DOI: https://doi.org/10.14710/nmjn.v14i3.61941

Global Trends of Diabetic Erectile Dysfunction Research from 2012 to 2022: A Bibliometric and Visualized Study

Yohanes Andy Rias orcid scopus  -  Nursing Study Program, Faculty of Health, Institut Ilmu Kesehatan Bhakti Wiyata Kediri, Indonesia
*Ratsiri Thato orcid  -  Faculty of Nursing, Chulalongkorn University, Thailand
Hsiu Ting Tsai orcid  -  Post-Baccalaureate Program in Nursing, College of Nursing, Taipei Medical University, Taiwan
Noor Rohmah Mayasari orcid  -  Department of Nutrition, Faculty of Sports and Health Sciences, Universitas Negeri Surabaya, Indonesia
Zulfa Avidiansyah orcid  -  Library and Information Science Program, Faculty of Humanities, Universitas Diponegoro, Indonesia
Iswanti Purwaningsih  -  Department of Nursing, Faculty of Medicine, Politeknik Kesehatan Karya Husada Yogyakarta, Indonesia
Suhartini Ismail orcid  -  Department of Nursing, Faculty of Medicine, Universitas Diponegoro, Indonesia
Open Access Copyright (c) 2025 by the Authors, Published by Department of Nursing, Faculty of Medicine, Universitas Diponegoro
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Abstract

Background: Several studies have been conducted to investigate the trends of erectile dysfunction (ED) among individuals with diabetes. Nonetheless, a comprehensive analysis of the literature concerning ED among individuals with diabetes is required, especially in the nursing field, which yet remains elusive.

Purpose: This study uses bibliometric and visualized analysis to analyze the global scientific trends and research keywords of previous studies on ED in diabetes published from 2012 to 2022.

Methods: The literature, specifically related to ED in diabetes, was obtained from the Web of Science Core Collection database. VOS viewer, Cite Space, and Excel 2019 were used to examine the journal title, research frontiers, authors, institutions, countries, and citation reports.

Results: A total of 2,367 articles on ED and diabetes between 2012 and 2022 were identified as of September 30, 2022. The global trend was comparatively declining in the last two years (2021 and 2022). International Journal of Impotence Research (568 papers) owned the highest number of publications. A.L. Burnett (41 papers) was the top most productive author, and T. F. Lue had the largest number of citations (842 citations) during the past decades. USA was the leading contributor in this field, with 668 articles. Active cooperation between countries and between institutions was observed. The main keywords and exciting topics related to ED were frontiers of physical activity included in therapy, quality of life, and oxidative stress.

Conclusion: Global trend of research on ED in people with diabetes increased up to 2020 and decreased in 2021 and 2022. Nurses and healthcare should explore the links between oxidative stress, physical activity, and quality of life among diabetes with ED.

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Keywords: Bibliometric analysis; diabetes; erectile dysfunction; oxidative stress; physical activity.

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Section: Articles
Language : EN
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  1. Allen, M. S. (2019). Physical activity as an adjunct treatment for erectile dysfunction. Nature Reviews Urology, 16(9), 553-562. https://doi.org/10.1038/s41585-019-0210-6
  2. Alzharani, A.A.Y., Alshami, A.M., Khan, M.A. et al. (2024). A bibliometric analysis of the scientific research on erectile dysfunction. Sexuality and Disability, 42, 701–715. https://doi.org/10.1007/s11195-024-09849-8
  3. Bao, B., Ke, M., Guo, J., Pan, Z., Huang, H., Ke, Z., Zhou, X., & Liu, B. (2022). Bibliometrics and visualisation analysis of literature on varicocele: From 2002 to 2021. Andrologia, 54(10), e14537. https://doi.org/10.1111/and.14537
  4. Belba, A., Cortelazzo, A., Andrea, G., Durante, J., Nigi, L., Dotta, F., Timperio, A. M., Zolla, L., Leoncini, R., Guerranti, R., & Ponchietti, R. (2016). Erectile dysfunction and diabetes: Association with the impairment of lipid metabolism and oxidative stress. Clinical Biochemistry, 49(1), 70-78. https://doi.org/10.1016/j.clinbiochem.2015.10.004
  5. Brooke, J. C., Walter, D. J., Kapoor, D., Marsh, H., Muraleedharan, V., & Jones, T. H. (2014). Testosterone deficiency and severity of erectile dysfunction are independently associated with reduced quality of life in men with type 2 diabetes. Andrology, 2(2), 205-211. https://doi.org/10.1111/j.2047-2927.2013.00177.x
  6. Castela, A., Gomes, P., Domingues, V. F., Paíga, P., Costa, R., Vendeira, P., & Costa, C. (2015). Role of oxidative stress-induced systemic and cavernosal molecular alterations in the progression of diabetic erectile dysfunction. Journal of Diabetes, 7(3), 393-401. https://doi.org/10.1111/1753-0407.12181
  7. Corona, G., Isidori, A. M., Aversa, A., Bonomi, M., Ferlin, A., Foresta, C., La Vignera, S., Maggi, M., Pivonello, R., Vignozzi, L., & Lombardo, F. (2020). Male and female sexual dysfunction in diabetic subjects: Focus on new antihyperglycemic drugs. Reviews in Endocrine and Metabolic Disorders, 21(1), 57-65. https://doi.org/10.1007/s11154-019-09535-7
  8. De Berardis, G., Pellegrini, F., Franciosi, M., Belfiglio, M., Di Nardo, B., Greenfield, S., Kaplan, S. H., Rossi, M. C., Sacco, M., & Tognoni, G. (2005). Longitudinal assessment of quality of life in patients with type 2 diabetes and self-reported erectile dysfunction. Diabetes Care, 28(11), 2637-2643. https://doi.org/10.2337/diacare.28.11.2637
  9. De Young, L., Yu, D., Bateman, R. M., & Brock, G. B. (2004). Oxidative stress and antioxidant therapy: Their impact in diabetes‐associated erectile dysfunction. Journal of Andrology, 25(5), 830-836. https://doi.org/10.1002/j.1939-4640.2004.tb02862.x
  10. Defeudis, G., Mazzilli, R., Tenuta, M., Rossini, G., Zamponi, V., Olana, S., Faggiano, A., Pozzilli, P., Isidori, A. M., & Gianfrilli, D. (2022). Erectile dysfunction and diabetes: A melting pot of circumstances and treatments. Diabetes/Metabolism Research and Reviews, 38(2), e3494. https://doi.org/10.1002/dmrr.3494
  11. Esposito, K., Ciotola, M., Giugliano, F., Schisano, B., Improta, L., Improta, M., Beneduce, F., Rispoli, M., De Sio, M., & Giugliano, D. (2007). Endothelial microparticles correlate with erectile dysfunction in diabetic men. International Journal of Impotence Research, 19(2), 161-166. https://doi.org/10.1038/sj.ijir.3901500
  12. Förstermann, U., & Sessa, W. C. (2012). Nitric oxide synthases: Regulation and function. European Heart Journal, 33(7), 829-837. https://doi.org/10.1093/eurheartj/ehr304
  13. Getie Mekonnen, E., Yeshita, H. Y., & Bishaw Geremew, A. (2021). Sexual dysfunction among men with diabetes mellitus attending chronic out-patient department at the three hospitals of Northwest Amhara region, Ethiopia: Prevalence and associated factors. PLoS One, 16(8), e0256015. https://doi.org/10.1371/journal.pone.0256015
  14. Giugliano, F., Maiorino, M., Bellastella, G., Gicchino, M., Giugliano, D., & Esposito, K. (2010). Determinants of erectile dysfunction in type 2 diabetes. International Journal of Impotence Research, 22(3), 204-209. https://doi.org/10.1038/ijir.2010.1
  15. Gurbuz, N., Gurkan, R., Ender Caylan, A., Surmen Usta, S., & Usta, M. F. (2022). The therapeutic effect of ALT-711 on erectile function in rats treated with high-level AGEs (advanced glycation end products) containing diet. International Journal of Impotence Research, 34(2), 222-228. https://doi.org/10.1038/s41443-021-00417-8
  16. Gutiérrez-Salcedo, M., Martínez, M. Á., Moral-Munoz, J. A., Herrera-Viedma, E., & Cobo, M. J. (2018). Some bibliometric procedures for analyzing and evaluating research fields. Applied Intelligence, 48(5), 1275-1287. https://doi.org/10.1007/s10489-017-1105-y
  17. Hadisuyatmana, S., Boyd, J. H., Efendi, F., Malik, G., Bauer, M., Reisenhofer, S. (2023). Non-medical and non-invasive interventions for erectile dysfunction in men with type 2 diabetes mellitus: A scoping review. Heliyon, 9(5), e15778. https://doi.org/10.1016/j.heliyon.2023.e15778
  18. Hui, J., He, S., Liu, R., Zeng, Q., Zhang, H., & Wei, A. (2020). Trends in erectile dysfunction research from 2008 to 2018: A bibliometric analysis. International Journal of Impotence Research, 32(4), 409-419. https://doi.org/10.1038/s41443-019-0161-8
  19. International Journal of Impotence Research. (2024). Journal Information. Springer Nature. https://www.nature.com/ijir/journal-information
  20. Kapoor, D., Clarke, S., Channer, K., & Jones, T. (2007). Erectile dysfunction is associated with low bioactive testosterone levels and visceral adiposity in men with type 2 diabetes. International Journal of Andrology, 30(6), 500-507. https://doi.org/10.1111/j.1365-2605.2007.00744.x
  21. Kouidrat, Y., Pizzol, D., Cosco, T., Thompson, T., Carnaghi, M., Bertoldo, A., Solmi, M., Stubbs, B., & Veronese, N. (2017). High prevalence of erectile dysfunction in diabetes: A systematic review and meta-analysis of 145 studies. Diabetic Medicine, 34(9), 1185-1192. https://doi.org/10.1111/dme.13403
  22. Maiorino, M. I., Bellastella, G., Giugliano, D., & Esposito, K. (2018). From inflammation to sexual dysfunctions: A journey through diabetes, obesity, and metabolic syndrome. Journal of Endocrinological Investigation, 41(11), 1249-1258. https://doi.org/10.1007/s40618-018-0872-6
  23. Maisonneuve H. (2022). COVID-19 as a source of poor publications. Joint Bone Spine, 89(6), 105427. https://doi.org/10.1016/j.jbspin.2022.105427
  24. Malavige, L., Jayaratne, S., Kathriarachchi, S., Sivayogan, S., Ranasinghe, P., & Levy, J. (2014). Erectile dysfunction is a strong predictor of poor quality of life in men with type 2 diabetes mellitus. Diabetic Medicine, 31(6), 699-706. https://doi.org/10.1111/dme.12412
  25. Malavige, L. S., & Levy, J. C. (2009). Erectile dysfunction in diabetes mellitus. The Journal of Sexual Medicine, 6(5), 1232-1247. https://doi.org/10.1111/j.1743-6109.2008.01168.x
  26. Minami, H., Furukawa, S., Sakai, T., Niiya, T., Miyaoka, H., Miyake, T., Yamamoto, S., Kanzaki, S., Maruyama, K., & Tanaka, K. (2018). Physical activity and prevalence of erectile dysfunction in Japanese patients with type 2 diabetes mellitus: The dogo study. Journal of Diabetes Investigation, 9(1), 193-198. https://doi.org/10.1111/jdi.12660
  27. Mitkov, M. D., Aleksandrova, I. Y., & Orbetzova, M. M. (2013). Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Medica (Plovdiv), 55(1), 55-63. https://doi.org/10.2478/folmed-2013-0006
  28. Morano, S., Gatti, A., Mandosi, E., Tiberti, C., Fallarino, M., Cipriani, R., Buchetti, B., Gandini, L., Sgrò, P., & Jannini, E. A. (2007). Circulating monocyte oxidative activity is increased in patients with type 2 diabetes and erectile dysfunction. The Journal of Urology, 177(2), 655-659. https://doi.org/10.1016/j.juro.2006.09.046
  29. Nisahan, B., Kumanan, T., Rajeshkannan, N., Peranantharajah, T., & Aravinthan, M. (2019). Erectile dysfunction and associated factors among men with diabetes mellitus from a tertiary diabetic center in Northern Sri Lanka. BMC Research Notes, 12, 210. https://doi.org/10.1186/s13104-019-4244-x
  30. Paniagua Cruz, A., Zhu, K. Y., Ellimoottil, C., Dauw, C. A., Sarma, A., & Skolarus, T. A. (2020). Characterizing the benign prostatic hyperplasia literature: A bibliometric analysis. Urology, 136, 202-211. https://doi.org/https://doi.org/10.1016/j.urology.2019.11.033
  31. Panwar, P., Navriya, S. C., Tendulkar, P., & Khapre, M. (2022). Major sexual function domains affected in the diabetic females: A cross-sectional study from North India. Indian Journal of Endocrinology and Metabolism, 26(5), 478-482. https://doi.org/10.4103/ijem.ijem_68_22
  32. Rahmanian, E., Salari, N., Mohammadi, M., & Jalali, R. (2019). Evaluation of sexual dysfunction and female sexual dysfunction indicators in women with type 2 diabetes: A systematic review and meta-analysis. Diabetology & Metabolic Syndrome, 11, 1-17. https://doi.org/10.1186/s13098-019-0469-z
  33. Raynaud, M., Goutaudier, V., Louis, K., Al-Awadhi, S., Dubourg, Q., Truchot, A., Brousse, R., Saleh, N., Giarraputo, A., Debiais, C., Demir, Z., Certain, A., Tacafred, F., Cortes-Garcia, E., Yanes, S., Dagobert, J., Naser, S., Robin, B., Bailly, É., Jouven, X., … Loupy, A. (2021). Impact of the COVID-19 pandemic on publication dynamics and non-COVID-19 research production. BMC Medical Research Methodology, 21, 255. https://doi.org/10.1186/s12874-021-01404-9
  34. Rezaee, M., Johnson, H., Munarriz, R., & Gross, M. (2019). 237 Bibliometric analysis of erectile dysfunction publications in urology and sexual medicine journals. The Journal of Sexual Medicine, 16(4), S115. https://doi.org/10.1016/j.jsxm.2019.01.244
  35. Rias, Y. A., Kurniawan, A. L., Chang, C. W., Gordon, C. J., & Tsai, H. T. (2020). Synergistic effects of regular walking and alkaline electrolyzed water on decreasing inflammation and oxidative stress, and increasing quality of life in individuals with type 2 diabetes: A community based randomized controlled trial. Antioxidants, 9(10), 946. https://doi.org/doi: 10.3390/antiox9100946
  36. Shiferaw, W. S., Akalu, T. Y., Petrucka, P. M., Areri, H. A., & Aynalem, Y. A. (2020). Risk factors of erectile dysfunction among diabetes patients in Africa: A systematic review and meta-analysis. Journal of Clinical & Translational Endocrinology, 21, 100232. https://doi.org/10.1016/j.jcte.2020.100232
  37. Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B. B., Stein, C., Basit, A., Chan, J. C. N., Mbanya, J. C., Pavkov, M. E., Ramachandaran, A., Wild, S. H., James, S., Herman, W. H., Zhang, P., Bommer, C., Kuo, S., Boyko, E. J., & Magliano, D. J. (2022). IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes research and clinical practice, 183, 109119. https://doi.org/10.1016/j.diabres.2021.109119
  38. Tang, Z., Song, J., Yu, Z., Cui, K., Ruan, Y., Liu, Y., Wang, T., Wang, S., Liu, J., & Yang, J. (2023). Inhibition of microRNA-92a improved erectile dysfunction in streptozotocin-induced diabetic rats via suppressing oxidative stress and endothelial dysfunction. The World Journal of Men’s Health, 41(1), 142-154. https://doi.org/10.5534/wjmh.210177
  39. Ventura, A. D., Browne, J. L., Pouwer, F., Speight, J., & Byrne, M. (2018). Emotional well-being factors associated with sexual dysfunction in adults with type 1 or type 2 diabetes: Results from diabetes MILES—Australia. International Journal of Sexual Health, 30(3), 237-249. https://doi.org/10.1080/19317611.2018.1470591
  40. Waltman, L. (2016). A review of the literature on citation impact indicators. Journal of Informetrics, 10(2), 365-391. https://doi.org/10.1016/j.joi.2016.02.007
  41. Wang, Q. (2018). A bibliometric model for identifying emerging research topics. Journal of the Association for Information Science and Technology, 69(2), 290-304. https://doi.org/https://doi.org/10.1002/asi.23930
  42. Wang, W., Fan, J., Huang, G., Zhu, X., Tian, Y., Tan, H., & Su, L. (2017). Meta-analysis of prevalence of erectile dysfunction in mainland China: Evidence based on epidemiological surveys. Sexual Medicine, 5(1), e19-e30. https://doi.org/10.1016/j.esxm.2016.10.001
  43. Wang, W., & Lu, C. (2020). Visualization analysis of big data research based on Citespace. Soft Computing, 24(11), 8173-8186. https://doi.org/10.1007/s00500-019-04384-7
  44. Zhao, B., Hong, Z., Wei, Y., Yu, D., Xu, J., & Zhang, W. (2019). Erectile dysfunction predicts cardiovascular events as an independent risk factor: A systematic review and meta-analysis. The Journal of Sexual Medicine, 16(7), 1005-1017. https://doi.org/https://doi.org/10.1016/j.jsxm.2019.04.004

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