DOI: https://doi.org/10.14710/nmjn.v13i2.48272

Chemotherapy-Induced Nausea and Vomiting (CINV) Based on Blood Types among Cancer Patients in Yogyakarta, Indonesia

*Dwi Kartika Rukmi orcid publons  -  Nursing Department, Faculty of Health, Universitas Jenderal Achmad Yani Yogyakarta, Indonesia
Muhamat Nofiyanto  -  Rumah Sakit Jiwa Daerah (RSJD) dr. Amino Gondohutomo, Indonesia
Open Access Copyright (c) 2023 Nurse Media Journal of Nursing
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Citation Format:
Abstract

Background: Studies related to blood type in cancer patients have been conducted extensively, but they are inclined to cancer incidence or survival rate. Meanwhile, there is limited research on Chemotherapy-Induced Nausea and Vomiting (CINV), the most disturbing side effect of chemotherapy, in relation to blood type.

Purpose: This study aimed to compare CINV frequency in cancer patients by blood groups in Yogyakarta, Indonesia.

Methods: A descriptive comparative study with a cross-sectional approach was conducted purposively on 70 chemotherapy patients in two hospitals in Yogyakarta. Patients with anticipatory CINV and brain cancer (primary or metastases) were excluded. The data were collected between July and November 2020 using a sheet for patient characteristics and a filled-in diary from the first to the seventh day post-chemotherapy to collect CINV data. The descriptive statistics and Kruskal Wallis test were used to analyze the data.

Results: Of 70 total samples, most of them were breast cancer (71.4%) and were in stage IV (50%). They received chemotherapy alone as their primary therapy (94.3%) and received moderate to high emetogenic agents (31.4% and 35.7%). Samples mostly had A blood type (34.3%) and had undergone chemotherapy for 3-18 months (min-max). As many as 64.6% of patients experienced CINV with a delayed type and experienced moderate severity (52.9%). The bivariate test showed no difference in CINV frequencies based on blood groups in general (p=0.068). However, based on the CINV onset, there was a significant difference in CINV frequencies in the A blood group against other blood groups (p=0.020) on the fourth post-chemotherapy day.

Conclusions:Unless the fourth-day post-chemotherapy, the frequency of CINV based on blood groups showed no difference. Since CINV incidence is still high, the provision of both pharmacological and non-pharmacological therapy to treat CINV has to be given to patients after chemotherapy. Blood group factors can be considered for more extensive management, especially in delayed CINV cases.

 

Fulltext View|Download
Keywords: Blood group; CINV; cancer; Yogyakarta

Article Metrics:

Article Info
Section: Articles
Language : EN
Recent articles
Women and Family Members’ Views Regarding Early Decisions about Breast Cancer Treatment: A Qualitative Study Foot Care among Diabetes Patients: A Concept Analysis Contextual Factors, Health History, and Daily Living Activities for Ovarian Cancer Risks: A Case-Control Study in Indonesia Editorial Back Matter Editorial Front Matter More recent articles
Most cited articles
Dyspnea Experience and Dyspnea Management in Patients with Chronic Obstructive Pulmonary Disease in Bangladesh The Lived Experiences of Mentoring Nurses in Malaysia Correlation between Coping Strategies and Quality of Life among Myocardial Infarction Patients in Nepal Perceived Ability to Practice in Disaster Management among Public Health Nurses in Aceh, Indonesia Effects of Peer Support Program on Self-Management in Patients with End-Stage Renal Disease Undergoing Hemodialysis More cited articles
  1. Aapro, M. (2018). CINV: Still troubling patients after all these years. Supportive Care in Cancer, 26(1), 5-9. https://doi.org/10.1007/s00520-018-4131-3
  2. Adhikari, G. P. (2021). Calculating the sample size in quantitative studies. Scholars' Journal, 4, 14-29. https://doi.org/10.3126/scholars.v4i1.42458
  3. Al Qadire, M. (2018). Chemotherapy-induced nausea and vomiting: Incidence and management in Jordan. Clinical Nursing Research, 27(6), 730-742. https://doi.org/10.1177/1054773817704586
  4. Alipour, N., Nikooseresht, M., & Zebarjadian, A. H. (2021). Effect of pre-and intraoperative anxiety on nausea and vomiting during spinal anaesthesia in cesarean section patients in a hospital in Hamadan, Iran, in 2016. Avicenna Journal of Neuro Psycho Physiology, 8(3), 161-166. https://doi.org/10.32592/ajnpp.2021.8.3.108
  5. Angahar, L. (2017). An overview of breast cancer epidemiology, risk factors, pathophysiology, and cancer risks reduction. MedCrave Online Journal of Biology and Medicine, 1(44), 92-96. https://doi.org/10.15406/mojbm.2017.01.00019
  6. Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R., Torre, L., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68, 394–424. https://doi.org/10.3322/caac.21492
  7. Celio, L. (2022). Emetogenicity of chemotherapy regimens and recommended prophylaxis: A review of MASCC/ESMO guidelines. EMJ. https://emj.emg-health.com/wp-content/uploads/sites/2/2022/06/Emetogenicity-of-Chemotherapy-Regimens-and-Recommended-Prophylaxis.pdf
  8. Chan, H., & Ismail, S. (2014). Side effects of chemotherapy among cancer patients in a Malaysian general hospital: Experiences, perceptions and informational needs from clinical pharmacists. Asian Pacific Journal of Cancer Prevention, 15(13), 5305-5309. https://doi.org/10.7314/apjcp.2014.15.13.5305
  9. Do, J., Cho, Y., & Jeon, J. (2015). Effects of a 4 weeks multimodal rehabilitation program on quality of life, cardiopulmonary function, and fatique in breast cancer patients. Journal of Breast Cancer, 18(1), 87–96. https://doi.org/10.4048/jbc.2015.18.1.87
  10. Dranitsaris, G., Molassiotis, A., Clemons, M., Roeland, E., Schwartzberg, L., Dielenseger, P., Jordan, K., Young, A., & Aapro, M. (2017). The development of a prediction tool to identify cancer patients at high risk for chemotherapy-induced nausea and vomiting. Annals of Oncology, 28(6), 1260-1267. https://doi.org/10.1093/annonc/mdx100
  11. Elahimanesh, F., Shabestani Monfared, A., Khosravifarsani, M., Akhavan Niaki, H., Abedian, Z., Hajian-Tilaki, K., Borzouisileh, S., Seyfizadeh, N., & Amiri, M. (2013). Is radiosensitivity associated to different types of blood groups? (A cytogenetic study). International Journal of Molecular and Cellular Medicine, 2(3), 131-135
  12. Escalante, J., McQuade, R. M., Stojanovska, V., & Nurgali, K. (2017). Impact of chemotherapy on gastrointestinal functions and the enteric nervous system. Maturitas, 105, 23-29. https://doi.org/10.1016/j.maturitas.2017.04.021
  13. Escobar, Y., Cajaraville, G., Virizuela, J. A., Álvarez, R., Muñoz, A., Olariaga, O., Tamés, M. J., Muros, B., Lecumberri, M. J., Feliu, J., Martínez, P., Adansa, J. C., Martínez, M. J., López, R., Blasco, A., Gascón, P., Calvo, V., Luna, P., Montalar, J., . . . Tornamira, M. V. (2015). Incidence of chemotherapy-induced nausea and vomiting with moderately emetogenic chemotherapy: ADVICE (Actual Data of Vomiting Incidence by Chemotherapy Evaluation) study. Supportive Care in Cancer, 23(9), 2833-2840. https://doi.org/10.1007/s00520-015-2809-3
  14. Francies, F. Z., Hull, R., Khanyile, R., & Dlamini, Z. (2020). Breast cancer in low-middle income countries: abnormality in splicing and lack of targeted treatment options. American Journal of Cancer Research, 10(5), 1568-1591
  15. Gautama, W. (2022). Breast cancer in Indonesia in 2022: 30 years of marching in place. Indonesian Journal of Cancer, 16(1), 1-2. https://doi.org/10.33371/ijoc.v16i1.920
  16. Gupta, K., Walton, R., & Kataria, S. P. (2021). Chemotherapy-induced nausea and vomiting: Pathogenesis, recommendations, and new trends. Cancer Treatment and Research Communications, 26, 100278. https://doi.org/10.1016/j.ctarc.2020.100278
  17. Habibi, M., Namimoghadam, A., Roghaye, K., Fashiri, P., Borzoueisileh, S., Elahimanesh, F., Amiri, F., & Moradi, G. (2016). Radiation-induced nausea and vomiting: Is ABO blood group as important as radiation and patient-related factors? An observational study. Medicine, 95(31), e4334. https://doi.org/10.1097/MD.0000000000004334
  18. Hayashi, T., Shimokawa, M., Matsuo, K., Nishimura, J., Iihara, H., Nakano, T., & Egawa, T. (2021). 5HT3RA plus dexamethasone plus aprepitant for controlling delayed chemotherapy-induced nausea and vomiting in colorectal cancer. Cancer Science, 112(2), 744-750. https://doi.org/10.1111/cas.14757
  19. Hutajulu, S. H., Prabandari, Y. S., Bintoro, B. S., Wiranata, J. A., Widiastuti, M., Suryani, N. D., Saptari, R. G., Taroeno-Hariadi, K. W., Kurnianda, J., Purwanto, I., Hardianti, M. S., & Allsop, M. J. (2022). Delays in the presentation and diagnosis of women with breast cancer in Yogyakarta, Indonesia: A retrospective observational study. PloS one, 17(1), e0262468. https://doi.org/10.1371/journal.pone.0262468
  20. International Agency for Research of Cancer (2018, September 12). Latest global cancer data. IARC. International Agency for Research of Cancer, World Health Organization. https://www.iarc.fr/wp-content/uploads/2018/09/pr263_E.pdf
  21. Jannat, F., Alipour, S., Noori, F., Ansari, S., Ashtab, T., Eskandari, A., Boroumand Sani, S., Orouji, M. G., D., & Dousti Amshaki, F. (2022). Comparison of the effectiveness of breast cancer education through two virtual methods for increasing knowledge in nurses. Nurse Media Journal of Nursing, 12(1), 100-110. https://doi.org/10.14710/nmjn.v12i1.41780
  22. Kapoor, A., Jain, A., Sharma, A., Shah, M., Chinthala, S., Nandhana, R., Bhargava, P., Ramaswamy, A., Srinivas, S., & Ostwal, V. (2020). Chemotherapy-induced nausea and vomiting in gastrointestinal cancer patients: Do we need to revisit guidelines? South Asian Journal of Cancer, 9(4), 245-249. https://doi.org/10.1055/s-0041-1729493
  23. Lavdaniti, M., & Tsitsis, N. (2014). Investigation of nausea and vomiting in cancer patients undergoing chemotherapy. Health Psychology Research, 2(3), 1550. https://doi.org/10.4081/hpr.2014.1550
  24. Levine, S. K., & Shega, J. W. (2013). How should medications be initiated and titrated to reduce acute and delayed nausea and vomiting in the setting of chemotherapy? In N. E. Goldstein & R. S. Morrison (Eds.), Evidence-Based Practice in Palliative Medicine (pp. 135-140). W.B. Saunders. https://doi.org/10.1016/B978-1-4377-3796-7.00025-2
  25. Mao, Y., Yang, W., Qi, Q., Yu, F., Wang, T., Zhang, H., Dai, J., Ma, H., Hu, Z., Shen, H., Li, G., & Jin, G. (2019). Blood groups A and AB are associated with increased gastric cancer risk: Evidence from a large genetic study and systematic review. BMC Cancer, 19(1), 164. https://doi.org/10.1186/s12885-019-5355-4
  26. Meo, S. A., Suraya, F., Jamil, B., Rouq, F. A., Meo, A. S., Sattar, K., Ansari, M. J., & Alasiri, S. A. (2017). Association of ABO and Rh blood groups with breast cancer. Saudi Journal of Biological Sciences, 24(7), 1609-1613. https://doi.org/10.1016/j.sjbs.2017.01.058
  27. Ministry of Health the Republic of Indonesia. (2019). Beban Kanker di Indonesia [Cancer burden in Indonesia]. Ministry of Health The Republic of Indonesia. https://www.studocu.com/id/document/universitas-udayana/antropologi-kesehatan/infodatin-kanker-2019/32696320
  28. National Cancer Institute. (2018). Support for people with cancer: Chemotherapy and you. National Cancer Institute. https://www.cancer.gov/publications/patient-education/chemotherapy-and-you.pdf
  29. Navari, R., & Rapoport, B. (2016). Fact fast: chemotherapy induced nausea and vomiting. From Science to Pharma. https://www.fromsciencetopharma.com/content/resources/FF_CINV_sample.pdf
  30. Parente, E. B., Harjutsalo, V., Lehto, M., Forsblom, C., Sandholm, N., Groop, P.-H., & FinnDiane Study Group. (2020). Relationship between ABO blood groups and cardiovascular disease in type 1 diabetes according to diabetic nephropathy status. Cardiovascular Diabetology, 19(1), 68. https://doi.org/10.1186/s12933-020-01038-z
  31. Phan T, P. V., & Murray K. . (2010). Blood group A is associated with higher incidence of nausea and vomiting in pregnancy. WebmedCentral Obstetrics and Gynaecology, 1(9), WMC00526. https://doi.org/10.9754/journal.wmc.2010.00526
  32. Rapoport, B. L. (2017). Delayed chemotherapy-induced nausea and vomiting: Pathogenesis, incidence, and current management. Frontiers in Pharmacology, 8, 19. https://doi.org/10.3389/fphar.2017.00019
  33. Sekine, I., Segawa, Y., Kubota, K., & Saeki, T. (2013). Risk factors of chemotherapy-induced nausea and vomiting: Index for personalized antiemetic prophylaxis. Cancer Science, 104, 711-717. https://doi.org/10.1111/cas.12146
  34. Shankar, A., Roy, S., Malik, A., Julka, P., & Rath, G. (2015). Prevention of chemotherapy-induced nausea and vomiting in cancer patients. Asian Pacific Journal of Cancer Prevention, 16(15), 6207-6213. https://doi.org/10.7314/apjcp.2015.16.15.6207
  35. Shen, L., Wu, J., Xiao, Q., Hong, M., Wang, S., Wang, J., Luo, Q., Lin, X., Lian, J., Xu, Y., Guo, G., & Wu, J. (2022). Association between ABO blood groups and postoperative pain in children after adenotonsillectomy: A prospective cohort study. BMC Anesthesiology, 22(1), 407. https://doi.org/10.1186/s12871-022-01953-6
  36. Shinta, N., & Surarso, B. (2016). Terapi mual muntah pasca kemoterapi [Nausea and vomitting post chemotherapy]. Jurnal THT - KL, 9(2), 74-83
  37. Sisman, H., Eti Aslan, F., Özgen, R., Alptekin, D., & Akil, Y. (2016). Validity and reliability study of the baxter animated retching faces nausea scale. Journal of Pediatric Surgical Nursing, 5(4), 98-106. https://doi.org/10.1097/jps.0000000000000114
  38. Solikhah, S., Perwitasari, D. A., & Rejeki, D. S. S. (2022). Geographic haracteristics of various cancers in Yogyakarta province, Indonesia: A spatial analysis at the community level. Asian Pacific Journal of Cancer Prevention, 23(4), 1231-1238. https://doi.org/10.31557/apjcp.2022.23.4.1231
  39. Watcha, M. F., Medellin, E., Lee, A. D., Felberg, M. A., & Bidani, S. A. (2018). Validation of the pictorial Baxter Retching Faces scale for the measurement of the severity of postoperative nausea in Spanish-speaking children. British Journal of Anaesthesia, 121(6), 1316-1322. https://doi.org/10.1016/j.bja.2018.07.036
  40. Xu, F., Yin, J.-w., Xiong, E.-f., He, H., Zhang, Q.-t., Fan, S.-w., Qin, X.-l., & Wang, S. (2019). Correlation between preoperative anxiety and ABO blood types: Evidence from a clinical cross-sectional study. Disease Markers, 2019, 1761693. https://doi.org/10.1155/2019/1761693
  41. Zhang, Y., Huang, Y., Song, F., & Chen, K. (2014). ABO bloods group and risk of cancer: A systematic review and meta analysis. Asian Pacific Journal of Cancer Prevention: APJCP, 15(11), 4643–4650. https://doi.org/10.7314/apjcp.2014.15.11.4643

Last update:

No citation recorded.

Last update: 2023-12-03 04:23:20

No citation recorded.