JOURNAL OF COASTAL DEVELOPMENT
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ANTIBACTERIAL ACTIVITIES OF BACTERIAL SYMBIONTS OF SOFT CORAL Sinularia sp. AGAINST TUBERCULOSIS BACTERIA
Abstract
Tuberculosis (TB) is caused by Mycobacterium tuberculosis. Although TB is a curable disease, it continues to
be one of the most important infectious causes of death worldwide. Indonesia ranks 3rd on the list of TB high
burden countries in the world with 86,000 cases deaths and the Multi Drug Resistant Tuberculosis (MDR TB)
estimated cases in Indonesia is 10,000. This research was aimed to isolate and characterize of soft coral
Sinularia sp.-associated bacteria having antibacterial activity against Tuberculosis bacteria. There were
109 isolates collected from Sinularia sp. Two isolates from Sinularia sp.-associated bacteria, SC4TGZ3 and
SC4TGZ4 were successfully screened for antibacterial against Tuberculosis bacteria. SC4TGZ3 was found to
inhibit the growth of MDR TB strain HE, MDR TB strain SR and H37Rv. Whereas, SC4TGZ4 was found to
inhibit the growth of MDR TB strain HE. Based on PCR amplification 16S rDNA softcoral bacateria were
identified as follows: SC4TGZ3 was closely related to Pseudovibrio sp. and SC4TGZ4 was closely related to
Alpha proteobacterium sp.
be one of the most important infectious causes of death worldwide. Indonesia ranks 3rd on the list of TB high
burden countries in the world with 86,000 cases deaths and the Multi Drug Resistant Tuberculosis (MDR TB)
estimated cases in Indonesia is 10,000. This research was aimed to isolate and characterize of soft coral
Sinularia sp.-associated bacteria having antibacterial activity against Tuberculosis bacteria. There were
109 isolates collected from Sinularia sp. Two isolates from Sinularia sp.-associated bacteria, SC4TGZ3 and
SC4TGZ4 were successfully screened for antibacterial against Tuberculosis bacteria. SC4TGZ3 was found to
inhibit the growth of MDR TB strain HE, MDR TB strain SR and H37Rv. Whereas, SC4TGZ4 was found to
inhibit the growth of MDR TB strain HE. Based on PCR amplification 16S rDNA softcoral bacateria were
identified as follows: SC4TGZ3 was closely related to Pseudovibrio sp. and SC4TGZ4 was closely related to
Alpha proteobacterium sp.
Keywords
Mycobacterium tuberculosis; Sinularia sp.; MDR-TB; Antibacterial activities; associated bacteria
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