Program Studi Bioteknologi Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro, Indonesia
BibTex Citation Data :
@article{Bioma46815, author = {Ilham Wandi and Jonathan Samudra and Roiyan Nur Khoirul Umam and Rina Sari Asih and Mursyidatun Nafiah and Siti Nur Jannah and Rejeki Ferniah}, title = {Eksplorasi Senyawa Antiretroviral dari Biji Tanaman Calophyllum inophyllum L. sebagai Alternatif Obat AIDS secara In Silico}, journal = {Bioma : Berkala Ilmiah Biologi}, volume = {24}, number = {1}, year = {2022}, keywords = {Calophyllum inophyllum L., In Silico, Molecular Docking, Protein U Virus, Retroviruses}, abstract = { Retroviruses are a type of positive-sense RNA virus single-stranded with DNA intermediates and as obligate parasites that target host cells. The principle of DNA replication of retorvirus is not in a regular pattern but in an inverted pattern. Therefore, a study was conducted to find candidates for natural compounds from the seeds of the plant Calophyllum inophyllum L. and found that the most potential as a candidate for AIDS drugs was Calophyllolid. However, further research needs to be done and needs to be considered. This is because the binding affinity number is too small. Based on the Lipinski test, Calophyllolid does not meet all Lipinski's rules so that its use as a drug will be used by injection or other means than oral. In the toxicity test, Calophyllolid has the same value as the other 3 compounds, so a special test is needed to eliminate some of the possible carcinogenicity. }, issn = {2598-2370}, pages = {24--29} doi = {10.14710/bioma.24.1.24-29}, url = {https://ejournal.undip.ac.id/index.php/bioma/article/view/46815} }
Refworks Citation Data :
Retroviruses are a type of positive-sense RNA virus single-stranded with DNA intermediates and as obligate parasites that target host cells. The principle of DNA replication of retorvirus is not in a regular pattern but in an inverted pattern. Therefore, a study was conducted to find candidates for natural compounds from the seeds of the plant Calophyllum inophyllum L. and found that the most potential as a candidate for AIDS drugs was Calophyllolid. However, further research needs to be done and needs to be considered. This is because the binding affinity number is too small. Based on the Lipinski test, Calophyllolid does not meet all Lipinski's rules so that its use as a drug will be used by injection or other means than oral. In the toxicity test, Calophyllolid has the same value as the other 3 compounds, so a special test is needed to eliminate some of the possible carcinogenicity.
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