Department of Pharmacy, Faculty of Pharmacy, Bakti Tunas Husada University, Tasikmalaya, Indonesia
BibTex Citation Data :
@article{JKSA68508, author = {Lilis Tuslinah and Laras Widyastuti and Mochamad Fathurohman}, title = {Validation of the Use of Anthocyanin as Indicators for Acid-Base Titration}, journal = {Jurnal Kimia Sains dan Aplikasi}, volume = {28}, number = {2}, year = {2025}, keywords = {Rambutan Peel (Nephelium lappaceum L.); Anthocyanins; Acid-Base Titration Indicator; Method Validation}, abstract = { Rambutan peel ( Nephelium lappaceum L. ) contains secondary metabolites, particularly flavonoids, including anthocyanins. Anthocyanins exhibit color changes in response to variations in pH, making them potential candidates for use as acid-base indicators. This study aims to validate using methanol fraction powder derived from rambutan peel as an acid-base titration indicator by evaluating method validation parameters such as precision, accuracy, and linearity. The fractionation process was conducted using liquid-liquid extraction with n -hexane, water, and methanol as solvents, followed by freeze-drying of the methanol fraction. The methanol fraction powder was analyzed and compared with the conventional phenolphthalein indicator to determine the color transition at the titration endpoint. The results indicated that the methanol fraction exhibited a color change to brown within a pH range of 8–11. Statistical analysis using an independent sample t -test showed no significant difference between the methanol fraction powder and phenolphthalein (significance value > 0.05). Therefore, based on the method validation results, including precision, accuracy, and linearity, the methanol fraction powder of rambutan peel demonstrates potential as a reliable acid-base indicator. }, issn = {2597-9914}, pages = {53--61} doi = {10.14710/jksa.28.2.53-61}, url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/68508} }
Refworks Citation Data :
Rambutan peel (Nephelium lappaceum L.) contains secondary metabolites, particularly flavonoids, including anthocyanins. Anthocyanins exhibit color changes in response to variations in pH, making them potential candidates for use as acid-base indicators. This study aims to validate using methanol fraction powder derived from rambutan peel as an acid-base titration indicator by evaluating method validation parameters such as precision, accuracy, and linearity. The fractionation process was conducted using liquid-liquid extraction with n-hexane, water, and methanol as solvents, followed by freeze-drying of the methanol fraction. The methanol fraction powder was analyzed and compared with the conventional phenolphthalein indicator to determine the color transition at the titration endpoint. The results indicated that the methanol fraction exhibited a color change to brown within a pH range of 8–11. Statistical analysis using an independent sample t-test showed no significant difference between the methanol fraction powder and phenolphthalein (significance value > 0.05). Therefore, based on the method validation results, including precision, accuracy, and linearity, the methanol fraction powder of rambutan peel demonstrates potential as a reliable acid-base indicator.
Article Metrics:
Last update:
Last update: 2025-03-26 00:44:13
As an article writer, the author has the right to use their articles for various purposes, including use by institutions that employ authors or institutions that provide funding for research. Author rights are granted without special permission.
Author who publishes a paper at JKSA has the broad right to use their work for teaching and scientific purposes without the need to ask permission, including: used for (i) teaching in the author's class or institution, (ii) presentation at meetings or conferences and distributing copies to participants ; (iii) training conducted by the author or author's institution; (iv) distribution to colleagues for research use; (v) use in the compilation of subsequent authors' works; (vi) inclusion in a thesis or dissertation; (vi) reuse of part of the article in another work (with citation); (vii) preparation of derivative works (with citation); (viii) voluntary posting on open websites operated by authors or author institutions for scientific purposes (follow the CC BY-SA License).
Authors and readers can copy and redistribute material in any media or format, and mix, modify, and build material for any purpose but they must provide appropriate credit (provide article citation or content), providing links to the license, and indicate if there are changes.
The authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Jurnal Kimia Sains dan Aplikasi (JKSA). Copyright encompasses rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations.
Reproduce any part of this journal, its storage in the database or its transmission by all forms or media is permitted does not need for written permission from JKSA. However, it should be cited as an honor in academic manners
JKSA and the Chemistry Department of Diponegoro University and the Editor make every effort to ensure that there are no data, opinions, or false or misleading statements published in JKSA. However, the content of the article is the sole and exclusive responsibility of each author.
The Copyright Transfer Form can be downloaded here: [Copyright Transfer Form - Indonesian] [Copyright Transfer Form - English]. The copyright form should be signed originally and send to the Editor in the form of printed letters, scanned documents sent via email or fax.
Adi Darmawan, Ph.D (Editor in Chief)
Editor in chief of Jurnal Kimia Sains dan Aplikasi (JKSA)
Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University
Visitor: View My Stats
Jurnal Kimia Sains dan Aplikasi is indexed in:
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
