DOI: https://doi.org/10.14710/jgi.8.2.79-84

Efek minuman cokelat (Theobroma cacao L.) terhadap peningkatan jumlah eritrosit dan kadar hemoglobin tikus putih anemia

Program Studi Gizi Klinik, Jurusan Kesehatan, Politeknik Negeri Jember, Indonesia

Received: 20 Mar 2019; Published: 2 Jun 2020.

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Abstract

Background : Anemia is a condition when the body do not have enough healthy red blood cells. Laboratory sign of anemia is decreases of erythrocytes and haemoglobin (Hb) level. Anemia can be caused by deficiency of nutritional intake.

Objectives : The purpose of this study was to determine changes in  the number of erythrocytes and  Hb levels of anemia rats which were intervened with chocolate drinks.

Methods : The design of this study was an experiment with a pretest-posttest control group design. The samples in this research were 21 male wistar rats. Rats were induced by NaNO2 25mg/gBB for 18 days, then followed by an intervention of chocolate drink 4.3ml / day for 14 days. The results will be tested using one way ANOVA test and paired T-Test.

Results : The results of this study showed that there were significant differences in the number of erythrocytes and Hb levels between groups before the intervention (p = 0.00) and (p = 0.011), so also after the intervention there is significant differences in the number of erythrocytes and Hb levels between groups (p = 0.00) and (p = 0.01).Paired T-Test results showed that there were significant differences in the number of erythrocytes and Hb levels before and after the study in the intervention group given chocolate drink (p = 0.00) and (p = 0.02).

Conclusion : Chocolate drinks have an effect on increasing the number of erythrocytes and Hb levels in anemia rats.

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Efek Minuman Cokelat terhadap Peningkatan Jumlah Eritrosit dan Kadar Hemoglobin Tikus Putih Anemia
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Keywords: anemia; chocolate; erythrocytes number; hemoglobin

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  3. World Health Organization (WHO). Global Prevalence of Anaemia. Geneva. 2015
  4. Sundaryono. Uji Aktivitas Senyawa Flavonoid Total dari Gynura segetum (Lour) Terhadap Peningkatan Eritrosit Dan Penurunan Leukosit Pada Mencit (Mus musculus).Jurnal Exacta, 2011;(9)2:8-16
  5. Kementerian Kesehatan Republik Indonesia. Riset Kesehatan Dasar. Jakarta. 2013
  6. Li S, Tan H, Wang N, Zhang Z, Lao L, Wong C, et al. The Role of Oxidative Stress and Antioxidants in Liver Diseases. 2015;10:26087–124
  7. Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015; 7;372(19):1832-43
  8. Yue Y, Wang Y, Li D, Song Z, Jiao H, Lin H. A central role for the mammalian target of rapamycin in LPS-induced anorexia in mice. J. Endocrinol. 2015;1;224:37-47
  9. Mita N. Formulasi Krim dari Kulit Buah Kakao (Theobroma cacao L.) Berkhasiat Antioksidan. Journal of Tropical Pharmacy and Chemistry. 2015;30;3(1):12-21
  10. Restuti, A. N. S., Yulianti, A., Oktafa, H., Alfafa,DN., Yani, FN., Kurniati, M., Wulandari, P., Analisis Aktivitas Antioksidan dan Uji Organoleptik Minuman Cokelat (Theobroma cacao L. Prosiding Seminar Nasional INAHCO. 2019:13-18. https://publikasi.polije.ac.id/index.php/inahco/article/view/1763/1105
  11. Restuti, A. N. S., Yulianti, A., Nuraini, N. Intervensi Bubuk Kakao terhadap Perubahan Kadar Gula Darah Puasa Tikus Sprague dawley Diabetes Melitus. Jurnal Riset Kesehatan. 2018;7(2):57–60. http://ejournal.poltekkes-smg.ac.id/ojs/index.php/jrk/article/view/3646/946
  12. Mazhar M, Faizi S, Gul A, Kabir N, Simjee SU. Effects of naturally occurring flavonoids on ferroportin expression in the spleen in iron deficiency anemia in vivo. RSC Adv. 2017;7(38):23238-45
  13. Fibach E, Rachmilewitz E. The Role of Oxidative Stress in Hemolytic Anemia. Current Molecular Medicine. 2008;609–19. DOI : 10.2174/156652408786241384. http://www.eurekaselect.com/67891/article (diakses 13 Maret 2019)
  14. Unigwe, C.R. dan P.E. Nwakpu. 2009. Effect of Ingestion of Garcinia kola Seed on Erythrocytes in Rabbits. Continental Journal. Veterynary Sciences 2009;3:7-10
  15. Lin CY, Hsiao WC, Huang CJ, Kao CF, Hsu GS. Heme oxygenase-1 induction by the ROS–JNK pathway plays a role in aluminum-induced anemia. J Inorg Biochem. 2013;1(128):221-8
  16. Yuningsih. Keracunan nitrat-nitrit pada ternak ruminansia dan upaya pencegahannya. Bogor : Balai Besar Penelitian Veteriner. 2007
  17. Zulkifli., Maruni, W.D., Yunan, J., Laksmi, S. Jumlah Eritrosit Darah Tepi Hewan Coba Tikus Putih (Rattus norvegicus) Strain Wistar Yang Diberikan Air Seduhan Kelopak Bunga Rosela Merah (Hibiscus sabdariffa). Media Bina Ilmiah. 2014;8(4):11-17. https://studylibid.com/doc/142500/2-jumlah-eritrosit-darah-tepi-hewan-coba-tikus
  18. Farikhah,A., Indriani, F., Yulianti, A., Restuti, ANS. Intervensi Bubuk Kakao Terhadap Kadar Hemoglobin Tikus Putih Galur Wistar Anemia. Prosiding Seminar Nasional INAHCO. 2019:80-91. https://publikasi.polije.ac.id/index.php/inahco/article/view/1771/1113

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