Antibacterial Activity of Jojoba Seed residue and Its Possible Active Compound

Irmanida Batubara; Arnold Patogi Siahaan; Eti Rohaeti; Ali Mahmoud Muddathir

doi:10.14710/jksa.25.6.218-223

DOI: https://doi.org/10.14710/jksa.25.6.218-223

Antibacterial Activity of Jojoba Seed residue and Its Possible Active Compound

Irmanida Batubara^{1, 2}

, Arnold Patogi Siahaan¹, Eti Rohaeti^{1, 2}

, Ali Mahmoud Muddathir³

¹Department of Chemistry, Faculty of Mathematics and Natural Science, IPB University, Bogor, Indonesia

²Tropical Biopharmaca Research Center, IPB University,Bogor, Indonesia

³Department of Horticulture, Faculty of Agriculture, University of Khartoum, Khartoum, Sudan

Received: 9 May 2022; Revised: 13 Jul 2022; Accepted: 18 Jul 2022; Published: 31 Jul 2022.

BibTex Citation Data :

@article{JKSA46119,
    author = {Irmanida Batubara and Arnold Siahaan and Eti Rohaeti and Ali Muddathir},
    title = {Antibacterial Activity of Jojoba Seed residue and Its Possible Active Compound},
    journal = {Jurnal Kimia Sains dan Aplikasi},
  volume = {25},
    number = {6},
    year = {2022},
    keywords = {Simmondsia chinensis; Embelin; Staphylococcus aureus; Escherichia coli},
    abstract = {Jojoba ( Simmondsia chinensis ) (Link) C.K. is a shrub plant widely used in cosmetics, especially jojoba oil. The residue will remain when producing jojoba oil and become waste. This study aimed to determine the antibacterial activity of Jojoba seed residue (JSR) and its possible active antibacterial compounds. JSR was collected from Sudan and extracted by maceration with  n -hexane, ethyl acetate, and 70% ethanol. The antibacterial activity was determined with the microdilution method against  Staphylococcus aureus  ( S. aureus ) and  Escherichia coli  ( E. coli ). The 70% ethanol extract showed the value of MIC and MBC against  E. coli , which was 7.8 mg/ml; meanwhile, against  S. aureus  was 3.9 mg/mL and 7.8 mg/mL, respectively. Fractionation of 70% ethanol extract using silica gel column chromatography with gradient elution produced ten fractions. Fraction 3 showed the MIC and MBC values in  E. coli  which were 3.1 mg/mL and 12 mg/ml, and in  S. aureus , which were 3.1 mg/mL and 6.2 mg/mL. The fractionation continued to Fraction 3 using preparative thin layer chromatography to collect subfraction 3.2 at an  Rf  value of 0.76, actively based on contact autobiography against  E. coli  and  S. aureus.  Embelin was detected in Subfraction 3.2 using liquid chromatography-mass spectrometry (UHPLC-Q-Orbitrap HRMS) and suggested as the active antibacterial component in JSR.},
   issn = {2597-9914},   pages = {218--223}  doi = {10.14710/jksa.25.6.218-223},
    url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/46119}
}

Citation Format:

Abstract

Jojoba (Simmondsia chinensis) (Link) C.K. is a shrub plant widely used in cosmetics, especially jojoba oil. The residue will remain when producing jojoba oil and become waste. This study aimed to determine the antibacterial activity of Jojoba seed residue (JSR) and its possible active antibacterial compounds. JSR was collected from Sudan and extracted by maceration with n-hexane, ethyl acetate, and 70% ethanol. The antibacterial activity was determined with the microdilution method against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The 70% ethanol extract showed the value of MIC and MBC against E. coli, which was 7.8 mg/ml; meanwhile, against S. aureus was 3.9 mg/mL and 7.8 mg/mL, respectively. Fractionation of 70% ethanol extract using silica gel column chromatography with gradient elution produced ten fractions. Fraction 3 showed the MIC and MBC values in E. coli which were 3.1 mg/mL and 12 mg/ml, and in S. aureus, which were 3.1 mg/mL and 6.2 mg/mL. The fractionation continued to Fraction 3 using preparative thin layer chromatography to collect subfraction 3.2 at an Rf value of 0.76, actively based on contact autobiography against E. coli and S. aureus. Embelin was detected in Subfraction 3.2 using liquid chromatography-mass spectrometry (UHPLC-Q-Orbitrap HRMS) and suggested as the active antibacterial component in JSR.

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Keywords: Simmondsia chinensis; Embelin; Staphylococcus aureus; Escherichia coli

Funding: IPB University (Bogor Agricultural University)

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Section: Research Articles

Language : EN

In Vol 25, No 6 (2022): Volume 25 Issue 6 Year 2022

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