Efek konsumsi yoghurt probiotik terhadap kadar low density lipoprotein pada penyandang diabetes mellitus tipe 2

Kartika Yuliani  -  Nutrition Study Program, Faculty of Health, Surabaya Nahdlatul Ulama University, Indonesia
Nyoman Kertia  -  Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Indonesia
*Lily Arsanti Lestari  -  Department of Health Nutrition, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Indonesia
Received: 31 Mar 2019; Published: 6 Feb 2020.
Open Access
Citation Format:
Article Info
Section: Articles
Language: EN; ID
In Vol 8, No 1 (2019)
Statistics: 288 158
Abstract

Background : As one of important markers of cardiovascular complication in patients with type 2 diabetes mellitus, low density lipoprotein (LDL) shall be maintained to be in normal range. Based on previous research, consumption of probiotic yogurt contains Lactobacillus acidophilus and Bifidobacterium animalis subsp. Lactis is presumed can improve LDL in patients with type 2 diabetes mellitus but the scientific evidence is still few.

Objectives: To investigate the effect of probiotic yogurt on LDL in patients with type 2 diabetes.

Methods: This study was double blinded randomized controlled trial which was conducted on 32 patientss with type 2 diabetes mellitus. Subjects were divided randomly into 2 groups and given 4 weeks intervention. Subjects in control group were given conventional yogurt while subjects in intervention group were given probiotic yogurt contains L. acidophilus LA5 and B. animalis subsp. Lactis Bb12. Food intake data was collected 4 times using 24-hour recall method during intervention period. LDL of subjects was measured before and after intervention.

Results: There was no significant difference between LDL before and after intervention in control group (128 – 148.5 mg/dL) and intervention group (130 – 120.5 mg/dL). Meanwhile, LDL after intervention in control group and intervention group were significantly different (p<0.05). LDL between energy and macronutrients intake categories were not significantly different.

Conclusion: Probiotic yogurt has a better LDL reduction effect in patients with type 2 diabetes mellitus than conventional yogurt, although the reduction is not significant.

Keywords: type 2 diabetes mellitus; probiotic; yogurt; low density lipoprotein; LDL

Article Metrics:

  1. Bugger H & Abel ED. Molecular mechanisms of diabetic cardiomyopathy. Diabetologia, 2014; 57(4): 660–671. doi: 10.1007/s00125-014-3171-6
  2. Pistrosch F, Natali A & Hanefeld M. Is hyperglycemia a cardiovascular risk factor?. Diabetes Care, 2011; 34(SUPPL. 2). doi: 10.2337/dc11-s207
  3. Fox CS, Golden SH, Anderson C, Bray GA, Burke LE, de Boer IH, et al. Update on Prevention of Cardiovascular Disease in Adults with Type 2 Diabetes Mellitus in Light of Recent Evidence. Circulation, 2015; 132: 691-718.
  4. Tangvarasittichai S. Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World Journal of Diabetes, 2015; 6(3): 456–480. doi: 10.4239/wjd.v6.i3.456
  5. Ejtahed HS, Mohtadi-nia J, Homayouni-rad A, Niafar M, Asghari-jafarabadi M, Mofid V. Probiotic yogurt improves antioxidant status in type 2 diabetic patientss. Nutrition Journal, 2012; 28: 539–543. doi: 10.1016/j.nut.2011.08.013
  6. Rezaei M, Sanagoo A, Jouybari L, Behnampoo N & Kavosi A. The Effect of Probiotic Yogurt on Blood Glucose and cardiovascular Biomarkers in Patientss with Type II Diabetes : A Randomized Controlled Trial. Evidence Based Journal, 2016; 6(4): 25–35. doi: 10.22038/ebcj.2016.7984
  7. Dirienzo DB. Effect of probiotics on biomarkers of cardiovascular disease : implications for heart-healthy diets. Nutrition Reviews, 2013; 72(1): 18–29. doi: 10.1111/nure.12084
  8. Laitinen K, Poussa T, Isolauri E, et al. Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial. The British journal of nutrition, 2009; 101(11): 1679–87. doi: 10.1017/S0007114508111461
  9. Joyce SA, MacSharry J, Casey PG, Kinsella M, Murphy EF, Shanahan F, et al. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proceedings of the National Academy of Sciences, 2014; 111(20): 7421–7426. doi: 10.1073/pnas.1323599111
  10. Perkeni. Pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia 2015. Jakarta: 2015.
  11. Moura CS, Lollo PCB, Morato PN, Esmerino EA, Margalho LP, Santos-junior VA, et al. Assessment of antioxidant activity, lipid profile, general biochemical and immune system responses of Wistar rats fed with dairy dessert containing Lactobacillus acidophilus La-5. Food Research International, 2016; 90: 275–280. doi: 10.1016/j.foodres.2016.10.042
  12. Everard A & Cani PD. Best Practice & Research Clinical Gastroenterology Diabetes , obesity and gut microbiota. Best Practice & Research Clinical Gastroenterology, 2013; 27(1): 73–83. doi: 10.1016/j.bpg.2013.03.007
  13. Ivey KL, Hodgson JM, Kerr DA, Thompson PL, Stojceski B & Prince RL. The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial. Nutrition, Metabolism and Cardiovascular Diseases, 2015; 25(1): 46-51.
  14. Singh RK, Chang HW,Yan D, Lee KM, Ucmak D, Wong K, et al. Influence of diet on the gut microbiome and implications for human health. Journal of translational medicine, 2017; 15(1): 73.
  15. Koh A, De Vadder F, Kovatcheva-Datchary P & Bäckhed F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell, 2016; 65(6): 1332-1345.
  16. Zhang Q, Wu Y & Fei X. Effect of probiotics on glucose metabolism in patientss with type 2 diabetes mellitus : A meta-analysis of randomized controlled trials. Medicina. Lithuanian University of Health Sciences, 2016; 52(1): 28–34. doi: 10.1016/j.medici.2015.11.008
  17. Shah NJ &Swami OC. Role of Probiotics in Diabetes: a Review of Their Rationale and Efficacy. Diabetes, 2017; 5[1]:104-110.
  18. Gill JM & Sattar N. Hepatic VLDL overproduction: is hyperinsulinemia or insulin resistance the culprit?. The Journal of Clinical Endocrinology & Metabolism, 2011; 96 (7): 2032–2034.
  19. Miremadi F, Ayyash M, Sherkat F, & Stojanovska L. Cholesterol reduction mechanisms and fatty acid composition of cellular membranes of probiotic Lactobacilli and Bifidobacteria. Journal of Functional Foods, 2014 Jul 1;9:295-305.
  20. Chaudhury A, Chitharanjan D, Dendi VSR, Kraleti S, Chada A, Ravilla R, et al. Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management. Frontiers in endocrinology, 2017, 8 (6).

The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) and Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro as publisher of the journal.

Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc., will be allowed only with a written permission from Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition).

Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition), Faculty of Medicine, Universitas Diponegoro, the Editors and the Advisory Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in the Indonesian Journal of Nutrition are sole and exclusive responsibility of their respective authors and advertisers.