1Jurusan Gizi, Fakultas Kedokteran, Universitas Sebelas Maret (UNS), Indonesia
2Fakultas Kedokteran, Universitas Diponegoro, Indonesia
BibTex Citation Data :
@article{JGI12329, author = {Kusmadewi Damayanti and Noor Wijayahadi and Niken Puruhita}, title = {Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum}, journal = {Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition)}, volume = {4}, number = {1}, year = {2016}, keywords = {Hepatoproteksi; klorofil; daun pepaya; AST serum; ALT serum}, abstract = { Background: Pharmacological therapy is one of the therapy modalities which carries the hepatic injury as one of its side effects. Nowadays, curcuma tablets has become choice of hepatoprotector. Other substance which has the possibilities of hepatoprotection activities is chlorophyll. The study is aimed to investigate the effect of papaya leaves chlorophyll extracts towards the serum AST and serum ALT levels on high-dose-paracetamol-induced Wistar rats. Materials and methods: This was an experimental study applying pretest-posttest controlled group design. Twenty eight Wistar rats 8-12 weeks age and weighted 185-220 grams assigned into four groups, namely group I (control), group II (paracetamol 750 mg/kg bw + no hepatoprotector agent), group III (paracetamol 750 mg/kg bw + curcuma 100 mg/kg bw), and group IV (paracetamol 750 mg/kg bw + papaya leaves chlorophyll extracts 300 mg/kg bw). The hepatoprotector agents were administered for a week, while the high dose paracetamol was administered for three consecutive days (day 5, 6, and 7). The pretest samples were drawn on the fifth day before the administration of high dose paracetamol, and the posttest samples were drawn on eightth day. Results: There were no difference among four groups on serum AST and serum ALT levels before the administration of high dose paracetamol, p=0.522 dan p=0.682, respectively. After the administration of high dose paracetamol, there were differences among four groups on both variables, both p=0.000. The post-hoc test showed that differences happened on all four groups (p<0.05). Conclusion: Chlorophyll extract of papaya leaves can inhibit liver injury on high-dose-paracetamol-induced-Wistar rats. }, issn = {2338-3119}, pages = {63--66} doi = {10.14710/jgi.4.1.63-66}, url = {https://ejournal.undip.ac.id/index.php/jgi/article/view/12329} }
Refworks Citation Data :
Background: Pharmacological therapy is one of the therapy modalities which carries the hepatic injury as one of its side effects. Nowadays, curcuma tablets has become choice of hepatoprotector. Other substance which has the possibilities of hepatoprotection activities is chlorophyll. The study is aimed to investigate the effect of papaya leaves chlorophyll extracts towards the serum AST and serum ALT levels on high-dose-paracetamol-induced Wistar rats.
Materials and methods: This was an experimental study applying pretest-posttest controlled group design. Twenty eight Wistar rats 8-12 weeks age and weighted 185-220 grams assigned into four groups, namely group I (control), group II (paracetamol 750 mg/kg bw + no hepatoprotector agent), group III (paracetamol 750 mg/kg bw + curcuma 100 mg/kg bw), and group IV (paracetamol 750 mg/kg bw + papaya leaves chlorophyll extracts 300 mg/kg bw). The hepatoprotector agents were administered for a week, while the high dose paracetamol was administered for three consecutive days (day 5, 6, and 7). The pretest samples were drawn on the fifth day before the administration of high dose paracetamol, and the posttest samples were drawn on eightth day.
Results: There were no difference among four groups on serum AST and serum ALT levels before the administration of high dose paracetamol, p=0.522 dan p=0.682, respectively. After the administration of high dose paracetamol, there were differences among four groups on both variables, both p=0.000. The post-hoc test showed that differences happened on all four groups (p<0.05).
Conclusion: Chlorophyll extract of papaya leaves can inhibit liver injury on high-dose-paracetamol-induced-Wistar rats.
Article Metrics:
Last update:
Studi Pengaruh Pemberian Tumis Daun Pepaya (Carica papaya L.) terhadap Produksi Asi dan Peningkatan Berat Badan Bayi
Pengaruh pemberian tumis daun pepaya (Carica papaya L.) terhadap produksi ASI dan peningkatan berat badan bayi
Last update: 2024-10-07 16:42:16
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) is published under licensed of a CC BY-SA Creative Commons Attribution-ShareAlike 4.0 International LicenseThe Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) and Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro as publisher of the journal.
Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc., will be allowed only with a written permission from Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition).
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition), Faculty of Medicine, Universitas Diponegoro, the Editors and the Advisory Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in the Indonesian Journal of Nutrition are sole and exclusive responsibility of their respective authors and advertisers.
View JGI Stats