skip to main content

Catfish Oil (Pangasius hypophthalmus) effect to ferritin and sTfR in iron deficiency anemia

1Department of Nutrition Science, Medical Faculty, Diponegoro University, Indonesia

2Department of Fisheries, Faculty of Fisheries and Marine Sciences, Diponegoro University, Indonesia

3Division Nutrition and Metabolic Disease, Dr. Kariadi Hospital, Indonesia

4 Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Indonesia

View all affiliations
Received: 9 Mar 2021; Published: 22 Dec 2021.

Citation Format:
Abstract

Background: Iron deficiency anemia is a micronutrient problem and the prevalence is still high. Catfish oil (Pangasius hypophthalmus) is a natural source of heme iron which can improve body iron levels.


Objectives: This study was aimed to examine and analyze the effect of catfish oil on ferritin and sTfR levels in male wistar rats with iron deficiency anemia models.


Materials and Methods: This study was conducted on male wistar rats which were divided into groups C- (standard feed), C+ (standard feed but had the iron removed), X1 (standard feed without iron but was supplemented with catfish oil), X2 (standard feed without iron but was supplemented with ferrous sulfate) for 14 days. Ferritin and sTfR levels were measured before and after intervention using ELISA.


Results: The study showed an increase ferritin levels in X1 (21.87 ng/ml ±0.76), X2 (24.47 ng/ml ±0.54) and there was no significant difference between the two (p=0.069; p>0.05); a decrease in C- (0.25 ng/ml ±0.43), C+ (0.32 ng/ml ±0.059) (p=0.00; p<0.05). The sTfR levels decreased before and after intervention (p=0.00; p<0.05) in C+ (0.24 μ/mL ±0.99), X1 (60.66 μ/mL ±0.29), X2 (62.10 μ/mL ±0.90) and increased in C- (0.40 μ/mL ±0.97).


Conclusions: The study indicates ferritin levels increased in the rats receiving catfish oil is not different from the rats that received ferrous sulfate and sTfR levels decreased significantly in wistar rats with iron deficiency anemia receiving catfish oil although the results were not as good as ferrous sulfate supplementation

Note: This article has supplementary file(s).

Fulltext View|Download |  common.other
Ethical Clearance
Subject
Type Other
  View (770KB)    Indexing metadata
 common.other
Surat Pernyataan Keaslian dan Persetujuan Peulis
Subject Surat Pernyataan Keaslian
Type Other
  Download (111KB)    Indexing metadata
Keywords: Catfish oil (Pangasius hypophthalmus); Ferritin; Iron Deficiency Anemia; sTfR

Article Metrics:

  1. Burke RM, Leon JS, Suchdev PS. Identification, prevention and treatment of iron deficiency during the first 1000 days. Nutrients. 2014;6(10):4093–114
  2. World Health Organization. Serum transferrin receptor levels for the assessment of iron status and iron deficiency in populations. WHO Vitam Miner Nutr Inf Syst [Internet]. 2014;4–7. Available from: http://apps.who.int/iris/bitstream/10665/133707/1/WHO_NMH_NHD_EPG_14.6_eng.pdf?ua=1
  3. Goddard AF, James MW, McIntyre AS, Scott BB. Guidelines for the management of iron deficiency anaemia. Gut. 2011;60(10):1309–16
  4. Falkingham M, Abdelhamid A, Curtis P, Fairweather-Tait S, Dye L, Hooper L. The effects of oral iron supplementation on cognition in older children and adults: A systematic review and meta-analysis. Nutr J. 2010;9(1):1–16
  5. Badan Penelitian dan Pengembangan Kesehatan. Riset Kesehatan Dasar (RISKESDAS 2013). Jakarta: Kementerian Kesehatan RI; 2013
  6. Janus J, Moerschel SK. Evaluation of anemia in children. Am Fam Physician. 2010;81(12):1463–71
  7. Athe R, Rao MVV, Nair KM. Impact of iron-fortified foods on Hb concentration in children (<10 years): A systematic review and meta-analysis of randomized controlled trials. Public Health Nutr. 2014;17(3):579–86
  8. Short MW, Domagalski JE. Iron deficiency anemia: Evaluation and management. Am Fam Physician. 2013;87(2):98–104
  9. Marks PW. Evaluation of anemia in children and adults. Nonmalignant Hematol Expert Clin Rev Quest Answers. 2016;3–12
  10. Kementerian RI. Tabel Komposisi Pangan Indonesia. Jakarta: Kementerian Kesehatan RI; 2018. 1–135 p
  11. Jairoun AA, Shahwan M, Zyoud S. Fish oil supplements, oxidatives status, and compliance behaviour: Regulatory challenges and opportunities. PLoS One. 2020;15(12):1–12
  12. Dewi IS, Hastuti US, Lestari U, Suwono H. The effects of kinds of lumus and the storage period on the quality of patin Wadi based on the results of nutrient tests. AIP Conf Proc [Internet]. 2017;1844(May):1–8. Available from: https://doi.org/10.1063/1.4983430
  13. Hastarini E, Fardiaz D. Karakteristik Minyak Ikan Dari Limbah Pengolahan Filet Ikan Patin. Agritech. 2012;32(4):403–10
  14. Estiasih T. Minyak Ikan: Teknologi dan Penerapannya untuk Pangan dan Kesehatan. Jakarta: Graha Ilmu; 2009
  15. Swastawati F, Al-Baarri AN, Agustini TW, Dewi EN, Wijayanti I, Prasetyo DYB, et al. Crude Cathepsin Activity and Quality Characteristic of Smoked Catfish (Pangasius pangasius) Processed by Different Smoking. J Teknol dan Ind Pangan. 2016;
  16. Suseno SH, Nurjanah, Jacoeb AM, Saraswati. Purification of Sardinella sp., oil: Centrifugation and bentonite adsorbent. Adv J Food Sci Technol. 2014;6(1):60–7
  17. World Health Organization. General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine. Geneva World Heal Ornganization. 2000;
  18. Saito H. Metabolism of Iron Stores. Nagoya J Med. 2014;76:235–54
  19. Lyden F. Handling Methods of Laboratory Mice and Rats. Vol. 657, Saint Louis University Biology Department. Swedish; 2016
  20. Amril AR, Irdoni, Nirwana. Sintesis Bio-Pelumas dari Minyak Limbah Ikan Patin dengan Pengaruh Kecepatan Pengadukan dan Suhu Reaksi. Jom F Tek. 2016;3(1):1–6
  21. Astuti R, Subagyo HW, Muis SF. Serum Transferrin Receptors of Iron Deficiency Anemic Rats That Feeding Tempe Fortification Combination Iron and Vitamin A. Proceeding International Seminar Education Technology. 2016;293–9
  22. Sari, R.N., Utomo, B.S.B, Basmal, J., & Hastarini E. Refining of Pangasius Oil from Fish Smoking By-products. JPB Kelaut dan Perikan. 2016;11(2):171–82
  23. Wheal MS, Decourcy-Ireland E, Bogard JR, Thilsted SH, Stangoulis JCR. Measurement of haem and total iron in fish, shrimp and prawn using ICP-MS: Implications for dietary iron intake calculations. Food Chem. 2016;201:222–9
  24. Wang FR, Xie Z-G, Ye X-Q, Deng S-G, Hu Y-Q, Xin G, et al. Effectiveness of Treatment of Iron Deficiency Anemia in Rats with Squid Ink Melanin-Fe. R Soc Chem. 2014;5:123–8
  25. Skolmowska D, Głąbska D. Analysis of heme and non-heme iron intake and iron dietary sources in adolescent menstruating females in a national Polish sample. Nutrients. 2019;11(5):1–21
  26. Timmer TC, de Groot R, Rijnhart JJM, Lakerveld J, Brug J, Perenboom CWM, et al. Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors: Results from Donor InSight. Haematologica. 2020;105(10):2400–6
  27. Young I, Parker HM, Rangan A, Prvan T, Cook RL, Donges CE, et al. Association between haem and non-haem iron intake and serum Ferritin in healthy young women. Nutrients. 2018;10(1):1–13
  28. Gropper S., Smith JL, Groff JL. Advanced Nutrition and Human Metabolisme. 5th ed. Wadsworth Cengange Learning; 2009
  29. Milman NT. Dietary iron intake in women of reproductive age in Europe: A review of 49 studies from 29 countries in the period 1993-2015. J Nutr Metab. 2019;2019:1–14
  30. Carrier J, Aghdassi E, Cullen J, Allard JP. Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis. J Nutr. 2002;132(10):3146–50
  31. Werner T, Wagner SJ, Martínez I, Walter J, Chang JS, Clavel T, et al. Depletion of luminal iron alters the gut microbiota and prevents Crohn’s disease-like ileitis. Gut. 2011;60(3):325–33
  32. Al-Alimi AA, Bashanfer S, Morish MA. Prevalence of Iron Deficiency Anemia among University Students in Hodeida Province, Yemen. Anemia. 2018;2018
  33. Roos N, Thorseng H, Chamnan C, Larsen T, Gondolf UH, Bukhave K, et al. Iron content in common Cambodian fish species: Perspectives for dietary iron intake in poor, rural households. Food Chem. 2007;104(3):1226–35

Last update:

No citation recorded.

Last update: 2024-05-19 09:30:36

No citation recorded.