Korelasi kadar hepcidin dan asupan makanan dengan serum transferrin reseptor dan hemoglobin pada remaja stunted overweight

*La Mani  -  Wakatobi District Health Office of Southeast Sulawesi Province, Indonesia
Siti Fatimah-Muis  -  Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Indonesia
Apoina Kartini  -  Department of Public Health Nutrition, Faculty of Public Health, Universitas Diponegoro, Indonesia
Received: 12 Aug 2019; Published: 6 Feb 2020.
Open Access
Citation Format:
Abstract

Background: Stunted overweight is associated with mild chronic inflammation. The state of inflammation will increase the expression of hepcidin, which affects the iron status of the body, besides the intake of protein, iron, and vitamin C.

Objective: To analyze the correlation of hepcidin levels and food intake (protein, iron, vitamin C) with serum transferrin receptors (sTfR) and hemoglobin in stunted overweight adolescents.

Method: The design of research was cross-sectional. The subjects were 64 adolescents stunted overweight aged 15-18 years in four high/vocational schools in the Banyumanik District, Semarang City. Measurement the level of hepcidin and sTfR was using the ELISA method and haemoglobin was using Cyanomethemoglobin method. Data on protein, iron, vitamin C intake was using the SQ-FFQ method. Bivariate analysis was using Pearson and Spearman correlation test then followed by multiple linear regression analysis.

Results: The result showed that 89.1% subjects had adequate intake of protein, 54.7% subjects had low intake of vitamin C, 76.6% subjects had low intake of iron. Hepcidin levels in all subjects were 100% normal. There were 7.8% subjects with a low sTfR and 7.8% with a low haemoglobin level. Statistic test showed there was correlation between hepcidin with haemoglobin and sTfR (p1 = 0,010 r1 = -0,319, p2 = 0,001, r2 = 0,569). From food intake, only intake iron was correlated with haemoglobin but not with sTfR. There was significant difference between the mean of haemoglobin and sTfR among girls and boys. Further analysis, showed that only hepcidin was a weak negative determinant for sTfR (R2 = 0,120). The determinant factors for haemoglobin were gender (p=0,001) and hepcidin (p =0,004) with the value of R2 = 0,577.

Conclusion: Hepcidin correlated with sTfR and haemoglobin while iron intake only correlated with hemoglobin.

Keywords: Stunted Overweight; Hepcidin; Iron Status; Food Intake

Article Metrics:

Article Info
Section: Articles
Language: EN
In Vol 8, No 1 (2019)
Statistics: 640 369
Related articles
Pengetahuan ibu, pola makan dan status gizi pada anak stunting usia 1-5 tahun di Kelurahan Bangetayu, Kecamatan Genuk, Semarang Keragaman pangan, pola asuh makan dan kejadian stunting pada balita usia 24-59 bulan Pengaruh suplementasi Zn terhadap perubahan indeks TB/U anak stunted usia 24-36 bulan Kartu pemantauan pertumbuhan panjang badan dapat meningkatkan nilai z-skor PB/U pada anak stunting Faktor risiko stunting pada anak umur 6-24 bulan di kecamatan Penanggalan kota Subulussalam provinsi Aceh
  1. Balitbang Kemenkes RI. Riset Kesehatan Dasar. Jakarta: Balitbang Kemenkes RI; 2013
  2. Santoso B, Sulistiowati E, Tuti S, Lamid A. Riset Kesehatan Dasar Provinsi Jawa Tengah. Jakarta: Balitbang KemenKes RI; 2013
  3. Weisa AS. Global Nutrition Targets 2025: Stunting Policy Brief. Geneva: WHO; 2014
  4. Martin VJ, Floronzio TM, Grillo LP, Franco MC, Martins PA, Clemente AP et al. Long-lasting effects of undernutrition. Int J Environ Res Public Health. 2011;8:1817-1846
  5. Prendergast AJ, Rukobo S, Chasekwa B, Mutasa K, Ntozini R, Mbuya MN et al. Stunting is characterized by chronic inflammation in zimbabwean infants. PLoS One. 2014;(2):1-11
  6. Syed S, Karim P, Manji KP, McDonald CM, Kisenge R , Aboud S et al. Biomarkers of systemic inflammation and growth in early infancy are associated with stunting in young Tanzanian children. Nutrients. 2018;10:1-14
  7. Baig U, Belsare P, Watve M, Jog M. Can Thrifty Gene (s) or Predictive Fetal Programming for Thriftiness Lead to Obesity ? J Obes. 2011;2011:1-11
  8. Hoffman DJ. Growth retardation and metabolic programming : implications and consequences for adult health and disease risk ଝ , ଝଝ Retardo do crescimento e programac ¸ ão metabólica : implicac ¸ ões e consequências para a saúde do adulto e o risco de doenc ¸ as. J Peditria. 2014;90(4):325-328
  9. Mukuddem-Petersen J, Kruger HS. Association between stunting and overweight among 10-15-y-old children in the North West Province of South Africa: The THUSA BANA Study. Int J Obes. 2014;(7):842-851
  10. Saraswati AT, Sulchan M. Kejadian sindrom metabolik pada remaja putri stunted obesity di Pedesaan Jepara. journl if Nutr Coll. 2016;5(3):192-197
  11. Kruger HS, Pretorius R, Chutte AE. Stunted, adiposity, and low-grade inflammation in African adolescents from a township high school. Nutr Elsevier Ltd. 2010;26:90-99
  12. Cheng HL, Bryant CE, Rooney KB, Steinbeck KS, Griffin HJ, Petocz P et al. Iron, Hepcidin and Inflammatory Status of Young Healthy Overweight and Obese Women in Australia. PLoS One. 2013;8(7):1-6
  13. Ridha NR, Daud D. Hubungan Kadar Hepcidin dengan Status Besi pada Inflamasi Akibat Obesitas. Sari Pediatr. 2014;16(3):161-166
  14. Hintze KJ, McClung JP. Hepcidin: A critical regulator of iron metabolism during hypoxia. Adv Hematol. 2011;(8):1-7
  15. Diedra M W, Andrews. NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108(9):3204-3209
  16. Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012;1823(9):1434-1443
  17. Ganz T. Hepcidin and iron regulation, 10 years later. Blood. 2011;117(17):4425-4433
  18. Cepeda-Lopez, Osendarp SJ, Boonstra AM, Aeberli I, Salazar FG, Feskens E et al. Sharply higher rates of iron deficiency in obese Mexican women and children are predicted by obesity-related inflammation rather than by differences in dietary iron intake. Am J Clin Nutr. 2011;93:975-983
  19. Sal E, Yenicesu I, Celik N, Pasaoglu H, Celik B, Pasaoglu OT, Kaya Z, Kocak U, Camurdan O, Bideci A CP. Relationship between obesity and iron deficiency anemia : is there a role of hepcidin ? Hematolgy. 2018;23(8):542-548
  20. Knutson D. Iron transport proteins : Gateways of cellular and systemic iron homeostasis. JBiolChem. 2017;292(31):12735-12744
  21. Hassan F, Salim S, Humayun A. Prevalence and Determinants of Iron Deficiency Anemia in Adolescents Girls of Low Income Communities in Lahore. Ann King Edward Med Univ. 2017;23(2):116-125
  22. Zimmermann MB, FHurrell R. Nutritional iron deficiency. Lancet. 2007;370:511-520
  23. Olumakaiye MF. Adolescent Girls With Low Dietary Diversity Score Are Predisposed to Iron Deficiency in Southwestern. ICAN. 2013;5(2):85-91
  24. Hurrel R, Engli I. Iron bioavailability and dietary reference values. Iron Bioavailab Diet Ref values1–4. 2010;91:1461-1467
  25. Brown JE. Nutrition Through The Life Cycle. Fourth Edi. USA: Wadsworth; 2011
  26. More S, Shivkumar V., Gangane N, Shende S. Effects of iron deficiency on cognitive function in school going adolescent females in rural area of central India. Anemia. 2013;2013:1-5
  27. Hassan TH, Badr MA, Karam NA, et al. Impact of iron deficiency anemia on the function of the immune system in children. Med (United States). 2016;95(47):1-5
  28. Kemenkes RI. Standar Antropometri Penilaian Status Gizi Anak. Jakarta: Kementerian Kesehatan RI; 2011
  29. Sumarmi S, Puspitasari N, Handajani R, Wirjatmadi B. Underweight as a Risk Factor for Iron Depletion and Iron- Deficient Erythropoiesis among Young Women in Rural Areas of East Java, Indonesia. Mal J Nutr. 2016;22(2):219-232
  30. WHO. Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. Geneva, Switzerland: Department of Nutrition for Health and Development (NHD); 2011
  31. Almatsier S. Penuntun Diet. Baru. Jakarta: Gramedia Pustaka Utama; 2006
  32. Kemenkes RI. Pedoman Gizi Seimbang. Jakarta: Kementerian Kesehatan RI; 2015
  33. Dahlan MS. Statistik Untuk Kedokteran Dan Kesehatan. Jakarta: Salemba Medika; 2011
  34. Kroot JJC, Tjalsma H, Fleming REF, Swinkels DW. Hepcidin in human iron disorders: Diagnostic implications. Clin Chem. 2011;57(12):1650-1669
  35. Tussing-humphreys M, Nemeth E, Fantuzzi G, et al. Elevated Systemic Hepcidin and Iron Depletion in Obese Premenopausal Females. Obesity. 2009;18(7):1449-1456
  36. Chaston T, Chung B, Mascarenhas M, et al. Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells. Hepatology. 2008;57:374-382
  37. Satwika KA. Hubungan antara asupan protein, vitamin C, zat besi dan inhibitor absorbsi besi dengan status besi pada pendonor darah di Palang Merah Kota Yogyakarta. Skripsi. 2016
  38. Whitney E, Rolfes S. Understanding Nutrition. Fourtin Editon. California: Cengage Learning; 2016
  39. Abbaspou N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014;19:164-174
  40. Nisa AK, Nissa C, Probosari E. Perbedaan asupan gizi dan kadar hemoglobin pada remaja perempuan obesitas dan tidak obesitas. JNutrition Coll. 2019;8(1):21-28
  41. Densupsoontorn N, Jirapinyo P, Kangwanpornsiri C. Micronutrient deficiencies in obese Thai children. Asia Pac J Clin Nutr. 2013;22(3):497-503
  42. Begum S,Faiaz M, Ahmed RM. Efffect of Cooking Temperature and Storage Period on Preservation of Water Soluble Vitamin C Content in Citrus Macroptera and Moringa Oleifera Lunk. Asian J Foof Agro-Industry. 2009;2(03):255-261
  43. Péneau S, Dauchet L, Vergnaud A-C, et al. Relationship between iron status and dietary fruit and vegetables based on their vitamin C and fiber content. Am J Clin Nutr. 2008;87:1298-1305
  44. Urrechaga E, Borque L, Escanero JF. Biomarkers of Hypochromia : The Contemporary Assessment of Iron Status and Erythropoiesis. Biomed Res Int. 2013;2013:1-8
  45. Choi JW, Pai SH. Associations between serum transferrin receptor concentrations and erythropoietic activities according to body iron status. Ann Clin Lab Sci. 2003;33(3):279-284
  46. Wallace D F. The Regulation of Iron Absorption and Homeostasis. Clin Biochem Rev. 2016;37(2):51-62

Last update: 2021-03-09 15:19:08

No citation recorded.

Last update: 2021-03-09 15:19:08

No citation recorded.

The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) and Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro as publisher of the journal.

Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc., will be allowed only with a written permission from Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition).

Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition), Faculty of Medicine, Universitas Diponegoro, the Editors and the Advisory Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in the Indonesian Journal of Nutrition are sole and exclusive responsibility of their respective authors and advertisers.