Chemical Composition, Antimicrobial, Cytotoxic and Antiplasmodial Activities of Three Sponges from Buton Islands, Indonesia

DOI: https://doi.org/10.14710/ik.ijms.22.3.147-154
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Article Metrics: (Click on the Metric tab below to see the detail)

Article Info
Submitted: 09-02-2017
Published: 22-08-2017
Section: Research Articles
Fulltext PDF Tell your colleagues Email the author

GC-MS analysis of the crude extracts of three different species of Indonesian marine sponges has been carried out for identification of bioactive compounds. The GC-MS analysis from Haliclona (Gellius) sp., Lamellodysidea herbacea, and Spheciospongia inconstans revealed the presence of 23, 21, 19 various compounds, respectively and mainly sterols and fatty acids. All the sponge species has been evaluated for antimicrobial activities, cytotoxicity using brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antiplasmodial activity. In this study, all the sponge species showed antimicrobial activities against at leastone of the test strains. Among them, the extract of sponge Lamellodysidea herbacea displayed activity against two Gram-positive bacteria (S. aureus and B. subtilis) and the Gram-negative bacteria V. cholerae, with inhibition zones of 10.3, 9.2 and 9.5 mm, respectively. The sponge Haliclona (Gellius) sp., showed significant activity against fungal pathogen C. albicans. The sponge Haliclona (Gellius) sp., displayed the ability to inhibit heme polymerization indicating an anti-Plasmodium function and also showed potent cytotoxic activity against the brine shrimp Artemia sp.

 

Keywords: GC-MS analysis, antimicrobial, sponges,bioactive

  1. Masteria Yunovilsa Putra  Orcid
    Pusat Penelitian Oseanografi - LIPI Jl. Pasir Putih I, Ancol Timur Jakarta Utara, 11048, Indonesia
  2. Tri Aryono Hadi 
    Pusat Penelitian Oseanografi - LIPI Jl. Pasir Putih I, Ancol Timur Jakarta Utara, 11048, Indonesia