Red dragon fruit (Hylocereus spp.) peel marmalade effectively improve blood glucose and lipid profile of hypercholesterolemic wistar rats

*Natalia Desy Putriningtyas orcid scopus  -  Nutrition, Public Health Science Department, Faculty of Sport Science, Universitas Negeri Semarang, Indonesia
Intan Permatasari  -  Dietisien Education, Nutrition Department, Poltekkes Kemenkes RI Yogyakarta, Indonesia
Dita Oktaviani  -  Family Pluit Hospital North Jakarta, Indonesia
Anastasia Servia Raha  -  Kalbu Intan Medika Hospital, Indonesia
Siti Wahyuningsih  -  Nutrition Science, Faculty of Health Science, Universitas Respati Yogyakarta, Indonesia
Received: 4 May 2020; Published: 18 Dec 2020.
DOI: https://doi.org/10.14710/jgi.9.1.61-67 View
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Abstract

Background: Polyphenols, antioxidants, dietary fiber, and vitamin contained in the red dragon fruit peel. Red dragon fruit peel can be processed into marmalade. Red dragon fruit peel marmalade has the potential to be a functional food. Functional food is food that has a physiological function based on scientific studies.

Objectives: The objective of this study is to analyze the effect of red dragon fruit peel marmalade on fasting blood glucose levels, HDL, LDL, and triglycerides levels of hypercholesterolemic Wistar rats.

Methods: This study used a pre-&post-test control group design. Hypercholesterolemic male Wistar rats were randomly assigned into five groups. Hypercholesterolemia was induced by 1% cholesterol powder and 0.5% cholic acid for two weeks. All groups received standard chow. Samples were grouped into five groups: K-; K+; K1 (0.94 g/kg b.wt/day); K2 (1.41 g/kg b.wt/day); K3 (1.88 g/kg b.wt/day). The intervention was carried out for 28 days. GDP level was measured using the GOD-PAP. HDL, LDL, and triglyceride were analyzed with spectrophotometry. GDP, HDL, LDL, and triglyceride levels were measured twice before fasting. A paired t-test and one-way ANOVA were used to analyze the data.

Results: The result showed that K-; K1; K2; K3 had a significant difference between groups before and after the intervention (p<0.05). Red dragon fruit peel Marmalade was able to reduce the levels of GDP, LDL, triglycerides, and increase HDL (p <0.05).

Conclusion: Red dragon fruit peel marmalade reduced fasting blood glucose levels, LDL, triglyceride levels, and increased HDL levels of hypercholesterolemic Wistar rats.

Note: This article has supplementary file(s).

Keywords: blood glucose level; lipid profile; marmalade; pectin; red dragon fruit peel

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