1Fakultas Ilmu Kesehatan, Universitas Esa Unggul, Indonesia
2Bagian Parasitologi, Fakultas Kedokteran, Universitas Diponegoro, Indonesia
3Bagian Patologi Klinik, Fakultas Kedokteran, Universitas Diponegoro, Indonesia
BibTex Citation Data :
@article{JGI16590, author = {Anugrah Novianti and Edi Dharmana and Nyoman Widyastiti}, title = {Melatonin menurunkan berat badan tetapi tidak menurunkan kadar TNF-α pada tikus wistar jantan yang diberi minyak jelantah selama 28 hari}, journal = {Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition)}, volume = {5}, number = {2}, year = {2017}, keywords = {non-alcoholic fatty liver, waste cooking oil, melatonin, TNF-α levels}, abstract = { Backgound: Non Alcoholic Fatty Liver Disease (NAFLD) occurs when the intake and free fatty acid synthesis occurs more frequently than its oxidation and resecretion in the blood. Melatonin is a powerful antioxidant that can boost the synthesis of endogenous antioxidants in the body, suppress the inflammatory response and inhibit the formation of steatosis. Objective: To analyze the effect of melatonin supplementation in reducing body weight andTNF-α levels in male Wistar rats were fed by waste cooking oil. Methods: True experimental studyusing post-test only control group design. This study was done on 18 male wistar rats were divided into 3 groups : the positive control group (P 0 ) was administrated waste cooking oil, the treated group 1 (P 1 ) was administrated waste cooking oil and 5mg/kgBW melatonin, and the treated group 2 (P 2 ) was administrated waste cooking oil and 10mg/kgBW melatonin for 28 days.Data analysis using One Way ANOVA test and followed by Tukey test to determine the most effective dose of melatonin. Results: There was significant difference in body weightbetween P 2 group and K 0 group (p=0,019) with the mean body weight difference was 19,167g lower than K 0 group. There was no difference in TNF-α levels between the three groups (p=0,155). Conclusion: Melatonin dose of 10mg/kgBWloses body weight male Wistar rats have given by waste cooking oil for 28 days, but does not reduce TNF-α levels. }, issn = {2338-3119}, pages = {127--132} doi = {10.14710/jgi.5.2.127-132}, url = {https://ejournal.undip.ac.id/index.php/jgi/article/view/16590} }
Refworks Citation Data :
Backgound: Non Alcoholic Fatty Liver Disease (NAFLD) occurs when the intake and free fatty acid synthesis occurs more frequently than its oxidation and resecretion in the blood. Melatonin is a powerful antioxidant that can boost the synthesis of endogenous antioxidants in the body, suppress the inflammatory response and inhibit the formation of steatosis.
Objective: To analyze the effect of melatonin supplementation in reducing body weight andTNF-α levels in male Wistar rats were fed by waste cooking oil.
Methods: True experimental studyusing post-test only control group design. This study was done on 18 male wistar rats were divided into 3 groups : the positive control group (P0) was administrated waste cooking oil, the treated group 1 (P1) was administrated waste cooking oil and 5mg/kgBW melatonin, and the treated group 2 (P2) was administrated waste cooking oil and 10mg/kgBW melatonin for 28 days.Data analysis using One Way ANOVA test and followed by Tukey test to determine the most effective dose of melatonin.
Results: There was significant difference in body weightbetween P2group and K0 group (p=0,019) with the mean body weight difference was 19,167g lower than K0 group. There was no difference in TNF-α levels between the three groups (p=0,155).
Conclusion: Melatonin dose of 10mg/kgBWloses body weight male Wistar rats have given by waste cooking oil for 28 days, but does not reduce TNF-α levels.
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Last update: 2024-11-20 01:14:36
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