DOI: https://doi.org/10.14710/jai.v0i0.57473

Sepsis-Induced Coagulopathy as a Risk for Postoperative Arterial Thrombosis: A Case Report

Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Sebelas Maret University/RSUD Dr. Moewardi, Surakarta, Indonesia

Received: 16 Aug 2023; Revised: 29 Nov 2024; Accepted: 7 Jan 2025; Available online: 10 Jan 2025.
Open Access Copyright 2021 JAI (Jurnal Anestesiologi Indonesia)
Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Citation Format:
Cover Image
Abstract

Background: Venous thromboembolic disease and arterial thrombosis are recognized as common causes of hospital mortality, especially in postoperative patients, those who are immobilized, and individuals with sepsis. Coagulopathy is a significant factor due to the interaction between inflammation and coagulation, stemming from widespread endothelial damage.

Case: We report manifestations of sepsis-induced coagulopathy (SIC) in a 64-year-old woman who was treated at the intensive care unit (ICU) of RSUD Dr. Moewardi with peripheral arterial disease. The patient was treated for 20 days in the ICU with a multidisciplinary approach. The patient's clinical outcome was good and planned for follow-up during outpatient care.

Discussion: Thrombosis and inflammation are distinct yet closely interconnected physiological processes. In a normal physiological context, the activation of the coagulation system by inflammation is a component of the body's defense mechanism against pathogens, aiming to restrict their spread within the bloodstream. This protective response involves the interaction between innate immune cells and platelets.

Conclusion: By gaining a deeper insight into sepsis-associated coagulopathy (microthrombopathy), we can develop effective treatments that specifically target the microthrombotic pathway involved in endothelial damage.

Note: This article has supplementary file(s).

Fulltext View|Download |  Copyright Transfer Agreement
Letter of Application for Publishing a Manuscript
Subject
Type Copyright Transfer Agreement
  Download (14KB)    Indexing metadata
 Research Materials
Tables, Figures
Subject
Type Research Materials
  Download (714KB)    Indexing metadata
 common.other
Checklist
Subject
Type Other
  Download (18KB)    Indexing metadata
 common.other
Copyright Transfer Agreement
Subject
Type Other
  Download (362KB)    Indexing metadata
Keywords: coagulopathy; intensivist; postoperative; sepsis; thrombosis

Article Metrics:

Article Info
Section: Case Reports
Language : EN
Recent articles
Comparison of The Effectiveness of Use Antiseptic Povidone Iodine 10% And Octenidine Hydrochloride 0.1% in The Action of Neuroaxial Blocks in Patients Who Will Surgery in Haji Adam Malik General Hospital Medan Comparison of Fluoxetine (20 Mg) and Amitriptyline (12.5 Mg) As Adjuvants for The Combination of Paracetamol and Morphine in Cancer Patients' Pain Relief Effectiveness and Efficiency of Peripheral Nerve Blocks as Adjunct to General Anaesthesia for Open Reduction and Internal Fixation Surgery at Primary Hospital in Tangerang Predictors of Severity and Management of Severe Leptospirosis Patients in Intensive Care Unit Low Dosage Regional Anesthesia for Bladder Tumors in Aortic Stenosis Patient Sepsis-Induced Coagulopathy as a Risk for Postoperative Arterial Thrombosis: A Case Report More recent articles
Most cited articles
Midazolam Intravena Dosis Rendah Tidak Mempengaruhi Nitric Oxide Intraperitoneal Mencit Balb/C Yang Terpapar Lipopolisakarida Patofisiologi Penyakit Jantung Koroner More cited articles
  1. Tsantes AG, Parastatidou S, Tsantes EA, Bonova E, Tsante KA, Mantzios PG, et al. Sepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines. Vol. 13, Life. MDPI; 2023
  2. Matevosyan K, Sarode R. Thrombosis, Microangiopathies, and Inflammation. Semin Thromb Hemost. 2015 Aug 15;41(6):556–62
  3. Nowroozpoor A, Bank MA, Jafari D. Limb Ischemia due to Extensive Arterial Thrombosis in the Absence of Venous Occlusion as an Unusual Complication of Critical Illness from COVID-19. Case Reports in Acute Medicine. 2021 Mar 19;4(1):23–31
  4. Olinic DM, Stanek A, T A Taru DA, Homorodean C, Olinic M. Acute limb ischemia: An update on diagnosis and management. Vol. 8, Journal of Clinical Medicine. MDPI; 2019
  5. Iba T, Arakawa M, Di Nisio M, Gando S, Anan H, Sato K, et al. Newly Proposed Sepsis-Induced Coagulopathy Precedes International Society on Thrombosis and Haemostasis Overt-Disseminated Intravascular Coagulation and Predicts High Mortality. J Intensive Care Med. 2020 Jul 1;35(7):643–9
  6. Iba T, Levi M, Thachil J, Helms J, Scarlatescu E, Levy JH. Communication from the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis on sepsis-induced coagulopathy in the management of sepsis. Journal of Thrombosis and Haemostasis. 2023 Jan 1;21(1):145–53
  7. Simmons J, Pittet JF. The coagulopathy of acute sepsis. Vol. 28, Current Opinion in Anaesthesiology. Lippincott Williams and Wilkins; 2015. p. 227–36
  8. Tsantes AG, Parastatidou S, Tsantes EA, Bonova E, Tsante KA, Mantzios PG, et al. Sepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines. Vol. 13, Life. MDPI; 2023
  9. Donzé JD, Ridker PM, Finlayson SRG, Bates DW. Impact of sepsis on risk of postoperative arterial and venous thromboses: Large Prospective cohort study. BMJ (Online). 2014;349
  10. Levine RL, LeClerc JR, Bailey JE, Monberg MJ, Sarwat S. Venous and arterial thromboembolism in severe sepsis. Thromb Haemost. 2008 May;99(5):892–8
  11. Stark K, Massberg S. Interplay between inflammation and thrombosis in cardiovascular pathology. Vol. 18, Nature Reviews Cardiology. Nature Research; 2021. p. 666–82
  12. Chang JC. Sepsis and septic shock: Endothelial molecular pathogenesis associated with vascular microthrombotic disease. Vol. 17, Thrombosis Journal. BioMed Central Ltd.; 2019
  13. Levi M, Scully M, Singer M. The role of ADAMTS-13 in the coagulopathy of sepsis. Vol. 16, Journal of Thrombosis and Haemostasis. Blackwell Publishing Ltd; 2018. p. 646–51
  14. Iba T, Levy JH, Raj A, Warkentin TE. Advance in the management of sepsis-induced coagulopathy and disseminated intravascular coagulation. Vol. 8, Journal of Clinical Medicine. MDPI; 2019
  15. Takeshita K, Izumisato T, Takane T, Nishihara K. A case of disseminated intravascular coagulation of sepsis that caused extreme-thrombocytopenia treated at a remote-island-hospital. J Gen Fam Med. 2023 Jan 1;24(1):50–3

Last update:

No citation recorded.

Last update: 2025-02-21 15:25:21

No citation recorded.