1Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, Jl. Prof. Soedarto, SH., Tembalang, Semarang, Indonesia
2Otolaryngology Department, Faculty of Medicine, Diponegoro University, Indonesia
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@article{JKSA15911, author = {Arthuro Romualdo and Wuryanti Wuryanti and Suprihati Suprihati}, title = {Uji Aktivitas Isolat L-Asparaginase Dari Rimpang Temulawak (Curcuma xanthorrhiza Roxb) Terhadap Sel Hela}, journal = {Jurnal Kimia Sains dan Aplikasi}, volume = {13}, number = {2}, year = {2010}, keywords = {Asparaginase; temulawak; isolasi; HeLa}, abstract = {L- asparaginase adalah enzim hidrolase yang mengkatalisis hidrolisis asparagin menjadi asam aspartat dan amonia. L- asparaginase diketahui membantu pengobatan kanker dengan menghambat sintetis protein sel kanker tanpa merusak sel normal. Metode yang dilakukan adalah isolasi enzim meliputi ekstraksi, fraksinasi dengan ammonium sulfat; karakterisasi dengan uji aktivitas spesifik dan uji sitotoksisitas pada sel HeLa. Aktivitas spesifik tertinggi isolat L- asparaginase fraksi amonium sulfat terdapat pada fraksi keempat sebesar 22,639 unit/mg. Selanjutnya fraksi keempat diujikan pada sel HeLa dalam uji sitotoksisitas. Berdasarkan hasil uji sitotoksisitas, isolat ini memiliki aktivitas penghambatan terhadap pertumbuhan sel HeLa dengan nilai LC 50 sebesar 309,74 ppm}, issn = {2597-9914}, pages = {41--45} doi = {10.14710/jksa.13.2.41-45}, url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/15911} }
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