Effect of HPMC Concentration and Liquid Addition Method on granules properties using High-Shear Wet Granulator

Abstract

Enhancing the physical properties of medicinal powders is largely dependent on the granulation process. This study investigates how the concentration of hydroxypropyl methylcellulose (HPMC) and the liquid addition technique (pouring versus syringe) interact to affect the distribution of granule sizes and its porosity  in a high-shear mixer setup. Both a 5% HPMC solution and distilled water (0% HPMC) were used to granulate calcium carbonate powder. The results showed that while excessive liquid addition using the pouring method led to uneven growth and agglomeration, an increase in binder viscosity improved granule homogeneity. On the other hand, the syringe method provided more uniform granules, showing its effectiveness in achieving controlled nucleation and growth. The impact of these parameters on granule characteristics was further supported by the design of response surface plots and models made easier by statistical analysis using Design-Expert software. The study's findings provide important information for improving wet granulation methods in the manufacturing of pharmaceuticals, especially with regards to guaranteeing the stability and uniformity of the final product.