DOI: https://doi.org/10.14710/jgi.11.2.95-109

SMALL DENSE LOW-DENSITY LIPOPROTEIN CHOLESTEROL AND CENTRAL OBESITY ASSOCIATED WITH DIABETES MELLITUS AMONG INDONESIAN ADULTS

1Departement of Community Nutrition, IPB University, Indonesia

2Department of Community Nutrition, Faculty of Human Ecology, IPB University, Indonesia

Received: 27 Nov 2022; Published: 24 Jun 2023.

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Abstract

ABSTRACT

Background: Small dense low-density lipoprotein (sdLDL-C) is an atherogenic lipoprotein. Increased sdLDL-C concentration was hypothesized to be associated with obesity and diabetes mellitus (DM).

Objectives: The study aimed to determine the association between sdLDL-C, central obesity, and DM among Indonesian adults, controlled by personal and clinical parameters.

Materials and Methods: This study used secondary data from Basic Health Research 2013 of the Ministry of Health, which applied a cross-sectional study design. For this purpose, 30,548 subjects aged 19-79 were analyzed. The sdLDL-C was performed by using Sampson Formula derived from conventional lipid panels. As investigated by Sampson, the formula referred to cLDL-C (calculated LDL-C) and ElbLDL-C (estimated large buoyant LDL-C).

Results: There was a positive association between sdLDL-C and central obesity (OR: 3.94; 95% CI: 3.13-3.89), as well as sdLDL-C and DM status (OR: 1.98; 95% CI; 1.43-2.75) after adjusting the personal and clinical parameters.

Conclusion: This study demonstrated that the increment of sdLDL-C level and central obesity affected DM status in Indonesian adults. It implies that the sdLDL-C was a potential biomarker to assess the risk of DM.

Keywords: Central obesity, Diabetes mellitus, Hypertension, Indonesian adult, sdLDL-C


 

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Keywords: Central obesity, Diabetes mellitus, Hypertension, Indonesian adult, sdLDL-C

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