1Dosen Program Studi D-IV Gizi Klinik, Jurusan Kesehatan, Politeknik Negeri Jember, Indonesia
2Dosen Patologi Klinik, Fakultas Kedokteran, Universitas Diponegoro, Indonesia
BibTex Citation Data :
@article{JGI8611, author = {Devi Ermawati and Banundari Rachmawati and Nyoman Widyastiti}, title = {Efek suplementasi β-carotene terhadap kolesterol total, trigliserida dan malondialdehid pada tikus sprague dawley yang diabet}, journal = {Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition)}, volume = {2}, number = {2}, year = {2014}, keywords = {β-carotene, total cholesterol, triglyceride, malondiadehyde, diabetic}, abstract = { Background : diabetes mellitus (DM) is associated with increased total cholesterol and triglyceride, also well characterized by increased malondialdehyde production. β-carotene has antioxidant activity, glycemic and lipid control. Objective : to analyze the effect of β-carotene on total cholesterol, triglyceride and MDA on diabetic Rattus norvegicus sprague dawley. Methods : thirty rats were randomly divided into 5 groups : 1 (STZ), 2 (STZ+β-carotene 1 mg/kg BW), 3 (STZ+β-carotene 10 mg/kg BW), 4 (STZ+β-carotene 20 mg/kg BW), 5 (normal). Streptozotocin induced intraperitoneal 40 mg/kg BW. β-carotene was given by nasogastric tube on alternate days within thirty days. Blood glucose level was measured by GOD-PAP, total cholesterol by CHOD-PAP, triglyceride by GPO and MDA by ELISA with TBARS methods. Hypothesis test used one way anova then followed by post hoc bonferroni to analyze the efficient dose effect. Results : there was a significant difference of total cholesterol (p=0.002) after β-carotene 10 mg/kg BW supplementation on alternate days within 30 days orally. β-carotene 10 mg/kg BW was the most efficient dose to lowering total cholesterol. There were significant differences of triglyceride (p=0.0001) and MDA (p=0.0001) after β-carotene 1, mg/kg BW, 10 mg/kg BW and 20 mg/kg BW supplementation on alternate days within 30 days orally. β-carotene 10 mg/kg BW was the most efficient dose to lowering triglyceride, while 20 mg/kg BW to lowering MDA. Conclusion : β-carotene 10 mg/kg BW is the most efficient dose to lowering total cholesterol and triglyceride. β-carotene 20 mg/kg BW is the most efficient dose to lowering MDA. }, issn = {2338-3119}, pages = {47--52} doi = {10.14710/jgi.2.2.47-52}, url = {https://ejournal.undip.ac.id/index.php/jgi/article/view/8611} }
Refworks Citation Data :
Background : diabetes mellitus (DM) is associated with increased total cholesterol and triglyceride, also well characterized by increased malondialdehyde production. β-carotene has antioxidant activity, glycemic and lipid control.
Objective : to analyze the effect of β-carotene on total cholesterol, triglyceride and MDA on diabetic Rattus norvegicus sprague dawley.
Methods : thirty rats were randomly divided into 5 groups : 1 (STZ), 2 (STZ+β-carotene 1 mg/kg BW), 3 (STZ+β-carotene 10 mg/kg BW), 4 (STZ+β-carotene 20 mg/kg BW), 5 (normal). Streptozotocin induced intraperitoneal 40 mg/kg BW. β-carotene was given by nasogastric tube on alternate days within thirty days. Blood glucose level was measured by GOD-PAP, total cholesterol by CHOD-PAP, triglyceride by GPO and MDA by ELISA with TBARS methods. Hypothesis test used one way anova then followed by post hoc bonferroni to analyze the efficient dose effect.
Results : there was a significant difference of total cholesterol (p=0.002) after β-carotene 10 mg/kg BW supplementation on alternate days within 30 days orally. β-carotene 10 mg/kg BW was the most efficient dose to lowering total cholesterol. There were significant differences of triglyceride (p=0.0001) and MDA (p=0.0001) after β-carotene 1, mg/kg BW, 10 mg/kg BW and 20 mg/kg BW supplementation on alternate days within 30 days orally. β-carotene 10 mg/kg BW was the most efficient dose to lowering triglyceride, while 20 mg/kg BW to lowering MDA.
Conclusion : β-carotene 10 mg/kg BW is the most efficient dose to lowering total cholesterol and triglyceride. β-carotene 20 mg/kg BW is the most efficient dose to lowering MDA.
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Last update: 2024-04-18 21:50:03
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