Pajanan Personal PM2.5 dan Perubahan Biokimia Darah pada Petugas Penyapu Jalan

*Doni Hikmat Ramdhan scopus  -  Departemen Keselamatan dan Kesehatan Kerja Fakultas Kesehatan Masyarakat Universitas Indonesia, Jakarta, Indonesia
Nurul Fajriyah  -  Departemen Keselamatan dan Kesehatan Kerja Fakultas Kesehatan Masyarakat Universitas Indonesia, Jakarta, Indonesia
Astri Yuniarti  -  Departemen Keselamatan dan Kesehatan Kerja Fakultas Kesehatan Masyarakat Universitas Indonesia, Jakarta, Indonesia
Received: 17 Dec 2019; Revised: 7 May 2020; Accepted: 8 May 2020; Published: 1 Oct 2020; Available online: 13 Aug 2020.
DOI: https://doi.org/10.14710/jkli.19.2.89-94 View
Copyright Transfer Agreement
Subject
Type CTA
  Download (16KB)    Indexing metadata
Open Access Copyright 2020 Jurnal Kesehatan Lingkungan Indonesia
License URL: http://creativecommons.org/licenses/by-sa/4.0

Citation Format:
Abstract

Latar belakang: Pajanan partikulatjalan raya akibat hasil pembakaran bahan bakar kendaraan dapat menyebabkan gangguan kesehatan yang dimulai dari perubahan kadar biokimia darah. Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan biokimia darah pada sampel terpajan partikulatdan tidak terpajan partikulat..

Metode: Penelitian ini bersifat deskriptif analitik dengan desain studi cross sectional. Populasi dalam penelitian ini adalah penyapu jalan raya yang bekerja membersihkan sampah dan kotoran di jalan raya. Melalui teknik purposive sampling didapatkan51 sampel yang diambil darahnya untuk diuji oleh laboratorium dan melihat kadar glukosa, insulin, hs-CRP, MDA dan TNF-α. Data dianalisis dengan uji t independen dan uji kai kuadrat.

Hasil: Hasil penelitian menunjukkan bahwa terdapat perbedaan kadar glukosa, insulin, MDA dan TNF-α pada kelompok terpajan partikulatdan kelompok tidak terpajan partikulat(p=0,025; p=0,001; p=0,006; p=0,039).  Namun, tidak terdapat perbedaan kadar hs-CRP pada kelompok terpajan partikulatdan kelompok tidak terpajan partikulat(p=0,169).

Simpulan: Disimpulkan bahwa pajanan partikulat halus atau ukuran diameter kurang 2.5 μm dapat berpengaruh terhadap kadar biokimia darah pada pekerja yang terpajan secara terus menerus, dilihat dari terdapat perbedaan pada glukosa, insulin, MDA dan TNF-α pada kedua kelompok sampel.

 

ABSTRACT

Title: PM2.5 Personal Exposure and Blood Biochemical Changes among Road Sweeper

Background: Highway particulate exposure due to the burning of vehicle fuel can cause health problems that begin with changes in blood biochemical levels. This study aims to determine whether there are differences in the biochemical blood samples exposed to PM2.5 and unexposed to PM2.5.

Methods: This study is a descriptive-analytic with a cross-sectional design study. The population is the road sweeper who works cleaning trash and dirt on the highway. Through a purposive sampling technique, 51 blood samples were taken to be tested by the laboratory and looked at glucose, insulin, hs-CRP, MDA and TNF-α levels. Data were analyzed by independent t-test and chi-square test.

Result: there were differences in the levels of glucose, insulin, MDA and TNF-α between exposed of PM2.5 and unexposed groups of PM2.5 (p = 0.025, p = 0.001, p = 0.006, p = 0.039). However, there was no difference in the levels of hs-CRP in the PM2.5 exposed group and the PM2.5 unexposed group (p = 0.169).

Conclusion: The conclusion was that exposure to fine particulate or PM2.5 can affect the blood biochemical level in workers who exposed continuously, seen from differences in glucose, insulin, MDA and TNF-α in both groups of samples.

Note: This article has supplementary file(s).

Keywords: glukosa; insulin; PM2.5; MDA; TNF-α

Article Metrics:

Article Info
Section: Research Articles
Language: ID
In Vol 19, No 2 (2020): Oktober 2020
Statistics: 404 235
Related articles
Kajian Sanitasi Lingkungan Pemukiman di Bantaran Sungai Musi Kota Palembang Penurunan Kadar Enzim Kolinesterase Tenaga Sprayer di Perkebunan Kelapa Sawit Pengaruh Kebisingan Terhadap Tekanan Darah dan Nadi pada Pekerja Pabrik Kayu PT. Muroco Jember Factors Associated with Cholinesterase Level of Spraying Workers Using Paraquat Herbicide at Oil Palm Plantation in East Kalimantan, Indonesia Penerapan UKS dengan PHBS di Wilayah Kerja Puskesmas Pancur Batu Kabupaten Deli Serdang Efektifitas Variasi Umpan Pada Fly Trap Dalam Pengendalian Kepadatan Lalat Di Tempat Pembuangan Sementara (TPS) Jalan Andong Yogyakarta
  1. Badan Pusat Statistik Provinsi DKI Jakarta. Statistik Daerah Provinsi DKI Jakarta 2019. Jakarta2019
  2. Ramdhan DH, Ito Y, Yanagiba Y, Yamagishi N, Hayashi Y, Li C, et al. Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormone. Toxicology letters. 2009;191(2-3):103-8
  3. Ramdhan DH. Penelitian Genom dan Implikasinya dalam Kesehatan Masyarakat di Indonesia. Kesmas: National Public Health Journal. 2014;9(1):1-5. doi: 10.21109/kesmas.v9i1.448
  4. Künzli N, Jerrett M, Garcia-Esteban R, Basagaña X, Beckermann B, Gilliland F, et al. Ambient air pollution and the progression of atherosclerosis in adults. PloS one. 2010;5(2):e9096
  5. Araujo JA. Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis. Air Quality, Atmosphere & Health. 2011;4(1):79-93. doi: 10.1007/s11869-010-0101-8
  6. Rice MB, Cavallari J, Fang S, Christiani D. Acute decrease in HDL cholesterol associated with exposure to welding fumes. Journal of occupational and environmental medicine/American College of Occupational and Environmental Medicine. 2011;53(1):17. doi: 10.1097/JOM.0b013e3182028d20
  7. Sun Q, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, et al. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation. 2009;119(4)
  8. Schneider A, Alexis NE, Diaz-Sanchez D, Neas LM, Harder S, Herbst MC, et al. Ambient PM2. 5 exposure up-regulates the expression of costimulatory receptors on circulating monocytes in diabetic individuals. Environmental health perspectives. 2010;119(6):778-83. doi: 10.1289/ehp.1002543
  9. Zhang Z, Chang L-y, Lau AK, Chan T-C, Chieh Chuang Y, Chan J, et al. Satellite-based estimates of long-term exposure to fine particulate matter are associated with C-reactive protein in 30 034 Taiwanese adults. International journal of epidemiology. 2017;46(4):1126-36. doi: 10.1093/ije/dyx069
  10. Wang G, Jiang R, Zhao Z, Song W. Effects of ozone and fine particulate matter (PM2. 5) on rat system inflammation and cardiac function. Toxicology letters. 2013;217(1):23-33. doi: 10.1016/j.toxlet.2012.11.009
  11. Ramdhan DH, Ahmad EF, Kurniasari F, Rizky ZP, Atmajaya H, Santoso M. Personal Exposure of Traffic Policeman to Particulate Matter in Jakarta: Distribution of Size, Chemical Composition, and Work Time. Kesmas: National Public Health Journal. 2019;14(2). doi: 10.21109/kesmas.v14i2.3165
  12. Liu Q, Gu X, Deng F, Mu L, Baccarelli AA, Guo X, et al. Ambient particulate air pollution and circulating C-reactive protein level: A systematic review and meta-analysis. International journal of hygiene and environmental health. 2019; 222(5):756-764. doi: 10.1016/j.ijheh.2019.05.005
  13. Zhang Y, Li T, Lin Z, Shi X, editors. Long-Term Exposure to Ambient PM2. 5 and Fasting Blood-Glucose in the Elder Cohort. ISEE Conference Abstracts; 2018
  14. Yuwono A, Setiawan B, Kania N, Widodo MA. Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes Melitus. Majalah Kedokteran Bandung. 2011;43(4):189-92. doi: 10.15395/mkb.v43n4.68
  15. Mendez R, Zheng Z, Fan Z, Rajagopalan S, Sun Q, Zhang K. Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue. American journal of translational research. 2013;5(2):224 -234
  16. Schneider A, Neas LM, Graff DW, Herbst MC, Cascio WE, Schmitt MT, et al. Association of cardiac and vascular changes with ambient PM 2.5 in diabetic individuals. Particle and fibre toxicology. 2010;7(1):14. doi: 10.1186/1743-8977-7-14
  17. Rodríguez-Colón SM, Li X, Shaffer ML, He F, Bixler EO, Vgontzas AN, et al. Insulin resistance and circadian rhythm of cardiac autonomic modulation. Cardiovascular diabetology. 2010;9(1):85
  18. Hertel S, Viehmann A, Moebus S, Mann K, Bröcker-Preuss M, Möhlenkamp S, et al. Influence of short-term exposure to ultrafine and fine particles on systemic inflammation. European journal of epidemiology. 2010;25(8):581-92. doi: 10.1007/s10654-010-9477-x
  19. Aydın A, Sipahi H, Charehsaz M. Nanoparticles toxicity and their routes of exposures. Recent Advances in Novel Drug Carrier Systems. 2012
  20. Gosal F, Waleleng BJ, Pandelaki K. TNF-a Level, HOMA-IR, and Non-Alcoholic Simple Steatohepatitis in Obese Senior High School Students. Journal of the Indonesian Medical Association. 2013;63(01)

Last update: 2021-03-03 06:48:01

No citation recorded.

Last update: 2021-03-03 06:48:02

No citation recorded.
Copyright 2020 Jurnal Kesehatan Lingkungan Indonesia
License URL: http://creativecommons.org/licenses/by-sa/4.0

The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Jurnal Kesehatan Lingkungan Indonesia (JKLI, p-ISSN: 1412-4939, e-ISSN:2502-7085) and Master Program of Environmental Health, Diponegoro University as the publisher of the journal. Copyright encompasses the rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms, and any other similar reproductions, as well as translations. 

JKLI journal and Master Program of Environmental Health, Diponegoro University, the Editors and the Advisory Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in the JKLI journal are the sole and exclusive responsibility of their respective authors and advertisers.

The Copyright Transfer Form can be downloaded here: [Copyright Transfer Form JKLI journal]
The copyright form should be signed originally and send to the Editorial Office in the form of original mail or scanned document to  jkli@live.undip.ac.id.