Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds

S. Anwar; S. D. Volkandari; A. S. Wulandari; W. P. B. Putra; E. Sophian; S. Said

doi:10.14710/jitaa.45.1.7-14

DOI: https://doi.org/10.14710/jitaa.45.1.7-14

Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds

*S. Anwar

- Research Center for Biotechnology-Indonesian Institute of Sciences (LIPI), Indonesia

S. D. Volkandari - Research Center for Biotechnology-Indonesian Institute of Sciences (LIPI), Indonesia

A. S. Wulandari - Research Center for Biotechnology-Indonesian Institute of Sciences (LIPI), Indonesia

W. P. B. Putra - Research Center for Biotechnology-Indonesian Institute of Sciences (LIPI), Indonesia

E. Sophian - Research Center for Biotechnology-Indonesian Institute of Sciences (LIPI), Indonesia

S. Said - Research Center for Biotechnology-Indonesian Institute of Sciences (LIPI), Indonesia

How to cite (IEEE): S. Anwar, S. D. Volkandari, A. S. Wulandari, W. P. B. Putra, E. Sophian, and S. Said, "Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds," Journal of the Indonesian Tropical Animal Agriculture, vol. 45, no. 1, pp. 7-14, May. 2020. https://doi.org/10.14710/jitaa.45.1.7-14

How to cite (APA): Anwar, S., Volkandari, S. D., Wulandari, A. S., Putra, W. P. B., Sophian, E., & Said, S. (2020). Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds. Journal of the Indonesian Tropical Animal Agriculture, 45(1), 7-14. https://doi.org/10.14710/jitaa.45.1.7-14

How to cite (BCREC): Anwar, S., Volkandari, S. D., Wulandari, A. S., Putra, W. P. B., Sophian, E., Said, S. (2020). Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds. Journal of the Indonesian Tropical Animal Agriculture, 45 (1), 7-14 (doi:10.14710/jitaa.45.1.7-14)

How to cite (Chicago): Anwar, S., S. D. Volkandari, A. S. Wulandari, W. P. B. Putra, E. Sophian, and S. Said. "Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds." Journal of the Indonesian Tropical Animal Agriculture 45, no. 1 (2020): 7-14. Accessed March 8, 2025. https://doi.org/10.14710/jitaa.45.1.7-14

How to cite (Vancouver): Anwar S, Volkandari SD, Wulandari AS, Putra WPB, Sophian E, Said S. Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds. Journal of the Indonesian Tropical Animal Agriculture [Online]. 2020 May;45(1):7-14. https://doi.org/10.14710/jitaa.45.1.7-14.

How to cite (Harvard): Anwar, S., Volkandari, S. D., Wulandari, A. S., Putra, W. P. B., Sophian, E., and Said, S., 2020. Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds. Journal of the Indonesian Tropical Animal Agriculture, [Online] Volume 45(1), pp. 7-14. https://doi.org/10.14710/jitaa.45.1.7-14 [Accessed 8 Mar. 2025].

How to cite (MLA8): Anwar, S., S. D. Volkandari, A. S. Wulandari, W. P. B. Putra, E. Sophian, and S. Said. "Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds." Journal of the Indonesian Tropical Animal Agriculture, vol. 45, no. 1, 26 May. 2020, pp. 7-14 , https://doi.org/10.14710/jitaa.45.1.7-14. Accessed 8 Mar. 2025.

BibTex Citation Data :

@article{JITAA25747,
    author = {S. Anwar and S. D. Volkandari and A. S. Wulandari and W. P. B. Putra and E. Sophian and S. Said},
    title = {Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds},
    journal = {Journal of the Indonesian Tropical Animal Agriculture},
  volume = {45},
    number = {1},
    year = {2020},
    keywords = {F94L mutation; MSTN gene; gene polymorphism; PCR-RFLP; local cattle},
    abstract = {       The F94L mutation of the            MSTN            gene (           MSTN           -F94L) is considered not to cause disrupted the function of the            myostatin            gene drastically. Interestingly, this mutation has a very significant effect on muscle mass, carcass, or meat yield and meat quality without any associated severe negative problems. This study aimed to confirm the            MSTN           -F94L mutation in four local cattle breeds in Indonesia. A total of 518 individuals (140 of Bali, 107 of Sumbawa, 168 of Pasundan, and 103 of Holstein-Friesian (H-F) cattle) were used in this study. Genotype identification was performed by PCR-RFLP method. In the present study showed that the wild-type C allele was fixed (1.000) in Bali, Sumbawa, and HF cattle. However, the wild-type C allele and the mutant A allele were found in Pasundan cattle, even though the frequency of the mutant A allele was very low (0.012). Therefore, in conclusion, the mutation of the            MSTN           -F94L was detected in Pasundan cattle but no in all three cattle breeds. However, the presence of the mutant A allele in Pasundan cattle allegedly derived from Limousin bulls. The further investigation in other local and exotic breeds and its crossing will answer the status of the            MSTN           -F94L mutation in local cattle breeds in Indonesia.       },
   issn = {2460-6278},   pages = {7--14}  doi = {10.14710/jitaa.45.1.7-14},
    url = {https://ejournal.undip.ac.id/index.php/jitaa/article/view/25747}
}

Refworks Citation Data :

@article{{JITAA}{25747}, author = {Anwar, S., Volkandari, S., Wulandari, A., Putra, W., Sophian, E., Said, S.}, title = {Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds}, journal = {Journal of the Indonesian Tropical Animal Agriculture}, volume = {45}, number = {1}, year = {2020}, doi = {10.14710/jitaa.45.1.7-14}, url = {https://ejournal.undip.ac.id/index.php/jitaa/article/view/25747} }

Citation Format:

Abstract

The F94L mutation of the MSTN gene (MSTN-F94L) is considered not to cause disrupted the function of the myostatin gene drastically. Interestingly, this mutation has a very significant effect on muscle mass, carcass, or meat yield and meat quality without any associated severe negative problems. This study aimed to confirm the MSTN-F94L mutation in four local cattle breeds in Indonesia. A total of 518 individuals (140 of Bali, 107 of Sumbawa, 168 of Pasundan, and 103 of Holstein-Friesian (H-F) cattle) were used in this study. Genotype identification was performed by PCR-RFLP method. In the present study showed that the wild-type C allele was fixed (1.000) in Bali, Sumbawa, and HF cattle. However, the wild-type C allele and the mutant A allele were found in Pasundan cattle, even though the frequency of the mutant A allele was very low (0.012). Therefore, in conclusion, the mutation of the MSTN-F94L was detected in Pasundan cattle but no in all three cattle breeds. However, the presence of the mutant A allele in Pasundan cattle allegedly derived from Limousin bulls. The further investigation in other local and exotic breeds and its crossing will answer the status of the MSTN-F94L mutation in local cattle breeds in Indonesia.

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Keywords: F94L mutation; MSTN gene; gene polymorphism; PCR-RFLP; local cattle

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Detection of F94L mutation of the MSTN gene in four Indonesian local cattle breeds

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