DOI: https://doi.org/10.14710/jgi.0.0.%25p

Identification of lactid acid bacteria from lemea's to lower blood sugar levels in mice's diabetes mellitus

Departemen of Nutrition, Poltekkes Kemenkes Bengkulu, Indonesia, Indonesia

Received: 21 Nov 2024; Revised: 7 Jan 2025; Accepted: 17 Feb 2025; Available online: 25 Feb 2025; Published: 30 Jun 2025.

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Abstract

Background: Diabetic is one of the main health problems in society throughout the world, so alternatives are needed to help prevent in creasing blood sugar levels. In this case, lactid acid bacteria (LAB) are able to inhibit the performance of the alpha glucosidase enzyme in breaking down carbohydrates into glucose, lowering blood sugar levels  so that lactic acid bacteria have potential in controlling hyperglycemia.

Objective: The purpose of this work is to assess the potential of four different strains of Lactobacillus that were isolated from lemea to reduce blood sugar levels in  mice.

Materials and Methods: Methods this study used a pre-test, post-test, control group design for its experimental methodology.

Results: The results of the study showed that giving pure culture of L. plantarum from Betung bamboo shoot lemea to mice with type 2 diabetes mellitus (type 2 DM) as treatment P2 was superior to giving acarbose, P1, P3, and P4 in reducing blood sugar levels with pancreatic damage 50% and lower than other treatments, while the pancreas of type 2 DM mice without therapy had the greatest damage score based on histopathological data.

Conclusion: Lactic acid bacteria from Lemea can help lower blood sugar levels and prevent the rate of damage to the pancreas of diabetic mice, with the best culture being L. plantarum from Lemea Betung bamboo shoots.

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Keywords: Blood sugar levels; lactid acid bacteria; lemea; pancreatic
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