Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Indonesia
BibTex Citation Data :
@article{JGI42677, author = {Sherlin Jami and Siti Fatimah-Muis and Ahmad Syauqy and Kusmiyati Tjahjono and Gemala Anjani}, title = {Effect of Moringa (Moringa oleifera) Leaf Flour Supplementation on Total Antioxidant Content of Sprague Dawley Rat Serum Given High-Fat Diet}, journal = {Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition)}, volume = {10}, number = {2}, year = {2022}, keywords = {High Fat Diet; Moringa Oleifera leaves Flour; TAC}, abstract = { Background : Moringa oleifera leaf is high in quercetin which can be a source of exogenous antioxidants. Together with endogenous antioxidants, both the antioxidants will be able to counteract oxidative stress conditions. Objectives : To analyze the effect of Moringa leaves flour supplementation on Total Antioxidants Content (TAC) of Sprague Dawley (SD) rat serum given a high-fat diet (HFD). Materials and Methods : A randomized control group post-test design was used on 24 SD rats which were divided into 4 groups, namely healthy control (K 1 ), HFD (K 2 ), supplementation with Moringa leaf flour at a dose of 100 mg/100 g BW/day (K 3 ), and a dose of 200 mg/100 g BW/day (K 4 ). After 28 days of supplementation, serum TAC was analyzed using the ELISA method. Data analysis used Paired-T Test, One Way ANOVA, and Post-Hoc Bonferroni follow-up test. Results : The results showed that the TAC of groups K1, K2, K3, and K4 respectively were 4.806 ± 0.239, 1.323 ± 0.292, 4.020 ± 0.239, and 5.123 ± 0.695. There was a significant difference in serum TAC (p=0.000) between supplementation groups. Significant differences in serum TAC were also found in the supplementation group compared to the HFD control group. Conclusion : Moringa leaves flour supplementation for 28 days at a dose of 200 mg/100 g BW/day increases serum total antioxidant content higher than at a dose of 100 mg/100 g BW/day. }, issn = {2338-3119}, pages = {141--149} doi = {10.14710/jgi.10.2.141-149}, url = {https://ejournal.undip.ac.id/index.php/jgi/article/view/42677} }
Refworks Citation Data :
Background: Moringa oleifera leaf is high in quercetin which can be a source of exogenous antioxidants. Together with endogenous antioxidants, both the antioxidants will be able to counteract oxidative stress conditions.
Objectives: To analyze the effect of Moringa leaves flour supplementation on Total Antioxidants Content (TAC) of Sprague Dawley (SD) rat serum given a high-fat diet (HFD).
Materials and Methods: A randomized control group post-test design was used on 24 SD rats which were divided into 4 groups, namely healthy control (K1), HFD (K2), supplementation with Moringa leaf flour at a dose of 100 mg/100 g BW/day (K3), and a dose of 200 mg/100 g BW/day (K4). After 28 days of supplementation, serum TAC was analyzed using the ELISA method. Data analysis used Paired-T Test, One Way ANOVA, and Post-Hoc Bonferroni follow-up test.
Results: The results showed that the TAC of groups K1, K2, K3, and K4 respectively were 4.806 ± 0.239, 1.323 ± 0.292, 4.020 ± 0.239, and 5.123 ± 0.695. There was a significant difference in serum TAC (p=0.000) between supplementation groups. Significant differences in serum TAC were also found in the supplementation group compared to the HFD control group.
Conclusion: Moringa leaves flour supplementation for 28 days at a dose of 200 mg/100 g BW/day increases serum total antioxidant content higher than at a dose of 100 mg/100 g BW/day.
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