A Pilot Study on Diabetes Distress, Insulin Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and HbA1c in Diabetic Patients

Tahiruddin Tahiruddin; Diah Indriastuti; Syahrul Syahrul; Andi Masyitha Irwan; Satriya Pranata

doi:10.14710/nmjn.v15i1.58052

DOI: https://doi.org/10.14710/nmjn.v15i1.58052

A Pilot Study on Diabetes Distress, Insulin Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and HbA1c in Diabetic Patients

*Tahiruddin Tahiruddin

- Sekolah Tinggi Ilmu Kesehatan (STIKes) Karya Kesehatan, Indonesia

Diah Indriastuti

- Bachelor of Nursing Study Program, Faculty of Medicine, Halu Oleo University, Indonesia

Syahrul Syahrul

- Department of Community and Family Health Nursing, Faculty of Nursing, Universitas Hasanuddin, Indonesia

Andi Masyitha Irwan

- Department of Community and Family Health Nursing, Faculty of Nursing, Universitas Hasanuddin, Indonesia

Satriya Pranata

- Department of Nursing, Faculty of Nursing and Health Sciences, Universitas Muhammadiyah Semarang, Indonesia

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

BibTex Citation Data :

@article{NMJN58052,
    author = {Tahiruddin Tahiruddin and Diah Indriastuti and Syahrul Syahrul and Andi Irwan and Satriya Pranata},
    title = {A Pilot Study on Diabetes Distress, Insulin Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and HbA1c in Diabetic Patients},
    journal = {Nurse Media Journal of Nursing},
  volume = {15},
    number = {1},
    year = {2025},
    keywords = {Diabetes; HbA1c; IGF-I; IGFBP-3},
    abstract = {  Background:  Diabetes distress refers to the emotional and psychological burden experienced by individuals in managing their condition, which can influence physiological outcomes and overall well-being. However, the relationship between HbA1c, insulin growth factor-I (IGF-I), and insulin-like growth factor binding protein-3 (IGFBP-3) with diabetes distress in diabetic patients remains elusive.     Purpose:  The objective of this study was to evaluate the association of IGF-I, IGFBP-3, and HbA1c with diabetes distress in diabetic patients.   Methods:  A cross-sectional design with purposive sampling was used to recruit subjects from the public health center in Kendari City, Southeast Sulawesi, Indonesia, from May to November 2021. A total of 30 diabetic patients were recruited. Distress data were collected using the Indonesian version of the Diabetes Distress Scale (DDS) questionnaire. HbA1c levels were measured using High-Performance Liquid Chromatography (HPLC). Serum levels of IGF-I and IGFBP-3 were measured using the ELISA (Enzyme-Linked Immunosorbent Assay) kit method. The data were analyzed using regression analysis.   Results:  Most respondents had moderate distress, with a DDS score of 53.4%, high IGF-I levels in 76.7%, and low IGFBP-3 levels in 76.7%. As many as 60% of respondents had an HbA1c level above 6.4%. IGF-I (ρ-value = 0.024) and IGFBP-3 levels (ρ-value = 0.042) were significantly correlated with diabetes distress. However, HbA1c levels were not significantly correlated with diabetes distress (ρ-value = 0.155).   Conclusion:  IGF-I and IGFBP-3 levels were associated with diabetes distress, but HbA1c was not. Patients with higher distress were found to have elevated serum levels of IGF-I and IGFBP-3. Future research should focus on stress management strategies that support efforts to prevent disease and complications associated with diabetes mellitus. },
   issn = {2406-8799},  doi = {10.14710/nmjn.v15i1.58052},
    url = {https://ejournal.undip.ac.id/index.php/medianers/article/view/58052}
}

Citation Format:

Abstract

Background: Diabetes distress refers to the emotional and psychological burden experienced by individuals in managing their condition, which can influence physiological outcomes and overall well-being. However, the relationship between HbA1c, insulin growth factor-I (IGF-I), and insulin-like growth factor binding protein-3 (IGFBP-3) with diabetes distress in diabetic patients remains elusive.

Purpose: The objective of this study was to evaluate the association of IGF-I, IGFBP-3, and HbA1c with diabetes distress in diabetic patients.

Methods: A cross-sectional design with purposive sampling was used to recruit subjects from the public health center in Kendari City, Southeast Sulawesi, Indonesia, from May to November 2021. A total of 30 diabetic patients were recruited. Distress data were collected using the Indonesian version of the Diabetes Distress Scale (DDS) questionnaire. HbA1c levels were measured using High-Performance Liquid Chromatography (HPLC). Serum levels of IGF-I and IGFBP-3 were measured using the ELISA (Enzyme-Linked Immunosorbent Assay) kit method. The data were analyzed using regression analysis.

Results: Most respondents had moderate distress, with a DDS score of 53.4%, high IGF-I levels in 76.7%, and low IGFBP-3 levels in 76.7%. As many as 60% of respondents had an HbA1c level above 6.4%. IGF-I (ρ-value = 0.024) and IGFBP-3 levels (ρ-value = 0.042) were significantly correlated with diabetes distress. However, HbA1c levels were not significantly correlated with diabetes distress (ρ-value = 0.155).

Conclusion: IGF-I and IGFBP-3 levels were associated with diabetes distress, but HbA1c was not. Patients with higher distress were found to have elevated serum levels of IGF-I and IGFBP-3. Future research should focus on stress management strategies that support efforts to prevent disease and complications associated with diabetes mellitus.

Fulltext

Keywords: Diabetes; HbA1c; IGF-I; IGFBP-3

Funding: Ministry of Education and Culture, Republic of Indonesia

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Language : EN

In Vol 15, No 1 (2025): (April 2025) (in progress)

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A Pilot Study on Diabetes Distress, Insulin Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and HbA1c in Diabetic Patients

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