Potential of Glutathione Antioxidant in the Hippocampus Repair: Preliminary Study on Bioactive Materials Antiaging of Snakehead Fish (Channa striata) in Animal Models of Aging

Sunarno Sunarno


DOI: https://doi.org/10.12777/ijse.8.1.22-25

Abstract


Snakehead fish meat contains active ingredients with anti-aging potential that serves as a precursor of glutathione. The ability of glutathione as an antiaging opportunities in the utilization of fish meat, especially snakehead fish. Snakehead fish meat contains several important amino acids, such as glutamine, cysteine​​, and glycine so the potential to be developed for the production of food that is nutritious and healthy. This study examines the essential amino acid composition of the antioxidant glutathione precursors found in snakehead fish from Rawa Pening Central Java to increase glutathione in the body and brain. The results showed that every 100g of snakehead fish meat from Rawa Pening containing glutamine (32.39%), cysteine ​​(6.61%), and glycine (9.69%). Snakehead fish meat extract given at a dose of 30 ml/kg/day in both types of animal models of aging effect on the increase in the content of glutathione and glutathione precursors, both in blood and hippocampus. Increased glutathione precursor of the most high to low, respectively glutamine, glycine, and cysteine​​. Availability of essential amino acids can support increased glutathione in the brain. This is indicated by an increase in glutathione hippocampus in both animal models, both on chronological aging or aging due to oxidative stress, respectively (0.822 and 0.359) mol/g bb compared to control tissue.

Keywords


glutathione; glutamine; glusine; cysteine; hippocampus; snakehead fish meat

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References


Daren KH, Dhaliwalm R, Andrew DRD, Drover J, Cote H, Wischmeyer P. 2007. Optimizing the dose of glutamine dipeptides and antioxidants in critically III patients: a phase I dose-finding study. J Parent Ent Nut 31(2):109-118.

Feoli AM, Siqueira IR, Almeida L, Tramontina AC, Vanzella C, Sbaraini S, Schweigert ID, Netto CA, Perry ML. 2010. Effects of protein malnutrition on oxidative status in rat brain. Nutrition 22:160-165.

Fernandes V, Rogero MM, Tirapegui J. 2010. Effects of supplementation with free glutamine and the peptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise. Cell Biochem Funct 28:24-30.

Reddy PH. 2009. Amyloid beta, mitochondrial structural, and functional dynamics in Alzheimer’s disease. Exp Neurol 218:286–292.

Sunarno. 2009. Peran glutation sebagai antioksidan dalam menghambat neurodegenerasi dan penuaan otak: Tinjauan khusus interaksi metabolik antara astrosit dan neuron dalam pertahanan terhadap reactive oxygen species (ROS). J. Sains Med 1(2): 185-210.

Sunarno, Manalu W, Kusumorini N, Ratih DA. 2013. Perbaikan respons seluler pada penuaan hipokampus yang diperantarai glutation hasil pemberian alanin-glutamin dipeptida. J. Vet 14(1): 61-71.

Wang H, Jia G, Huang L, Wu C, Wang K. 2010. Study on the absorption and transport of different glutamine dipeptides in small intestine of weaned piglets. J Anim Plant Sci 7(1):751-759.




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