DOI: https://doi.org/10.14710/jai.v0i0.71031

The Efficacy of High-Albumin Formula Supplementation (Albumed milk) on Serum Albumin Levels in Critically Ill Patients with Sepsis

Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Brawijaya/RSUD Dr. Saiful Anwar, Malang, Indonesia

Received: 12 Feb 2025; Revised: 23 Jan 2026; Accepted: 3 Feb 2026; Available online: 5 Feb 2026.
Open Access Copyright 2026 JAI (Jurnal Anestesiologi Indonesia)
Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

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Abstract

Background: Septic, an infection-induced condition, triggers an inflammatory response leading to life-threatening organ dysfunction and hypoalbuminemia. Albumed milk, containing extracts from egg whites and sprouts, has been considered a potential intervention to prevent hypoalbuminemia.

Objective: This study aimed to evaluate the impact of albumed milk on elevating serum albumin levels in septic patients in the intensive care unit (ICU).

Methods: An experimental study involved two groups totaling 40 patients. The control group received a standard ICU diet, while the treatment group received half of the regular ICU diet supplemented with 30 grams of albumed milk every 8 hours. Albumin levels were measured on days 0 and 3.

Results: A significant reduction in average albumin levels occurred in the control group at 0.605 units (p-value = 0.006). Conversely, the treatment group showed a non-significant decrease, with an average reduction in albumin level of 0.03 units (p = 0.839).

Conclusion: Albumed milk administration preserves albumin levels in septic patients compared to control patients without albumed, who show albumin level reduction. This highlights the potential utility of albumed milk as a supplementary measure in mitigating septic-related hypoalbuminemia.

 

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Keywords: albumed milk; critical care; intensive care; intensive care nursing; nutrition in intensive care

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Section: Original Articles
Language : EN
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  1. Perbatasari I.D, Suryono I.D, Uyun Y. Kadar Albumin Darah sebagai Prediktor Risiko Kematian Di ICU RSUP Dr Sardjito Tahun 2014. Jurnal Komplikasi Anestesi. 2016. 3 (2) : 17-22
  2. Manggabarani S, Tiro N, Laboko A.I, Umar M. Karakteristik Kandungan Albumin Pada Jenis Ikan di Pasar Kota Makassar. Jurnal Dunia Gizi. 2018. 1 (1) doi: 10.33085/jdg.v1i1.2906
  3. Matsuoka R, Kurihara H, Nishijima N, Oda Y, Handa A. Egg white hydrolysate retains the nutritional value of proteins and is quickly absorbed in rats. 2019. Sci World J
  4. Detarun P, Srichamnanturakit V, Isaramalai SA, Rakpanusit T. Enhancing nutritional care with egg white supplementation on serum albumin level for home-based bed-ridden elderly patients. Funct Foods Heal Dis. 2022;12(6):308–24
  5. Mishra V, Heath RJ (2021). Structural and biochemical features of human serum albumin essential for eukaryotic cell culture. Int J Mol Sci. 2021;22(16)
  6. Wiryana M. Nutrisi Pada Penderita Sakit Kritis. Jurnal Penyakit Dalam. 2007 ; 8 (2) Mei 2007
  7. Widya Y, Mahmud, Prima A. Hipoalbuminemia: Pengaruhnya pada Farmakokinetika Agen-agen Anestesi. Jurnal Komplikasi Anestesi. 2017. 5(1) :83-91
  8. Akirov A, Iraqi-Masri H, Atamna A. Low Albumin Levels Are Associated with Mortality Risk in Hospitalized Patients. The American Journal of Medicine. 2017; 130(1465):11-19
  9. Kendall, H., Abreu, E., & Cheng, A. Serum albumin trend predicts mortality in ICU patients with sepsis. Biol. Res. Nurs. 2019 ; 21(3), 237–244
  10. Arnau-Barres I, Guerri-Fernandez R, Luque S, Sorli L, Vazquez O, Miralles R. Serum albumin is a strong predictor of sepsis outcome in elderly patients. Eur J Clin Microbiol Infect Dis. 2019; 38(4):743–746. doi: 10.1007/s10096-019-03478-2
  11. Singer M, Deutschman CS, Seymour CW et al. The Third International Consensus definitions for sepsis and septic shock (Sepsis-3). JAMA.. 2016 315(8):801–810
  12. Mogensen T. H. Pathogen recognition and inflammatory signaling in innate immune defenses. Clinical microbiology reviews. 2009; 22(2), 240–273. https://doi.org/10.1128/CMR.00046-08
  13. Hauser, C. J., & Otterbein, L. E. Danger signals from mitochondrial DAMPs in trauma and post-injury sepsis. European journal of trauma and emergency surgery: official publication of the European Trauma Society. 2018; 44(3), 317–324. https://doi.org/10.1007/s00068-018-0963-2
  14. Soeters PB, Wolfe R, Shenkin A, et al. Hypoalbuminemia: Pathogenesis and Clinical Significance. Journal of Parenteral and Enteral Nutrition. 2018. 43(2) :181-93 https://doi.org/10.1002/jpen.1451
  15. Frej, C. et al. Sphingosine 1‐phosphate and its carrier apolipoprotein M in human sepsis and inescherichia colisepsis in baboons, Journal of Cellular and Molecular Medicine. 2016; 20(6), pp. 1170–1181. doi: 10.1111/jcmm.12831
  16. Arroyo, V., García-Martinez, R., and Salvatella, X. Human serum albumin, systemic inflammation, and cirrhosis, Journal of Hepatology. 2014; 61(2), pp. 396–407. doi: 10.1016/j.jhep.2014.04.012
  17. Yulianda D, Maharani L, Wulandari M. Penggunaan Albumin Oral dan Albumin Injeksi pada Pasien Sirosis Hepar di RSUD Prof. Dr. Margono Soekarjo Purwokerto. Acta Pharm Indo. 2020; 8(1) :8-15
  18. Gatta, A., Verardo, A., Bolognesi, M. Hypoalbuminemia, Internal and Emergency Medicine. 2012; 7 (3): S193–S199
  19. Nugroho. Alit Y. Perbandingan Efektivitas Terapi Albumin Ekstrak Ikan Gabus Murni Dibanding Human Albumin 20% Terhadap Kadar Albumin Dan pH Darah Pada Pasien Hipoalbuminemia. Tesis. Pascasarjana Universitas Sebelas Maret, Surakarta. 2016
  20. Wada, A., Nakamura, M., Kobayashi, K., Kuroda, A., Harada, D., Kido, S., & Kuwahata, M. (2023). Effects of amino acids and albumin administration on albumin metabolism in surgically stressed rats.. JPEN. Journal of Parenteral and Enteral Nutrition. https://doi.org/10.1002/jpen.2472
  21. Levitt, D. G., & Levitt, M. D. (2016). Human serum albumin homeostasis: a new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements. International journal of general medicine, 9, 229– 255. https://doi.org/10.2147/IJGM.S102819
  22. Prastowo A, Lestariana W, Nurdjanah S, et al. Keefektifan ekstrak putih telur terhadap peningkatan albumin dan penurunan IL-1β pada pasien tuberkulosis dengan hipoalbuminemia. Jurnal Gizi Klinik Indonesia. 2014; 10(3):111-18
  23. Azhar, M. Biomolekul Sel Karbohidrat, Protein dan Ezim. Journal of Chemical Information and Modeling; 2016
  24. Moman RN, Gupta N, Varacallo M. Physiology, Albumin [Internet]. StatPearls Publishing. 2022 [cited 2023 Sep 20]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459198
  25. Zhou, N., Zhao, Y., Yao, Y., Wu, N., Xu, M., Du, H., Wu, J., & Tu, Y. Antioxidant Stress and Anti-Inflammatory Activities of Egg White Proteins and Their Derived Peptides: A Review. Journal of agricultural and food chemistry, 70(1), 5–20. https://doi.org/10.1021/acs.jafc.1c04742
  26. Lee JH, Paik HD. Anticancer and immunomodulatory activity of egg proteins and peptides: a review. Poult Sci. 2019. 98(12):6505–16
  27. Tagashira, A., Nishi, K., Matsumoto, S., & Sugahara, T. Anti-inflammatory effect of lysozyme from hen egg white on mouse peritoneal macrophages. Cytotechnology. 2018. 70(3), 929–938. https://doi.org/10.1007/s10616-017-0184-2
  28. Zuhrotun, A. Aktivitas Antidiabetes Ekstrak Etanol Biji Buah Alpukat (Persea americana mill) Bentuk Bulat. Tesis. Bandung : Program Pasca Sarjana Universitas Padjadjaran. Hal : 12. 2007
  29. Sabir, A. Pemanfaatan Flavonoid di Bidang Kedokteran GIGI. Majalah Kedokteran Gigi (Dental Journal), Edisi Khusus Temu Ilmiah Nasional . 2003. III : 81-87
  30. Dedyanto H.S. Suplemen Putih Telur dalam Tatalaksana Hipoalbumin. Continuing Medical Education. 20214. 8 (10) : 410-413
  31. Han T, Cheng T, Liao Y, et al. Analysis of the value of the blood urea nitrogen to albumin ratio as a predictor of mortality in patients with sepsis. J Inflamm Res. 2022. 15:1227–1235. doi: 10.2147/JIR.S356893
  32. Kim MH, Ahn JY, Song JE, et al. The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe sepsis or septic shock treated with early goal- directed therapy. PLoS One. 2015; 10(7):e0132109
  33. Yu Y, Wu W, Dong Y, Li J. C-reactive protein-to-albumin ratio predicts sepsis and prognosis in patients with severe burn injury. Mediators Inflamm. 2021; 6621101. doi: 10.1155/2021/6621101
  34. Qin Z, Li H, Wang L, et al. Systemic immune-inflammation index is associated with increased urinary albumin excretion: a population-based study. Front Immunol. 2022; 13:863640. doi: 10.3389/fimmu.2022.863640
  35. Hsieh M, Liao S, Chia-rong hsieh V, How C. Occurrence and impact of gastrointestinal bleeding and major adverse cardiovascular events during sepsis: a 15-year observational study. Emerg Med Int. 2020; 9685604. doi: 10.1155/2020/9685604
  36. Syamsiatun NH, Siswati T. Pemberian ekstra jus putih telur terhadap kadar albumin dan Hb pada penderita hipoalbuminemia. J Gizi Klin Indones. 2015;12(2):54–61
  37. Gonzalez Demejia, E. and Manuel Real Hernandez, L. Antioxidant potential of mung bean vigna radiata albumin peptides produced by enzymatic hydrolysis and analyzed by biochemical and in silico methods 2020; [Preprint]. doi: 10.1021/scimeetings.0c00808

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