DOI: https://doi.org/10.14710/jai.v0i0.69122

Combination of Vitamin D and Vitamin E Against Bacterial Infections

Faculty of Medical Science, Universitas Prima Indonesia, Medan, Indonesia

Received: 13 Dec 2024; Revised: 4 Jun 2025; Accepted: 5 Jun 2025; Available online: 10 Jun 2025; Published: 31 Jul 2025.
Open Access Copyright 2021 JAI (Jurnal Anestesiologi Indonesia)
Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Citation Format:
Cover Image
Abstract

Bacterial infections are a significant health problem worldwide, caused by various microorganisms that can infect different parts of the human body. Bacteria are single-celled microorganisms that can be found in various environments, including in the human body, and most of them are harmless. However, some species of bacteria can cause serious infections and inflammation that require proper medical attention. Some examples of bacteria that cause infections include Streptococcus pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Vibrio cholerae, Mycobacterium tuberculosis, Escherichia coli, and Staphylococcus aureus. A sufficient vitamin D level in the body can enhance antimicrobial activity against various pathogens, including bacteria, viruses, and fungi. Vitamin E is known to be a powerful antioxidant and has a positive effect on the immune system. It plays a role in protecting immune cells from oxidative damage and enhancing the immune response to infection. The combination of vitamins D and E offers significant potential in the prevention and management of bacterial infections, as both contribute to improved immunological function through different and complementary mechanisms.

Note: This article has supplementary file(s).

Fulltext View|Download |  common.other
Copyright Transfer Agreement
Subject
Type Other
  Download (631KB)    Indexing metadata
Keywords: bacterial infection; inflammation; Staphlococcus aureus; vitamin D; vitamin E

Article Metrics:

Article Info
Section: Literature Reviews
Language : EN
Recent articles
Comparison of The Effects of Fentanyl versus Ketamine on The Quality of Recovery Post General Anesthesia with QoR-40 Scoring in Laparotomy Surgery Intrathecal Dexmedetomidine-Fentanyl Combination versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia: A Comparative Study at Haji Adam Malik General Hospital Colorado Pediatric Airway Score (COPUR) as a Predictor of Intubation Difficulty in Children Aged 1-8 Years Role of Neuroprotective Agents in the Anesthetic Management of Brain Tumors for Patients with Recidive Cystic Tumor with Signs of Intracranial Hypertension Underwent Re-Craniotomy Decompression Tumor Resection: Case Report Nutrition Therapy in Post-Hartmann’s Procedure Patients in The Intensive Care Unit Thoracic Spinal Anesthesia (TSA) in Patients with Congestive Heart Failure and Pleural Effusion Undergoing Breast Tumor Surgery: A Case Report Malignant Hyperthermia Combination of Vitamin D and Vitamin E Against Bacterial Infections More recent articles
Most cited articles
Patofisiologi Penyakit Jantung Koroner Midazolam Intravena Dosis Rendah Tidak Mempengaruhi Nitric Oxide Intraperitoneal Mencit Balb/C Yang Terpapar Lipopolisakarida More cited articles
  1. Doron S, Gorbach SL. Bacterial Infections: Overview [Internet]. Heggenhougen HK (Kris), editor. ScienceDirect. Oxford: Academic Press; 2008. p. 273–82
  2. Fadrian. ANTIBIOTIK, INFEKSI DAN RESISTENSI. Pertama. Hidayat S, editor. Padang: Andalas University Press ; 2023
  3. Taylor TA, Unakal CG. Staphylococcus Aureus Infection [Internet]. National Library of Medicine. StatPearls Publishing; 2023
  4. Audran M, Kumar R. The Physiology and Pathophysiology of Vitamin D. Mayo Clinic Proceedings [Internet]. 1985 Dec 1;60(12):851–66
  5. PubChem. Cholecalciferol. Nih.gov. PubChem; 2019
  6. Ardiaria M. Peran Vitamin D Dalam Pencegahan Influenza Dan Covid-19. Actanutrica. 2020 May 22;8(2):79–85
  7. Liang H, Wang Y, Liu F, Duan G, Long J, Jin Y, et al. The Application of Rat Models in Staphylococcus aureus Infections. Pathogens [Internet]. 2024 May 21 [cited 2024 Sep 12];13(6):434–4
  8. Yisak H, Ewunetei A, Kefale B, Mamuye M, et al. Effect of Vitamin D on COVID-19 infection and Prognosis : A systematic review. Risk Management and Healthcare Policy. 2021 Jan; Volume 14:31-8
  9. Bikle D. Vitamin D: Production, Metabolism, and Mechanisms of Action [Internet]. Nih.gov. MDText.com, Inc.; 2017
  10. Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, Tmava Berisha A, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. European Journal of Clinical Nutrition. 2020 Jan 20;74(11):1–16
  11. Vitamin E [Internet]. Mims.com. 2022 [cited 2024 Sep 11]. Available from: https://mims.com/indonesia/drug/info/vitamin%20e?mtype=generic
  12. Mohd Zaffarin AS, Ng SF, Ng MH, Hassan H, Alias E. Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability. International Journal of Nanomedicine. 2020 Dec;Volume 15:9961–74
  13. PubChem. Vitamin E [Internet]. Nih.gov. PubChem; 2019. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Vitamin-E
  14. Irawan, Alvian Oscar. Pengaruh Vitamin D3 terhadap Kadar IL-6, HS-CRP, dan Tekanan Darah pada Tikus Putih Jantan Model Penyakit Ginjal Kronis Unilateral Obstruction (UUO). DISERTASI UNIVERSITAS NEGERI SEBELAS NOVEMBER [Internet]. 2024
  15. Alsufiani HM, AlGhamdi SA, AlShaibi HF, Khoja SO, Saif SF, Carlberg C. A Single Vitamin D3 Bolus Supplementation Improves Vitamin D Status and Reduces Proinflammatory Cytokines in Healthy Females. Nutrients [Internet]. 2022 Sep 24 [cited 2024 Sep 13];14(19):3963–3
  16. M Sakarya, Fo Eris, Ab Derbent, Koca U, S Tüzün, T Onat, et al. The antioxidant effects of vitamin C and vitamin E on oxidative stress. Clinical intensive care. 1999 Dec 1;10(6):245–50
  17. Holmes NE, Charles PGP. Safety and Efficacy Review of Doxycycline. Clinical Medicine Therapeutics [Internet]. 2009 Jan;1:CMT.S2035
  18. Mustafa Atli, Mehmet Erikoglu, Adnan Kaynak, Esen HH, Kurban S. The effects of selenium and vitamin E on lung tissue in rats with sepsis. Clinical and investigative medicine. 2012 Apr 1;35(2):48–8
  19. Fan X, Yin J, Yin J, Weng X, Ding R. Comparison of the anti‑inflammatory effects of vitamin E and vitamin D on a rat model of dextran sulfate sodium‑induced ulcerative colitis. Experimental and Therapeutic Medicine. 2023 Jan 13;25(2)
  20. Olliver M, Spelmink L, Hiew J, Meyer-Hoffert U, Henriques-Normark B, Bergman P. Immunomodulatory Effects of Vitamin D on Innate and Adaptive Immune Responses to Streptococcus pneumoniae. The Journal of Infectious Diseases. 2013 Aug 6;208(9):1474–81
  21. Charoenngam N, Holick MF. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients [Internet]. 2020 Jul 15;12(7):2097
  22. Sîrbe C, Rednic S, Grama A, Pop TL. An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases. International Journal of Molecular Sciences [Internet]. 2022 Aug 29;23(17):9784
  23. Hartmann Ms, Mousavi S, Bereswill S, Heimesaat Mm. Vitamin E as promising adjunct treatment option in the combat of infectious diseases caused by bacterial including multi-drug resistant pathogens – Results from a comprehensive literature survey. European Journal of Microbiology & Immunology [Internet]. 2020 Nov 5 10(4):193–201
  24. Soltani S, Sedigheh B, Farzin Hadizadeh, Fatemeh Roodbari, Vahid Soheili. New Insight into Vitamins E and K1 as Anti-Quorum-Sensing Agents against Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 2021 May 18;65(6)
  25. Camargo CA, Sluyter J, Stewart AW, Khaw KT, Lawes CMM, Toop L, et al. Effect of Monthly High-Dose Vitamin D Supplementation on Acute Respiratory Infections in Older Adults: A Randomized Controlled Trial. Clinical Infectious Diseases. 2019 Aug 17;
  26. Olszowiec-Chlebna M, Koniarek-Maniecka A, Brzozowska A, Błauż A, Rychlik B, Stelmach I. Vitamin D inhibits pro-inflammatory cytokines in the airways of cystic fibrosis patients infected by Pseudomonas aeruginosa- pilot study. Italian Journal of Pediatrics. 2019 Mar 29;45(1)
  27. Bou Ghanem EN, Lee JN, Joma BH, Meydani SN, Leong JM, Panda A. The Alpha-Tocopherol Form of Vitamin E Boosts Elastase Activity of Human PMNs and Their Ability to Kill Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology. 2017 May 3;7
  28. Muharraran F, Gusbakti Rusip, Rosa Paradita Dalimunthe. Potential of Hydrogel Acemannan Aloe Vera (Aloe vera) on Wound Healing After Tooth Extraction In vivo Via Regulation of Inflammatory Response. Bioscmed [Internet]. 2022Apr.25;6(6):1908-13
  29. Siregar, Angraini, et al. "Uji Aktivitas Antibakteri Ekstrak Etanol Daun Pegagan (Centella Asiatica (L.) Urb) pada Bakteri S. Aureus." Pharmasipha, vol. 6, no. 1, 31 Mar. 2022, pp. 21-28
  30. Wu, Y., Lin, X., Song, F., Xue, D., Wang, Y."Vitamin D3 promotes autophagy in THP 1 cells infected with Mycobacterium tuberculosis Experimental and Therapeutic Medicine 23, no. 3 (2022): 240. https://doi.org/10.3892/etm.2022.11
  31. Wu, D., Zhou, S., Hu, S., & Liu, B. (2017). Inflammatory responses and histopathological changes in a mouse model of Staphylococcus aureus-induced bloodstream infections. Journal of infection in developing countries, 11(4), 294–305. https://doi.org/10.3855/jidc.7800
  32. Yamshchikov AV, Desai NS, Blumberg HM, Ziegler TR, Tangpricha V. Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials. Endocr Pract. 2009 Jul-Aug;15(5):438-49. doi: 10.4158/EP09101.ORR.PMID:19491064;PMCID:PMC2855046
  33. Wejse C. Vitamin D as supplementary treatment for tuberculosis—a double-blind randomized, placebo-controlled trial. Am J Respir Crit Care Med. 2009;179:843–850. doi: 10.1164/rccm.200804-567OC
  34. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over‐the‐counter supplement. N Engl J Med 2001; 345: 66–67
  35. Benemei S, Gallo E, Giocaliere E, Bartolucci G, Menniti‐Ippolito F, Firenzuoli F, et al It's time for new rules on vitamin D food supplements. Br J Clin Pharmacol 2013; 76: 825–826
  36. Traber MG. Vitamin E inadequacy in humans: causes and consequences. Adv Nutr. 2014 Sep;5(5):503-14
  37. Patel A, Caruana EJ, Hodson J, Morrison R, Khor B, Gysling S, Trevis J, Mangel T, Benson R, Zakeri R, Manders J, Vaja R, Rogers L, Baker P, Pournaras DJ, Thickett D, Hewison M, Naidu B, Lim E. Role of vitamin D supplementation in modifying outcomes after surgery: a systematic review of randomised controlled trials. BMJ Open. 2024 Jan 17;14(1):e073431. doi: 10.1136/bmjopen-2023-073431.PMID:38233048;PMCID:PMC10806719
  38. Iglar PJ, Hogan KJ. Vitamin D status and surgical outcomes: a systematic review. Patient Saf Surg 2015;9:14. 10.1186/s13037-015-0060-y

Last update:

No citation recorded.

Last update: 2025-08-19 01:46:46

No citation recorded.