DOI: https://doi.org/10.14710/jitaa.44.3.243-251

Exploring effects of betaine-homocysteine methyltransferase (BHMT) gene polymorphisms on fatty acid traits and cholesterol in sheep

J. P. Munyaneza  -  Graduate School of IPB University, IPB University, Indonesia
*A. Gunawan  -  Department of Animal Production and Technology, Faculty of Animal Science, IPB University, Indonesia
R. R. Noor  -  Department of Animal Production and Technology, Faculty of Animal Science, IPB University, Indonesia
Open Access Copyright (c) 2019 Journal of the Indonesian Tropical Animal Agriculture

How to cite (IEEE): J. P. Munyaneza, A. Gunawan, and R. R. Noor, "Exploring effects of betaine-homocysteine methyltransferase (BHMT) gene polymorphisms on fatty acid traits and cholesterol in sheep," Journal of the Indonesian Tropical Animal Agriculture, vol. 44, no. 3, pp. 243-251, Sep. 2019. https://doi.org/10.14710/jitaa.44.3.243-251
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Abstract

This study was aimed to explore the effects of Betaine-Homocysteine Methyltransferase (BHMT) gene polymorphisms on fatty acid traits and cholesterol in lambs. This study used a total of 147 blood samples for genotyping including 19 Javanese Fat-Tailed (JFT), 16 Javanese Thin-Tailed (JTT), 41 Composite Garut (CG), 35 Compass Agrinak (CA) and 36 Barbados Black Belly Cross (BC). A total of 61 rams as representative from five breed of sheep were selected for association study. Identification of BHMT single nucleotide polymorphisms was analyzed by PCR-RFLP method. Association of BHMT genotypes with fatty acid traits and cholesterol was performed by T-TEST. BHMT genotyping resulted into three genotypes (CC, CT and TT). Gene frequency of BHMT (g. 9947372 C>T) was in Hardy-Weinberg Equilibrium, excluding Javanese Fat-Tailed sheep. Association of BHMT genotypes with fatty acid traits resulted into a significant association (P<0.05) with C14:1, C17:1 and C18:0 fatty acids but not with cholesterol in sheep. SNP g. 9947372 (C>T) of BHMT gene might be a useful marker for selecting and producing sheep meat with desirable fatty acids.

 

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Keywords: BHMT; Fatty acid; Sheep; SNP

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