DOI: https://doi.org/10.14710/jab.v%25vi%25i.20880

Melanocortin-4 Receptor (MC4R) gene polymorphism and its effect on growth traits in Madura cattle

P. W. Prihandini  -  Faculty of Animal Science, Universitas Gadjah Mada, Indonesia
S. Sumadi  -  Faculty of Animal Science, Universitas Gadjah Mada, Indonesia
G. Suparta  -  Faculty of Animal Science, Universitas Gadjah Mada, Indonesia
*D. Maharani  -  Faculty of Animal Science, Universitas Gadjah Mada, Indonesia
Open Access Copyright (c) 2019 Journal of the Indonesian Tropical Animal Agriculture

Citation Format:
Abstract

Melanocortin-4 receptor (MC4R) gene has an important role in the regulation of feed intake and energy balance control. The objective of this study was to identify the single nucleotide polymorphisms (SNPs) of MC4R gene and their association with growth traits in Madura cattle. A total of 198 calves were used in this study.Forward primer: 5’-GTCGGGCGTCTTGTTCATC-3’and reverse primer: 5’-GCTTGTGTTTAGCATCGCGT-3’ were used to amplify approximately 493 bp of MC4R gene. The results showed that two SNPs, g.1133C>G and g.1108C>T were identified by direct sequencing. The PCR-RFLP method was performed to genotype all individuals studied based on SNP g.1133C>G, and its SNP was significantly associated with shoulder height (SH) at yearling age (P<0.05). Animals with GG genotype had a higher SH (110.35±6.40cm) than those with CC (102.00±8.00 cm) and CG genotype (105.96±6.23 cm). The SNP g.1133 C>G changed amino acid from valine to leucine. In conclusion, the SNP g.1133C>G of the MC4R gene may be used as a marker-assisted selection for SH trait in Madura cattle.


Fulltext View|Download
Keywords: melanocortin 4 receptor gene; single nucleotide polymorphisms; growth trait; and Madura cattle

Article Metrics:

Article Info
Section: Articles
Language : EN
Recent articles
Cross-sectional survey on environmental pollution surrounding poultry production cluster area Modeling for determining the superiority of Holstein bulls as frozen semen producer and genetic source for milk production In vitro rumen fermentability kinetics of parboiled rice bran Front-matter (March 2019) Back-matter (March 2019) More recent articles
Most cited articles
CORN SUBSTITUTION USING FERMENTED SOLID CASSAVA-WASTE ON BROILER CHICKEN RUMINAL FERMENTATION AND BLOOD GLUCOSE AT LOW AND HIGH LEVEL INTAKE OF GROWING AND MATURE KACANG GOAT Correlations between age of Bali bull and semen production at National Artificial Insemination Center, Singosari - Indonesia SOME FACTORS AFFECTING INTENSIVE REARING ADOPTION ON BEEF CATTLE FARMERS IN WAJO REGENCY, SOUTH SULAWESI PROVINCE PRE-SLAUGHTER STRESS ESTIMATION BY FOURIER TRANSFORM INFRARED SPECTROSCOPY ANALYSIS More cited articles

Last update:

  1. Assessment of the association of the MOGAT1 and MOGAT3 gene with growth traits in different growth stages in Holstein calves

    Gökhan Gökçe, Mervan Bayraktar. Archives Animal Breeding, 65 (3), 2022. doi: 10.5194/aab-65-301-2022

  2. Candidacy of genes associated with economic traits for Madura cattle in Sonok area

    T Nugroho, D Maharani, T S M Widi. IOP Conference Series: Earth and Environmental Science, 1001 (1), 2022. doi: 10.1088/1755-1315/1001/1/012018

  3. The association of SNP g.880A/G with body weight in F1 cross Dorper x Garut sheep

    A P Z N L Sari, I R Athifa, Panjono, R Hidayat, Y G Noor, D Maharani. IOP Conference Series: Earth and Environmental Science, 888 (1), 2021. doi: 10.1088/1755-1315/888/1/012002

Last update: 2024-11-19 11:44:04

  1. Polymorphism of MC4R gene associated with feed intake, nutrient digestibility, ADG and FCR at post-weaning in Bligon goats

    Latifah L.. Journal of the Indonesian Tropical Animal Agriculture, 45 (3), 2020. doi: 10.14710/jitaa.45.3.173-180