Pemblokiran Gugus Amino dalam L-Sistein dan L-Valin Melalui Pembentukan Formamida

Pratama Jujur Wibawa; Ismiyarto Ismiyarto

doi:10.14710/jgi.%v.%i.%p

DOI: https://doi.org/10.14710/jgi.%25v.%25i.%25p

Pemblokiran Gugus Amino dalam L-Sistein dan L-Valin Melalui Pembentukan Formamida

Pratama Jujur Wibawa

, Ismiyarto Ismiyarto

Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, Indonesia

Published: 1 Aug 2002.

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Abstract

Dalam penelitian ini telah dilakukan reaksi pemblokiran gugus amina pada L-valin dan pada L-sistein menggunakan asam format untuk membentuk, secara berurutan, formamida L-valin dan formamida L-sistein. Kedua formamida asam amino ini akan digunakan lebih lanjut untuk mensintesis asam 6-aminopenisilinat (6-APA), suatu zat antara kunci untuk membuat antibiotic baru turunan β-laktam. Reaksi dilaksanakan dengan alat refluks pada suhu sekitar 50-60°C selama 60-90 menit. Pada akhir reaksi dilakukan pemisahan pelarut menggunakan penguap berputar Buchii dan dilakukan pemurnian dengan metoda rekristalisasi menggunakan etanol. KristaI hasil pemblokiran gugus amina pada L-valin mempunyai titik leleh 153-154°C, sedangkan hasil pemblokiran gugus amina pada L-sistein titik lelehnya 129-131°C. Kedua kristal ini masing-masing memberikan noda tunggal pada plat KLT silika gel 60F₁₅₄. Hasil analisis spektra IR dari masing-masing kristal ini menunjukkan bahwa reaksi pemblokiran berhasil dilakukan dan senyawa yang terbentuk merupakan formamida L-valin dan formamida L-sistein

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Keywords: agen pemblokir; formamida L-valin,formamida L-sistein

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Section: Research Articles

Language : ID

In Vol 5, No 2 (2002): Volume 5 Issue 2 Year 2002

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