1Department of Aquatic Product Technology, Faculty of Fisheries and Marine Sciences, IPB University, Indonesia
2Center for Coastal and Marine Resource Studies (PKSPL), International Research Institute for Maritime,, Indonesia
3Ocean and Fisheries (LRI i-MAR), IPB University, Indonesia
4 Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University, Indonesia
5 Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Malaysia
BibTex Citation Data :
@article{IK.IJMS70497, author = {Kustiariyah Tarman and Mega Safithri and Rahadita Maura Amanda Saputra and Ria Gusharani Silitonga and Maheswari Alfira Dwicesaria and Chen Wai Wong and Iriani Setyaningsih}, title = {Bioactive Properties of Commercially Cultivated Spirulina platensis in Indonesia: Evaluation of Anticancer and Antioxidant Potentials}, journal = {ILMU KELAUTAN: Indonesian Journal of Marine Sciences}, volume = {30}, number = {2}, year = {2025}, keywords = {A549 cancer cell line; doxorubicin; HeLa cell; microalgae; scaling up}, abstract = { Spirulina platensis is a commercially cultivated cyanobacterium known for its rich bioactive compounds, including phenolics, flavonoids, and phycocyanin, which contribute to its antioxidant and anticancer properties. While previous studies focused on laboratory-grown strains, this study evaluates the total flavonoid and phenolic content, antioxidant activity, and in vitro anticancer effects of ethanol extracts from two commercial manufacturers (MA and MB). The antioxidant potential was assessed using DPPH and FRAP assays, while cytotoxicity against A549 lung and HeLa cervical cancer cells was determined via MTT assays. Results indicated that MB exhibited higher flavonoid (12.52 ± 0.23 mg QE.g -1 DW) and phenolic content (19.10 ± 0.66 mg GAE.g -1 DW) than MA, correlating with stronger antioxidant activity (FRAP: 16.55 ± 0.1 µmol TE.g -1 DW vs. 11.1 ± 0.29 µmol TE.g -1 DW). DPPH inhibition reached 80.33% (MA) and 77.77% (MB). MB also demonstrated greater anticancer activity, with 28.31% inhibition in A549 cells at 100 ppm, compared to MA’s 20.6%, and 33.85% inhibition in HeLa cells at 50 ppm. Both extracts displayed preferential toxicity toward cancer cells over normal Chang cells, supporting their potential as safer alternatives to chemotherapy. This study confirms the dual therapeutic potential of commercially cultivated S. platensis as an antioxidant and anticancer agent, highlighting its applications in pharmaceutical and nutraceutical industries. Further research is recommended to isolate and identify the bioactive compounds responsible for its cytotoxic effects. }, issn = {2406-7598}, pages = {301--310} doi = {10.14710/ik.ijms.30.2.301-310}, url = {https://ejournal.undip.ac.id/index.php/ijms/article/view/70497} }
Refworks Citation Data :
Spirulina platensis is a commercially cultivated cyanobacterium known for its rich bioactive compounds, including phenolics, flavonoids, and phycocyanin, which contribute to its antioxidant and anticancer properties. While previous studies focused on laboratory-grown strains, this study evaluates the total flavonoid and phenolic content, antioxidant activity, and in vitro anticancer effects of ethanol extracts from two commercial manufacturers (MA and MB). The antioxidant potential was assessed using DPPH and FRAP assays, while cytotoxicity against A549 lung and HeLa cervical cancer cells was determined via MTT assays. Results indicated that MB exhibited higher flavonoid (12.52 ± 0.23 mg QE.g-1 DW) and phenolic content (19.10 ± 0.66 mg GAE.g-1 DW) than MA, correlating with stronger antioxidant activity (FRAP: 16.55 ± 0.1 µmol TE.g-1 DW vs. 11.1 ± 0.29 µmol TE.g-1 DW). DPPH inhibition reached 80.33% (MA) and 77.77% (MB). MB also demonstrated greater anticancer activity, with 28.31% inhibition in A549 cells at 100 ppm, compared to MA’s 20.6%, and 33.85% inhibition in HeLa cells at 50 ppm. Both extracts displayed preferential toxicity toward cancer cells over normal Chang cells, supporting their potential as safer alternatives to chemotherapy. This study confirms the dual therapeutic potential of commercially cultivated S. platensis as an antioxidant and anticancer agent, highlighting its applications in pharmaceutical and nutraceutical industries. Further research is recommended to isolate and identify the bioactive compounds responsible for its cytotoxic effects.
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