THE ACUTE TOXICITY AND BONE-MERROW MICRONUCLEUS TESTS OF WATER EXTRACT FROM Avicennia marina FRUITS IN MICE

Gao Xiu-mei, Han Wei-Dong, Yu Zen-ji


Abstract


The acute toxicity and mutagenesis of water extract from Avicennia marina fruits in mice were studied
with the oral acute toxicity test according to Karber’s method and the bone-marrow micronucleus test
for mutagenic observation.The results showed the water extract from A. marina fruits presented theacute
per oral toxicity at LD50 >10.000 mg/kg; the bone-marrow nicrobucleus test indicated no mutagenic
effects. Water extract from A.Marina fruits belong to non toxic compounds and has no mutagenic effects
under the experimental conditions.

Keywords


Water extract from Avicennia marina fruits; Acute toxicity test; bone-marrow micronucleus test; mutagenesis

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