DOI: https://doi.org/10.14710/nmjn.v13i2.53640

Contextual Factors, Health History, and Daily Living Activities for Ovarian Cancer Risks: A Case-Control Study in Indonesia

*Restuning Widiasih orcid scopus publons  -  Department of Maternity Nursing, Faculty of Nursing, Universitas Padjadjaran, Indonesia
Windy Natasha  -  Department of Maternity Nursing, Faculty of Nursing, Universitas Padjadjaran, Indonesia
Tosin Popoola orcid scopus  -  School of Nursing and Midwifery, University of Newcastle, Australia
Katherine Nelson scopus  -  School of Nursing, Midwifery and Health Practice, Victoria University of Wellington, New Zealand
Open Access Copyright (c) 2023 Nurse Media Journal of Nursing
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Citation Format:
Abstract

Background: Women are encouraged to aware for risk factors that may aid in the early detection of ovarian cancer before symptoms and sign appear. However, limited studies evaluated the broad aspects of the risk factors for ovarian cancer, particularly in Indonesia. For a more thorough analysis of ovarian cancer risk factors, more variables and a research approach that can make it easier to uncover risk factors of ovarian cancer are necessary. Detecting factors associated with ovarian cancer could serve as the foundation for developing an early warning model.

Purpose: The aim of this study was to analyze contextual factors, reproductive health history, and Activity Daily Living (ADLs) associated with ovarian cancer risks.

Methods: This retrospective case-control study included 408 women with a 1:1 balanced composition: 204 women diagnosed with ovarian cancer and 204 without. The study was conducted at the Cancer Referral Hospital in West Java Province, Indonesia, from April to November 2020. The instrument was developed based on previous studies and hospital medical/nursing records. The data were analyzed using the Chi-square test and the logistic regression test. The sensitivity and specificity were examined using the Receiver Operating Characteristic (ROC).

Results: The variables significantly associated with an increased risk of developing ovarian cancer were advanced age (≥ 45 years) with an odds ratio (OR) of 19.76, low education (OR: 225.00), obesity (OR: 6.04), prior surgery (OR: 51.06), parity (OR: 110.38), and poor sleep quality (OR: 15.75). These factors were found to have the strongest associations with ovarian cancer development.

Conclusion: The present study has identified risk factors that have a statistically significant association with the occurrence of ovarian cancer. Healthcare practitioners have the potential to employ this information as foundational data for future research in the development of a self-detection tool for assessing the risk of ovarian cancer.
Fulltext View|Download
Keywords: Ovarian cancer; risk factors of cancer; women health

Article Metrics:

Article Info
Section: Articles
Language : EN
Recent articles
The Relationships between Physical and Emotional Symptoms and Health-Related Quality of Life of Patients after Percutaneous Coronary Intervention Factors Influencing the Quality of Life in Thai Cancer Patients Receiving Chemotherapy during COVID-19 Pandemic Foot Care among Diabetes Patients: A Concept Analysis Editorial Back Matter Editorial Front Matter More recent articles
Most cited articles
EFFECTIVENESS OF MUSIC THERAPY TOWARD REDUCING PATIENT’S ANXIETY IN INTENSIVE CARE UNIT Relationships between Triage Knowledge, Training, Working Experiences and Triage Skills among Emergency Nurses in East Java, Indonesia The Competencies, Roles and Scope of Practice of Advanced Psychiatric Nursing in Indonesia Spirituality Intervention and Outcomes: Corner stone of Holistic Nursing Practice Providing Basic Needs and Encouragement as Strategies in Managing Aggression in Dementia Clients More cited articles
  1. Aarestrup, J., Trabert, B., Ulrich, L. G., Wentzensen, N., Sørensen, T. I. A., & Baker, J. L. (2019). Childhood overweight, tallness, and growth increase risks of ovarian cancer. Cancer Epidemiology, Biomarkers & Prevention, 28(1), 183–188. https://doi.org/10.1158/1055-9965.EPI-18-0024
  2. Acheson, L. S., Wang, C., Zyzanski, S. J., Lynn, A., Ruffin, M. T., Gramling, R., Rubinstein, W. S., O’Neill, S. M., & Nease, D. E. J. (2010). Family history and perceptions about risk and prevention for chronic diseases in primary care: A report from the family healthware impact trial. Genetics in Medicine: Official Journal of the American College of Medical Genetics, 12(4), 212–218. https://doi.org/10.1097/GIM.0b013e3181d56ae6
  3. Agusweni, T., Dewi, Y. I., & Erwin, E. (2020). Gambaran faktor risiko insiden kanker ovarium di RSUD Arifin Achmad Provinsi Riau [Description of ovarian cancer incidence risk factors in Arifin Achmad Hospital, Riau Province]. Jurnal Ners Indonesia, 11(1), 36–50
  4. Alberg, A. J., Moorman, P. G., Crankshaw, S., Wang, F., Bandera, E. V, Barnholtz-Sloan, J. S., Bondy, M., Cartmell, K. B., Cote, M. L., Ford, M. E., Funkhouser, E., Kelemen, L. E., Peters, E. S., Schwartz, A. G., Sterba, K. R., Terry, P., Wallace, K., & Schildkraut, J. M. (2016). Socioeconomic status in relation to the risk of ovarian cancer in African-American women: A population-based case-control study. American Journal of Epidemiology, 184(4), 274–283. https://doi.org/10.1093/aje/kwv450
  5. Arania, R., & Windarti, I. (2015). Karakteristik pasien kanker ovarium di Rumah Sakit Dr. H. Abdul Moeloek Bandar Lampung tahun 2009-2013 [Characteristics of ovarian cancer patients at Dr. H. Abdul Moeloek Bandar Lampung in 2009-2013]. Juke Unila, 5(9), 43–47. https://juke.kedokteran.unila.ac.id/index.php/juke/article/view/633
  6. Arora, T., Mullangi, S., & Lekkala, M. R. (2023). Ovarian cancer. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK567760/
  7. Bell, K. (2013). Constructions of “infertility” and some lived experiences of involuntary childlessness. Affilia, 28(3), 284–295. https://doi.org/10.1177/0886109913495726
  8. Bhatti, P., Cushing-Haugen, K. L., Wicklund, K. G., Doherty, J. A., & Rossing, M. A. (2013). Nightshift work and risk of ovarian cancer. Occupational and Environmental Medicine, 70(4), 231–237. https://doi.org/10.1136/oemed-2012-101146
  9. Bodelon, C., Wentzensen, N., Schonfeld, S. J., Visvanathan, K., Hartge, P., Park, Y., & Pfeiffer, R. M. (2013). Hormonal risk factors and invasive epithelial ovarian cancer risk by parity. British Journal of Cancer, 109(3), 769–776. https://doi.org/10.1038/bjc.2013.344
  10. Bolarinwa, O. A. (2015). Principles and methods of validity and reliability testing of questionnaires used in social and health science researches. The Nigerian Postgraduate Medical Journal, 22(4), 195–201. https://doi.org/10.4103/1117-1936.173959
  11. Chen, Y., Tan, F., Wei, L., Li, X., Lyu, Z., Feng, X., Wen, Y., Guo, L., He, J., Dai, M., & Li, N. (2018). Sleep duration and the risk of cancer: A systematic review and meta-analysis including dose–response relationship. BMC Cancer, 18(1), 1149. https://doi.org/10.1186/s12885-018-5025-y
  12. Cohen, J. (1988). The effect size index: Statistical power analysis for the behavioral sciences. Abingdon-on-Thames: Routledge Academic
  13. Crane, T. E., Khulpateea, B. R., Alberts, D. S., Basen-Engquist, K., & Thomson, C. A. (2014). Dietary intake and ovarian cancer risk: A systematic review. Cancer Epidemiology, Biomarkers & Prevention, 23(2), 255–273. https://doi.org/10.1158/1055-9965.EPI-13-0515
  14. Cresswell, J. (2013). Research design: Qualitative, quantitative, and mixed methods approaches. Sage Publications
  15. Dixon-Suen, S. C., Webb, P. M., Wilson, L. F., Tuesley, K., Stewart, L. M., & Jordan, S. J. (2019). The association between hysterectomy and ovarian cancer risk: A population-based record-linkage study. Journal of the National Cancer Institute, 111(10), 1097–1103. https://doi.org/10.1093/jnci/djz015
  16. Goldstein, M. R., & Mascitelli, L. (2011). Surgery and cancer promotion: Are we trading beauty for cancer? QJM: An International Journal of Medicine, 104(9), 811–815. https://doi.org/10.1093/qjmed/hcr039
  17. Hajian-Tilaki, K. (2013). Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation. Caspian Journal of Internal Medicine, 4(2), 627–635. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755824/
  18. Huusom, L. D., Frederiksen, K., Høgdall, E. V. S., Glud, E., Christensen, L., Høgdall, C. K., Blaakaer, J., & Kjær, S. K. (2006). Association of reproductive factors, oral contraceptive use and selected lifestyle factors with the risk of ovarian borderline tumors: A Danish case-control study. Cancer Causes & Control, 17(6), 821–829. https://doi.org/10.1007/s10552-006-0022-x
  19. Jauhari, T. F., Mulawardhana, P., & Saraswati, W. (2016). Gambaran faktor risiko penderita kanker ovarium di RSUD Dr. Soetomo Surabaya [Description of ovarian cancer risk factors in RSUD Dr. Sutomo Surabaya]. Journal Unair. https://e-journal.unair.ac.id/JUXTA/article/view/21108/11666
  20. Jiang, S.-S., Shen, L.-P., Ruan, H.-F., Li, L., Gao, L.-L., & Wan, L.-H. (2014). Family function and health behaviours of stroke survivors. International Journal of Nursing Sciences, 1(3), 272–276. https://doi.org/https://doi.org/10.1016/j.ijnss.2014.05.024
  21. Kamajaya, I. G. N. A. T., Brahmantara, B. N., & Wirawan, A. A. N. A. P. (2021). Profile of ovarian cancer patients in Mangusada Badung regional public hospital. Indonesian Journal of Cancer, 15(3), 117–124
  22. Kemppainen, J., Hynninen, J., Virtanen, J., & Seppänen, M. (2019). PET/CT for evaluation of ovarian cancer. Seminars in Nuclear Medicine, 49(6), 484–492. https://doi.org/10.1053/j.semnuclmed.2019.06.010
  23. Koskela-Niska, V., Lyytinen, H., Riska, A., Pukkala, E., & Ylikorkala, O. (2013). Ovarian cancer risk in postmenopausal women using estradiol-progestin therapy - A nationwide study. Climacteric : The Journal of the International Menopause Society, 16(1), 48–53. https://doi.org/10.3109/13697137.2012.663818
  24. La Vecchia, C. (2017). Ovarian cancer: Epidemiology and risk factors. European Journal of Cancer Prevention, 26(1), 55–62. https://doi.org/10.1097/CEJ.0000000000000217
  25. Latief, S., Syahruddin, F. I., Nulanda, M., & Mokhtar, S. (2023). Faktor risiko penderita kanker ovarium di Rumah Sakit Ibnu Sina Makassar [Risk factors for ovarian cancer patients at the Ibnu Sina Hospital Makassar]. Wal’afiat Hospital Journal, 4(1), 46–56. https://whj.umi.ac.id/index.php/whj/article/view/101
  26. Lowdermilk, D., L., Perry, S., & Cashion, K. (2013). Buku keperawatan maternitas [Maternity nursing book]. Salemba Medika
  27. Mahoney, D. E., & Pierce, J. D. (2022). Ovarian cancer symptom clusters: Use of the NIH symptom science model for precision in symptom recognition and management. Clinical Journal of Oncology Nursing, 26(5), 533–542. https://doi.org/10.1188/22.CJON.533-542
  28. Matahari, R., Utami, F. P., & Sugiharti. (2018). Keluarga berencana dan kontrasepsi [Family Planning and Contraception]. Penerbit Pustaka Ilmu
  29. Mathieu, K. B., Bedi, D. G., Thrower, S. L., Qayyum, A., & Bast, R. C. J. (2018). Screening for ovarian cancer: Imaging challenges and opportunities for improvement. Ultrasound in Obstetrics & Gynecology, 51(3), 293–303. https://doi.org/10.1002/uog.17557
  30. Matulonis, U. A., Sood, A. K., Fallowfield, L., Howitt, B. E., Sehouli, J., & Karlan, B. Y. (2016). Ovarian cancer. Nature Reviews. Disease Primers, 2, 16061. https://doi.org/10.1038/nrdp.2016.61
  31. Mohammadian, M., Ghafari, M., Khosravi, B., Salehiniya, H., Aryaie, M., Bakeshei, F. A., & Mohammadian-Hafshejani, A. (2017). Variations in the incidence and mortality of ovarian cancer and their relationship with the human development index in European Countries in 2012. Biomedical Research and Therapy, 4(08), 1541–1557
  32. MOHRI. (2018a). Berapa takaran normal air agar tidak kekurangan cairan dalam tubuh ? [What is the normal dose of water so as not to lack fluids in the body?]. http://p2ptm.kemkes.go.id/preview/infografhic/berapa-takaran-normal-air-agar-tidak-kekurangan-cairan-dalam-tubuh
  33. MOHRI. (2018b). Hasil utama RISKESDAS 2018 [The main results of RISKESDAS 2018]. https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil-riskesdas-2018_1274.pdf
  34. MOHRI. (2018c). Kebutuhan tidur sesuai usia [Sleep needs according to age]. https://promkes.kemkes.go.id/wp-content/uploads/pdf/publikasi_materi_promosi/ InformasiCERDIK/6.Istirahat Cukup_285x285mm.pdf
  35. MOHRI. (2018d). Klasifikasi obesitas setelah pengukuran IMT [Obesity classification after BMI measurement]. http://p2ptm.kemkes.go.id/infographic-p2ptm/obesitas/klasifikasi-obesitas-setelah-pengukuran-imt
  36. MOHRI. (2019). Penyakit kanker di indonesia berada pada urutan 8 di Asia Tenggara dan urutan 23 di Asia [Cancer in Indonesia is ranked 8th in Southeast Asia and 23rd in Asia]. http://p2p.kemkes.go.id/penyakit-kanker-di-indonesia-berada-pada-urutan-8-di-asia-tenggara-dan-urutan-23-di-asia/
  37. Momenimovahed, Z., & Salehiniya, H. (2019). Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer, 11, 151–164. https://doi.org/10.2147/BCTT.S176070
  38. Nababan, E. H. F., Sihotang, J., Sasputra, I. N., & Damanik, E. M. B. (2021). Faktor risiko kanker ovarium jenis epitelial di RSUD Prof. Dr. WZ Johannes Kota Kupang Nusa Tenggara Timur tahun 2016-2019 [Risk factors for epithelial ovarian cancer at Prof. Dr. WZ Johannes, City of Kupang, East Nusa Tenggara, 2016-2019]. Cendana Medical Journal (CMJ), 9(2), 198–206. https://ejurnal.undana.ac.id/index.php/CMJ/article/view/5966
  39. Nahm, F. S. (2022). Receiver operating characteristic curve: Overview and practical use for clinicians. Korean Journal of Anesthesiology, 75(1), 25–36. https://doi.org/10.4097/kja.21209
  40. National Cancer Institute. (2020). Cancer statistic. https://www.cancer.gov/about-cancer/understanding/statistics
  41. National Population and Family Planning Agency. (2018). Ingin nikah, harus perhatikan usia ideal. Ini yang direkomendasikan BKKBN [Want to get married, must pay attention to the ideal age. This is recommended by the BKKBN]. https://batam.tribunnews.com/2018/10/07/ingin-nikah-harus-perhatikan-usia-ideal-ini-yang-direkomendasikan-bkkbn
  42. Oksuz, E., Malhan, S., Gonen, M. S., Kutlubay, Z., Keskindemirci, Y., & Tabak, F. (2021). COVID-19 healthcare cost and length of hospital stay in Turkey: Retrospective analysis from the first peak of the pandemic. Health Economics Review, 11(1), 39. https://doi.org/10.1186/s13561-021-00338-8
  43. Our World in Data. (2016). Alcohol consumption. OurWorldInData.Org. https://ourworldindata.org/alcohol-consumption#citation
  44. Public Relations West Java Regional Government Agency. (2020). Gubernur Ridwan Kamil tetapkan Kepgub UMK 2020 [Governor Ridwan Kamil stipulates the 2020 UMK Governor Decree]. http://bappeda.jabarprov.go.id/gubernur-ridwan-kamil-tetapkan-kepgub-umk-2020/
  45. Purwoko, M. (2018). Hubungan tingkat pendidikan dan pekerjaan dengan tingkat pengetahuan mengenai kanker ovarium pada wanita [Relationship between education and occupational level with level of knowledge about ovarian cancer in women]. Mutiara Medika: Jurnal Kedokteran dan Kesehatan, 18(2), 45–48. https://journal.umy.ac.id/index.php/mm/article/view/4744
  46. Ribeiro, A. L. P., Campos, M. S., Baptista, L. M. G., & de Sousa, M. R. (2010). The Valsalva maneuver in Chagas disease patients without cardiopathy. Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society, 20(2), 79–83. https://doi.org/10.1007/s10286-009-0044-z
  47. Saryono. (2009). Sindrom Premenstruasi: Mengungkap tabir sensitifitas perasaan menjelang menstruasi [Premenstrual Syndrome: Uncovering the veil of sensitive feelings before menstruation]. Nuha Medika
  48. Schüler, S., Ponnath, M., Engel, J., & Ortmann, O. (2013). Ovarian epithelial tumors and reproductive factors: A systematic review. Archives of Gynecology and Obstetrics, 287(6), 1187–1204. https://doi.org/10.1007/s00404-013-2784-1
  49. Staley, S. A., Tucker, K. R., & Clark, L. H. (2020). The role of obesity in the development and management of gynecologic cancer. Obstetrical & Gynecological Survey, 75(5), 308–316. https://doi.org/10.1097/OGX.0000000000000779
  50. The Central Statistics Bureau of Indonesia. (2020). Subjek 6: Tenaga kerja [Subject 6: Manpower]. https://www.bps.go.id/subject/6/tenaga-kerja.html
  51. Tworoger, S. S., & Huang, T. (2016). Obesity and ovarian cancer. recent results in cancer research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer, 208, 155–176. https://doi.org/10.1007/978-3-319-42542-9_9
  52. Umakanthan, S., Chattu, V. K., & Kalloo, S. (2019). Global epidemiology, risk factors, and histological types of ovarian cancers in Trinidad. Journal of Family Medicine and Primary Care, 8(3), 1058–1064. https://doi.org/10.4103/jfmpc.jfmpc_384_18
  53. Umami, A., Sudalhar, S., Lufianti, A., Paulik, E., & Molnár, R. (2021). Factors associated with genital hygiene behaviors in cervical cancer patients in surakarta, Indonesia. Nurse Media Journal of Nursing, 11(1), 94–103. https://doi.org/10.14710/NMJN.V11I1.35829
  54. UNICEF. (2018). Child marriage in Indonesia. Unicef.Org. https://www.unicef.org/indonesia/media/1446/file/Child_Marriage_Factsheet.pdf
  55. Widodo, J., Musyabiq Wijaya, S., & Rudiyanto, W. (2019). Hubungan faktor risiko (Riwayat keluarga, obesitas, dan alat kontrasepsi) terhadap derajat histopatologi kanker ovarium di RSUD Dr. H. Abdul Moeloek Bandar Lampung tahun 2018 [Relationship of risk factors (family history, obesity, and contraceptives) and the histopathological grade of ovarian cancer at RSUD Dr. H. Abdul Moeloek Bandar Lampung in 2018. Medula, 8(2), 154–160
  56. World Health Organization. (2020). Statement: World no tobacco day 2020. Www.Who.Int
  57. Wulandari, E. T., Nuraeni, R., & Maesaroh, S. (2019). Perbedaan usia menarche pasien kanker payudara dan pasien kanker ovarium yang menjalani pengobatan di rumah sakit [Difference in menarche age of breast cancer patients and ovarian cancer patients undergoing treatment in hospitals]. Wellness and Healthy Magazine, 1(2), 115–122
  58. Zhan, X., Wang, J., Pan, S., & Lu, C. (2017). Tea consumption and the risk of ovarian cancer: A meta-analysis of epidemiological studies. Oncotarget, 8(23), 37796–37806. https://doi.org/10.18632/oncotarget.16890

Last update:

  1. Risk Factors for Ovarian Cancer in South America: A Literature Review

    Sergio Jara-Rosales, Roxana González-Stegmaier, Elena S. Rotarou, Franz Villarroel-Espíndola. Journal of Personalized Medicine, 14 (9), 2024. doi: 10.3390/jpm14090992

Last update: 2024-12-21 04:36:42

No citation recorded.