1Department of Chemistry, Faculty Mathematics and Natural Sciences, Nusa Bangsa University, Bogor 16166, Indonesia
2Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Kawasan Sains dan Teknologi (KST) B.J Habibie (PUSPIPTEK) Serpong, South Tangerang, Banten, Indonesia
3Department of Biology, Faculty of Mathematics and Natural Sciences, Nusa Bangsa University, Bogor 16166, Indonesia
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@article{JKSA85814, author = {Ricson Pemimpin Hutagaol and Tjandrawati Mozef and Dinda Nayla Faza and Desy Satiyaningsih and Salsa Nabila Safitri}, title = {Evaluation of the Antibacterial Activity of a Cycloartane-Type Triterpenoid from Aglaia shawiana Against Multidrug-Resistant Bacteria Type}, journal = {Jurnal Kimia Sains dan Aplikasi}, volume = {29}, number = {8}, year = {2026}, keywords = {Aglaia; Lagerenol; Chromatography; Bioactivity; Resistance}, abstract = {Aglaia is the largest Genus in the Meliaceae family and is endemic to Indonesia. This study aims to isolate secondary metabolites from Aglaia shawiana that exhibit biological activity against multidrug-resistant pathogenic bacteria. Normal hexane extracts of Aglaia shawiana twigs were isolated and fractionated using various gravity column chromatography methods, resulting in a pure isolate. The structure of the pure isolate was determined by one-dimensional nuclear magnetic resonance spectroscopy and reference analysis. The pure isolate is a cycloartane-type tetracyclic triterpenoid compound named lagerenol. This study marks the first time that lagerenol has been successfully isolated as a pure, single compound. This is also the first time this compound has been discovered in the Meliaceae family. This study presents the first data on the biological activity of this compound. Previous research to determine the activity of compounds against bacteria has largely been conducted by evaluating them against standard bacterial strains; as a result, there remains a data gap regarding their efficacy against drug-resistant strains. Bioactivity of this compound was tested against four types of bacteria: two Gram-positive strains, Bacillus subtilis and Pseudomonas aeruginosa , and two Gram-negative strains, Staphylococcus aureus and Escherichia coli . However, lagerenol has not shown any activity at concentrations up to 100 ppm against any of the test bacteria. Tetracycline, which was used as a positive control, also showed no activity against the two types of Gram-negative bacteria tested. Therefore, it is also necessary to test their activity at higher concentration ranges to obtain more comprehensive data.}, issn = {2597-9914}, pages = {538--544} doi = {10.14710/jksa.29.8.538-544}, url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/85814} }
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