Efektivitas ekstrak umbi sarang semut (myrmecodia pendens merr.& perry) sebagai penurun kadar glukosa darah tikus sprague dawley  yang diabetes mellitus

Maxianus Kopong Raya; Anang M. Legowo; Noor Wijayahadi

doi:10.14710/jgi.4.2.138-144

DOI: https://doi.org/10.14710/jgi.4.2.138-144

Efektivitas ekstrak umbi sarang semut (myrmecodia pendens merr.& perry) sebagai penurun kadar glukosa darah tikus sprague dawley yang diabetes mellitus

Maxianus Kopong Raya¹ , Anang M. Legowo², Noor Wijayahadi³

¹Program Studi Gizi, Poltekkes Kemenkes Jayapura, Indonesia

²Fakultas Peternakan dan Pertanian, Universitas Diponegoro, Indonesia

³Fakultas Kedokteran, Universitas Diponegoro, Indonesia

Published: 30 Jun 2016.

BibTex Citation Data :

@article{JGI16310,
    author = {Maxianus Raya and Anang Legowo and Noor Wijayahadi},
    title = {Efektivitas ekstrak umbi sarang semut (myrmecodia pendens merr.& perry) sebagai penurun kadar glukosa darah tikus sprague dawley  yang diabetes mellitus},
    journal = {Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition)},
  volume = {4},
    number = {2},
    year = {2016},
    keywords = {Diabetes mellitus, sarang semut stem, water extract, fasting blood glucose},
    abstract = {   Background :    Diabetes Mellitus (DM) is a disease associated with pancreatic β cell damage   and causes hyperglycemia     Antioxidants were effective in reducing the state of hyperglycemia that was triggered by free radicals. Sarang semut   contain  s flavonoids and tannins that act as antioxidants.     Objective :    The p  urpose       to analyze the effectiveness     of sarang semut   stem   extract as lowering blood glucose   on   diabetic white male Sprague Dawley rats  .      Method :    True experimental with 30 rats which   divided into five groups : negative control (DM  + water  ), positive control (DM+glibenklamid)   and 3 treatment groups of   DM     +   water extract of  sarang semut stem powder   90 mg/200g  BW,   180 mg/200g   BW and   360/200g   BW respectively  .   DM was induced by   65mg/kg  BW   Streptozotocin and 230 mg/kg  BW   Nicotinamide   intraperitonealy  .   E  xtract   was   given     by sonde.   The d  ata   was   analy  zed     by   Kruskall-Wallis and Mann-Whitney.        Results :    IC 50  value o  f    sarang semut   stem   extract   were   6,56-10,07 mg/ml in powder and 9,12-15,62 mg/ml whole. The average rats weight   alteration     on groups of negative control, positive control,  and 3 treatment groups of   DM     +   water extract of  sarang semut stem powder   90 mg/200g  BW,   180 mg/200g   BW and   360/200g   BW before and after treatment were -7,60± -0,40; 25,80±0,51; 16,40±0,44; 17,20±1,28 dan 19,20±0,06 gram respectively (ρ=0,001).   The average   fasting blood glucose level on groups of negative control, positive control,  and 3 treatment groups of   DM     +   water extract of  sarang semut stem powder   90 mg/200g  BW,   180 mg/200g   BW and   360/200g   BW before and after treatment were 3,33±2,42; -122,44±-0,51; -79,42±-11,38; -94,08±-11,97 and -134,66±-2,59 mg/dL respectively (ρ=0,001).          Conclusion :    T  he IC 50  value in sarang semut   stem     powder   was   higher than a whole   form  .   Dose   of   360 mg/200g BW   lowered blood glucose   better   than     90 and 180   /200g BW   dosage.    },
   issn = {2338-3119},   pages = {138--144}  doi = {10.14710/jgi.4.2.138-144},
    url = {https://ejournal.undip.ac.id/index.php/jgi/article/view/16310}
}

Citation Format:

Abstract

Background : Diabetes Mellitus (DM) is a disease associated with pancreatic β cell damage and causes hyperglycemia Antioxidants were effective in reducing the state of hyperglycemia that was triggered by free radicals. Sarang semut contains flavonoids and tannins that act as antioxidants.

Objective : The purpose to analyze the effectiveness of sarang semut stem extract as lowering blood glucose on diabetic white male Sprague Dawley rats.

Method : True experimental with 30 rats which divided into five groups : negative control (DM+ water), positive control (DM+glibenklamid) and 3 treatment groups of DM + water extract of sarang semut stem powder 90 mg/200gBW, 180 mg/200g BW and 360/200g BW respectively. DM was induced by 65mg/kgBW Streptozotocin and 230 mg/kgBW Nicotinamide intraperitonealy. Extract was given by sonde. The data was analyzed by Kruskall-Wallis and Mann-Whitney.

Results : IC₅₀ value of sarang semut stem extract were 6,56-10,07 mg/ml in powder and 9,12-15,62 mg/ml whole. The average rats weight alteration on groups of negative control, positive control, and 3 treatment groups of DM + water extract of sarang semut stem powder 90 mg/200gBW, 180 mg/200g BW and 360/200g BW before and after treatment were -7,60± -0,40; 25,80±0,51; 16,40±0,44; 17,20±1,28 dan 19,20±0,06 gram respectively (ρ=0,001). The average fasting blood glucose level on groups of negative control, positive control, and 3 treatment groups of DM + water extract of sarang semut stem powder 90 mg/200gBW, 180 mg/200g BW and 360/200g BW before and after treatment were 3,33±2,42; -122,44±-0,51; -79,42±-11,38; -94,08±-11,97 and -134,66±-2,59 mg/dL respectively (ρ=0,001).

Conclusion : The IC₅₀ value in sarang semut stem powder was higher than a whole form. Dose of 360 mg/200g BW lowered blood glucose better than 90 and 180 /200g BW dosage.

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Keywords: Diabetes mellitus, sarang semut stem, water extract, fasting blood glucose

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In Vol 4, No 2 (2016)

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