DOI: https://doi.org/10.14710/jgi.8.2.149-153

Effect of zinc on milkfish nastar-cookies to albumin and hemoglobin levels in HIV/AIDS patients

1Departement of Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Indonesia

2Departement of Fishery Products Technology, Faculty of Fisheries and Marine Science, Universitas Diponegoro, Indonesia

3Internal Medicine of RSUP. Dr. Karyadi Semarang, Faculty of Medicine, Universitas Diponegoro, Indonesia

Received: 5 Nov 2019; Published: 2 Jun 2020.

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Abstract

Background: Human Immunodeficiency Virus (HIV) destroys the antibody system, which causes faster protein breakdown resulting in lower albumin concentration. Zinc supplementation when added to protein in milkfish flour may increase albumin and zinc levels that associated with activity of the aminolevulinic acid dehydrase (ALAD) that synthesizes heme.

Objectives: This study aimed to prove the effect of zinc and milkfish flour addition on albumin and hemoglobin levels in HIV/AIDS patients.

Methods: An experimental study with randomized pre and post-test with the control group design using control subjects (n=17) and treatment (n=21). The administration of milkfish nastar with zinc to treatment group was 100 g/day for 60 days, while the control group was given milkfish nastar without zinc 100 g/day for 60 days. The measurement of albumin level used auto photometric with enzymatic color test methods and reticulated method for hemoglobin level measurement conducted before and after treatments. Data were analyzed using Shapiro-Wilk, paired t-test, and independent t-test with a significance value at p<0.05.

Results: The means of albumin level in the treatment group increased by 7.03%, while the control group increased by 4.33% (p>0.05). Means of hemoglobin level in the treatment group increased by 12.0%, while the control group increased by 7.9% (p<0.05).

Conclusion: Albumin and hemoglobin levels increased after milkfish nastar administration with zinc addition in HIV/AIDS patients.

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Keywords: albumin; HIV-AIDS; hemoglobin; milkfish nastar cookies; zinc supplementation
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  1. Back-Brito GN, El Ackhar VNR, Querido SMR, dos Santos SSF, Jorge AOC, Reis ASM et al. Sthapylococcus spp, enterobacteriaceae and pseudomonadaceae oral isolates from brazilian HIV-positive patients. correlation with CD4 cell counts and viral load. Arch Oral Biol. 2011;56(10):1041-6
  2. Yuliyanasari N. Global burden desease human immunodeficiency virus acquired immune deficiency syndrome (HIV/AIDS). Qanun Medika. 2017;1(1):65-77
  3. Alvarez-Uria G, Midde M, Pakam R, Naik PK. Diagnostic and prognostic value of serum albumin for tuberculosis in HIV infected patients eligible for antiretroviral therapy : data from an HIV cohort study in India. Bioimpacts. 2013;3(3):123–8
  4. Suharto S, Saptaningrum E, Wijayanti K, Sutarmi S, Warijan W, Hendromastuti A et al. The influence of zinc supplementationon nutritional status among children under five years of age at Blora district. Jurnal Keperawatan Indonesia. 2011;1(1):1-9
  5. Mocchegiani E, Muzzioli M. Therapeutic application of zinc in human immunodeficiency virus againsts opportunistik. J Nutr. 2000;130:1424–31
  6. Asikin A, Bambang W, Soeroso J. Zinc sulfate increases lymphocyte CD4 count in HIV/AIDS patients at icuid Dr. Soetomo Hospital Surabaya. FMI. 2012;48:17-19
  7. Rahfiludin MZ, Ginandjar P. The effect of zinc and vitamin c supplementition on hemoglobin an hematocrit levels and immune respons impatients with plasmadium vivax malaria. Southeast Asian J Trop Med Public Health. 2013;44(5):733-9
  8. Boldt J. Use of albumin : an update. Br J Anaesth. 2010;104(3):276-84)
  9. Glabska D, Staniec A, Guzek D. Assessment of validity and reproducibility of the zinc-specific dietary intake questionnaire conducted for young polish female respondents. Nutrients. 2018;10(1):104
  10. Rahler JF, Ben-Horin S, Chowers Y, Conlon C, De Munter P, D'Haens G et al. Europen evidance based consensus on the prevention, diagnosis and management opportunitic infections in inflammatory bowel disease. J Chron's Colitis. 2009;3(2):47-91
  11. Pasricha SR, Drakesmith H, Black J, Hipgrave D, Biggs BA. Control of iron deviciency anemia in low and middle income countries. Blood. 2013;121(14):2607-17
  12. Nasronudin. HIV & AIDS Pendekatan Biologi Molekuler, Klinis, dan Sosial. Surabaya: Airlangga University Press;2014
  13. Wu X, Ge J, Yang C, Hou M, Liu Z. Facile synthesis of multiple enzyme-containing metal–organic frameworks in a biomolecule-friendly environment. ChemComm. 2015;51(69):13408-11
  14. World Health Organization. Pencegahan AIDS melalui promosi kesehatan: Masalah yang sensitif. Bandung: Penerbit ITB; 2007
  15. Johannessen A, Naman E, Gundersen SG, Bruun JN. Antiretroviral treatment reverses HIV-associated anemia in rural Tanzania. BMC Infect Dis. 2011;11(1):190
  16. Garg N, White CE. Mechanism of zinc oxide retardation in alkali-activated materials: an in situ X-ray pair distribution function investigation. J Mater Chem A. 2017;5(23):11794-804
  17. Anene A, Mba OI, Afam-Anene OC, Nwanguma E. Proximate and mineral quality changes in fillets of three fish species (Mugil cephalus, Chrysichthys nigrodititatus and Oreochromis niloticus) at frozen storage (Sub 0˚ C). International Journal of Nutrition and Food Sciences. 2015;4(3):402-8
  18. Fosu MO, Frimpong FO, Arthur MO. Factors associated with haemoglobin prevalence among Ghanaian children aged 6–59 months. J Biology Agric Healthc. 2014;4(2):132-40
  19. Moretti D, Goede JS, Zeder C, Jiskra M, Chatzinakou V, Tjalsma H, Melse-Boonstra A, Brittenham G, Swinkels DW, Zimmermann MB. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood. 2015;126(17):1981-9
  20. Gulen H, Hanimeli O, Karaca O, Taneli F. α-Thalassemia frequency and mutations in children with hypochromic microcytic anemias and relation with β-thalassemia, iron deficiency anemia. Pediatr Hematol Oncol. 2012;29(3):241-6

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