Effects of high-protein high-fiber meal replacements on weight loss and dietary composition in overweight women: A randomized controlled trial

Esti Nurwanti; Harry Freitag Luglio Muhammad; Ngan Thi Kim Nguyen; Naufal Muharam Nurdin

doi:10.14710/jgi.14.1.102-110

DOI: https://doi.org/10.14710/jgi.14.1.102-110

Effects of high-protein high-fiber meal replacements on weight loss and dietary composition in overweight women: A randomized controlled trial

Esti Nurwanti^{1, 2}, Harry Freitag Luglio Muhammad^{3, 4}, Ngan Thi Kim Nguyen⁵, Naufal Muharam Nurdin^{6, 7}

¹Gizi Nusantara Research Center, PT. Inovasi Gizi Nusantara, Jakarta Barat, DKI Jakarta, Indonesia , Indonesia

²Department of Nutrition, Faculty of Health, Universitas Aisyah Pringsewu, Pringsewu, Lampung, Indonesia

³Gizi Nusantara Research Center, PT. Inovasi Gizi Nusantara, Jakarta, Indonesia, Indonesia

⁴ Department of Nutrition, Universitas Dhyana Pura, Badung, Bali, Indonesia

⁵ Programs of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei, Taiwan

⁶ Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, West Java, Indonesia

⁷ Faculty of Medicine, IPB University, Bogor, West Java, Indonesia

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Received: 21 Oct 2025; Revised: 28 Nov 2025; Accepted: 2 Dec 2025; Available online: 30 Dec 2025; Published: 30 Dec 2025.

BibTex Citation Data :

@article{JGI78507,
    author = {Esti Nurwanti and Harry Muhammad and Ngan Nguyen and Naufal Nurdin},
    title = {Effects of high-protein high-fiber meal replacements on weight loss and dietary composition in overweight women: A randomized controlled trial},
    journal = {Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition)},
  volume = {14},
    number = {1},
    year = {2025},
    keywords = {Diet; meal replacement; obesity; weight loss},
    abstract = {   ABSTRACT      Background : Energy deficit is essential for weight loss; however, an effective weight loss program should also focus on improving dietary composition.   Objective:  This study aims to evaluate the effects of high-protein, high-fiber dietary supplements on weight loss and body composition improvements in overweight individuals.   Methods : This experimental study utilized a randomized controlled trial (RCT) design. Participants were women and were randomly assigned to either a control group or an intervention group. Criteria of this study are: Female aged 20-30 years; Body Mass Index (BMI) between 25 and 30 kg/m²; No allergies, including soy allergies; Fasting blood glucose level (FBG) < 100 mg/dL. The control group received 2 sessions of nutritional counselling by nutritionists to follow a low-calorie diet, while the intervention group received the same counselling along with a daily meal replacement containing 184 kcal energy, 17 grams of protein and 5 grams of dietary fiber.   Results : After an 8-week weight loss program, participants in the intervention group experienced significantly greater weight loss (-3.4 ± 0.43 kg) compared to the control group (-2.4 ± 0.5 kg) ( p = 0.047 ). Additionally, a higher proportion of participants in the intervention group (62%) achieved the 5% weight loss threshold compared to the control group (28%) (Chi-Square  p = 0.033 ). The intervention group also showed improvements in macronutrient composition compared to control, with a greater reduction in fat intake (-7.1 vs 2.1,  p = 0.013 ) and increased consumption of protein (5.9 vs 1.8,  p = 0.002 ) and fiber (7.21 vs 4.26,  p = 0.026 ).   Conclusion : The use of high-protein, high-fiber meal replacements was associated with improvement of weight loss compared to standard low-calorie diet counselling alone.   Keywords : Diet; meal replacement; obesity; weight loss  },
   issn = {2338-3119},   pages = {102--110}  doi = {10.14710/jgi.14.1.102-110},
    url = {https://ejournal.undip.ac.id/index.php/jgi/article/view/78507}
}

Citation Format:

Abstract

ABSTRACT

Background: Energy deficit is essential for weight loss; however, an effective weight loss program should also focus on improving dietary composition.

Objective: This study aims to evaluate the effects of high-protein, high-fiber dietary supplements on weight loss and body composition improvements in overweight individuals.

Methods: This experimental study utilized a randomized controlled trial (RCT) design. Participants were women and were randomly assigned to either a control group or an intervention group. Criteria of this study are: Female aged 20-30 years; Body Mass Index (BMI) between 25 and 30 kg/m²; No allergies, including soy allergies; Fasting blood glucose level (FBG) < 100 mg/dL. The control group received 2 sessions of nutritional counselling by nutritionists to follow a low-calorie diet, while the intervention group received the same counselling along with a daily meal replacement containing 184 kcal energy, 17 grams of protein and 5 grams of dietary fiber.

Results: After an 8-week weight loss program, participants in the intervention group experienced significantly greater weight loss (-3.4 ± 0.43 kg) compared to the control group (-2.4 ± 0.5 kg) (p = 0.047). Additionally, a higher proportion of participants in the intervention group (62%) achieved the 5% weight loss threshold compared to the control group (28%) (Chi-Square p = 0.033). The intervention group also showed improvements in macronutrient composition compared to control, with a greater reduction in fat intake (-7.1 vs 2.1, p = 0.013) and increased consumption of protein (5.9 vs 1.8, p = 0.002) and fiber (7.21 vs 4.26, p = 0.026).

Conclusion: The use of high-protein, high-fiber meal replacements was associated with improvement of weight loss compared to standard low-calorie diet counselling alone.

Keywords: Diet; meal replacement; obesity; weight loss

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