DOI: https://doi.org/10.14710/jgi.10.2.135-140

Anthropometric Markers, Visceral Adipocyte Index, Inflammation Markers and Bone Density in Reproductive Obese Women

1Doctoral Program of Medical and Health Science, Faculty of Medicine, Universitas Diponegoro, Indonesia

2Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Indonesia

3Department of Anatomy, Faculty of Medicine, Universitas Diponegoro, Indonesia

Received: 9 Nov 2021; Published: 1 Jun 2022.

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Abstract

Background: Obesity has been associated with the risk of various diseases. The correlation between anthropometry and bone health is complex. Visceral adipocyte index (VAI) is one of the compositions of body fat compositions that mostly associated with proinflammatory cytokine, which can stimulate C- reactive protein (CRP) that affects bone density.

Objectives: This study aimed to prove the correlation between VAI, CRP and BMD in Asian reproductive obese women

Materials and Methods: A cross sectional study was conducted in November 2020 - February 2021 and a total of 134 women of reproductive age with obesity participated in this study. Weight, height, body mass index (BMI) and rate of visceral fat were measured by body composition analyzer. Waist (WC) and hip circumferences (HC) measured by using tape; lipid profile and CRP level were examined using a clinical chemistry automatic analyzer, and the examination of bone mineral density (BMD) using dual-energy x-ray absorptiometry. Waist to hip ratio (WHR)and VAI calculated manually. Pearson and Spearman test were used for statistical analysis.

Results: There were positive weak correlations between weight, height, BMI, WC, HC, rate of visceral fat, WHR and VAI. There were weak positive correlations between HC, WHR and CRP. There were positive moderate correlations between weight, height, BMI, waist, visceral fat, WHR and CRP.

Conclusion: Although there were correlations between anthropometric parameters and VAI and also CRP, but we did not found correlation between VAI and CRP to all BMD parameters.

Note: This article has supplementary file(s).

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Keywords: VAI; CRP; BMD; anthropometry; obesity; women

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Section: Articles
Language : EN
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  1. Kemenkes. Riset kesehatan Dasar. Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI; 2018
  2. Shapses SA, Pop LC, Wang Y. Obesity is a concern for bone health with aging. Nutr Res. 2017;39:1-13
  3. Pablo Pd, Cooper MS, Buckley CD. Association Between Bone Mineral Density andC-Reactive Protein in a Large Population-Based Sample. Arthritis and Rheumatism RTHRITIS & RHEUMATISM. 2012;64:2624–31
  4. Singh V, Tripathi P, Singh M, Kulshrestha MR, Tiwari V. Obesity and High Sensitivity C-Reactive Protein Level in Indian Population. EC Cardiology. 2019;6:1082-8
  5. Ishii S, Cauley JA, Greendale GA, Crandall CJ, Danielson ME, Ouchi Y, et al. C-Reactive Protein, Bone Strength, and Nine-Year Fracture Risk: Data From the Study of Women’s Health Across the Nation (SWAN). J Bone Miner Res. 2013;28:1-21
  6. Aguirre L, Napoli N, Waters D, Qualls C, Villareal DT, Armamento-Villareal R. Increasing Adiposity Is Associated With Higher Adipokine Levels and Lower Bone Mineral Density in Obese Older Adults. J Clin Endocrinol Metab. 2014;99:3290 –7
  7. Campos RMS, Lazaretti-Castro M, Mello MTd, Tock L, Silva PL, Corgosinho FC, et al. Influence of visceral and subcutaneous fat in bone mineral density of obese adolescents. Arq Bras Endocrinol Metab. 2012;56(1):12-8
  8. Liu CT, Broe KE, Zhou Y, Boyd SK, Cupples LA, Hannan MT, et al. Visceral Adipose Tissue Is Associated With Bone Microarchitecture in the Framingham Osteoporosis Study. J Bone Miner Res. 2017;32(1):143-50
  9. Zhang P, Peterson M, Su GL, Wang SC. Visceral adiposity is negatively associated with bone density and muscle attenuation. Am J Clin Nutr. 2015;101:337-43
  10. Greco EA, Lenzi A, Migliaccio S. The obesity of bone. Ther Adv Endocrinol Metab Syndr Relat Disord. 2015;6:273-86
  11. Goldani H, Adami FS, Antunes MT, Rosa LH, Fassina P, Grave MTQ, et al. Applicatility of the visceral adiposity index (VAI) in the prediction of the components of the metabolic syndrome in elderly. Nutr Hosp. 2015;32:1609-15
  12. Amato MC, Giordano C. Visceral Adiposity Index: An Indicator of Adipose Tissue Dysfunction. International Journal of Endocrinology. 2014;2014:1-7
  13. Choi J, Joseph L, Pilote L. Obesity and C-reactive protein in various populations: a systematic review and meta-analysis. Obesity reviews. 2013;14:232–44
  14. Zatterale F, Longo M, Naderi J, Raciti GA, Desiderio A, Miele C, et al. Chronic Adipose Tissue Inflammation Linking Obesity to Insulin resistance and Type 2 Diabetes. Front Physiol 10:1607. 2020;10:1-20
  15. Lara-Castillo N. Estrogen Signaling in Bone. Appl Sci. 2021;11:1-15
  16. Singh D, Sanyal S, Chattopadhya N. The role of estrogen in bone growth and formation: changes at puberty. Cell Health and Cytoskeleton. 2011;3:1-12
  17. Karlafti E, Lampropoulou-Adamidou K, Tournis S, Trovas G, Triantafyllopoulos IK. Effect of estrogen on bone cells: what is new? Journal of Research and Practice on the Musculoskeletal System. 2019;3:113-22
  18. Ji M-X, Yu Q. Primary osteoporosis in postmenopausal women. Chronic Diseases and Translational Medicine. 2015;1:9-13
  19. Sharma M, Chandra SB. The Critical Role of Estrogen in Menopausal Osteoporosis. J Contemp Med. 2017;7:418-27
  20. Liu Y, Song C-Y, Wu S-S, Liang Q-H, Yuan L-Q, Liao E-Y. Novel Adipokines and Bone Metabolism. International Journal of Endocrinology. 2013;2013:1-9
  21. Jin J, Wang Y, Jiang H, Kourkoumelis N, Renaudineau Y, Deng Z. The impact of obesity through fat depots and adipokines on bone homeostasis. AME Med J. 2018;3(10):1-9
  22. Kuo T-R, Chen C-H. Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives. Biomarker Research. 2017;5:1-9
  23. Hong L, Liu D, Wu F, Wang M, Cen Y, Ma L. Correlation between Bone Turnover Markers and Bone Mineral Density in Patients Undergoing Long-Term Anti-Osteoporosis Treatment: A Systematic Review and Meta-Analysis. Appl Sci. 2020;10:1-16
  24. Carbone F, Lattanzio MS, Minetti S, Ansaldo AM, Ferrara D, Molina-Molina E, et al. Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria. Int J Mol Sci. 2019;20:5981
  25. Ferreira FG, Segheto W, Silva DCGd, Pereira PF, Longo GZ. Visceral adiposity index associated with behavioral and inflammatory parameters in adults: a population based study. Nutr Hosp. 2018;35
  26. Rodríguez-Hernández H, Simental-Mendía LE, Rodríguez-Ramírez G, Reyes-Romero MA. Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation International Journal of Endocrinology. 2013;2013:1-11
  27. Song Z, Xiaoli AM, Yang F. Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues. Nutrients. 2018;10:1-22

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