DOI: https://doi.org/10.14710/jksa.26.10.404-410

Synthesis and Characterization of Fe-doped Hydroxyapatite/ZnO Nanocomposites Using the Coprecipitation Method from Processed Limestone

1Master of Chemistry Study Program, Faculty of Science and Informatics, Jenderal Achmad Yani University, Cimahi, Indonesia

2Center for Applied Nuclear Science and Technology (PSTNT)-Nuclear Energy Research Organization (ORTN)-National Innovation Research Agency (BRIN), Bandung, Indonesia, Indonesia

Received: 8 Sep 2023; Revised: 18 Dec 2023; Accepted: 20 Dec 2023; Published: 23 Dec 2023.
Open Access Copyright 2023 Jurnal Kimia Sains dan Aplikasi under http://creativecommons.org/licenses/by-sa/4.0.

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Abstract
Hydroxyapatite (HAp) is the main inorganic component that forms teeth and bones. The abundant limestone reservoir in Indonesia can be utilized as a natural resource for the green synthesis of hydroxyapatite. The objective of synthesizing Fe-doped hydroxyapatite/ZnO nanocomposites is to enhance the magnetic properties of hydroxyapatite, facilitating its utilization as a biomaterial in drug delivery systems. This application proves valuable in regulating the timing and location of active substance decay in pharmaceuticals. The coprecipitation method was employed to synthesize Fe-doped hydroxyapatite (Fe-HAp) at varying concentrations of 0%, 2.5%, 5%, and 10% mol. Subsequently, Fe- HAp/ZnO nanocomposites were crafted with a weight ratio 4:1 through straightforward homogenization between nano Fe-HAp and nano ZnO, utilizing ethanol as a solvent. The analytical tools employed for characterization included X-ray fluorescence (XRF), X-ray diffraction (XRD), and Vibrating Sample Magnetometer (VSM). XRF analysis revealed that the Ca/P ratio in the Fe- HAp/ZnO nanocomposite decreased with increasing Fe dopant concentration, while the weight percentage of ZnO remained consistent across all nanocomposites. The XRD results demonstrated the presence of typical diffraction patterns of HAp and ZnO in the Fe-HAp/ZnO nanocomposite. However, secondary phases such as β-TCP, CaCO3, and Fe2O3 were observed in the Fe-HAp sample. The crystallite size of the Fe-HAp/ZnO nanocomposite generated in this study ranged from 29 to 38 nm. VSM characterization outcomes indicated that the substitution of Fe(III) can modify the diamagnetic properties of hydroxyapatite, rendering it ferromagnetic or superparamagnetic, depending on the dopant concentration employed.
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Keywords: limestone; iron; doped hydroxyapatite; nanocomposites; zinc oxide
Funding: Universitas Jenderal Achmad Yani under contract SKEP/194/UNJANI/VI/2023; PPS-PTM under contract 180/E5/PG.02.00.PL/2023

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Language : EN
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  1. Aleksandra Szcześ, Lucyna Hołysz, Emil Chibowski, Synthesis of hydroxyapatite for biomedical applications, Advances in Colloid and Interface Science, 249, (2017), 321-330 https://doi.org/10.1016/j.cis.2017.04.007
  2. V. Sarath Chandra, Ganga Baskar, R. V. Suganthi, K. Elayaraja, M. I. Ahymah Joshy, W. Sofi Beaula, R. Mythili, Ganesh Venkatraman, S. Narayana Kalkura, Blood Compatibility of Iron-Doped Nanosize Hydroxyapatite and Its Drug Release, ACS Applied Materials & Interfaces, 4, 3, (2012), 1200-1210 https://doi.org/10.1021/am300140q
  3. Monika Šupová, Substituted hydroxyapatites for biomedical applications: A review, Ceramics International, 41, 8, (2015), 9203-9231 https://doi.org/10.1016/j.ceramint.2015.03.316
  4. A. Joseph Nathanael, D. Mangalaraj, S. I. Hong, Y. Masuda, Synthesis and in-depth analysis of highly ordered yttrium doped hydroxyapatite nanorods prepared by hydrothermal method and its mechanical analysis, Materials Characterization, 62, 12, (2011), 1109-1115 https://doi.org/10.1016/j.matchar.2011.09.008
  5. Vijay Kumar Mishra, Birendra Nath Bhattacharjee, Om Parkash, Devendra Kumar, Shyam Bahadur Rai, Mg-doped hydroxyapatite nanoplates for biomedical applications: A surfactant assisted microwave synthesis and spectroscopic investigations, Journal of Alloys and Compounds, 614, (2014), 283-288 https://doi.org/10.1016/j.jallcom.2014.06.082
  6. Zafer Evis, Bengi Yilmaz, Metin Usta, Salim Levent Aktug, X-ray investigation of sintered cadmium doped hydroxyapatites, Ceramics International, 39, 3, (2013), 2359-2363 https://doi.org/10.1016/j.ceramint.2012.08.087
  7. Suja Jose, M. Senthilkumar, K. Elayaraja, M. Haris, Amal George, A. Dhayal Raj, S. John Sundaram, A. K. H. Bashir, M. Maaza, K. Kaviyarasu, Preparation and characterization of Fe doped n-hydroxyapatite for biomedical application, Surfaces and Interfaces, 25, (2021), 101185 https://doi.org/10.1016/j.surfin.2021.101185
  8. Anna Tampieri, Teresa D’Alessandro, Monica Sandri, Simone Sprio, Elena Landi, Luca Bertinetti, Silvia Panseri, Giancarlo Pepponi, Joerg Goettlicher, Manuel Bañobre-López, Jose Rivas, Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite, Acta Biomaterialia, 8, 2, (2012), 843-851 https://doi.org/10.1016/j.actbio.2011.09.032
  9. Daniela Predoi, Simona Liliana Iconaru, Steluta Carmen Ciobanu, Silviu-Adrian Predoi, Nicolas Buton, Christelle Megier, Mircea Beuran, Development of Iron-Doped Hydroxyapatite Coatings, Coatings, 11, 2, (2021), 186 https://doi.org/10.3390/coatings11020186
  10. Negar Alizadeh, Abdollah Salimi, Facile Synthesis of Fe-Doped Hydroxyapatite Nanoparticles from Waste Coal Ash: Fabrication of a Portable Sensor for the Sensitive and Selective Colorimetric Detection of Hydrogen Sulfide, ACS Omega, 7, 47, (2022), 42865-42871 https://doi.org/10.1021/acsomega.2c04905
  11. Kaiqian Shu, Chitiphon Chuaicham, Yuto Noguchi, Longhua Xu, Keiko Sasaki, In-situ hydrothermal synthesis of Fe-doped hydroxyapatite photocatalyst derived from converter slag toward xanthate photodegradation and Cr(VI) reduction under visible-light irradiation, Chemical Engineering Journal, 459, (2023), 141474 https://doi.org/10.1016/j.cej.2023.141474
  12. N. A. S. Mohd Pu'ad, P. Koshy, H. Z. Abdullah, M. I. Idris, T. C. Lee, Syntheses of hydroxyapatite from natural sources, Heliyon, 5, 5, (2019), e01588 https://doi.org/10.1016/j.heliyon.2019.e01588
  13. Ayan K. Barui, Rajesh Kotcherlakota, Chitta R. Patra, Chapter 6 - Biomedical applications of zinc oxide nanoparticles, in: A.M. Grumezescu (Ed.) Inorganic Frameworks as Smart Nanomedicines, William Andrew Publishing, 2018, https://doi.org/10.1016/B978-0-12-813661-4.00006-7
  14. Emon Barua, Ashish B. Deoghare, Sushovan Chatterjee, Pranav Sapkal, Effect of ZnO reinforcement on the compressive properties, in vitro bioactivity, biodegradability and cytocompatibility of bone scaffold developed from bovine bone-derived HAp and PMMA, Ceramics International, 45, 16, (2019), 20331-20345 https://doi.org/10.1016/j.ceramint.2019.07.006
  15. Vignesh R. Sivaperumal, Rajkumar Mani, Veerababu Polisetti, Kanakaraj Aruchamy, Taehwan Oh, One-Pot Hydrothermal Preparation of Hydroxyapatite/Zinc Oxide Nanorod Nanocomposites and Their Cytotoxicity Evaluation against MG-63 Osteoblast-like Cells, Molecules, 28, 1, (2023), 345 https://doi.org/10.3390/molecules28010345
  16. Saryati Saryati, Sulistioso Giat S., Ari Handayani, Supardi Supardi, Puji Untoro, Bambang Sugeng, Hidroksiapatit Berpori dari Kulit Kerang, Jurnal Sains Materi Indonesia, 13, 4, (2018), 31-35
  17. Sri Wardhani, Darjito Darjito, Sintesis Hidroksiapatit dari Tulang Sapi dengan Metode Basah-pengendapan, Brawijaya University, 2014
  18. Omer Kaygili, Sergey V. Dorozhkin, Tankut Ates, Ahmed A. Al-Ghamdi, Fahrettin Yakuphanoglu, Dielectric properties of Fe doped hydroxyapatite prepared by sol–gel method, Ceramics International, 40, 7, Part A, (2014), 9395-9402 https://doi.org/10.1016/j.ceramint.2014.02.009
  19. Robert D. Shannon, Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides, Acta crystallographica section A: crystal physics, diffraction, theoretical and general crystallography, 32, 5, (1976), 751-767 https://doi.org/10.1107/S0567739476001551
  20. P. Scherrer, Bestimmung der inneren Struktur und der Größe von Kolloidteilchen mittels Röntgenstrahlen, in: Kolloidchemie Ein Lehrbuch, Springer, Berlin, Heidelberg, 1918, https://doi.org/10.1007/978-3-662-33915-2_7
  21. Hülya Güneş Ateş, Omer Kaygili, Niyazi Bulut, Fatih Osmanlıoğlu, Serhat Keser, Beyhan Tatar, Bahroz Kareem Mahmood, Tankut Ates, Filiz Ercan, Ismail Ercan, Burhan Ates, İmren Özcan, Investigation of the structural, thermal, magnetic and cell viability properties of Ce/Sr co-doped hydroxyapatites, Journal of Molecular Structure, 1283, (2023), 135318 https://doi.org/10.1016/j.molstruc.2023.135318
  22. C. C. Silva, I. F. Vasconcelos, A. S. B. Sombra, M. A. Valente, Magnetic properties study on Fe-doped calcium phosphate, Physica Scripta, 80, (2009), 055706 https://doi.org/10.1088/0031-8949/80/05/055706
  23. Ram Kishore Singh, M. Srivastava, N. K. Prasad, Sharad Awasthi, Arunkumar Dhayalan, S. Kannan, Iron doped β-Tricalcium phosphate: Synthesis, characterization, hyperthermia effect, biocompatibility and mechanical evaluation, Materials Science and Engineering: C, 78, (2017), 715-726 https://doi.org/10.1016/j.msec.2017.04.130

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