DOI: https://doi.org/10.14710/jai.v0i0.57473

Sepsis-coagulopathy as a risk of postoperative arterial thromboses: A case report.

Departement Anesthesiology and Intensive Therapy, RSUD Dr. Moewardi, Universitas Sebelas Maret, Surakarta, Indonesia., Indonesia

Received: 16 Aug 2023; Revised: 29 Nov 2024; Accepted: 7 Jan 2025; Available online: 10 Jan 2025.
Open Access Copyright 2021 JAI (Jurnal Anestesiologi Indonesia)
Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

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Abstract

Introduction: Venous thromboembolic disease and arterial thrombosis are known causes of death in hospital, particularly among postoperative, immobilized and septic medical patients. Coagulopathy plays a key role through the mechanism of crosstalk between inflammation and coagulation as a result of systemic endothelial injury. Case: We report manifestations of sepsis-induced coagulopathy in a 64-year-old woman who was treated at the Intensive Care Unit of RSUD Dr. Moewardi with peripheral arterial disease. The patient was treated for 20 days in the intensive care unit with multidisciplinary approach. The patient's clinical outcome was good and planned for follow-up during outpatient care. Discussion: Thrombosis and inflammation are separate but strongly related physiological processes. Physiologically, inflammation-dependent activation of the coagulation system is part of the host response to pathogens aimed at limiting their systemic spread in the bloodstream. Conclusion: This response is achieved through interactions between innate immune cells and platelets called immunothrombosis.

 

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Keywords: coagulopathy; intensivist; postoperative; septic; thrombosis.

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Section: Case Reports
Language : ID
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