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Eksplorasi Senyawa Antiretroviral dari Biji Tanaman Calophyllum inophyllum L. sebagai Alternatif Obat AIDS secara In Silico

*Ilham Aris Wandi  -  Program Studi Bioteknologi Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro, Indonesia
Jonathan Alva Samudra  -  Program Studi Bioteknologi Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro, Indonesia
Roiyan Nur Khoirul Umam  -  Program Studi Bioteknologi Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro, Indonesia
Rina Sari Asih  -  Program Studi Bioteknologi Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro, Indonesia
Mursyidatun Nafiah  -  Program Studi Bioteknologi Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro, Indonesia
Siti Nur Jannah  -  Program Studi Bioteknologi Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro, Indonesia
Rejeki Siti Ferniah  -  Program Studi Bioteknologi Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro, Indonesia

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Abstract

Retroviruses are a type of positive-sense RNA virus single-stranded with DNA intermediates and as obligate parasites that target host cells. The principle of DNA replication of retorvirus is not in a regular pattern but in an inverted pattern. Therefore, a study was conducted to find candidates for natural compounds from the seeds of the plant Calophyllum inophyllum L. and found that the most potential as a candidate for AIDS drugs was Calophyllolid. However, further research needs to be done and needs to be considered. This is because the binding affinity number is too small. Based on the Lipinski test, Calophyllolid does not meet all Lipinski's rules so that its use as a drug will be used by injection or other means than oral. In the toxicity test, Calophyllolid has the same value as the other 3 compounds, so a special test is needed to eliminate some of the possible carcinogenicity.

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Keywords: Calophyllum inophyllum L., In Silico, Molecular Docking, Protein U Virus, Retroviruses

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Last update: 2024-03-19 12:11:41

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