Effect of HPMC Concentration and Liquid Addition Method on granules properties using High-Shear Wet Granulator

shahad qutaiba waleed

doi:10.14710/reaktor.24.3.102-108

DOI: https://doi.org/10.14710/reaktor.24.3.102-108

Effect of HPMC Concentration and Liquid Addition Method on granules properties using High-Shear Wet Granulator

*shahad qutaiba waleed - Department of chemical Engineering, university of Diayla, Iraq

Received: 19 Mar 2025; Published: 25 Apr 2025.

Citation Format:

Abstract

Enhancing the physical properties of medicinal powders is largely dependent on the granulation process. This study investigates how the concentration of hydroxypropyl methylcellulose (HPMC) and the liquid addition technique (pouring versus syringe) interact to affect the distribution of granule sizes and its porosity in a high-shear mixer setup. Both a 5% HPMC solution and distilled water (0% HPMC) were used to granulate calcium carbonate powder. The results showed that while excessive liquid addition using the pouring method led to uneven growth and agglomeration, an increase in binder viscosity improved granule homogeneity. On the other hand, the syringe method provided more uniform granules, showing its effectiveness in achieving controlled nucleation and growth. The impact of these parameters on granule characteristics was further supported by the design of response surface plots and models made easier by statistical analysis using Design-Expert software. The study's findings provide important information for improving wet granulation methods in the manufacturing of pharmaceuticals, especially with regards to guaranteeing the stability and uniformity of the final product.

Note: This article has supplementary file(s).

Fulltext View|Download | Data Set

Cumulative percentage for experiments

Subject	Cumulative percentage
Type	Data Set
	Download (21KB) Indexing metadata

Article Metrics:

Article Info

Section: Research Article

Language : EN

In Volume 24 No.3 December 2024

Recent articles

Synthesis of Poly(NIPAM) for Efficient Trypsin Purification Using Affinity Precipitation Technique Effect of Freeze-Drying Pre-treatment on the Properties of Activated Carbon Derived from Arabica Coffee Pulp Extraction of Scandium and Removal of Iron from Bauxite Residue using Hydrochloric Acid Solution with/without Addition of EDTA Breaking Boundaries in Renewable Energy: Portable Bio-Photovoltaic Systems for the IoT Era More recent articles

Most cited articles

PEMBUATAN KITOSAN DARI LIMBAH CANGKANG UDANG SERTA APLIKASINYA DALAM MEREDUKSI KOLESTEROL LEMAK KAMBING KARAKTERISASI PROSES PENGERINGAN JAGUNG DENGAN METODE MIXED-ADSORPTION DRYING MENGGUNAKAN ZEOLITE PADA UNGGUN TERFLUIDISASI Filter Cake Utilization as Filler of 15-15-15+5S Compound Fertilizer: Particle Size Distribution and Granule Crushing Strength Properties KARAKTERISASI FILM KOMPOSIT ALGINAT DAN KITOSAN EFEK PENYIMPANAN BIODIESEL BERDASARKAN STUDI KAJIAN DEGRADASI BIODIESEL CPO More cited articles

Last update:

No citation recorded.

Last update: 2025-04-25 21:55:00

No citation recorded.

In order for REAKTOR to publish and disseminate research articles, we need non-exclusive publishing rights (transferred from the author(s) to the publisher). This is determined by a publishing agreement between the Author(s) and REAKTOR. This agreement deals with transferring or licensing the publishing copyright to REAKTOR while Authors still retain significant rights to use and share their published articles. REAKTOR supports the need for authors to share, disseminate, and maximize the impact of their research and these rights in any databases.

As a journal author, you have the right to use your article for many purposes, including by your employing institute or company. These Author rights can be exercised without the need to obtain specific permission. Authors publishing in BCREC journals have wide rights to use their works for teaching and scholarly purposes without needing to seek permission, including, but not limited to:

use for classroom teaching by the Author or the Author's institution and presentation at a meeting or conference and distributing copies to attendees;
use for internal training by the author's company;
distribution to colleagues for their research use;
use in a subsequent compilation of the author's works;
inclusion in a thesis or dissertation;
reuse of portions or extracts from the article in other works (with full acknowledgment of the final article);
preparation of derivative works (other than commercial purposes) (with full acknowledgment of the final article);
voluntary posting on open websites operated by the author or the author’s institution for scholarly purposes,

(but it should follow the open access license of Creative Common CC-by-SA License).

Authors/Readers/Third Parties can copy and redistribute the material in any medium or format and remix, transform, and build upon the material for any purpose, even commercially. Still, they must give appropriate credit (the name of the creator and attribution parties (authors detail information), a copyright notice, an open access license notice, a disclaimer notice, and a link to the material), provide a link to the license, and indicate if changes were made (Publisher indicates the modification of the material (if any).

Authors/Readers/Third Parties can read, print and download, redistribute or republish the article (e.g., display in a repository), translate the article, download for text and data mining purposes, reuse portions or extracts from the article in other works, sell or re-use for commercial purposes, remix, transform, or build upon the material, they must distribute their contributions under the same license as the original Creative Commons Attribution-ShareAlike (CC BY-SA).