skip to main content

The Relationship Between Interleukin-1β Levels and Visual Analog Scale Value in Preeclampsia Patients Who Received Perioperative C-Sectional Parecoxib With Spinal Anesthesia

1Doctoral Program of Biomedicine, Faculty of Medicine, Andalas University, Padang, Indonesia

2Department of Anesthesiology and Critical Care, Faculty of Medicine, Riau University, Riau, Indonesia

3Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Padang, Indonesia

4 Department of Obstetrics and Gynecology, Faculty of Medicine, Sumatera Utara University, Medan, Indonesia

5 Department of Anesthesiology and Critical Care, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia

View all affiliations
Received: 18 Dec 2023; Revised: 28 Feb 2024; Accepted: 29 Feb 2024; Available online: 28 Jun 2024; Published: 31 Jul 2024.
Open Access Copyright 2024 JAI (Jurnal Anestesiologi Indonesia)

Citation Format:
Cover Image
Abstract

Background: Interleukin1β (IL-1β) increases during inflammation and functions as a mediator that terminates endothelial dysfunction and regulates cellular apoptosis in preeclampsia. Parecoxib is a potential agent because of its superiority as an analgesic and anti-inflammatory that can work peripherally and centrally, with minimal side effects on the mother and baby.

Objective: This study aimed to determine the relationship between IL-1β levels and visual analog scale (VAS) scores in preeclampsia patients who received parecoxib perioperatively for cesarean section with spinal anesthesia.

Methods: Non-experimental cross-sectional research on preeclampsia patients who received perioperative parecoxib and underwent cesarean section with spinal anesthesia as many as 18 people at Arifin Ahmad Hospital, Riau Province, and Bina Kasih Hospital, Pekanbaru. Samples were taken by Consecutive Sampling.

Result: There was a moderate negative correlation between IL-1β and VAS (p <0.05; correlation coefficient -0.487).

Conclusion: In preeclampsia patients who received parecoxib following a 24-hour spinal anesthetic cesarean surgery, there is a correlation between IL-1β levels and VAS scores.

Note: This article has supplementary file(s).

Fulltext View|Download |  Research Instrument
Hubungan antara Kadar Interleukin-1β dan Nilai Visual Analogue Scale pada Pasien Preeklamsia yang Mendapatkan Parecoxib Perioperatif Seksio Sesarea Dengan Anestesi Spinal
Subject Sitokin; Parecoxib; Preeklampsia; Interleukin-1beta; Visual analogue scale
Type Research Instrument
  Download (103KB)    Indexing metadata
 common.other
Graphical Abstract
Subject
Type Other
  View (112KB)    Indexing metadata
 common.other
CTA
Subject
Type Other
  Download (481KB)    Indexing metadata
 common.other
Etichal Clearance
Subject
Type Other
  Download (80KB)    Indexing metadata
Keywords: cytokines; interleukin-1beta; parecoxib; preeclampsia; visual analogue scale

Article Metrics:

  1. Hogan MC, Foreman KJ, Naghavi M, Ahn SY, Wang M, Makela SM, et al. Maternal mortality for 181 countries, 1980–2008: a systematic analysis of progress towards Millennium Development Goal 5. The Lancet. 2010 May;375(9726):1609–23. https://doi.org/10.1016/S0140-6736(10)60518-1
  2. Wanderer JP, Leffert LR, Mhyre JM, Kuklina E V., Callaghan WM, Bateman BT. Epidemiology of Obstetric-Related ICU Admissions in Maryland. Crit Care Med. 2013 Aug;41(8):1844–52. https://doi.org/10.1097/CCM.0b013e31828a3e24
  3. National Population and Family Planning Board (BKKBN) SI (BPS), M of H (Kemenkes), and I. Indonesia Demographic and Health Survey 2017 National Population and Family Planning Board Jakarta, Indonesia Statistics Indonesia Jakarta, Indonesia Ministry of Health Jakarta, Indonesia The DHS Program ICF Rockville, Maryland, USA [Internet]. 2018
  4. Fitriani H, Setya R A, Keni M. Risk Factors Of Preeclampsia Among Pregnant Women In Indonesia. KnE Life Sciences. 2021 Mar 15;836–41. https://doi.org/10.18502/kls.v6i1.8761
  5. Harahap S. Faktor-faktor yang BerhubungandenganKejadianPreeklampsia Pada Ibu Bersalin di RSUD Arifin Achmad Kota PekanbaruTahun 2018. [Pekanbaru]; 2020
  6. Amash A, Holcberg G, Sheiner E, Huleihel M. Magnesium Sulfate Normalizes Placental Interleukin-6 Secretion in Preeclampsia. Journal of Interferon & Cytokine Research. 2010 Sep;30(9):683–90. https://doi.org/10.1089/jir.2010.0011
  7. Rusterholz C, Hahn S, Holzgreve W. Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia. Semin Immunopathol. 2007 Jun 19;29(2):151–62. https://doi.org/10.1007/s00281-007-0071-6
  8. Sibai BM. Imitators of Severe Pre-eclampsia. Semin Perinatol. 2009 Jun;33(3):196–205. https://doi.org/10.1053/j.semperi.2009.02.004
  9. Wang J, Huang Y, Huang Y, Zhou J, Liu X. Effect of lipoxin A4 on IL-1β production of monocytes and its possible mechanism in severe preeclampsia. Journal of Huazhong University of Science and Technology [Medical Sciences]. 2010 Dec 22;30(6):767–70. https://doi.org/10.1007/s11596-010-0655-6
  10. Ma Y, Ye Y, Zhang J, Ruan CC, Gao PJ. Immune imbalance is associated with the development of preeclampsia. Medicine. 2019 Apr;98(14):e15080. https://doi.org/10.1097/MD.0000000000015080
  11. Schug SA, Joshi GP, Camu F, Pan S, Cheung R. Cardiovascular Safety of the Cyclooxygenase-2 Selective Inhibitors Parecoxib and Valdecoxib in the Postoperative Setting: An Analysis of Integrated Data. AnesthAnalg. 2009 Jan;108(1):299–307. https://doi.org/10.1213/ane.0b013e31818ca3ac
  12. Glare P, Aubrey KR, Myles PS. Transition from acute to chronic pain after surgery. The Lancet. 2019 Apr;393(10180):1537–46. https://doi.org/10.1016/S0140-6736(19)30352-6
  13. Zhu XT, Chen L, Lin JH. Selective COX-2 inhibitor versus non-selective COX-2 inhibitor for the prevention of heterotopic ossification after total hip arthroplasty. Medicine. 2018 Aug;97(31):e11649. https://doi.org/10.1097/MD.0000000000011649
  14. Paech MJ, Salman S, Ilett KF, OʼHalloran SJ, Muchatuta NA. Transfer of Parecoxib and Its Primary Active Metabolite Valdecoxib via Transitional Breastmilk Following Intravenous Parecoxib Use After Cesarean Delivery. AnesthAnalg. 2012 Apr;114(4):837–44. https://doi.org/10.1213/ANE.0b013e3182468fa7
  15. Djafar Z. Dinamika Kadar C-Reaktive Protein pada ProsedurLaparotomiGinekologidengan Multimodal Preventif Analgesia Kombinasi Epidural Buvipacain dan Parecoxib 40 mg. [Makassar]; 2013
  16. Haeruddin H, Ahmad MR. PengaruhPemberian Parecoxib Terhadap Kadar Il-6 dan Intensitas Nyeri PascabedahLaparotomiGinekologi. Vol. V, JurnalAnestesiologi Indonesia. 2013
  17. Ahmad MR, Bisri T. Multimodal Analgesic Effect on Proinflammatory and Anti-inflammatory Cytokines Serum. International Journal of Integrated Health Sciences. 2014;2(1):15–22. https://doi.org/10.15850/ijihs.v2n1.272
  18. Vincent NTF, Darmayasa IM, Suardika A. Risk factors of preeclampsia and eclampsia in Sanglah General Hospital from March 2016 to March 2017. Intisari Sains Medis. 2018 May 1;9(2). https://doi.org/10.15562/ism.v9i2.162
  19. Liu F, Wang Z, Qiu Y, Wei M, Li C, Xie Y, et al. Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat. J Neuroinflammation. 2017 Dec 31;14(1):70. https://doi.org/10.1186/s12974-017-0822-9
  20. Gabayl E, Wolfl G, Shavitl Y, Yirmiyal R, Tall M. Chronic blockade of interleukin‐1 (IL‐1) prevents and attenuates neuropathic pain behavior and spontaneous ectopic neuronal activity following nerve injury. European Journal of Pain. 2011 Mar 13;15(3):242–8. https://doi.org/10.1016/j.ejpain.2010.07.012
  21. Yokoyama M, Itano Y, Katayama H, Morimatsu H, Takeda Y, Takahashi T, et al. The Effects of Continuous Epidural Anesthesia and Analgesia on Stress Response and Immune Function in Patients Undergoing Radical Esophagectomy. AnesthAnalg. 2005 Nov;101(5):1521–7. https://doi.org/10.1213/01.ANE.0000184287.15086.1E
  22. Shavit Y, Fridel K, Beilin B. Postoperative Pain Management and Proinflammatory Cytokines: Animal and Human Studies. Journal of Neuroimmune Pharmacology. 2006 Nov 16;1(4):443–51. https://doi.org/10.1007/s11481-006-9043-1

Last update:

No citation recorded.

Last update: 2024-10-11 14:03:29

No citation recorded.