DOI: https://doi.org/10.14710/jgi.7.2.92-98

Kebiasaan konsumsi kopi teratur dan pengaruhnya terhadap resorpsi tulang: C-telopeptida dan kalsium serum pada olahragawan

1Bagian Fisiologi, Fakultas Kedokteran, Universitas Syiah Kuala, Indonesia

2Bagian Bedah/sub devisi Orthopaedic dan Traumatology, Fakultas Kedokteran, Universitas Syiah Kuala, Indonesia

Received: 4 Mar 2019; Published: 14 Jun 2019.

Citation Format:
Abstract

Background: Coffee is believed and predicted as one of the risk factors for osteoporosis in sedentary and athletes. Long term regular consumption of coffee can lead to hypocalcemia, increase bone resorption and risk of osteoporosis.

Objectives: The aim of the study was to analyze the effect of regular coffee consumption on bone resorption, thus predicting the risk of osteoporosis in athletes. The assessment risk of osteoporosis was done by measuring the biomarkers of bone resorption, namely: C-telopeptide (CTx) and serum calcium levels.

Methods: The design of this study was a cross-sectional study. The subjects were athletes with regular exercise (aerobic exercise 2 times a week, for 50-60 minutes each training session). The total of samples were 50 people (male = 37; non-coffee=21 and coffee=16 and female=13; non-coffee=7 and coffee=6). Non-coffee is a group that does not consume coffee. Coffee drinkers are a group who regularly consume coffee daily at a dose of 1-2 cups per day (150-200 ml / cup). Coffee consumption habits were obtained from questionnaire interviews. The sampling technique was a total sampling. Examination of serum CTx levels was carried out by the Electro Chemiluminescence Assay method and serum calcium levels were examined using the O-cresolphthalein complexone method. Data were analyzed using the normality test (Kolmogorov-Smirnov), homogeneity (Levene's test) and independent sample t-test, with a significant degree of 95% (p<0.05).

Results: The results showed that there was no difference between CTx in male and also female non-coffee (0.415 ng/mL vs. 0.586 ng/mL; p=0.09) and coffee drinkers (0.380 ng/mL vs. 0.512 ng/mL; p=0.35). The normal CTx level is 0.016-0.584 ng/mL. Calcium levels in male (9.70 mg/dL vs. 9.30 mg/dL; p=0.61) and female (9.28 mg/dL vs. 9.23 mg/dL; p=0.72) non-coffee and coffee drinkers were not significantly different. The normal Calcium levels is 9.2-11.0 mg/dL.

Conclusion: Regular consumption of coffee does not cause increased CTx and decreased calcium in athletes. Coffee does not cause increased bone resorption, triggers hypocalcemia, therefore regular coffee consumption in physiological doses (1-2 cups/day) is not at risk for early osteoporosis in young athletes.

Note: This article has supplementary file(s).

Fulltext View|Download |  Research Instrument
Untitled
Subject
Type Research Instrument
  Download (752KB)    Indexing metadata
Keywords: coffee;C-telopeptida; calcium; osteoporosis; athletes

Article Metrics:

Article Info
Section: Articles
Language : EN
Recent articles
Estimasi potensi kerugian ekonomi akibat wasting pada balita di indonesia Status antioksidan dan oksidatif laki-laki yang mengalami kegemukan dengan pemberian minuman rosela ungu Riwayat paparan pestisida dan kekurangan asupan zat gizi sebagai faktor risiko kejadian anemia pada ibu hamil di daerah pertanian More recent articles
Most cited articles
Pengaruh pendidikan gizi terhadap pengetahuan, praktik gizi seimbang dan status gizi pada anak sekolah dasar Faktor risiko stunting pada anak umur 6-24 bulan di kecamatan Penanggalan kota Subulussalam provinsi Aceh Determinan kejadian stunting pada bayi usia 6 bulan di Kota Semarang Front Matter Pengetahuan ibu, pola makan dan status gizi pada anak stunting usia 1-5 tahun di Kelurahan Bangetayu, Kecamatan Genuk, Semarang More cited articles
  1. Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. Eur J Rheumatol. 2017;4:46-56
  2. Kementerian Kesehatan RI. Data & kondisi penyakit osteoporosis di Indonesia. Kementrian Kesehatan RI : Jakarta. 2015. hal. 1-8
  3. Alshanbari MF, Alsofyani EM, Almalki DM, Alswat Abdullah K. Caffeine effect on bone mineral density: a cross-sectional study. J Clin Diagnostic Res. 2018;12(2):10-13
  4. Garnero P. The utility of biomarkers in osteoporosis management. Mol Diagn Ther. 2017:1-18
  5. Szulc P, Naylor K, Hoyle NR, Eastell R, Leary ET. Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability. Osteoporos Int. 2017;28:2541-2556
  6. Eastell R, Szulc P. Series Osteoporosis 2: Use of bone turnover markers in postmenopausal osteoporosis. LANCET Diabetes Endocrinol. 2017;8587(17):1-16
  7. Szulc P, Umr I. Bone turnover: Biology and assessment tools. Best Pract Res Clin Endocrinol Metab. 2018;32(5):725-738
  8. Cornelis MC. The Impact of caffeine and coffee on human health. Nutrients. 2019;11(416):11-14
  9. Bae J, Park J, Im S, Song D. Coffee and health. Integr Med Res. 2014;3:189-191
  10. Li Q, Liu Y, Sun X, et al. Caffeinated and decaffeinated coffee consumption and risk of all-cause mortality: a dose – response meta-analysis of cohort studies. J Hum Nutr Diet. 2019;(2):1-9
  11. Yoshihara T, Zaitsu M, Shiraishi F, Arima H. Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure , pulse rate , and calculation speed after caffeine intake: A prospective , double blind , randomized trial in healthy volunteers. J Pharmacol Sci. 2019;139(3):209-214
  12. Safitri EY, Fitranti DY. Hubungan asupan kafein dengan kalsium urin pada laki-laki dewasa awal. Journal of Nutrition College. 2015;4(2):457-462
  13. Heaney RP. Effects of caffeine on bone and the calcium economy. Food Chem Toxicol. 2002;40:1263-1270
  14. Macedo RM, Brentegani LG, Lacerda SA De. Effects of coffee intake and intraperitoneal caffeine on bone repair process - a histologic and histometric study. Braz Dent J. 2015;26(2):175-180
  15. Lacerda SA, Matuoka RI, Macedo RM, Petenusci SO, Campos AA, Brentegani LG. Bone quality associated with daily intake of coffee: a biochemical ,radiographic and histometric study. Braz Dent J. 2010;21(3):199-204
  16. Yusni Y, Rahman S. Effects of regular coffee consumption on serum C-terminal telopeptides type I collagen (CTx) and calcium levels in female young adults. J Food Nutr Res. 2019;7(3):201-204
  17. Ooi FK, Sahrir NA. Physical Activity , Bone remodelling and bone metabolism markers. J Exerc Sport Orthop. 2018;5(2):1-4
  18. Wilson DJ. Osteoporosis and sport. Eur J Radiol. 2019;110(August):169-174
  19. Macknight JM. Os teopenia and osteoporosis in female athletes. Clin Sports Med. 2017;36(4):687-702
  20. Pentyala S, Mysore P, Pentyala S, et al. Osteoporosis in female athletes. Int J Clin Ther Diagnosis. 2013;1(1):5-11
  21. Yusni, Amiruddin. Pemenuhan kebutuhan kalsium dan besi atlet sepakbola Junior Banda Aceh. J Sport Pedagog. 2015;5(2):1-4
  22. Nichols JF, Rauh MJ, Lawson MJ, Ji M, Barkai H. Prevalence of the female athlete triad syndrome among high school athletes. Arch Pediatr Adolesc Med. 2006;160(Feb):137-142
  23. Tofalo R, Sant M, Te A. Coffee: health effects. Encycl Food Heal. 2016:237-243
  24. Cortés A, Casadó-anguera V, Moreno E, Casadó V. Caffeine , adenosine A 1 receptors , and brain cortex. molecular aspects. Elsevier; 2016 (3):741-752
  25. Chubb SAP. Measurement of C-terminal telopeptide of type I collagen (CTX) in serum. Clin Biochem. 2012;45(12):928-935
  26. Michelsen J, Wallaschofski H, Friedrich N, et al. Reference intervals for serum concentrations of three bone turnover markers for men and women. Bone. 2013;57(2):399-404
  27. Gray J. Caffeine, coffee and health. Nutr Food Sci. 1998;(6):314-319
  28. Choi M. Moderate intake of caffeine has no effect on bone health in growing male rats. Curr Top Nutraceutical Res. 2011;9(3):77-82
  29. Kim SY. Coffee consumption and risk of osteoporosis. Korean J Fam Med. 2014;35(1):4082
  30. Lopez-garcia E, Guallar-castillon P, Leon-muñoz L, Graciani A, Rodriguez-artalejo F. Coffee consumption and health-related quality of life. Clin Nutr. 2013;33(1):143-9

Last update:

No citation recorded.

Last update: 2024-11-24 20:01:38

No citation recorded.