A Cycloartane Triterpenoid and Steroid from The Leaves of Aglaia shawiana Merr. (Meliaceae)

Ricson Pemimpin Hutagaol; Tjandrawati Mozef; Sofa Fajriah; Gian Primahana; Muhammad Eka Prasetya; Miskah Yumna; Heriansyah Rangkuti

doi:10.14710/jksa.27.7.307-315

DOI: https://doi.org/10.14710/jksa.27.7.307-315

A Cycloartane Triterpenoid and Steroid from The Leaves of Aglaia shawiana Merr. (Meliaceae)

Ricson Pemimpin Hutagaol¹

, Tjandrawati Mozef²

, Sofa Fajriah²

, Gian Primahana²

, Muhammad Eka Prasetya², Miskah Yumna¹, Heriansyah Rangkuti¹

¹Department of Chemistry, Faculty of Mathematics and Natural Sciences, Nusa Bangsa University, Bogor 16166, Indonesia

²Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research, and Innovation Agency (BRIN), Kawasan Sains dan Teknologi (KST) B.J Habibie (PUSPIPTEK) Serpong, South Tangerang, Banten, Indonesia

Received: 13 Apr 2024; Revised: 10 Jun 2024; Accepted: 25 Jun 2024; Published: 31 Jul 2024.

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Abstract

Natural products and their structural analogs are the main sources of pharmacotherapy. Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties. This research focuses on isolating the terpenoid group from Aglaia shawiana, to provide a basis for further research to identify lead compounds for drug development. The hexane extract of Aglaia shawiana leaves was isolated using vacuum liquid chromatography and gravity column chromatography, employing solvents with varying polarities. The isolation process yielded two compounds: compound 1 and compound 2. A total of 15 mg of a pure isolate was obtained for compound 1, and 4.5 mg for compound 2. Their structures were characterized using 1D NMR (¹H, ¹³C, DEPT 135) and 2D NMR (HMQC, HMBC, ¹H-¹H COSY) and by comparing them with previously reported spectral data. It was concluded that compound 1 has the molecular formula C₃₀H₅₀O₃, is a triterpenoid type cycloartane, and is named cycloartan-3β,29-diol-24-one, while compound 2 has the molecular formula C₃₀H₅₂O, is a steroid compound, and is named 23a-homostigmast-5en-3β-ol. These compounds were discovered for the first time in this species.

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Keywords: glaia shawiana; Elucidation; Isolation; Natural; Meliaceae

Funding: National Research and Innovation Agency (BRIN) IndonesiaI64/II/HK/2022

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Section: Research Articles

Language : EN

In Vol 27, No 7 (2024): Volume 27 Issue 7 Year 2024

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