Difference of thrombocyte profile between obesity and central obesity in women

Melki Hadisasmitajaya; Meita Hendrianingtyas; Edward Kurnia Setiawan Limijadi

doi:10.14710/jgi.12.1.21-30

DOI: https://doi.org/10.14710/jgi.12.1.21-30

Difference of thrombocyte profile between obesity and central obesity in women

Melki Hadisasmitajaya, Meita Hendrianingtyas, Edward Kurnia Setiawan Limijadi

Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Indonesia

Received: 1 May 2023; Published: 28 Dec 2023.

BibTex Citation Data :

@article{JGI54004,
    author = {Melki Hadisasmitajaya and Meita Hendrianingtyas and Edward Kurnia Limijadi},
    title = {Difference of thrombocyte profile between obesity and central obesity in women},
    journal = {Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition)},
  volume = {12},
    number = {1},
    year = {2023},
    keywords = {central obesity; MPV; PLT; P-LCR},
    abstract = {  Background:  Obesity considered as a low-grade inflammation. Increased body fat has known to trigger inflammation. Platelet profile is a number of platelet-related parameters that can predict inflammation consisting of: platelet count (PLT), Platelet Larger Cell Ratio (P-LCR), Mean Platelet Volume (MPV). Differences in platelet profiles (PLT, P-LCR, MPV) in women with and without central obesity have only been investigated in a few studies.   Objective:  To prove differences in platelet profiles in women with and without central obesity.   Materials and Methods : A cross-sectional observational study was conducted on 88 women with and without central obesity in RSND during July-September 2021. Data included age, abdominal circumference, hip circumference, PLT, P-LCR, and MPV. PLT, P-LCR, and MPV were measured using Sysmex XS-500i instrument. Statistical analysis was using Mann-Whitney test.   Results:  Mean of women PLT with and without central obesity were 338.72±71.09x10 3 /uL and 309.09±44.36x10 3 /uL. Difference platelet levels in women with and without central obesity was p=0.022. Median MPV of women with and without central obesity were 10.5 (8.5-11.8)fL and 9.7 (8.5-11.6)fL. Difference MPV values in women with and without central obesity was p=0.000. Median P-LCR of women with and without central obesity were 28.2 (12.3-44.3)% and 21.5 (15.2-37.1)%, respectively. Difference P-LCR value in women with and without central obesity was p=0.002.   Conclusion:  Platelet profiles (PLT, MPV, P-LCR) can be used as a marker of chronic low-grade inflammation in women with central obesity.    Keywords :    central obesity; MPV; PLT; P-LCR   },
   issn = {2338-3119},   pages = {31--35}  doi = {10.14710/jgi.12.1.21-30},
    url = {https://ejournal.undip.ac.id/index.php/jgi/article/view/54004}
}

Citation Format:

Abstract

Background: Obesity considered as a low-grade inflammation. Increased body fat has known to trigger inflammation. Platelet profile is a number of platelet-related parameters that can predict inflammation consisting of: platelet count (PLT), Platelet Larger Cell Ratio (P-LCR), Mean Platelet Volume (MPV). Differences in platelet profiles (PLT, P-LCR, MPV) in women with and without central obesity have only been investigated in a few studies.

Objective: To prove differences in platelet profiles in women with and without central obesity.

Materials and Methods: A cross-sectional observational study was conducted on 88 women with and without central obesity in RSND during July-September 2021. Data included age, abdominal circumference, hip circumference, PLT, P-LCR, and MPV. PLT, P-LCR, and MPV were measured using Sysmex XS-500i instrument. Statistical analysis was using Mann-Whitney test.

Results: Mean of women PLT with and without central obesity were 338.72±71.09x10³/uL and 309.09±44.36x10³/uL. Difference platelet levels in women with and without central obesity was p=0.022. Median MPV of women with and without central obesity were 10.5 (8.5-11.8)fL and 9.7 (8.5-11.6)fL. Difference MPV values in women with and without central obesity was p=0.000. Median P-LCR of women with and without central obesity were 28.2 (12.3-44.3)% and 21.5 (15.2-37.1)%, respectively. Difference P-LCR value in women with and without central obesity was p=0.002.

Conclusion: Platelet profiles (PLT, MPV, P-LCR) can be used as a marker of chronic low-grade inflammation in women with central obesity.

Keywords : central obesity; MPV; PLT; P-LCR

Fulltext View|Download

Keywords: central obesity; MPV; PLT; P-LCR

Article Metrics:

Article Info

Section: Articles

Language : EN

In Vol 12, No 1 (2023): December

Recent articles

Liprotide-encapsulated vitamin D3 modulates circulated PTH levels and improved bone microstructure Difference of thrombocyte profile between obesity and central obesity in women Psychosocial stress, food preferences, and screen time with nutritional status of women of reproductive age in Sukamulya Village, Tangerang Regency More recent articles

Most cited articles

Pengaruh pendidikan gizi terhadap pengetahuan, praktik gizi seimbang dan status gizi pada anak sekolah dasar Pengaruh pendidikan gizi terhadap pengetahuan dan sikap tentang gizi anak Sekolah Dasar Kadar seng dan kadar malondialdehyde pada penderita multi drug resistant tuberculosis dan tuberkulosis sensitif Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar Keragaman pangan, pola asuh makan dan kejadian stunting pada balita usia 24-59 bulan More cited articles

Kemenkes RI. Hasil Riset Kesehatan Dasar Tahun 2018. Kementrian Kesehatan RI. 2018;53(9):1689–99
Molla MD, Wolde HF, Atnafu A. Magnitude of Central Obesity and its Associated Factors Among Adults in Urban Areas of Northwest Ethiopia. Diabetes Metab Syndr Obes. 2020; 6(13):4169-4178. DOI: 10.2147/DMSO.S279837
Ahmad N, Adam SIM, Nawi AM, Hassan MR, Ghazi HF. Abdominal Obesity Indicators: Waist Circumference or Waist-to-hip Ratio in Malaysian Adults Population. International journal of preventive medicine. 2016; 7:82. DOI: 10.4103/2008-7802.183654
Twomey L, Wallace RG, Cummins PM, Degryse B, Sheridan S, Harrison M, et al. Platelets: From Formation to Function. In: Lasakosvitsch F, Garnes SDA, editors. Homeostasis [Online]. Rijeka: IntechOpen; 2019. DOI: 10.5772/intechopen.80924
Cecen S. Platelet Activation is a Risk Factor for Obesity. The Turkish Journal of Endocrinology and Metabolism. 2020; 24:132–7. DOI: 10.25179/tjem.2019-72995
Cohen E, Margalit I, Shochat T, Goldberg E, Krause I. Markers of Chronic Inflammation in Overweight and Obese Individuals and the Role of Gender: A Cross-Sectional Study of a Large Cohort. J Inflamm Res. 2021 Feb 25; 14:567-573. DOI: 10.2147/JIR.S294368
Ali U, Gibbs R, Knight G, Tsitsikas D. Sex-divided reference intervals for mean platelet volume, platelet large cell ratio and plateletcrit using the Sysmex XN-10 automated haematology analyzer in a UK population. Hematology, Transfusion and Cell Therapy. 2019; 41(2):153–7. DOI: 10.1016/j.htct.2018.09.005
Lim JU, Lee JH, Kim JS, Hwang YI, Kim TH, Lim SY, Yoo KH, Jung KS, Kim YK, Rhee CK. Comparison of World Health Organization and Asia-Pacific body mass index classifications in COPD patients. Int J Chron Obstruct Pulmon Dis. 2017; 21(12):2465-2475. DOI: 10.2147/COPD.S141295
Mederico M, Paoli M, Zerpa Y, Briceño Y, Gómez-Pérez R, Martínez JL, Camacho N, Cichetti R, Molina Z, Mora Y, Valeri L; Grupo de trabajo CREDEFAR. Reference values of waist circumference and waist/hip ratio in children and adolescents of Mérida, Venezuela: comparison with international references. Endocrinol Nutr. 2013;60(5):235-42. DOI: 10.1016/j.endonu.2012.12.003
Daly ME. Determinants of platelet count in humans. Haematologica. 2011; 96(1):10-3. DOI: 10.3324/haematol.2010.035287
Demirin H, Ozhan H, Ucgun T, Celer A, Bulur S, Cil H, Gunes C, Yildirim HA. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res. 2011;128(4):358-60. DOI: 10.1016/j.thromres.2011.05.007
Khan MI, Ullah I. Diagnostic importance of mean platelet volume, platelet distribution width and platelet large cell ratio as screening tool in immune thrombocytopenia. Porto Biomed J. 2020; 5(6):e094. DOI: 10.1097/j.pbj.0000000000000094
Han S, Gan D, Wang G, Ru Y, Huang C, Lin J, et al. Associations of Platelet Indices with Body Fat Mass and Fat Distribution. Obesity (Silver Spring, Md). 2018; 26(10):1637–43. DOI: 10.1002/oby.22294
Castro AM, Macedo-de la Concha LE, Pantoja-Meléndez CA. Low-grade inflammation and its relation to obesity and chronic degenerative diseases. Revista Médica del Hospital General de México. 2017; 80(2):101–5. DOI: 10.1016/j.hgmx.2016.06.011
Aktas G, Kocak MZ, Taslamacioglu Duman T, Erkus E, Atak BM, Sit M, et al. Mean Platelet Volume (MPV) as an inflammatory marker in type 2 diabetes mellitus and obesity. Bali Medical Journal. 2018;7(3):650–3. DOI: 10.15562/bmj.v7i3.806
Hildebrandt X, Ibrahim M, Peltzer N. Cell death and inflammation during obesity: "Know my methods, WAT(son)". Cell Death Differ. 2023; 30(2):279-292. DOI: 10.1038/s41418-022-01062-4
Alshehri OM, Seoudi MA, Sahli KA, Elkhawanky MM. The Platelet Indices in Patients with Obesity in Najran Area, Saudi Arabia [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl) https://abstracts.isth.org/abstract/the-platelet-indices-in-patients-with-obesity-in-najran-area-saudi-arabia/

Last update:

No citation recorded.

Last update: 2024-11-22 16:33:23

No citation recorded.

Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) is published under licensed of a CC BY-SA Creative Commons Attribution-ShareAlike 4.0 International License

The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) and Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro as publisher of the journal.

Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc., will be allowed only with a written permission from Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition).

Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition), Faculty of Medicine, Universitas Diponegoro, the Editors and the Advisory Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in the Indonesian Journal of Nutrition are sole and exclusive responsibility of their respective authors and advertisers.