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Potensi Senyawa Antibakteri dari Ekstrak Akar Manis (Glycyrrhiza glabra L) terhadap Bacillus cereus

Potential of Antibacterial Compounds from Sweet Root Extract (Glycyrrhiza glabra L) on Bacillus cereus

Universitas 17 Agustus 1945, Indonesia

Received: 18 Feb 2019; Revised: 7 May 2019; Accepted: 13 May 2019; Published: 31 Jul 2019; Available online: 31 May 2019.
Open Access Copyright 2019 Jurnal Kimia Sains dan Aplikasi under http://creativecommons.org/licenses/by-sa/4.0.

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Abstract

The high number of poisoning food and diarrheal diseases caused by Bacillus cereus bacteria has been treated with chemical drugs and traditionally herbal plants. One of the commonly used herbal plants is sweet root (Glycyrrhiza glabra L.). This study aims to extract and fractionate sweet root plants, determine the antibacterial activity and identify the types of bioactive compounds as antibacterial compounds. The extraction process uses a maceration technique and fractionation using buthanol, ethyl acetate, and hexan solvents. Antibacterial activity was carry out by the diffusion method and identification of bioactive compounds by GCMS analysis. This study showed that greatest antibacterial activity was found in ethyl acetate fraction with a strong category and MIC value of 12,5%. This study for the first time also revealed that the types of bioactive compounds from sweet root plants (Glycyrrhiza glabra L.) as antibacterial compounds are n-Hexadecanoic as a fatty acid group and 4H-Pyran 4-one 2.3 dihydro-3, 5-dihydroxy-6 methyl from the flavonoid group.

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Keywords: Antibacterial; Bacillus cereus; bioactive; Glycyrrhiza glabra L; sweet root
Funding: Faculty of Pharmacy, 17 Augustus 1945 University, Jakarta 14350, Indonesia

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