BibTex Citation Data :
@article{NMJN58052, author = {Tahiruddin Tahiruddin and Diah Indriastuti and Syahrul Syahrul and Andi Irwan and Satriya Pranata}, title = {A Pilot Study on Diabetes Distress, Insulin Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and HbA1c in Diabetic Patients}, journal = {Nurse Media Journal of Nursing}, volume = {15}, number = {1}, year = {2025}, keywords = {Diabetes; HbA1c; IGF-I; IGFBP-3}, abstract = { Background: Diabetes distress refers to the emotional and psychological burden experienced by individuals in managing their condition, which can influence physiological outcomes and overall well-being. However, the relationship between HbA1c, insulin growth factor-I (IGF-I), and insulin-like growth factor binding protein-3 (IGFBP-3) with diabetes distress in diabetic patients remains elusive. Purpose: The objective of this study was to evaluate the association of IGF-I, IGFBP-3, and HbA1c with diabetes distress in diabetic patients. Methods: A cross-sectional design with purposive sampling was used to recruit subjects from the public health center in Kendari City, Southeast Sulawesi, Indonesia, from May to November 2021. A total of 30 diabetic patients were recruited. Distress data were collected using the Indonesian version of the Diabetes Distress Scale (DDS) questionnaire. HbA1c levels were measured using High-Performance Liquid Chromatography (HPLC). Serum levels of IGF-I and IGFBP-3 were measured using the ELISA (Enzyme-Linked Immunosorbent Assay) kit method. The data were analyzed using regression analysis. Results: Most respondents had moderate distress, with a DDS score of 53.4%, high IGF-I levels in 76.7%, and low IGFBP-3 levels in 76.7%. As many as 60% of respondents had an HbA1c level above 6.4%. IGF-I (ρ-value = 0.024) and IGFBP-3 levels (ρ-value = 0.042) were significantly correlated with diabetes distress. However, HbA1c levels were not significantly correlated with diabetes distress (ρ-value = 0.155). Conclusion: IGF-I and IGFBP-3 levels were associated with diabetes distress, but HbA1c was not. Patients with higher distress were found to have elevated serum levels of IGF-I and IGFBP-3. Future research should focus on stress management strategies that support efforts to prevent disease and complications associated with diabetes mellitus. }, issn = {2406-8799}, doi = {10.14710/nmjn.v15i1.58052}, url = {https://ejournal.undip.ac.id/index.php/medianers/article/view/58052} }
Refworks Citation Data :
Background: Diabetes distress refers to the emotional and psychological burden experienced by individuals in managing their condition, which can influence physiological outcomes and overall well-being. However, the relationship between HbA1c, insulin growth factor-I (IGF-I), and insulin-like growth factor binding protein-3 (IGFBP-3) with diabetes distress in diabetic patients remains elusive.
Purpose: The objective of this study was to evaluate the association of IGF-I, IGFBP-3, and HbA1c with diabetes distress in diabetic patients.
Methods: A cross-sectional design with purposive sampling was used to recruit subjects from the public health center in Kendari City, Southeast Sulawesi, Indonesia, from May to November 2021. A total of 30 diabetic patients were recruited. Distress data were collected using the Indonesian version of the Diabetes Distress Scale (DDS) questionnaire. HbA1c levels were measured using High-Performance Liquid Chromatography (HPLC). Serum levels of IGF-I and IGFBP-3 were measured using the ELISA (Enzyme-Linked Immunosorbent Assay) kit method. The data were analyzed using regression analysis.
Results: Most respondents had moderate distress, with a DDS score of 53.4%, high IGF-I levels in 76.7%, and low IGFBP-3 levels in 76.7%. As many as 60% of respondents had an HbA1c level above 6.4%. IGF-I (ρ-value = 0.024) and IGFBP-3 levels (ρ-value = 0.042) were significantly correlated with diabetes distress. However, HbA1c levels were not significantly correlated with diabetes distress (ρ-value = 0.155).
Conclusion: IGF-I and IGFBP-3 levels were associated with diabetes distress, but HbA1c was not. Patients with higher distress were found to have elevated serum levels of IGF-I and IGFBP-3. Future research should focus on stress management strategies that support efforts to prevent disease and complications associated with diabetes mellitus.
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Last update: 2025-05-24 01:12:47
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