DOI: https://doi.org/10.14710/jgi.9.1.61-67

Red dragon fruit (Hylocereus spp.) peel marmalade effectively improve blood glucose and lipid profile of hypercholesterolemic wistar rats

1Nutrition, Public Health Science Department, Faculty of Sport Science, Universitas Negeri Semarang, Indonesia

2Dietisien Education, Nutrition Department, Poltekkes Kemenkes RI Yogyakarta, Indonesia

3Family Pluit Hospital North Jakarta, Indonesia

4 Kalbu Intan Medika Hospital, Indonesia

5 Nutrition Science, Faculty of Health Science, Universitas Respati Yogyakarta, Indonesia

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Received: 4 May 2020; Published: 18 Dec 2020.

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Abstract

Background: Polyphenols, antioxidants, dietary fiber, and vitamin contained in the red dragon fruit peel. Red dragon fruit peel can be processed into marmalade. Red dragon fruit peel marmalade has the potential to be a functional food. Functional food is food that has a physiological function based on scientific studies.

Objectives: The objective of this study is to analyze the effect of red dragon fruit peel marmalade on fasting blood glucose levels, HDL, LDL, and triglycerides levels of hypercholesterolemic Wistar rats.

Methods: This study used a pre-&post-test control group design. Hypercholesterolemic male Wistar rats were randomly assigned into five groups. Hypercholesterolemia was induced by 1% cholesterol powder and 0.5% cholic acid for two weeks. All groups received standard chow. Samples were grouped into five groups: K-; K+; K1 (0.94 g/kg b.wt/day); K2 (1.41 g/kg b.wt/day); K3 (1.88 g/kg b.wt/day). The intervention was carried out for 28 days. GDP level was measured using the GOD-PAP. HDL, LDL, and triglyceride were analyzed with spectrophotometry. GDP, HDL, LDL, and triglyceride levels were measured twice before fasting. A paired t-test and one-way ANOVA were used to analyze the data.

Results: The result showed that K-; K1; K2; K3 had a significant difference between groups before and after the intervention (p<0.05). Red dragon fruit peel Marmalade was able to reduce the levels of GDP, LDL, triglycerides, and increase HDL (p <0.05).

Conclusion: Red dragon fruit peel marmalade reduced fasting blood glucose levels, LDL, triglyceride levels, and increased HDL levels of hypercholesterolemic Wistar rats.

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Keywords: blood glucose level; lipid profile; marmalade; pectin; red dragon fruit peel

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Language : EN
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  1. Venkadeswaran K, Muralidharan A, Annadurai T, Ruban V, Sundararajan M, Anandhi R, et al. Antihypercholesterolemic and antioxidative potential of an extract of the plant, piper betle, and its active constituent, eugenol, in Triton WR-1339- Antihypercholesterolemic and antioxidative potential of an extract of the plant, piper betle, and I. Evid Based Complement Altern Med. 2014;2014:1-10
  2. Song H, Chu Q, Yan F, Yang Y, Han W, Zheng X. Red pitaya betacyanins protects from diet‐induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice. J Gastroenterol Hepatol. 2016;31(8):1462-9
  3. Bloomer RJ, Trepanowski JF, Kabir MM, Jr RJA, Dessoulavy ME. Impact of short-term dietary modification on postprandial oxidative stress. Nutr J. 2012;11(16):1-9
  4. Maćkowiak K, Torlińska-Walkowiak N, Torlińska B. Dietary fibre as an important constituent of the diet. Postep Hig Med Dosw. 2016;70:104-9
  5. Choo WS, Yong WK. Antioxidant properties of two species of Hylocereus fruits. Advances in Applied Science Research. 2011;2(3):418-25
  6. Laxmi SN, Tjandrakirana, Kuswanti N. Pengaruh filtrat kulit buah naga merah (Hylocereus polyrhizus) terhadap kadar glukosa darah mencit (Mus musculus) yang diinduksi glukosa. Lentera Bio. 2017;6(1):1-5
  7. Wahyuni R. Pemanfaatan kulit buah naga super merah (Hylocereus costaricensis) sebagai sumber antioksidan dan pewarna alami pada pembuatan jelly. Jurnal Teknologi Pangan. 2011;2(1):69-85
  8. Nurliyana R, Zahir S, Suleiman M, Aisyah M, Rahim K. Antioxidant study of pulps and peels of dragon fruits : a comparative study. IFRJ. 2010;17:367-75
  9. Zaidel DNA, Rashid JM, Hamidon NH, Salleh LM, Kassim ASM. Extraction and characterisation of pectin from dragon fruit (hylocereus polyrhizus) peels. Chemical Engineering Transactions. 2017;56:805-10
  10. Wolf B. Confectionery and sugar-based Foods [Internet]. Reference Module in Food Science. Elsevier; 2016. 1-4 p
  11. Smith DA. Jams and preserves/ Methods of manufacture. Encycl Food Sci Nutr. 2003;3409–15
  12. Puspita R, Ardiaria M, Syauqy A. Perbedaan efek seduhan kulit dan jus buah naga merah (Hylocereus polyrhizus) terhadap kadar kolesterol LDL serum tikus Sprague dawley dislipidemia. Jurnal Kedokteran Diponegoro. 2016;5(4):1559-67
  13. Faadlilah N, Ardiaria M. Efek pemberian seduhan kulit buah naga merah (Hylocereus polyrhizus) terhadap kadar HDL tikus Sprague dawley dislipidemia. Journal of Nutrition College. 2016;5(4):280-8
  14. Farikha IN, Anam C, Widowati E. Pengaruh jenis dan konsentrasi bahan penstabil alami terhadap karakteristik fisikokimia sari buah naga merah (Hylocereus polyrhizus ) selama penyimpanan. Jurnal Teknosains Pangan. 2013;2(1):30-8
  15. Charan J, Kantharia N. How to calculate sample size in animal studies? J Pharmacol Pharmacother. 2013;4(4):303-6
  16. Murase T, Yamada N, Uchimura H. Accumulation of intermediate density lipoprotein in the plasma of cholesterol-fed hypothyroid rats. Metabolism. 1983;32(2):146-50
  17. Menteri Kesehatan RI. Peraturan Menteri Kesehatan Republik Indonesia Nomor 30 Tahun 2013 tentang Pencantuman Informasi Kandungan Gula, Garam, dan Lemak serta Pesan Kesehatan untuk Pangan Olahan dan Pangan Siap Saji. Jakarta; 2013
  18. Hadi NA, Mohamad M, Rohin MAK, Yusof RM. Effects Of red pitaya fruit (Hylocereus Polyrhizus) consumtion on blood glucose level and lipid profile in type 2 diabetic subjects. Borneo Science [Internet]. 2012;(31):113-29
  19. Panjuantiningrum F. Pengaruh pemberian buah naga merah (Hylocereus polyrhizus) terhadap kadar glukosa darah tikus putih yang diinduksi aloksan. Surakarta: Universitas Sebelas Maret; 2009
  20. Saji N, Francis N, Schwarz LJ, Blanchard CL, Santhakumar AB. Rice bran derived bioactive compounds modulate risk factors of cardiovascular disease and type 2 diabetes mellitus: An updated review. Vol. 11, Nutrients. MDPI AG; 2019
  21. Jaya IKD. Morphology and physiology of pitaya and it future prospects in Indonesia. Crop Agro. 2010;3(1):44-50
  22. Asgary S, Rastqar A, Keshvari M. Functional food and cardiovascular disease prevention and treatment : A Review. J Am Coll Nutr [Internet]. 2018;37(5):429-55
  23. Tvrzicka E, Kremmyda LS, Stankova B, Zak A. Fatty acids as biocompounds: Their role in human metabolism, health and disease - a review. part 1: Classification, dietary sources and biological functions. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011;155(2):117-30
  24. Yadav AK, Singh SV. Osmotic dehydration of fruits and vegetables: a review. J Food Sci Technol. 2014;51(9):1654-73
  25. Paruntu OL, Ranti IN. Analisis kandungan vitamin C, mutu organoleptik, mutu fisik dan kimia marmalade bunga rosella merah (Hibiscus sabdariffa, Linn) pada konsentrasi gula bervariasi. Gizido. 2015;7(2):404-7
  26. Badan Standarisasi Nasional. SNI Marmalade (SNI 01-4467-1998). Jakarta: Badan Standarisasi Nasional- BSN; 1998. 1-5 p
  27. Larasati I. Aktivitas antioksidan sirup kombinasi ekstrak kulit manggis dan daun sirsak dengan penambahan variasi konsentrasi gula pasir. Surakarta: Universitas Muhammadiyah Surakarta; 2015
  28. Kamanna VS, Kashyap ML. Mechanism of action of niacin. Am J Cardiol. 2008;101(8 SUPPL. 1)
  29. Kamanna VS, Ganji SH, Kashyap ML. Recent advances in niacin and lipid metabolism. Curr Opin Lipidol. 2013;24(3):239-45
  30. Werdiningsih W. Efek pemberian kulit buah naga merah (Hylocereus polyrhizus) terhadap perubahan profil lipid tikus putih (Rattus norvegicus) jantan yang diberi diet tinggi lemak. Surabaya: Universitas Airlangga; 2017
  31. Zainoldin K hazmi, Baba AS. The Effect of Hylocereus polyrhizus and Hylocereus undatus on physicochemical, proteolysis, and antioxidant activity in yogurt. World Academy Science, Engineering and Technology. 2009;(60):361-6
  32. Estruch R, Martínez-González MA, Corella D, Basora-Gallisá J, Ruiz-Gutiérrez V, Covas MI, et al. Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk. J Epidemiol Community Health. 2009;63(7):582-8
  33. Ayala A, Muñoz MF, Arguelles S. Lipid Peroxidation: production, metabolism, and signaling mechanism of malondialdehyde and 4- Hydroxy-2-Nonenal. Oxidative Medicine and Cellular Longevity. 2014;98:1-32
  34. Grygiel-Górniak B. Peroxisome proliferator-activated receptors and their ligands: Nutritional and clinical implications - A review. Nutr J. 2014;13(17):1-10
  35. Pramana IDGA, Ardiaria M, Syauqy A. Perbedaan efek seduhan kulit dan jus buah naga merah (Hylocereus polyrhizus) terhadap kadar trigliserida serum tikus Sprague Dawley dislipidemia. Jurnal Kedokteran Diponegoro [Internet]. 2016;5(4):994-1006
  36. Wakil SJ, Abu-Elheiga LA. Fatty acid metabolism: Target for metabolic syndrome. J Lipid Res. 2009;50 (Suppl): S138-43
  37. Meidayanti Putri N, Gunawan IWG, Suarsa IW. Aktivitas antioksidan antosianin dalam ekstrak etanol kulit buah naga super merah (Hylocereus costaricensis) dan analisis kadar totalnya. Jurnal Kimia. 2015;9(2):243-51
  38. Yuliana AR. Efek pemberian seduhan kulit buah naga merah ( Hylocereus polyrhizus ) terhadap kadar trigliserida tikus Sprague dawley dislipidemia. Semarang: Universitas Diponegoro; 2016

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