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Hubungan antara Neutrofil Limfosit dengan Lama Rawatan dan Angka Kematian Pasien COVID-19 di RSUD Meuraxa Banda Aceh

*Evi Maryani  -  Fakultas Kedokteran, Universitas Abulyatama, Aceh|Universitas Abulyatama, Indonesia
Nur Fitriani  -  Fakultas Kedokteran, Universitas Abulyatama, Aceh|Universitas Abulyatama, Indonesia
Andri Andri  -  Fakultas Kedokteran, Universitas Abulyatama, Aceh|Universitas Abulyatama, Indonesia
Open Access Copyright 2023 MEDIA KESEHATAN MASYARAKAT INDONESIA under http://creativecommons.org/licenses/by-sa/4.0/.

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Abstract

Pendahuluan: Corona virus disease (COVID-19) adalah penyakit yang menyerang sistem pernapasan disebabkan oleh virus SARS CoV-2. Pasien yang terinfeksi COVID-19 mengalami penurunan sistem imun akibat peningkatan rasio neutrofil disertai penurunan limfosit. Hal tersebut dapat mempengaruhi lama rawatan dan kematian pasien. Tujuan pada penelitian ini untuk mengetahui peningkatan dan penurunan rasio neutrofil limfosit (RNL) disertai hubungan terhadap lama rawatan dan kematian pasien COVID-19.

Metode: Jenis penelitian deskriptif analitik pendekatan cross sectional pengambilan data dengan purposive sampling pada bulan Januari-Oktober 2021 berjumlah 200 sampel. Data diambil dari catatan rekam medik pasien sesuai kriteria inklusi. Data dalam penelitian ini dilakukan analisis univariat, bivariat, dan multivariat.

Hasil: Hasil analisis univariat menunjukkan jumlah pasien dengan RNL >3,13 lebih banyak dibandingkan dengan ≤3,13. Pasien COVID-19 dengan lama rawatan <14 hari lebih banyak dibandingkan ≥14 hari. Pasien yang dirawat dengan status sembuh lebih banyak dibandingan meninggal. Analisis bivariat mendapatkan hasil tidak terdapat hubungan antara RNL dengan lama rawatan dengan nilai p sebesar 0,908 (Lebih dari α 0,05). Akan tetapi, terdapat hubungan antara peningkatan RNL dengan kematian pasien (nilai p = 0,001). Analisis multivariat regresi logistik multinomial pada RNL dan lama rawatan berpengaruh terhadap kematian pasien COVID-19.

Kesimpulan: Kesimpulan terdapat hubungan antara peningkatan RNL dengan kematian, tetapi tidak terdapat hubungan antara RNL dengan lama rawatan.

Kata kunci: COVID-19, Rasio Neutrofil Limfosit (RNL), lama rawatan, kematian pasien

 

Title: Relationship Between Neutrophil Lymphocytes and Length of Care and Death Rate of Covid-19 Patients in Meuraxa Hospital Banda Aceh

Background: Corona virus disease (COVID-19) is a disease that affects the respiratory system caused by the SARS CoV-2 virus. Patients infected with COVID-19 experience a decrease in the immune system due to an increase in the ratio of neutrophils accompanied by a decrease in lymphocytes. This can affect the length of treatment and death of the patient.  to determine the increase and decrease in the ratio of neutrophil lymphocytes (RNL) along with the relationship to the length of treatment and death of COVID-19 patients.

Method: This type of descriptive analytical research with a cross-sectional approach, data were collected by purposive sampling in January-October 2021, totaling 200 samples. Data were taken from patient medical records according to the inclusion criteria. The data in this study were analyzed using univariate, bivariate, and multivariate.

Result: The results of the univariate analysis showed that the number of patients with RNL >3.13 was higher than that of those with ≤3.13. More COVID-19 patients with a length of stay <14 days than ≥14 days. More patients who were treated with recovery status than died. Bivariate analysis showed that there was no relationship between RNL and length of stay, with a p value of 0.908 (more than α 0.05). However, there is a relationship between increased RNL and patient death (p value = 0.001). Multivariate analysis of multinomial logistic regression on RNL and length of stay has an effect on the death of COVID-19 patients.

Discussion: There is a correlation between increased RNL and mortality, but there is no correlation between RNL and duration of stay.

Keywords: COVID-19, Neutrophil Lymphocyte Ratio (RNL), length of stay, patient death

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Keywords: COVID-19; Rasio Neutrofil Limfosit (RNL); lama rawatan; kematian pasien

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  1. Natalia, Yulia. Hubungan antara rasio neutrofil limfosit dengan derajat keparahan COVID-19 pada pasien di RSUD Prof. Dr. Margono Soekarjo. Skripsi thesis, Jawa tengah: Universitas Jenderal Soedirman; 2022
  2. Yusra, Pangestu N. COVID-19, SARS-CoV-2, pemeriksaan laboratorium. Departemen Patologi Klinik, RSUPN Cipto Mangunkusumo, Jakarta. Medical Hospital Jurnal Clinical Medical. 2020. Vol. 7(1):304-3193
  3. Lagunas-Rangel FA. Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis. J Med Virol. 2020;92
  4. Hamid S, Mir MY, Rohela GK. Novel coronavirus disease (COVID-19): a pandemic (epidemiology, pathogenesis and potential therapeutics). New Microbes New Infect. 2020;35:100679
  5. Ragab D, Salah Eldin H, Taeimah M, Khattab R, Salem R. The COVID-19 Cytokine Storm; What We Know So Far. Front Immunol. 2020:1-4
  6. Pakos IS, Lo KB, Salacup G, et al. Characteristics of peripheral blood differential counts in hospitalized patients with COVID-19. Eur J Haematol. 2020;105(6):773-778
  7. Li X, Liu C, Mao Z, et al. Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis. Crit Care. 2020;24(1):1-10
  8. Ponti G, Maccaferri M, Ruini C, Tomasi A, Ozben T. Biomarkers associated with COVID-19 disease progression. Crit Rev Clin Lab Sci. 2020;0(0):389-399
  9. Simadibrata DM, Lubis AM. D-dimer levels on admission and all-cause mortality risk in COVID-19 patients: A meta-Analysis. Epidemiol Infect. Published online 2020
  10. Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in coronavirus disease 2019 patients: A systematic review and meta-analysis. Int J Infect Dis. 2020;94(January):91-95
  11. Nastiti DAW, Cahyawati WASN, Panghiyangani R. Korelasi Rasio Neutrofil Limfosit dengan Lama Rawat Inap. Homeostasis. 2022;5(1):127
  12. King AH, Mehkri O, Rajendram P, Wang X, Vachharajani V, Duggal A. A High Neutrophil
  13. Lymphocyte Ratio Is Associated With Increased Morbidity and Mortality in Patients With Coronavirus Disease 2019. Crit Care Explor. 2021;3(5):e0444
  14. Liu J, Liu Y, Xiang P, et al. Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage. J Transl Med. 2020;18(1):1-12
  15. Kurnia MA, Nababan D, Irennius Girsang V, Siagan MT, Tarigan F. Prediktor Lama Rawatan Pasien Covid-19 Melalui Parameter Biomarker Di Rumah Sakit Umum Haji Medan Tahun 2020-2021. J Ilmu Kedokt dan Kesehat. 2022;9(3):969-979
  16. Baihaqi FA, Rumaropen H. Faktor-Faktor yang Berhubungan dengan Lama Rawat Inap Pasien COVID-19 di RSUD Serui Provinsi Papua: Studi Potong Lintang. J Penyakit Dalam Indones. 2022;8(4):187
  17. Rafingah S, Muhani N, Seniwati S, Sukmalara D. Hubungan Umur dan Status Komorbid dengan tingkat kematian pasien covid-19 di RSUD dr. Chasbullah Abdul Madjid Kota Bekasi. Poltekita J Ilmu Kesehat. 2022;16(2):164-169. https://jurnal.poltekkespalu.ac.id/index.php/JIK/article/view/721
  18. Brurberg KG, Fretheim A. COVID-19: The relationship between age, comorbidity and diseas severity -a rapid review, 1st update-. Oslo Nor Inst Public Heal. Published online 2020:9637-9637
  19. Drew C, Adisasmita AC. Gejala dan komorbid yang memengaruhi mortalitas pasien positif COVID-19 di Jakarta Timur, Maret-September 2020. Tarumanagara Med J. 2021;3(2):274-283
  20. Hidayati S, Adnan N. Faktor - Faktor yang Berhubungan dengan Kematian Pasien COVID-19 Lansia di Ruang Rawat Inap RSUD Kabupaten Karanganyar. J Epidemiol Kesehat Indones. 2023;6(2):69-74

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