reaksi kulit terutama akibat obat yang jarang ditemui dan dapat menyebabkan kematian.Metode: Penelitian dilakukan secara retrospektif dengan mengumpulkan data rekam medik RSUP MH Palembang periode 2006–2008, sebanyak 43 pasien rawat inap yang didiagnosis sebagai SSJ, SSJ/NET, dan NET. Variabel yang dievaluasi meliputi usia, jenis kelamin, angka kejadian penyakit, obat yang menyebabkan penyakit, lama perawatan, dan hasil pengobatan.Hasil: Hasil evaluasi menunjukkan jumlah kasus SSJ merupakan yang terbanyak dibandingkan NE lainnya, usia terbanyak SSJ terdapat pada kelompok usia 26-36 orang (11 orang atau 25,5%), rasio laki-laki/perempuan sebesar: 55,8%:44,2%. Obat yang terbanyak berturut-turut ialah parasetamol, amoksisilin, tetrasiklin, kotrimoksasol, metampiron, siprofloksasin dan karbamazepin. Lama perawatan pasien SSJ ialah 8,9 ± 5,5 dan SSJ/NET 13,2 ± 3,9 hari, dan semua pasien (kecuali yang pulang paksa) sembuh pada evaluasi paska rawat. Penelitian retrospektif ini mengungkap tingginya angka kejadian SSJ di RSUP MH periode 2006-2008, dibandingkan angka kejadian yang dilaporkan dalam kepustakaan. Terdapat perbedaan jenis obat penyebab SSJ di RSUP Palembang dari obat penyebab risiko tinggi yang dilaporkan dalam literatur.Simpulan: Walaupun masih terdapat silang pendapat penggunaan steroid sistemik pada SSJ, penelitian ini menunjukkan pemakaian steroid memberikan hasil yang memuaskan.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4297
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009; 234-239
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4297/3915
oai:ojs.ejournal.undip.ac.id:article/4580
2013-06-26T12:57:43Z
mmi:ART
Konseling Laktasi Intensif dan Pemberian Air Susu Ibu (ASI) Eksklusif Sampai 3 Bulan
Ambarwati, Ria
Muis, Siti Fatimah
Susantini, Purwanti
Intensive lactation counseling, exclusive breastfeeding, 3 months
Intensive lactation counseling and exclusive breastfeeding up to 3 monthsBackground: In 2010 within the area of Semarang Municipality, exclusive breastfeeding by mothers to their babies reaches up to only 20,06%. One of the problems is the lack of lactation counseling especially by the health service institutions.Objectives: To reveal the effect of intensive lactation counseling on exclusive breastfeeding up to 3 months.Method: This research study is designed as a quasi-experiment of non-equivalent control group. The population of this study is a group of mothers who were in the 7th to 8th months of pregnancy bearing the second child or more. The number of the subjects is 25 mothers who were grouped into 2, that is the experimental groups of 12(n=12) and control group of 13 (n=13). The group underwent a treatment of intensive lactation counseling of 9 times on 2 stages, the first was four-time treatments during the medical examination on their pregnancy of 7th-8th months. The second stage of treatments was done by home visit for 5 times during week 1, 2, 4, 8, and 12 after giving birth by sertified lactation counselors for 40 workhours. These counselors had the experience of at least 5 clients counseling. The control group got the usual counseling that they normally received from the midwives at the Health Primary Center and private midwives nearby.Results: The group without intensive lactation counseling shows no gain of knowledge, attitude towards early initiation of breastfeeding, exclusive breastfeeding, breastmilk and no increase of the number of exclusive breastfeeding on their babies prior to and during the study. The group with intensive lactation breastfeeding shows a significant gain in every aspects being studied and significant increase (five fold) of the number of exclusive breastfeeding on their babies that born prior to and during the study from2(16.7%) to 10(83.3%).Conclusion: Intensive lactation counseling increases the practice of exclusive breastfeeding up to 3 months and should be performed by health care delivery system.Keywords: Intensive lactation counseling, exclusive breastfeeding, 3 months ABSTRAKLatar belakang: Ibu yang memberikan ASI eksklusif di Kota Semarang Tahun 2010 hanya mencapai 20,06%. Salah satu penyebabnya adalah kurangnya konseling laktasi di sarana pelayanan kesehatan.Tujuan: Mengetahui pengaruh konseling laktasi intensif terhadap pemberian ASI eksklusif sampai 3 bulan.Metode: Penelitian dengan rancangan quasi experiment non equivalent control group. Populasi adalah ibu hamil trimester 3 dengan usia kehamilan 7-8 bulan pada anak kedua atau lebih. Jumlah sampel 25 ibu hamil yang dikelompokkan menjadi 2 yaitu kelompok perlakuan (n=12) dan kelompok kontrol (n=13). Kelompok perlakuan mendapat konseling laktasi intensif sebanyak 9 kali yaitu 4 kali pada saat pemeriksaan kehamilan umur 7-8 bulan dan kunjungan rumah sebanyak 5 kali pada minggu ke-1, 2, 4, 8, 12 setelah kelahiran oleh konselor laktasi yang memiliki sertifikat pelatihan konselor laktasi. Kelompok kontrol mendapat konseling pada pemeriksaan kehamilan yang selama ini dilakukan oleh bidan di Puskesmas dan Bidan Praktik Swasta.Hasil: Pada kelompok yang tidak mendapat konseling laktasi intensif tidak ada perubahan skor pengetahuan, sikap terhadap inisiasi menyusu dini, ASI eksklusif, ASI, menyusui dan tidak ada peningkatan jumlah ibu yang memberikan ASI eksklusif sampai 3 bulan pada anak yang dilahirkan sebelum dan selama penelitian. Kelompok yang mendapat konseling laktasi yang intensif menunjukkan ada perubahan skor pada semua anak dan peningkatan jumlah ibu yang memberikan ASI eksklusif sampai 3 bulan pada anak yang dilahirkan selama penelitian menjadi 5 kali lipat.Simpulan: Konseling laktasi intensif dapat meningkatkan jumlah ibu yang melaksanakan ASI eksklusif sampai 3 bulan dan perlu dilaksanakan oleh semua sarana pelayanan persalinan.
MEDIA MEDIKA INDONESIANA
2013-03-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4580
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012; 201-208
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4580/4172
oai:ojs.ejournal.undip.ac.id:article/21830
2019-01-25T14:21:01Z
mmi:ART
Derajat Sindroma Distres Respirasi pada Foto Thorax dan Derajat Asfiksia pada Neonatus Prematur
Ningrum, Farah Hendara
Sukmaningtyas, Hermina
Wahyuni, Mardiana
Respiratory distress syndrome; APGAR score; premature neonates; chest X-ray
The degrees of respiratory distress syndrome from thorax X-ray and degrees of asphyxia in preterm neonatesBackground: Respiration Distress Syndrome (RDS) is a complication of prematurity lung disorder and common causes of premature neonatal morbidity. Clinically RDS provides signs of asphyxia that can be assessed with APGAR score. Chest X-ray can also diagnose and determine the degree of RDS radiologically. This study aims to find the relationship degree of RDS clinically with radiologically.Methods: Analytic observational study with cross-sectional design. The subjects were premature neonates with asphyxia in Kariadi General Hospital Semarang who had APGAR score and RDS on the standard Chest x-ray examination and selected using consecutive sampling method. The relationship between the RDS clinical degree based on APGAR score with radiological degrees tested with the Chi square test (X2) and Kendall tau-b. There were four grading for RDS. Chest x-ray images were interpretated by 2 expert radiologists independently and then Kappa value was evaluated.Results: There were 23 RDS cases consisted 12 severe, 8 moderate and 3 mild asphyxia cases. Radiologically showed grade I (9), grade II (5), grade III (5) and grade IV (4) neonates. Kappa value=1 (p<0.001). Chi square test (X2) showed clinical asphyxia degree was not significantly different with the degree of RDS on chest x-ray. Kendall tau-b correlation test showed a significant and moderate degree correlation (r=0.5; p=0.01).Conclusions: The degree of asphyxia in premature infants are in line with radiological images.ABSTRAKLatar belakang: Sindroma distres respirasi (SDR) yang bermanifestasi dalam bentuk asfiksia merupakan kelainan paru komplikasi prematuritas penyebab tersering morbiditas neonatus prematur. X-foto thorax membantu diagnosis SDR sekaligus menentukan derajat SDR. Penelitian ini bertujuan menilai hubungan derajat klinis SDR dengan derajat radiologi.Metode: Studi observasional analitik dengan rancangan cross-sectional. Subjek penelitian adalah neonatus prematur dengan asfiksia di RSUP Dr. Kariadi Semarang yang mempunyai skor APGAR serta mendapatkan pemeriksaan X-foto thoraks standar. Pemilihan subjek menggunakan metode consecutive sampling. Terdapat empat derajat SDR secara radiologis Hubungan antara derajat klinis SDR berdasarkan skor APGAR dengan derajat radiologis diuji dengan Chi square(X2) dan derajat korelasi dengan uji Kendall tau-b. Hasil X-foto thorax diinterpretasi terpisah oleh 2 ahli radiologi dan diuji Kappa. Hasil: Dijumpai 23 asfiksia neonatus prematur dengan SDR terdiri dari 12 kasus asfiksia berat, 8 kasus asfiksia sedang dan 3 kasus asfiksia ringan. Secara radiologis ditemukan SDR derajat I sebanyak 9, 5 derajat II, 5 derajat III dan derajat IV pada 4 neonatus. Nilai Kappa=1 (p<0,001). Derajat asfiksia secara klinis tidak berbeda bermakna dengan derajat radiologi SDR (Chi square(X2) p=0,007). Uji korelasi Kendall tau-b menunjukkan korelasi bermakna tingkat sedang (r=0,5; p=0,01) antara derajat asfiksia secara klinis dengan derajat radiologi SDR. Simpulan: Derajat asfiksia pada bayi prematur sejalan dengan derajat radiologik foto thorax pada SDR.
MEDIA MEDIKA INDONESIANA
2010-04-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21830
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010; 33-26
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21830/14586
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3120
2012-04-09T13:32:18Z
mmi:ART
Faktor HLA-DRB pada Penderita Tuberkulosis Paru dengan Pengobatan Strategi DOTS
Indreswari, Sri Andarini
Hadisaputro, Suharyo
Soesatyo, Marsetyawan HNE
Handono, Kusworini
Tuberculosis, human leukocyte antigen (HLA)
ABSTRACTHLA-DRB factor in pulmonal tuberculosis with DOTS strategic treatmentBackground: Tuberculosis remains one of the world’s greatest public health problems, especially in developing countries. In Indonesia the results of DOTS strategic treatment and conversion have not been fruitful results. Many factors play important roles in the success of DOTS strategic treatment, but a little attention was given to the immuno genetics aspects. This study was aimed at theassociation between HLA-DRB factors and clinical output on DOTS strategic treatment (after first 2 months of treatment):conversion of sputum smear positive.Method: A nested case control study was carried out. The exposure variables were alleles of HLA-DRB (result of PCR examination), while the independent variables were sputum smear positive and negative (result of laboratories examination with Ziehl Neelsen staining, Niacin test). Body mass index (BMI) and sex were confounding variables. Odds ratio (OR) was calculated using bivariate and logistic regression for multivariate analysis.Result: A total sample of 73 new patients with active tuberculosis (sputum smear positive) in developing treatment with DOTS strategic treatment, consist of 34 cases and 39 controls. The odds ratio (OR) of HLA-DRB1*1502 and HLA-DRB5*01 were 3.2 (95%CI: 1.103-9.287). The OR of HLA-DRB1*1201 was 0.305 (95% CI: 0.117-0.798), OR of HLA-DRB3*01 was 0.214 (95% CI: 0.077- 0.592). The PAR (population attributable rate) of HLA-DRB1*1502 and HLA-DRB%*01 were 42.64%. While confounding variables were analyzed, only allele HLA-DRB1*1502 was significant, OR 4.9 (95% CI: 1.234-15.617), the probability was 70.57%.Conclusion: HLA-DRB1*1502 is an allele is a risk factor for the conversion of sputum smear positive after 2 months of treatment.Keywords: Tuberculosis, human leukocyte antigen (HLA)ABSTRAKLatar belakang: Di Indonesia hasil pengobatan tuberkulosis paru belum optimal. Penyebab kekurangberhasilan pengobatan ini belum diketahui, khususnya yang berkaitan dengan faktor imunogenetika. Penelitian bertujuan menjelaskan hubungan faktor HLADRBdengan kesembuhan klinis, dalam hal ini terjadinya konversi BTA pasca 2 bulan pengobatan dengan strategi DOTS.Metoda: Rancangan penelitian adalah nested case control, pada penderita baru tuberkulosis paru dengan pemeriksaan sputum BTA positif yang mendapat pengobatan strategi DOTS selama 2 bulan. Jenis alel (HLA-DRB) yang ditemukan dengan pemeriksaan PCR dinyatakan sebagai variabel paparan, variabel efek adalah hasil pemeriksaan sputum (BTA) dengan pengecatan Ziehl Neelsen yangditeruskan dengan tes Niacin pasca 2 bulan pengobatan. Sebagai variabel perancu ditetapkan BMI dan jenis kelamin. Analisis dilakukan dengan menghitung rasio odds dengan chi-square dan regresi logistik.Hasil: Jumlah sampel 73, diperoleh dari 158 penderita baru berobat jalan yang diikuti selama 2 bulan, terdiri dari 34 kasus (BTA tetap positif pasca 2 bulan pengobatan) dan 39 kontrol (BTA menjadi negatif). Penelitian dilakukan di BP4, 12 puskesmas dan RSUD di Kota Semarang. Hasil penelitian adalah besar risiko (OR) HLA-DRB1*1502 dan HLA-DRB5*01 untuk tidak terjadinya konversi BTA 3,2 (95% CI: 1,103-9,287). Alel HLA-DRB1*1201 dan alel HLA-DRB3*01 merupakan alel yang bersifat protektifdengan OR 0,305 (95% CI: 0,117-0,798), sedangkan HLADRB3*01 dengan OR 0,214 (95% CI: 0,077-0,592). PAR untuk alel HLADRB1* 1502 dan HLA-DRB5*01 sebesar 42,64%. Apabila variabel perancu dimasukkan dalam analisis, maka hanya alel HLA-DRB1*1502 yang secara signifikan merupakan faktor risiko untuk tidak terjadinya konversi BTA pasca 2 bulan awal pengobatan dengan strategi DOTS. OR 4,9 (95% CI:1,234-15,617). Probabilitas untuk HLA-DRB1*1502 adalah sebesar 70,57%.Simpulan: Alel HLA-DRB1*1502 merupakan faktor risikountuk tidak terjadinya konversi BTA pasca 2 bulanpengobatan, dengan probabilitas cukup besar.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3120
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 1 Year 2011; 34-41
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3120/2800
oai:ojs.ejournal.undip.ac.id:article/21907
2019-01-29T13:28:22Z
mmi:ART
Intensitas Latihan Interval dan Aktivitas Antioksidan Endogen
Doewes, Muchsin
Kiyatno, Kiyatno
Interval training; SOD and GPx antioxidants
Interval training intensity and endogen antioxidant activityBackground: Physical training increases free radical generation which is balanced by endogenous antioxidant generation e.g. SOD (superoxide dismutase) and GPx (glutathione peroxidase). This later is influenced by intensity, duration, muscle type and age. The aims of this study is to compare the three kinds of interval training intensity in enhancing SOD and GPx activity.Method: An experimental quantitative study with the posttest only control group design was used in this study. Thirty six students of JPOK-FKIP Sebelas Maret University were randomly selected to become the experimental subjects and divided into four groups (1) intensive repetition runing 10x50 m, (2) extensive repetition runing 3x400 m, (3) continuous aerobic training past running 30 minutes, and (4) controlled group. The interval training were treated 3x per week for 8 weeks. At the 8th week SOD and GPx activity were determined by using enzymatic method with Cobas Mira instrument. The t-test with SPSS 13.0 for window program was use for analyzing all collected data with 95% CI.Result: There were significance difference the SOD and GPx activity between extensive repetition group with controlled group (p<0.05).Conclusion: The extensive repetition intensity is the significance for enhancing the enzymatic activity of SOD and GPx to compare with control group, and have the higher level than intensive repetition and continuous aerobic training.ABSTRAKLatar belakang: Latihan fisik meningkatkan pembentukan radikal bebas yang diimbangi peningkatan pembentukan antioksidan endogen seperti SOD (superoxide dismutase) dan GPx (glutathione peroxidase). Pembentukan antioksidan SOD dan GPx dipengaruhi oleh intensitas latihan, durasi, jenis otot yang dilatih dan umur. Tujuan penelitian ini untuk membandingkan tiga kelompok intensitas latihan interval yang meningkatkan aktivitas enzim SOD dan GPx.Metode: Jenis penelitian kuantitatif–eksperimental menggunakan rancangan penelitian the posttest only control group design. Subyek penelitian diambil secara acak sederhana (n=36), dibagi menjadi 4 kelompok (1). K1: intensive repetition lari 10x50 m, (2). K2: extensive repetition lari 3x400 m, (3). K3: continuous aerobic training lari cepat 30 menit; (4). K4: kelompok kontrol. Latihan interval dilakukan 3 kali/minggu dilakukan berkesinambungan selama 8 minggu berturut-turut. Pada minggu ke delapan diambil 5 mL darah untuk diperiksa aktivitas SOD dan GPx menggunakan metode enzimatik dengan alat Cobas Mira. Analisis data dengan uji t menggunakan program komputer SPSS 13.0 for Window dengan tingkat kepercayaan 95%.Hasil: Terjadi perbedaan bermakna kadar SOD dan GPx pada extensive repetition dengan kelompok kontrol (p<0,05).Simpulan: Aktivitas enzim SOD dan GPx paling tinggi pada latihan interval extensive repetition dibanding intensive repetition dan continuous aerobic training, dan berbeda bermakna dengan kelompok kontrol.
MEDIA MEDIKA INDONESIANA
2010-12-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21907
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 3 YEAR 2010; 141-146
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21907/14643
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3249
2012-04-20T07:57:42Z
mmi:ART
Asupan Lemak dan Ekspresi Gen eNOS3 Alel Glu298Asp pada Penderita Hipertensi Etnik Minangkabau
Sulastri, Delmi
NI, Lipoeto
Zubir, Nasrul
Jamsari, Jamsari
Essensial hipertension, eNOS3 gene, NO plasma level
ABSTRACTIntake of fat and Gen eNOS3 Alel Glu298Asp expression in hypertensive Minangkabau personsBackground: eNOS 3 gene is one of the important genes which is related to the high prevalence of hypertension essensial. This gene expresses the nitric oxide synthase (NOS) enzyme which regulates the synthesis of nitric oxide (NO) in human body.Methods: A research has been done on hypertensive and normotensive patients aged 30-65 years old. The main purpose of this research was to evaluate the association of fat intake on eNOS3 gene Glu298Asp allel expression in hypertension subjects in Minangkabau ethnicity. One hundred thirty subjects had been interview about their eating habits, and measured their omega-3, eNOS3 gene and NO plasma level. The data were analysed with t-tes and chi-square.Results: The hypertensive’s plasma NO concentration was 26.91±15.40 μM/L and normotensive’s was 25.79±15.04 μM/L. 52.5% of the hypertensive subjects and 47.5% of the normotensive has eNOS3 gene heterozygotes GT allele. Mean rates for total fat, SFA, MUFA and PUFA consumption of hypertensive subjects are 28.05±6.57%, 12.31±4.21%, 4.21±1.79%, 3.77±1.97% and normotensive are 30.14±13.98%, 12.58±4.22%, 4.40±2.22%, 4.00±1.96%. Mean rate for plasma omega-3 concentration of hypertensive subjects is 14.45±0.10μg/dL and normotensive is 14.49±1.00 μg/dL. There is significant relationship between omega-3 with NO plasma level on hypertension with GT heterozygote alleles.Conclusion: In hypertensive patients with GT heterozygote alleles, only omega-3 plasma is associated with NO2 plasma.Keywords: Essensial hipertension, eNOS3 gene, NO plasma levelABSTRAKLatar belakang: Gen eNOS3 alel Glu298Asp merupakan salah satu gen yang berhubungan dengan kejadian hipertensi esensial. Kemampuan Gen eNOS3 alel ini untuk mensintesis enzim nitric oxide synthase (NOS) berkurang sehingga sintesis nitric oxide (NO) menurun.Metode: Penelitian pada subyek hipertensi dan normotensi berusia 30-65 tahun bertujuan untuk melihat hubungan asupan lemak dengan ekspresi gen eNOS3 alel Glu298Asp. Seratus tiga puluh subyek, diwawancara pola makannya lalu dilakukan pemeriksaan kadar omega-3 dan omega-6 plasma, gen eNOS3, serta kadar NO plasma. Data yang diperoleh dianalisis menggunakan uji T dan chi-square.Hasil: Kadar NO plasma subyek hipertensi adalah 26,91±15,40 μM/L dan normotensi 25,79±15,04 μM/L. 52,5% subyek hipertensi dan 47,5% normotensi mempunyai polimorfisme gen eNOS3 alel heterozigot GT. Rerata persentase asupan lemak total, ALJ, ALTJT, ALTJG pada subyek hipertensi adalah 28,05±6,57%, 12,31±4,21%, 4,21±1,79%, 3,77±1,97% dan pada subyek normotensi adalah 30,14±13,98%, 12,58±4,22%, 4,40±2,22%, 4,00±1,96%. Rerata kadar omega-3 plasma subyek hipertensi adalah 14,45±0,10 μg/dL dan normotensi 14,49±1,00 μg/dL. Terdapat hubungan kadar omega-3 dengan NO plasma pada penderita hipertensi dengan alel heterozigot GT.Simpulan: Pada penderita hipertensi dengan alel heterozigot GT, hanya omega-3 plasma yang berhubungan dengan kadar NO2 plasma.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3249
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 1 Year 2011; 59-67
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3249/2917
oai:ojs.ejournal.undip.ac.id:article/3795
2012-07-16T11:20:45Z
mmi:ART
Karakteristik Penderita Sindroma Terowongan Karpal (STK) di Poliklinik Instalasi Rehabilitasi Medik RS Dr. Kariadi Semarang 2006
Tamba, Lusan Maria T
Pudjowidyanto, Handojo
carpal tunnel syndrome, clinical manifestation, medical rehabilitation program
ABSTRACTThe characteristics of carpal tunnel syndrome of patients in the medical rehabilitation (PMR) outpatient clinic Dr. Kariadi Hospital Semarang 2006Background: Carpal tunnel syndrome (CTS) is a common clinical disorder in daily practice, especially in the PMR outpatient clinic Dr. Kariadi Hospital Semarang. However it seems there is no pattern of patient characteristic and medical rehabilitation programs applied for the CTS patients. The objective of this study was to explore patient characteristics and the medical rehabilitation programs.Methods: The study was an observational descriptive study. Data were collected from medical records of new patients diagnosed with CTS in PMR Department Dr. Kariadi Hospital Semarang in 2006.Results: There were 34 patients (4% of 838 new patients) diagnosed with CTS, 32 (94,1%) were female and 2 (5,9%) were male, 18 (53%) with unilateral CTS and 16 (47%) with bilateral CTS. Most of them were 41-50 (38,2%) and 51-60 years old (35,3%) and dominantly were house wife (61,8%). The most frequent clinical manifestations were numbness (97%), with positive Tinel’s sign (88,2%). Electrodiagnostic examination was done in 17 subjects (50%). The most frequent medical rehabilitation program isultrasound therapy (76,5%), six times a week.Conclusion: CTS patients are predominantly women with positive Tinel sign, and therapy given is mostly ultrasound and ortotic prosthetic with splint.Key Words: carpal tunnel syndrome, clinical manifestation, medical rehabilitation programABSTRAKLatar belakang: Sindroma Terowongan Karpal (STK) merupakan gangguan yang sering ditemukan dalam praktek sehari-hari, khususnya di Poliklinik Instalasi Rehabilitasi Medik (IRM) RS Dr. Kariadi Semarang. Namun hingga saat ini belum diketahui karakteristik penderita dan program rehabilitasi yang diberikan. Penelitian ini bertujuan untuk mengetahui pola penderita STK dan program rehabilitasi medik yang diberikan.Metode: Penelitian bersifat observasional deskriptif. Data diperoleh dari rekam medis pasien dengan diagnosis STK yang berobat pertama kali ke Poliklinik IRM RS Dr. Kariadi Semarang tahun 2006, meliputi karakteristik penderita dan program rehabilitasi medik.Hasil: Selama 1 tahun (2006) didapatkan 34 penderita STK baru, yaitu 4% dari seluruh pasien baru (838 orang). Sebanyak 32 orang (94,1%) adalah perempuan dan 2 orang (5,9%) laki-laki, 18 (53%) unilateral dan 16 (47%) bilateral. Kelompok usia terbanyak adalah 41-50 tahun (38,2%) dan 51-60 tahun (35,3%). Pekerjaan terbanyak adalah ibu rumah tangga (61,8%). Keluhan/gejala terbanyak adalah parestesi (97%) dengan Tanda Tinel positif didapatkan pada 88,2% penderita. Pemeriksaan elektrodiagnostikdilakukan pada 17 orang (50%). Program rehabilitasi terbanyak diberikan adalah terapi ultrasound pada 26 orang (76,5%) dengan frekuensi setiap hari selama satu minggu.Simpulan: Penderita STK predominan perempuan dengan Tanda Tinel positif dan terapi yang diberikan adalah ultrasound dan splint ortotik prostetik.
MEDIA MEDIKA INDONESIANA
2012-07-16
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/3795
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 1 Year 2008; 11-16
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3795/3479
oai:ojs.ejournal.undip.ac.id:article/4034
2012-09-20T10:00:36Z
mmi:ART
Pola Asuh Ibu, Kejadian Diare dan Pertumbuhan Sampai 4 Bulan pada Bayi yang Mengalami Hambatan Pertumbuhan Dalam Rahim
Berek, Thresia Dewi Kartini
Faizah, Zinatul
Purwaningsih, Endang
Pada pola asuh ibu hanya praktik ibu memberi makan bayi berhubungan dengan pertumbuhan bayi yang lahir IUGR
ABSTRACTMother caring pattern, diarrhea occurrence and growth in the first four months of infants with intra uterine growth retardationBackground: Infants with Intra Uterine Growth Retardation (IUGR) are very sensitive toward infection especially diarrhea. Diarrhea may disrupt growth, while good quality of mother caring pattern improve growth. This study aimed to see the association between mother caring pattern, diarrhea occurrence and the growth of infants with IUGR.Methods: This prospective cohort study was conducted in 44 IUGR infants with from birth to 4 months old. Data were collected by interviews to the mother, using a structured questionnaire and observation. The variables measured were mother caring pattern, diarrhea occurrences, environmental sanitation, health service utility and growth. Data were analyzed using Pearson and Rank-Spearman correlation tests, as well as multiple linear regressions.Results: Eighty-eight point six percents of the respondents had good quality of caring pattern. The mean diarrhea episode per child was 0.84 (±1.1), with duration of 1.8 days/episode. Cummulative incidence of diarrhea was 84.1% and incidence density of diarrhea was 3.1 person-years. Diarrhea occurrences in subjects who were partially breastfed were higher than the subjects who wereexclusively breastfed. There was a correlation between mother’s feeding practice and growth (WAZ: p<0.004, BMI: p<0.039). There was no correlation between mother’s caring pattern, diarrhea occurrences, environmental sanitation, health service utility and growth. Environmental sanitation, health service utility, diarrhea occurrences, mother’s caring pattern of feeding, nursing andhygiene, were all contributed to 31.7% of WAZ scores.Conclusions: Among the mother caring pattern, only feeding practice was correlated to the growth of infants with IUGR, while diarrhea occurrences was not correlated. It is recommended that mothers of infants with IUGR should be given counseling with regard to infant feeding practice.Keywords: Pola Asuh Ibu, Kejadian Diare dan Pertumbuhan Sampai 4 Bulanpada Bayi yang Mengalami Hambatan Pertumbuhan Dalam RahimABSTRAKLatar Belakang: Bayi dengan hambatan pertumbuhan dalam rahim (IUGR) sangat rentan terhadap infeksi terutama diare yang dapat mengganggu pertumbuhannya. Pola asuh ibu diharapkan dapat memperbaiki dan menunjang pertumbuhan optimal bayi yang lahir dengan IUGR. Penelitian ini bertujuan untuk mengetahui hubungan pola asuh ibu dan kejadian diare dengan pertumbuhan bayi dengan IUGR.Metode: Penelitian kohort prospektif pada 44 bayi IUGR sampai umur 4 bulan. Variabel yang diamati: pola asuh ibu, kejadian diare, sanitasi lingkungan, pemanfaatan pelayanan kesehatan dan pertumbuhan. Analisis data dengan korelasi Pearson, Rank- Spearman dan analisis regresi linier ganda.Hasil: Pola asuh ibu 88,6% baik. Rerata episode diare 0,84(±1,16) dengan lama diare 1,8 hari/episode. Insidensi kumulatif diare 84,1% dan densitas insiden diare 3,1 orang-tahun. Kejadian diare subyek ASI parsial lebih banyak dibandingkan subyek ASI eksklusif. Ada hubungan antara praktik ibu memberi makan bayi dengan pertumbuhan bayi (BB/U p<0,004 dan BMI p<0,039). Tidak ada hubungan pola asuh ibu, kejadian diare, sanitasi lingkungan dan pemanfaatan pelayanan kesehatan dengan pertumbuhan bayi. Secara bersama-sama sanitasi lingkungan, pemanfaatan pelayanan kesehatan, kejadian diare, praktik ibu memberi makan,merawat, menjaga kebersihan diri dan bayi berpengaruh terhadap pertumbuhan bayi dengan kontribusi terbesar dari skor-Z BB/U(31,7%).Simpulan: Pada pola asuh ibu hanya praktik ibu memberi makan bayi berhubungan dengan pertumbuhan bayi yang lahir IUGRsampai umur 4 bulan.
MEDIA MEDIKA INDONESIANA
2012-07-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4034
MEDIA MEDIKA INDONESIANA; 2008:MMI Volume 43 Issue 3 Year 2008; 122-129
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4034/3706
oai:ojs.ejournal.undip.ac.id:article/4267
2013-06-26T12:59:31Z
mmi:ART
Proteksi Probiotik pada Mukosa Ileum Mencit yang Terpajan Lipopolisakarida Escherichia Coli
Athiyyah, Alpha Fardah
Setiawati, Ariani
Darma, Andy
Endaryanto, Anang
Sudiana, I Ketut
Ranuh, Reza
MS, Subijanto
Probiotic, LPS, Escherichia coli, protection, immunology
Probiotic’s protection in ileal mucosa of mice after lipopolysaccaride Escherichia coliBackground: Gastrointestinal infection is one of the major causes of morbidity in children. Diarrhea is the common manifestation. Diarrheal prevention needs a balance mucosal immune system. Probiotic used in prevention of gastrointestinal infection needs to be considered. The aim of the study is to prove probiotic protection in ileal mucosa after lipopolysaccaride (LPS) Escherichia coli O55:B5 inoculation anatomically and immunologically.Method: Experimental study with male Balb/c, age 10-12 weeks, body weight 30-40g and randomized into treatment group and placebo group. Treatment group received mix probiotic for 14 days and on day 15 were inoculated by LPS Escherichia coli O55:B5, and day 16-21 were given mix probiotic again. Placebo group received LPS Escherichia coli O55:B5 on day 15. Mice necropsy were conducted at day 22. Immunohistochemistry examination used to look for amount expression cell for IL-2, IFN-γ, TNF-α, IL-4, IL-5,IL-6, IL-10 dan TGF-β in ileal mucosa. Scanning electron microscope was used to see ileal mucosal structure. Statistic analysis used in this study was multivariate analysis.Results: Sixteen Balb/c mices were randomized into 2 groups, each group consist 8 mices. There was significant difference on amount of cells expression IL-5 (p=0.022), IL-6 (p=0.05), and also on amount of cells expression TGF-β (p=0.036). On probiotic- LPS group, there was no Th1 domination but on the other hand, Treg became dominant. Th1 and Th2 response were still balance. Structural damages occurred in LPS group and did not occur in probiotic-LPS group.Conclusion: Probiotic protection in ileal Balb/c mice mucosa after LPS Escherichia coli O55:B5 inoculation is through anatomy and immunology changes.Keywords: Probiotic, LPS, Escherichia coli, protection, immunologyABSTRAKLatar belakang: Infeksi gastrointestinal dengan manifestasi tersering diare merupakan salah satu infeksi yang sering terjadi pada anak. Pencegahan diare memerlukan keseimbangan sistem imun mukosa yang baik. Penggunaan probiotik untuk pencegahan terhadap infeksi gastrointestinal perlu dipikirkan. Penelitian ini bertujuan untuk membuktikan proteksi probiotik pada ileum mencit yang terpajan lipopolisakarida (LPS) Escherichia coli O55:B5 secara anatomis dan imunologis.Metode: Uji eksperimental dengan menggunakan mencit Balb/c jantan berusia 10-12 minggu, berat badan 30-40g dan dirandomisasi menjadi kelompok perlakuan dan kelompok kontrol. Kelompok perlakuan mendapatkan mix probiotik selama 14 hari, hari ke-15 mendapatkan LPS Escherichia coli O55:B5 dan hari ke-16-21 kembali mendapatkan mix probiotik. Kelompok kontrol mendapatkan LPS Escherichia coli O55:B5 saja pada hari ke-15. Seluruh mencit dinekropsi pada hari ke-22. Pemeriksaan imunohistokimia untuk melihat ekspresi sel penghasil sitokin IL-2, IFN-, TNF-α, IL-4, IL-5, IL-6, IL-10 dan TGF-ß di jaringan ileum. Scanning microscope electron (SEM) untuk melihat struktur mukosa ileum. Analisis statistik yang digunakan adalah analisis multivariat.Hasil: Enam belas ekor mencit Balb/c terbagi menjadi dua kelompok, masing-masing 8 mencit. Pada kelompok probiotik-LPS didapatkan perbedaan bermakna dibandingkan dengan kelompok LPS pada jumlah penghasil sitokin IL-5 (p=0,022), IL-6 (p=0,050) dan jumlah sel penghasil sitokin TGF-β (p=0,036). Pada kelompok probiotik-LPS, dominasi respon Th1 tidak terlihat lagi dan menimbulkan dominasi Treg pada kelompok ini. Posisi Th1 dan Th2 masih dapat dipertahankan secara seimbang. Kerusakan struktur yang terjadi pada kelompok LPS tidak didapatkan pada kelompok Probiotik-LPS.Simpulan: Proteksi probiotik pada mukosa ileum yang terpajan LPS Escherichia coli terjadi secara anatomi dan imunologi.
MEDIA MEDIKA INDONESIANA
2012-12-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4267
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012; 80-85
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4267/3888
oai:ojs.ejournal.undip.ac.id:article/4284
2012-12-15T12:41:07Z
mmi:ART
Keadaan Sosio-Ekonomi dan Status Pb Darah Anak pada Pemajanan Pb Lingkungan
Sunoko, Henna Rya
Children blood lead level, housing condition, earning, education
The socio-economic factor and children blood lead level in environmental lead exposureBackground: Low level lead exposures usually are coming from various environmental sources including air, food and water. This has important implications with respect to its regulation. The socio-economic factors can also affect blood lead level in children. This study was aimed to examine the influence of housing condition, earning and education of children’ primary caregivers on children blood lead levels.Methods: The study involved 54 children aged 5-10-years, coming from Gebang Sari, Sekaran and Moro Demak. Cross-sectional design was adopted in this research. The collected data were analyzed using non parametric Wilcoxon signed rank test to determine the mean differences of lead among the locations. OR prevalence and frequencies as well as cross tabulation of blood lead level and housing condition, earning and education data were also analyzed.Results: There were significance differences amongst Gebang Sari, Sekaran and Moro Demak children blood lead levels (p<0.05). Gebang Sari ambient lead air was the highest compared to those of other two locations. Compared to Sekaran and Moro Demak, Gebang Sari was dominated by higher children’ primary caregivers earning and education levels. OR prevalence of >10 ppb lead cut-off for earning level was 2.332 (1.49, 3.65). OR prevalence of >10 ppb lead cut-off for education level was 2.092 (1.295, 3.382).Conclusions: Children blood lead levels were not only influenced by ambient air lead but also by housing condition, earning and education of their primary caregivers.Keywords: Children blood lead level, housing condition, earning, educationABSTRAKLatar belakang: Toksisitas akibat pemajanan Pb lingkungan pada dosis rendah dapat berasal dari berbagai sumber seperti udara, air dan makanan. Hal ini mempunyai implikasi penting terhadap regulasi. Faktor sosio-ekonomi juga berpengaruh terhadap kadar Pb darah anak. Penelitian ini ditujukan untuk mempelajari pengaruh kondisi rumah, tingkat pendapatan dan pendidikan dari orang tua atau wali anak terhadap kadar Pb darah anak.Metoda: Penelitian mengikutsertakan 54 anak, umur 5-10 tahun, berasal dari Gebang Sari, Sekaran dan Moro Demak. Penelitian didesain secara cross-sectional. Data dianalisis secara non-parametrik dengan Wilcoxon signed rank test untuk mengetahui rerata kadar Pb darah anak antar lokasi. OR prevalensi, frekuensi dan tabulasi silang antara kadar Pb darah dengan kondisi rumah, pendapatan dan pendidikan juga dianalisis.Hasil: Terdapat beda yang bermakna antara kadar Pb darah subjek di Gebang Sari dan Sekaran dengan Kadar Pb darah subjek di Moro Demak (p<0,05). Kadar Pb udara ambien Gebang Sari tertinggi dibanding kadar Pb udara di dua lokasi lainnya. Tingkat pendapatan dan pendidikan orang tua atau wali subjek penelitian Gebang Sari lebih tinggi dibanding Sekaran dan Moro Demak. OR prevalensi pada cut-off Pb >10 ppb untuk tingkat pendapatan adalah 2,332 (1,49, 3,65). OR prevalensi pada cut-off Pb >10 ppb untuk tingkat pendidikan adalah 2,092 (1,295, 3,382).Simpulan: Kadar Pb darah anak tidak hanya dipengaruhi oleh kadar Pb udara ambien tetapi juga dipengaruhi oleh kondisi rumah, tingkat pendapatan dan pendidikan orang tua atau wali.
MEDIA MEDIKA INDONESIANA
2012-12-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4284
MEDIA MEDIKA INDONESIANA; 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009; 202-212
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4284/3904
oai:ojs.ejournal.undip.ac.id:article/4573
2013-06-26T12:57:43Z
mmi:ART
Pengaruh Larutan Ekstrak Siwak (Salvadora persica) Terhadap Streptococcus mutans: Studi In Vitro dan In Vivo
Santoso, Oedijani
Wardani, Aini Pramoda
Kusumasari, Nila
Siwak extract solution, S. mutans, salivary pH
The influence of Siwak (Salvadora persica) extract solution on Streptococcus mutans, in vitro and in vivo studyBackground: Streptococcus mutans is the primary cause of dental caries. Siwak (Salvadora persica) may improve oral health with antibacterial effects and prevent decreasing of salivary pH. The aim of this research was to know the influence of siwak extract solution on the growth of S.mutans (in vitro) and salivary pH (in vivo).Method: I. Laboratory experimental with the post test only control group design using S.mutans as samples. The intervention groups were given siwak extract solution at various concentrations 3.1%, 6.2%, 12.5%, 25%, 50%, and 100%. The data was obtained by visually observing the growth of S.mutans colonies. Statistical test used the Kruskal-Wallis test followed by Mann-Whitney test. II. Clinical trial with the post test only control group design. 74 samples divided randomly into two groups they were control and test group. The test group rinse the mouth with 25% the siwak extract solution. Salivary pH was measured using Hanna digital pH meter with 0,1 sensitivity. The data analyzed by Shapiro-Wilk test continued by Mann-Whitney test.Result: I. Test group with concentrations of 50% and 100% were no visible growth of S.mutans, however another group still appeared the growth of S.mutans. Kruskal-Wallis test revealed a significant difference (p=0.003), Mann-Whitney test which also showed a significant difference (p=0.025). II. There was significant different on salivary pH at the test group compared to the control group (p<0.05).Conclusion: I. Siwak extract solution can inhibit the growth of S.mutans, concentration of 50% is the lowest concentration that effective to inhibit the growth of S. mutans. II. Giving the solution of siwak extract 25% can increase salivary pH significantly.Keywords: Siwak extract solution, S. mutans, salivary pH ABSTRAKLatar belakang: Streptococcus mutans merupakan penyebab utama karies. Siwak (Salvadora persica) mampu meningkatkan kesehatan mulut dengan efek antibakterial dan mencegah penurunan pH saliva. Tujuan penelitian untuk mengetahui pengaruh larutan ekstrak siwak terhadap pertumbuhan S.mutans (in vitro) dan pH saliva (in vivo).Metode: I. Eksperimental laboratorik rancangan the post test only control group design, S.mutans sebagai sampel. Perlakuan diberikan larutan ekstrak siwak konsentrasi 100%, 50%, 25%, 12,5%, 6,2%, dan 3,1%, penilaian pertumbuhan koloni S.mutans secara visual. Analisis data dengan uji Kruskal-Wallis dilanjutkan dengan uji Mann-Whitney. II. Uji klinis rancangan the post test only control group design. Sampel 74 orang, secara random dibagi dua kelompok kontrol dan perlakuan diberikan larutan ekstrak siwak 25% untuk kumur. pH saliva diukur dengan pH meter digital Hanna dengan sensitivitas 0,1. Analisis data dengan uji Shapiro- Wilk dilanjutkan dengan uji Mann-Whitney.Hasil: I. Kelompok perlakuan konsentrasi 50% dan 100% tidak tampak adanya pertumbuhan S. mutans, namun kelompok yang lain masih tampak adanya pertumbuhan S. mutans. Uji Kruskal-Wallis didapatkan perbedaan signifikan (p=0,003), uji Mann-Whitney juga didapatkan perbedaan signifikan (p=0,025). II. Terdapat perbedaan bermakna pada pH saliva antara kelompok perlakuan dibanding kontrol (p<0,05).Simpulan: I. Larutan ekstrak siwak dapat menghambat pertumbuhan S. mutans, konsentrasi 50% adalah konsentrasi terendah yang efektif menghambat pertumbuhan S. mutans. II. Kumur larutan ekstrak siwak 25% dapat meningkatkan pH saliva secara bermakna.
MEDIA MEDIKA INDONESIANA
2013-03-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://ejournal.undip.ac.id/index.php/mmi/article/view/4573
MEDIA MEDIKA INDONESIANA; 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012; 163-167
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/4573/4165
oai:ojs.ejournal.undip.ac.id:article/21825
2019-01-25T14:21:01Z
mmi:ART
Hipertensi pada Obesitas Masa Anak
Mexitalia, Mexitalia
Herumuryawan, M
Sakundarno, M
Subagio, Hertanto Wahyu
Soemantri, Agustinus
Obesity; hypertension; body mass index; children
Background: The prevalence of obesity in children increased rapidly in recent years. One of the comorbidity of obesity is the premature onset of cardiovascular risk factors such as hypertension. The objective of the study is to describe the relationship between obesity and the elevated of blood pressure in children.Method: The population for this cross-sectional study was students in one of the junior high school in Semarang with the mean age of 13.5 years. The anthropometric and blood pressure data were taken in 2006. BMI was measured with bioelectrical impedance analysis (BIA) Omron Karada Scan and classified based on International Obesity Task Force according to CDC 2000 graphs. The blood pressure was measured by using Omron Digital type SEM-1 and classified based on national high blood pressure education program (NHBPEP). Anova, Spearman correlation and chi-square test were performed to analyze the data.Result: Of 1.129 students (50.7% boys and 49.3% girls), 185 (16.4%) were overweight and 160 (14.2%) were obese. Hypertension was detected in 304 students (26.9%). There were significant correlation between systolic blood pressure with BMI (r=0.466) and diastolic blood pressure with BMI (r=0.337). The risk to hypertension in overweight was 2.8 times greater (OR=2.79; 95% CI 1.97-3.96 p<0.001) and in obesity was 6.6 times greater (OR=6.61; 95% CI 4.59-9.52 p0.001) than normoweight children. Chinese race has 1.4 times greater risk to have hypertension than native Indonesian children.Conclusion: Overweight and obeis children have greater risk for hypertension than normal children. AbstrakLatar belakang: Prevalensi obesitas pada anak meningkat pesat dalam beberapa tahun terakhir. Salah satu komorbiditas obesitas yang terjadi sejak dini adalah penyakit kardiovaskuler seperti hipertensi. Tujuan dari penelitian ini adalah mengetahui hubungan antara obesitas dengan peningkatan tekanan darah pada anak.Metode: Desain penelitian adalah belah lintang dengan populasi adalah siswa sebuah SLTP di kota Semarang dengan rerata umur 13,5 tahun. Pengambilan data antropometri dan tekanan darah dilakukan tahun 2006. Indeks massa tubuh (IMT) diukur Bioelectrical Impedance Analysis (BIA) Omron Karada Scan dan status gizi ditetapkan berdasarkan kriteria International Obesity Task Force dengan memakai grafik CDC 2000. Tekanan darah diukur dengan Omron Digital type SEM-1 dan ditetapkan berdasarkan klasifikasi National High Blood Pressure Education Program (NHBPEP), dinyatakan hipertensi bila tekanan darah >persentil ke-90. Data dianalisis dengan Anova, Spearman correlation dan chi-square. Hasil: Dari 1.129 siswa (50,7% laki-laki dan 49,3% perempuan), 185 (16.4% adalah gizi lebih dan 160 (14,2%) obesitas. Didapatkan 304 siswa (26,9%) dengan hipertensi. Terdapat korelasi signifikan antar IMT dengan tekanan darah sistolik (r=0,466) dan tekanan darah diastolik (r=0,337). Risiko untuk terjadi hipertensi meningkat 2,8 kali (OR=2,79; 95% CI 1,97-3,96 p<0,001) pada anak dengan gizi lebih dan 6,6 kali (OR=6,61; 95% CI 4,59-9,52 p0,001) pada anak dengan obesitas. Ras Tionghoa mempunyai risiko 1,4 kali lebih tinggi untuk terjadi hipertensi dibandingkan pribumi.
MEDIA MEDIKA INDONESIANA
2019-01-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21825
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010; 1-6
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21825/14581
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3244
2012-04-19T10:06:05Z
mmi:ART
Respons Histopatologik Karsinoma Serviks Uteri Setelah Pemberian Kemoradiasi
Iskandar, T Mirza
Mexitalia, Maria
Sarjadi, Sarjadi
Dharmana, Edi
Pramono, Noor
Cervical carcinoma, chemoradiation, histopahological response
ABSTRACTFactors associated with histopathologic responses of cervical cancer after chemoradiation therapyIntroduction: Cervical carcinoma is the second most common women cancer in the world. A combined of surgical, radiation and chemotherapy is the main cervical carcinoma treatment. The histopathological response is one performance to assess the result of the treatment. The purpose of the study is to analyze the factors of cervical cancer which contributes to the histopathological response after chemoradiation treatment.Methods: The design of the study was a case control, done at Dr. Kariadi Hospital Semarang in 2008. Patients with biopsy-proven cervical carcinoma were entered into the study. The variables of risk factors included the stage of the cancer by FIGO staging, the type and differentiation of the tumour, the anemia and the history of the transfusion and the immunotherapy by BCG vaccine. The histopathological response was assessed after the chemoradiation treatment. Chi-square was used to analyze the risk factors and logistic regression was used for the multivariate analysis.Results: Between April-August 2008, 77 patients finished the chemoradiation treatment. The type of the cancer was squamous cell carcinoma (71.4%) and the stage was III B (81.8%). The staging, type and differentiation of the tumor, and the history of transfusion did not contributes to the histopathological response. After adjustment of other factors, the contribution of anemia to poor histopathological response were 6.25 times (95% CI 1.12-34.90; p=0.037) higher than good histopahological response.Conclusion: Anemia is the risk factor of poor histopathological response of cervical carcinoma after chemoradiation therapy.Keywords: Cervical carcinoma, chemoradiation, histopahological responseABSTRAKPendahuluan: Karsinoma serviks uteri (KSU) merupakan kanker kedua terbanyak pada wanita di seluruh dunia. Sampai saat ini terapi pilihan utama KSU adalah operasi, radiasi dan kemoterapi. Salah satu penilaian keberhasilan terapi adalah dengan respon histopatologik. Tujuan penelitian ini adalah menilai faktor-faktor yang berperan terhadap respons histopatologik setelah terapi kemoradiasi.Metode: Desain penelitian adalah kasus kontrol. Penelitian dilakukan di RSUP Dr. Kariadi Semarang. Kriteria inklusi adalah KSU yang telah menyelesaikan kemoradiasi. Faktor-faktor yang dinilai berperan terhadap respons histopatologi adalah tipe histologis dan diferensiasi tumor, stadium tumor berdasarkan FIGO, anemia dan riwayat transfusi serta pemberian imunoterapi dengan BCG. Analisis statistik menggunakan kai-kuadrat dan regresi logistik.Hasil: Selama periode April-Agustus 2008 terdapat 77 penderita yang menyelesaikan kemoradiasi. Sebagian besar penderita berada pada stadium IIIB (71,4%) dan mempunyai tipe histologi karsinoma sel skuamosa (81,8%). Stadium tumor, tipe histologi dan diferensiasi tumor, riwayat transfusi serta imunoterapi BCG tidak berperan pada respons histopatologik. Setelah memperhitungkan faktor perancu, risiko anemia terhadap respons histopatologi yang jelek adalah 6,25 kali (95% CI 1,12-34,90; p=0,037).Simpulan: Anemia merupakan faktor risiko terjadinya respon histopatologik yang jelek pada penderita karsinoma serviks uterisetelah mendapatkan terapi kemoradiasi.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3244
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 3 Year 2011; 174-180
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3244/2915
oai:ojs.ejournal.undip.ac.id:article/21902
2019-01-29T12:32:27Z
mmi:ART
Kejadian Pasung di Jawa Tengah
Fitrikasari, Alifiati
Stocks; stocks deprivation; schizophrenia
Shackelled/stocked psychiatric cases in Central JavaBackground: Stocks deprivation to person with mental disorder is against human rights, but is stll commonly practiced in developing countries including Indonesia. There is not yet a study on this issue in Central Java. The study aimed to describe the characteristic of stocks deprivation subjects, socio cultural condition of the community.Method: A qualitative ethnographic study with a cross sectional design was carried in Kabupaten Pati, Pekalongan, Jepara, Rembang, Salatiga and Blora. In depth interview was done by a psychiatrist using unstructured questenaire. Result of the interview are presented in a descriptive and narrative explaination.Results: Twenty seven stocks deprivation cases were found, consisted of 21 males and 6 females and most of them were diagnosed as schizophrenics, but some families to consider the subject because of ill spirit. Reasons prevent the deprivation of the subjects berserk, lost or become public scorn around, especially young children. All of them were from economically deprived families. Duration of deprivation was between 8 months to 28 years. Ways of deprivation was mostly chained or tied and put away from main house. As the initiator of most stocks are families on the grounds as family and community efforts in maintaining social order (for not disturbing the environment) within the limitation of economics and education.Conclusion: Stocks deprivation is mainly an ignorancy economic and cultural issues with ignorancy on mental health management being worsened by poverty as the main factor. Solution and prevention on this issue should be a mental health promotion at primary health care service level.ABSTRAKLatar belakang: Pemasungan terhadap orang yang mengidap gangguan kejiwaan merupakan tindakan yang bertentangan dengan HAM, tetapi masih umum ditemukan di negara berkembang, termasuk di Indonesia. Belum ada penelitian mengenai masalah ini di Jawa Tengah. Studi bertujuan untuk mengetahui karakteristik subyek pasung dan memahami budaya pasung yang hidup dalam masyarakat dan untuk menemukan solusi terhadap praktek pemasungan.Metode: Dilaksanakan studi kualitatif etnografi dengan pendekatan belah lintang, di kabupaten Pati, Pekalongan, Jepara, Rembang, Salatiga dan Blora. Data diperoleh dengan interview mendalam dan di analisis secara diskriptif naratif.Hasil: Didapatkan 27 kasus pasung, terdiri dari 21 pria dan 6 wanita, dan hampir semua terdiagnosis sebagai skizofrenia, tetapi sebagian keluarga menganggap sakit subyek karena kesambet makhluk halus. Alasan pemasungan mencegah subyek mengamuk, hilang, menjadi cemooh masyarakat sekitar terutama anak-anak kecil. Seluruh subyek penelitian berasal dari masyarakat miskin. Masa pemasungan berkisar antara 8 bulan sampai 28 tahun. Metode pasung terbanyak dengan diikat tali maupun rantai dan ditempatkan di ruang yang terpisah dengan rumah utama. Sebagai inisiator pasung terbanyak adalah keluarga dengan alasan sebagai upaya masyarakat dan keluarga dalam menjaga tertib sosial (tidak mengganggu lingkungan) dalam keterbatasan ekonomi (kemiskinan) dan pendidikan.Simpulan: Pasung merupakan masalah ketidaktahuan, dan ekonomi budaya masyarakat di mana faktor yang paling berpengaruh adalah ketidaktahuan masyarakat tentang penanganan gangguan jiwa yang diperberat oleh faktor ekonomi yang kurang. Pemecahan atau pencegahannya memerlukan pendekatan program promosi kesehatan jiwa di tingkat pelayanan kesehatan primer.
MEDIA MEDIKA INDONESIANA
2010-12-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/21902
MEDIA MEDIKA INDONESIANA; 2010:MMI VOLUME 44 ISSUE 3 YEAR 2010; 101-106
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/21902/14638
Copyright (c) 2019 MEDIA MEDIKA INDONESIANA
oai:ojs.ejournal.undip.ac.id:article/3022
2012-04-05T12:09:09Z
mmi:ART
Ekstrak Bawang Putih (Allium sativum) dan Ekspresi Insulin serta Derajat Insulitis Pankreas Tikus Sprague-Dawley yang Diinduksi Streptozotocin
Dewi, Meira
Wijaya, Indra
Wijayahadi, Noor
Allium sativum, streptozotocin, insulin expression, level of insulitis
ABSTRACTAllium sativum, insulin expression and insulitis degree of pancreas Sprague-Dawley rat induced by streptozotocinBackground: The organic-sulphur content in Allium sativum has been scientifically proven to be a potent insulin-mimetic, antioxidant, and anti-inflammation agent by inhibiting the activity of NF-κβ. This research is aimed at finding out the effect of Allium sativum extract towards insulitis level and insulin expression in pancreas of Sprague-Dawley male rats.Method: This research used a randomized post test only controlled group design. There were 28 rats, two were randomly selected for the initial blood glucose test prior to treatment, two were selected on the tenth day after streptozotocin induction to ensure that all rats were in hyperglycaemia condition, and the remains as many as 24 rats were grouped into four groups: three treatmentgroups were administered with Allium sativum in levelled doses of 0.1, 0.25, 0.5 grams/kgBW/day for 14 days, and one group were act as control negative. Kruskall Wallis test continued with Mann Whitney test were used, with significance level of p<0.05.Results: The insulitis level and insulin expression of rats’ pancreas in the three treatment groups showed significant difference compared with the group without treatment showing dose-dependent result. However, it was not able to completely restore the damage pancreas.Conclusion: Allium sativum extract may play important role in restoring damage pancreas.Keywords: Allium sativum, streptozotocin, insulin expression, level of insulitisABSTRAKLatar belakang: Kandungan organosulfur pada Allium sativum secara ilmiah memiliki berbagai potensi sebagai agen insulinomimetic, antioksidan dan antiinflamasi dengan menghambat aktivitas NF-κß. Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak Allium sativum terhadap derajat insulitis dan ekspresi insulin pankreas tikus Sprague-Dawley jantan.Metode: Penelitian ini menggunakan desain randomized post test only controlled group. Hewan coba sebanyak 28 ekor tikus, dua ekor tikus diambil acak sebelum perlakuan untuk diperiksa gula darah awal, dua ekor setelah hari ke sepuluh induksi streptozotocin untuk memastikan tikus sudah dalam keadaan hiperglikemia dan sisanya dua puluh empat ekor tikus, dibagi dalam empat kelompok: tiga kelompok perlakuan diberi ekstrak Allium sativum dosis bertingkat 0,1, 0,25, 0,50 g/kgBB/hari selama 14 hari, dan satu kelompok sebagai kontrol negatif. Digunakan uji non parametrik Kruskal Wallis dilanjutkan Mann Whitney dengan taraf kemaknaan p<0,05.Hasil: Derajat insulitis dan ekspresi insulin pankreas tikus pada ketiga kelompok perlakuan menunjukkan perbedaan bermakna dibandingkan dengan kelompok yang tidak mendapat perlakuan dan bersifat dose – dependent, namun belum dapat mengembalikan pulau Langerhan kembali ke keadaan normal.Simpulan: Ekstrak Allium sativum berpeluang memperbaiki pankreas yang rusak.
MEDIA MEDIKA INDONESIANA
2012-04-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://ejournal.undip.ac.id/index.php/mmi/article/view/3022
MEDIA MEDIKA INDONESIANA; 2011:MMI Volume 45 Issue 2 Year 2011; 105-112
0126-1762
eng
https://ejournal.undip.ac.id/index.php/mmi/article/view/3022/2705