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Effect of formaldehyde-based additive against African swine fever virus in complete swine feed

V. D. Ly orcid  -  Department of Biochemistry and Immunology, National Institute of Veterinary Research (NIVR), Viet Nam
T. V. Hoang orcid  -  Department of Biochemistry and Immunology, National Institute of Veterinary Research (NIVR), Viet Nam
A. K. Dang orcid  -  Department of Biochemistry and Immunology, National Institute of Veterinary Research (NIVR), Viet Nam
*S. Aupanun orcid  -  Department of Research and Development, LINQ Technology Corporation, Thailand
C. Wongpukdee  -  Department of Research and Development, LINQ Technology Corporation, Thailand
Open Access Copyright (c) 2022 Journal of the Indonesian Tropical Animal Agriculture
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Abstract
African swine fever (ASF) is currently considered the serious contagious disease of the swine in-dustry worldwide. The feed and feed ingredients have been recognized as a potential risk factor for Af-rican swine fever virus (ASFV) transmission. No commercial vaccines and effective drugs against ASFV are available to date. This study aimed to examine the antimicrobial SALTEC™ 512, a formal-dehyde-based additive, at an application rate of 1.0; 2.0; and 3.0 kg/t feed against ASFV in complete swine feed. The effect of SALTEC™ 512 was evaluated by a contaminated ASFV feed assay. Our study reveals that SALTEC™ 512 inactivated ASF/VN/Pig/Hue/1270 strain in complete swine feed at an inclusion rate of 1.0 kg/t feed on Day 1 post inoculation. The most effective action was noticed at an inclusion level of 3.0 kg/t feed on Day 7 post inoculation. The antiviral activity of SALTEC™ 512 against ASF/VN/Pig/Hue/1270 was dose and time-dependent. Overall, SALTEC™ 512 may be a po-tential additive to reduce the risk of ASFV transmission via feed contamination.

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Keywords: African swine fever virus; Feed; Formaldehyde-based additive; SALTEC™ 512

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