DOI: https://doi.org/10.14710/jksa.29.3.227-244

Mechanisms of Action, Resistance, Toxicity, and Recent Developments of Cisplatin as Anticancer Agent: A Comprehensive Review

1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Makassar, South Sulawesi 90245, Indonesia

2Department of Pharmacy, School of Pharmacy, Akademi Farmasi Yamasi, Makassar, South Sulawesi 90222, Indonesia

Received: 14 Dec 2025; Revised: 4 Mar 2026; Accepted: 5 Mar 2026; Published: 22 Apr 2026.
Open Access Copyright 2026 Jurnal Kimia Sains dan Aplikasi under http://creativecommons.org/licenses/by-sa/4.0.

Citation Format:
Cover Image
Abstract

Cisplatin is among the most potent chemotherapy agents used to treat a range of cancers, including those affecting the ovaries, testes, lungs, and bladder. Its primary mode of operation involves creating cross-links in DNA, which blocks cell division and gene expression, ultimately leading to programmed cell death. Unfortunately, its therapeutic benefits are frequently undermined by harmful side effects and the development of resistance in cancer cells. This research seeks to delve deeply into cisplatin’s mechanisms, covering how it enters cells, gets activated internally, and interacts with DNA and key proteins. Additionally, it explores advancements in nanoparticle-based cisplatin delivery systems and platinum (Pt[IV]) compounds designed to enhance systemic absorption and reduce overall toxicity. Drawing on a review of 166 studies across five key databases, modifications to drug-delivery methods have shown notable improvements in cisplatin’s performance across different cancer types. As a result, innovative formulations and tactics to tackle resistance could broaden cisplatin’s role as a more targeted and safer cancer-fighting drug. This review was conducted using a structured literature search without a formal risk-of-bias assessment.

Fulltext View|Download Email colleagues
Keywords: Cisplatin; Mechanism of action; Anti-cancer drugs; Drug resistance; DNA damage

Article Metrics:

Article Info
Section: Review
Language : EN
Most cited articles
Skrining Metabolit Sekunder Bakteri Endofit yang Berfungsi sebagai Antidiabetes dari Daun Mimba (Azadirachta Indica) Sintesis Bahan Hibrida Amino-Silika dari Abu Sekam Padi Melalui Proses Sol-Gel Lempung Terpilar Silika untuk Penghilangan Fenol dalam Air Molecular Docking of Interaction between E-Cadherin Protein and Conformational Structure of Cyclic Peptide ADTC3 (Ac-CADTPC-NH2) Simulated on 20 ns New Chemicals and Routes for the Preparation of Gelatin/HA Composites using the Wet Precipitation Method More cited articles
  1. Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray, Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries, CA: A Cancer Journal for Clinicians, 71, 3, (2021), 209-249 https://doi.org/10.3322/caac.21660
  2. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L. Siegel, Lindsey A. Torre, Ahmedin Jemal, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA: A Cancer Journal for Clinicians, 68, 6, (2018), 394-424 https://doi.org/10.3322/caac.21492
  3. Sumit Ghosh, Cisplatin: the first metal based anticancer drug, Bioorganic Chemistry, 88, (2019), 102925 https://doi.org/10.1016/j.bioorg.2019.102925
  4. Timothy C. Johnstone, Kogularamanan Suntharalingam, Stephen J. Lippard, The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs, Chemical Reviews, 116, 5, (2016), 3436-3486 https://doi.org/10.1021/acs.chemrev.5b00597
  5. Clarissa Ribeiro Reily Rocha, Matheus Molina Silva, Annabel Quinet, Januario Bispo Cabral-Neto, Carlos Frederico Martins Menck, DNA repair pathways and cisplatin resistance: an intimate relationship, Clinics, 73, Supplement 1, (2018), e478s https://doi.org/10.6061/clinics/2018/e478s
  6. L. H. Einhorn, Treatment of testicular cancer: a new and improved model, Journal of Clinical Oncology, 8, 11, (1990), 1777-1781 https://doi.org/10.1200/JCO.1990.8.11.1777
  7. L. Kelland, The resurgence of platinum-based cancer chemotherapy, Nature Reviews Cancer 7, 8, (2007), 573-584 https://doi.org/10.1038/nrc2167
  8. Ana-Maria Florea, Dietrich Büsselberg, Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects, Cancers, 3, 1, (2019), 1351-1371 https://doi.org/10.3390/cancers3011351
  9. Lauren Amable, Cisplatin resistance and opportunities for precision medicine, Pharmacological Research, 106, (2016), 27-36 https://doi.org/10.1016/j.phrs.2016.01.001
  10. Rabbab Oun, Yvonne E. Moussa, Nial J. Wheate, The side effects of platinum-based chemotherapy drugs: a review for chemists, Dalton Transactions, 47, 19, (2018), 6645-6653 https://doi.org/10.1039/C8DT00838H
  11. Dong Wang, Stephen J. Lippard, Cellular processing of platinum anticancer drugs, Nature Reviews Drug Discovery, 4, (2005), 307–320 https://doi.org/10.1038/nrd1691
  12. T. Makovec, Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy, Radiology and Oncology, 53, 2, (2019), 148-158 https://doi.org/10.2478/raon-2019-0018
  13. Zahid H. Siddik, Cisplatin: mode of cytotoxic action and molecular basis of resistance, Oncogene, 22, (2003), 7265-7279 https://doi.org/10.1038/sj.onc.1206933
  14. Shahana Dilruba, Ganna V. Kalayda, Platinum-based drugs: past, present and future, Cancer Chemotherapy and Pharmacology, 77, (2016), 1103-1124 https://doi.org/10.1007/s00280-016-2976-z
  15. L. Galluzzi, L. Senovilla, I. Vitale, J. Michels, I. Martins, O. Kepp, M. Castedo, G. Kroemer, Molecular mechanisms of cisplatin resistance, Oncogene, 31, (2011), 1869-1883 https://doi.org/10.1038/onc.2011.384
  16. L. Galluzzi, I. Vitale, J. Michels, C. Brenner, G. Szabadkai, A. Harel-Bellan, M. Castedo, G. Kroemer, Systems biology of cisplatin resistance: past, present and future, Cell Death & Disease, 5, (2014), e1257 https://doi.org/10.1038/cddis.2013.428
  17. Shang-Hung Chen, Jang-Yang Chang, New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment, International Journal of Molecular Sciences, 20, 17, (2019), 4136 https://doi.org/10.3390/ijms20174136
  18. Shanta Dhar, Weston L. Daniel, David A. Giljohann, Chad A. Mirkin, Stephen J. Lippard, Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) Warheads, Journal of the American Chemical Society, 131, 41, (2019), 14652-14653 https://doi.org/10.1021/ja9071282
  19. Nial J. Wheate, Shonagh Walker, Gemma E. Craig, Rabbab Oun, The status of platinum anticancer drugs in the clinic and in clinical trials, Dalton Transactions, 39, 35, (2010), 8113-8127 https://doi.org/10.1039/C0DT00292E
  20. P. B. Tchounwou, S. Dasari, F. K. Noubissi, P. Ray, S. Kumar, Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy, Journal of Experimental Pharmacology, 13, (2021), 303-328 https://doi.org/10.2147/JEP.S267383
  21. Jana Kasparkova, Victoria Marini, Yousef Najajreh, Dan Gibson, Viktor Brabec, DNA Binding Mode of the Cis and Trans Geometries of New Antitumor Nonclassical Platinum Complexes Containing Piperidine, Piperazine, or 4-Picoline Ligand in Cell-Free Media. Relations to Their Activity in Cancer Cell Lines, Biochemistry, 42, 20, (2003), 6321-6332 https://doi.org/10.1021/bi0342315
  22. Katherine S. Lovejoy, Ryan C. Todd, Shuzhong Zhang, Michael S. McCormick, J. Alejandro D'Aquino, Joyce T. Reardon, Aziz Sancar, Kathleen M. Giacomini, Stephen J. Lippard, cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: uptake, structure, function, and prospects, Proceedings of the National Academy of Sciences of the United States of America, 105, 26, (2018), 8902-8907 https://doi.org/10.1073/pnas.0803441105
  23. Maria Kartalou, John M. Essigmann, Recognition of cisplatin adducts by cellular proteins, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 478, 1-2, (2015), 1-21 https://doi.org/10.1016/S0027-5107(01)00142-7
  24. Dan Gibson, Multi-action Pt(IV) anticancer agents; do we understand how they work?, Journal of Inorganic Biochemistry, 191, (2019), 77-84 https://doi.org/10.1016/j.jinorgbio.2018.11.008
  25. Yi Shi, Shu-An Liu, Deborah J. Kerwood, Jerry Goodisman, James C. Dabrowiak, Pt(IV) complexes as prodrugs for cisplatin, Journal of Inorganic Biochemistry, 107, 1, (2012), 6-14 https://doi.org/10.1016/j.jinorgbio.2011.10.012
  26. Hristo P. Varbanov, Michael A. Jakupec, Alexander Roller, Frank Jensen, Mathea Sophia Galanski, Bernhard K. Keppler, Theoretical Investigations and Density Functional Theory Based Quantitative Structure–Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes, Journal of Medicinal Chemistry, 56, 1, (2012), 330-344 https://doi.org/10.1021/jm3016427
  27. Ga Young Park, Justin J. Wilson, Ying Song, Stephen J. Lippard, Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile, Proceedings of the National Academy of Sciences of the United States of America, 109, 30, (2016), 11987-11992 https://doi.org/10.1073/pnas.1207670109
  28. Timothy C. Johnstone, Ga Young Park, Stephen J. Lippard, Understanding and Improving Platinum Anticancer Drugs – Phenanthriplatin, Anticancer Research, 34, 1, (2014), 471-476
  29. Giuliano Ciarimboli, Membrane Transporters as Mediators of Cisplatin Effects and Side Effects, Scientifica, 2012, (2012), 473829
  30. Stephen B. Howell, Roohangiz Safaei, Christopher A. Larson, Michael J. Sailor, Copper Transporters and the Cellular Pharmacology of the Platinum-Containing Cancer Drugs, Molecular Pharmacology, 77, 6, (2018), 887-894 https://doi.org/10.1124/mol.109.063172
  31. Navjotsingh Pabla, Robert F. Murphy, Kebin Liu, Zheng Dong, The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity, American Journal of Physiology-Renal Physiology, 296, 3, (2019), F505-F511 https://doi.org/10.1152/ajprenal.90545.2008
  32. Seiko Ishida, Frank McCormick, Karen Smith-McCune, Douglas Hanahan, Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator, Cancer Cell, 17, 6, (2010), 574-583 https://doi.org/10.1016/j.ccr.2010.04.011
  33. Alison K. Holzer, Goli Samimi, Kuniyuki Katano, Wiltrud Naerdemann, Xinjian Lin, Roohangiz Safaei, Stephen B. Howell, The Copper Influx Transporter Human Copper Transport Protein 1 Regulates the Uptake of Cisplatin in Human Ovarian Carcinoma Cells, Molecular Pharmacology, 66, 4, (2016), 817-823 https://doi.org/10.1124/mol.104.001198
  34. Christopher A. Larson, Brian G. Blair, Roohangiz Safaei, Stephen B. Howell, The Role of the Mammalian Copper Transporter 1 in the Cellular Accumulation of Platinum-Based Drugs, Molecular Pharmacology, 75, 2, (2009), 324-330 https://doi.org/10.1124/mol.108.052381
  35. Kuniyuki Katano, Akira Kondo, Roohangiz Safaei, Alison Holzer, Goli Samimi, Misako Mishima, Yien-Ming Kuo, Myriam Rochdi, Stephen B. Howell, Acquisition of Resistance to Cisplatin is Accompanied by Changes in the Cellular Pharmacology of Copper, Cancer Research, 62, 22, (2018), 6559-6565
  36. Roohangiz Safaei, Barrett J. Larson, Timothy C. Cheng, Michael A. Gibson, Shinji Otani, Wiltrud Naerdemann, Stephen B. Howell, Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells, Molecular Cancer Therapeutics, 4, 10, (2005), 1595-1604 https://doi.org/10.1158/1535-7163.MCT-05-0102
  37. Helen H. W. Chen, Macus Tien Kuo, Improving radiotherapy in cancer treatment: Promises and challenges, Oncotarget, 8, (2017), 62742-62758 https://doi.org/10.18632/oncotarget.18409
  38. Atsushi Yonezawa, Satohiro Masuda, Sachiko Yokoo, Toshiya Katsura, Ken-ichi Inui, Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family), The Journal of Pharmacology and Experimental Therapeutics, 319, 2, (2006), 879-886 https://doi.org/10.1124/jpet.106.110346
  39. Giuliano Ciarimboli, Thomas Ludwig, Detlef Lang, Hermann Pavenstädt, Hermann Koepsell, Hans-Jürgen Piechota, Jörg Haier, Ulrich Jaehde, Jochen Zisowsky, Eberhard Schlatter, Cisplatin Nephrotoxicity Is Critically Mediated via the Human Organic Cation Transporter 2, The American Journal of Pathology, 167, 6, (2019), 1477-1484 https://doi.org/10.1016/S0002-9440(10)61234-5
  40. Jason A. Sprowl, Cynthia S. Lancaster, Navjotsingh Pabla, Edwin Hermann, Ashley M. Kosloske, Alice A. Gibson, Lie Li, Dorothea Zeeh, Eberhard Schlatter, Laura J. Janke, Giuliano Ciarimboli, Alex Sparreboom, Cisplatin-Induced Renal Injury Is Independently Mediated by OCT2 and p53, Clinical Cancer Research, 20, 15, (2014), 4026-4035 https://doi.org/10.1158/1078-0432.CCR-14-0319
  41. Jing Zhang, Wen Zhou, Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients, Food and Chemical Toxicology, 50, 7, (2012), 2289-2293 https://doi.org/10.1016/j.fct.2012.03.077
  42. Shaloam Dasari, Paul Bernard Tchounwou, Cisplatin in cancer therapy: molecular mechanisms of action, European Journal of Pharmacology, 740, (2016), 364-378 https://doi.org/10.1016/j.ejphar.2014.07.025
  43. Ryan C. Todd, Stephen J. Lippard, Inhibition of transcription by platinum antitumor compounds, Metallomics, 1, 4, (2009), 280-291 https://doi.org/10.1039/B907567D
  44. Elizabeth R. Jamieson, Stephen J. Lippard, Structure, Recognition, and Processing of Cisplatin−DNA Adducts, Chemical Reviews, 99, 9, (1999), 2467-2498 https://doi.org/10.1021/cr980421n
  45. Alan Eastman, The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes, Pharmacology & Therapeutics, 34, 2, (1987), 155-166 https://doi.org/10.1016/0163-7258(87)90009-X
  46. Patricia M. Takahara, Amy C. Rosenzweig, Christin A. Frederick, Stephen J. Lippard, Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin, Nature, 377, (1995), 649-652 https://doi.org/10.1038/377649a0
  47. Yongwon Jung, Stephen J. Lippard, Direct Cellular Responses to Platinum-Induced DNA Damage, Chemical Reviews, 107, 5, (2007), 1387-1407 https://doi.org/10.1021/cr068207j
  48. Christine M. Sorenson, Alan Eastman, Mechanism of cis-Diamminedichloroplatinum(II)-induced Cytotoxicity: Role of G2 Arrest and DNA Double-Strand Breaks, Cancer Research, 48, (1988), 4484-4488
  49. Gerke E. Damsma, Aaron Alt, Florian Brueckner, Thomas Carell, Patrick Cramer, Mechanism of transcriptional stalling at cisplatin-damaged DNA, Nature Structural & Molecular Biology, 14, 12, (2007), 1127-1133 https://doi.org/10.1038/nsmb1314
  50. Qing He, Cynthia H. Liang, Stephen J. Lippard, Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin, Proceedings of the National Academy of Sciences of the United States of America, 97, 11, (2000), 5768-5772 https://doi.org/10.1073/pnas.100108697
  51. Patricia M. Takahara, Christin A. Frederick, Stephen J. Lippard, Crystal Structure of the Anticancer Drug Cisplatin Bound to Duplex DNA, Journal of the American Chemical Society, 118, 49, (1996), 12309-12321 https://doi.org/10.1021/ja9625079
  52. Sabine S. Lange, Kei-ichi Takata, Richard D. Wood, DNA polymerases and cancer, Nature Reviews Cancer, 11, (2011), 96-110 https://doi.org/10.1038/nrc2998
  53. Deborah B. Zamble, David Mu, Joyce T. Reardon, Aziz Sancar, Stephen J. Lippard, Repair of Cisplatin−DNA Adducts by the Mammalian Excision Nuclease, Biochemistry, 35, 31, (1996), 10004-10013 https://doi.org/10.1021/bi960453+
  54. Andrew N. Blackford, Stephen P. Jackson, ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response, Molecular Cell, 66, 6, (2017), 801-817 https://doi.org/10.1016/j.molcel.2017.05.015
  55. Alexandre Maréchal, Lee Zou, DNA Damage Sensing by the ATM and ATR Kinases, Cold Spring Harbor Perspectives in Biology, 5, (2013), a012716 https://doi.org/10.1101/cshperspect.a012716
  56. Alberto Ciccia, Stephen J. Elledge, The DNA Damage Response: Making It Safe to Play with Knives, Molecular Cell, 40, 2, (2010), 179-204 https://doi.org/10.1016/j.molcel.2010.09.019
  57. Jiri Bartek, Jiri Lukas, DNA damage checkpoints: from initiation to recovery or adaptation, Current Opinion in Cell Biology, 19, 2, (2007), 238-245 https://doi.org/10.1016/j.ceb.2007.02.009
  58. Edward R. Kastenhuber, Scott W. Lowe, Putting p53 in Context, Cell, 170, 6, (2017), 1062-1078 https://doi.org/10.1016/j.cell.2017.08.028
  59. Arnold J. Levine, The many faces of p53: something for everyone, Journal of Molecular Cell Biology, 11, 7, (2019), 524-530 https://doi.org/10.1093/jmcb/mjz026
  60. Katsunori Nakano, Karen H. Vousden, PUMA, a Novel Proapoptotic Gene, Is Induced by p53, Molecular Cell, 7, 3, (2001), 683-694 https://doi.org/10.1016/S1097-2765(01)00214-3
  61. William A. Freed-Pastor, Carol Prives, Mutant p53: one name, many proteins, Genes Development, 26, (2012), 1268-1286 http://dx.doi.org/10.1101/gad.190678.112
  62. Magali Olivier, Monica Hollstein, Pierre Hainaut, TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use, Cold Spring Harbor Perspectives in Biology, 2, 1, (2010), a001008 https://doi.org/10.1101/cshperspect.a001008
  63. Brandon J. Aubrey, Gemma L. Kelly, Ana Janic, Marco J. Herold, Andreas Strasser, How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?, Cell Death & Differentiation, 25, 1, (2017), 104-113 https://doi.org/10.1038/cdd.2017.169
  64. Erwin F. Wagner, Ángel R. Nebreda, Signal integration by JNK and p38 MAPK pathways in cancer development, Nature Reviews Cancer, 9, (2009), 537-549 https://doi.org/10.1038/nrc2694
  65. Xinbing Sui, Na Kong, Li Ye, Weidong Han, Jichun Zhou, Qin Zhang, Chao He, Hongming Pan, p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents, Cancer Letters, 344, 2, (2014), 174-179 https://doi.org/10.1016/j.canlet.2013.11.019
  66. Jonas Cicenas, Egle Zalyte, Amos Bairoch, Pascale Gaudet, Kinases and Cancer, Cancers, 10, 3, (2018), 63 https://doi.org/10.3390/cancers10030063
  67. A. S. Dhillon, S. Hagan, O. Rath, W. Kolch, MAP kinase signalling pathways in cancer, Oncogene, 26, (2007), 3279-3290 https://doi.org/10.1038/sj.onc.1210421
  68. Susan Elmore, Apoptosis: A Review of Programmed Cell Death, Toxicologic Pathology, 35, 4, (2007), https://doi.org/10.1080/01926230701320337
  69. Douglas R. Green, Fabien Llambi, Cell Death Signaling, Cold Spring Harbor Perspectives in Biology, 7, (2015), a006080 http://dx.doi.org/10.1101/cshperspect.a006080
  70. Halime Kalkavan, Douglas R. Green, MOMP, cell suicide as a BCL-2 family business, Cell Death & DIfferentiation, 25, (2018), 46-55 https://doi.org/10.1038/cdd.2017.179
  71. Peter E. Czabotar, Guillaume Lessene, Andreas Strasser, Jerry M. Adams, Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy, Nature Reviews Molecular Cell Biology, 15, 1, (2013), 49-63 https://doi.org/10.1038/nrm3722
  72. Tudor Moldoveanu, Ariele Viacava Follis, Richard W. Kriwacki, Douglas R. Green, Many players in BCL-2 family affairs, Trends Biochemical Sciences, 39, 3, (2014), 101-111 https://doi.org/10.1016/j.tibs.2013.12.006
  73. Florian J. Bock, Stephen W. G. Tait, Mitochondria as multifaceted regulators of cell death, Nature Reviews Molecular Cell Biology, 21, (2019), 85-100 https://doi.org/10.1038/s41580-019-0173-8
  74. Shujun Yuan, Christopher W. Akey, Apoptosome Structure, Assembly, and Procaspase Activation, Structure, 21, 4, (2013), 501-515 https://doi.org/10.1016/j.str.2013.02.024
  75. David R. McIlwain, Thorsten Berger, Tak W. Mak, Caspase Functions in Cell Death and Disease, Cold Spring Harbor Perspectives in Biology, 5, 4, (2013), a008656 https://doi.org/10.1101/cshperspect.a008656
  76. Rebecca C. Taylor, Sean P. Cullen, Seamus J. Martin, Apoptosis: controlled demolition at the cellular level, Nature Reviews Molecular Cell Biology, 9, (2008), 231-241 https://doi.org/10.1038/nrm2312
  77. Andreas Strasser, Philipp J. Jost, Shigekazu Nagata, The Many Roles of FAS Receptor Signaling in the Immune System, Immunity, 30, 2, (2016), 180-192 https://doi.org/10.1016/j.immuni.2009.01.001
  78. A. R. Safa, c-FLIP, a master anti-apoptotic regulator, Experimental Oncology, 34, 3, (2012), 176-184
  79. Olivier Micheau, Jürg Tschopp, Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes, Cell, 114, 2, (2003), 181-190 https://doi.org/10.1016/S0092-8674(03)00521-X
  80. Honglin Li, Hong Zhu, Chi-jie Xu, Junying Yuan, Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis, Cell, 94, 4, (2019), 491-501 https://doi.org/10.1016/S0092-8674(00)81590-1
  81. Lorenzo Galluzzi, Ilio Vitale, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Margherita Annicchiarico-Petruzzelli, Alexey V. Antonov, Eli Arama, Eric H. Baehrecke, Nickolai A. Barlev, Nicolas G. Bazan, Francesca Bernassola, Mathieu J. M. Bertrand, Katiuscia Bianchi, Mikhail V. Blagosklonny, Klas Blomgren, Christoph Borner, Patricia Boya, Catherine Brenner, Michelangelo Campanella, Eleonora Candi, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K. M. Chan, Navdeep S. Chandel, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gerald M. Cohen, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D’Angiolella, Ted M. Dawson, Valina L. Dawson, Vincenzo De Laurenzi, Ruggero De Maria, Klaus-Michael Debatin, Ralph J. DeBerardinis, Mohanish Deshmukh, Nicola Di Daniele, Francesco Di Virgilio, Vishva M. Dixit, Scott J. Dixon, Colin S. Duckett, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Gian Maria Fimia, Simone Fulda, Ana J. García-Sáez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Pierre Golstein, Eyal Gottlieb, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Atan Gross, Gyorgy Hajnoczky, J. Marie Hardwick, Isaac S. Harris, Michael O. Hengartner, Claudio Hetz, Hidenori Ichijo, Marja Jäättelä, Bertrand Joseph, Philipp J. Jost, Philippe P. Juin, William J. Kaiser, Michael Karin, Thomas Kaufmann, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Richard A. Knight, Sharad Kumar, Sam W. Lee, John J. Lemasters, Beth Levine, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos López-Otín, Scott W. Lowe, Tom Luedde, Enrico Lugli, Marion MacFarlane, Frank Madeo, Michal Malewicz, Walter Malorni, Gwenola Manic, Jean-Christophe Marine, Seamus J. Martin, Jean-Claude Martinou, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Sonia Melino, Edward A. Miao, Jeffery D. Molkentin, Ute M. Moll, Cristina Muñoz-Pinedo, Shigekazu Nagata, Gabriel Nuñez, Andrew Oberst, Moshe Oren, Michael Overholtzer, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Mauro Piacentini, Paolo Pinton, Jochen H. M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Markus Rehm, Rosario Rizzuto, Cecilia M. P. Rodrigues, David C. Rubinsztein, Thomas Rudel, Kevin M. Ryan, Emre Sayan, Luca Scorrano, Feng Shao, Yufang Shi, John Silke, Hans-Uwe Simon, Antonella Sistigu, Brent R. Stockwell, Andreas Strasser, Gyorgy Szabadkai, Stephen W. G. Tait, Daolin Tang, Nektarios Tavernarakis, Andrew Thorburn, Yoshihide Tsujimoto, Boris Turk, Tom Vanden Berghe, Peter Vandenabeele, Matthew G. Vander Heiden, Andreas Villunger, Herbert W. Virgin, Karen H. Vousden, Domagoj Vucic, Erwin F. Wagner, Henning Walczak, David Wallach, Ying Wang, James A. Wells, Will Wood, Junying Yuan, Zahra Zakeri, Boris Zhivotovsky, Laurence Zitvogel, Gerry Melino, Guido Kroemer, Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, Cell Death & Differentiation, 25, (2018), 486-541 https://doi.org/10.1038/s41418-017-0012-4
  82. Dana E. Christofferson, Junying Yuan, Necroptosis as an alternative form of programmed cell death, Current Opinion in Cell Biology, 22, 2, (2010), 263-268 https://doi.org/10.1016/j.ceb.2009.12.003
  83. Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht, Rachid Skouta, Eleina M. Zaitsev, Caroline E. Gleason, Darpan N. Patel, Andras J. Bauer, Alexandra M. Cantley, Wan Seok Yang, Barclay Morrison, Brent R. Stockwell, Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death, Cell, 149, 5, (2012), 1060-1072 https://doi.org/10.1016/j.cell.2012.03.042
  84. Daolin Tang, Rui Kang, Tom Vanden Berghe, Peter Vandenabeele, Guido Kroemer, The molecular machinery of regulated cell death, Cell Research, 29, 5, (2019), 347-364 https://doi.org/10.1038/s41422-019-0164-5
  85. Rossella Marullo, Erica Werner, Natalya Degtyareva, Bryn Moore, Giuseppe Altavilla, Suresh S. Ramalingam, Paul W. Doetsch, Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions, PLoS One, 8, 11, (2013), e81162 https://doi.org/10.1371/journal.pone.0081162
  86. Markus Kleih, Kathrin Böpple, Meng Dong, Andrea Gaißler, Simon Heine, Monilola A. Olayioye, Walter E. Aulitzky, Frank Essmann, Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells, Cell Death & Disease, 10, 11, (2019), 851 https://doi.org/10.1038/s41419-019-2081-4
  87. Yanhua Zheng, Yong Shi, Changhai Tian, Chunsun Jiang, Haijing Jin, Jianjun Chen, Alex Almasan, Hong Tang, Quan Chen, Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide, Oncogene, 23, 6, (2016), 1239-1247 https://doi.org/10.1038/sj.onc.1207205
  88. Paloma Bragado, Alejandro Armesilla, Augusto Silva, Almudena Porras, Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation, Apoptosis, 12, (2007), 1733-1742 https://doi.org/10.1007/s10495-007-0082-8
  89. Sherif Y. Saad, Tawfeeg A. Najjar, Ammar C. Al-Rikabi, The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats, Pharmacological Research, 43, 3, (2001), 211-218 https://doi.org/10.1006/phrs.2000.0769
  90. Michael Schieber, Navdeep S. Chandel, ROS Function in Redox Signaling and Oxidative Stress, Current Biology, 24, 10, (2014), R453-R462 https://doi.org/10.1016/j.cub.2014.03.034
  91. Edouard I. Azzam, Jean-Paul Jay-Gerin, Debkumar Pain, Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury, Cancer Letters, 327, 1-2, (2012), 48-60 https://doi.org/10.1016/j.canlet.2011.12.012
  92. Antonio Ayala, Mario F. Muñoz, Sandro Argüelles, Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal, Oxidative Medicine and Cellular Longevity, 2014, (2014), 360438 https://doi.org/10.1155/2014/360438
  93. M. J. Davies, Protein oxidation and peroxidation, Biochemical Journal, 473, 7, (2016), 805-825 https://doi.org/10.1042/BJ20151227
  94. Helene Pelicano, Dennis Carney, Peng Huang, ROS stress in cancer cells and therapeutic implications, Drug Resistance Updates, 7, 2, (2017), 97-110 https://doi.org/10.1016/j.drup.2004.01.004
  95. Dunyaporn Trachootham, Jerome Alexandre, Peng Huang, Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?, Nature Reviews Drug Discovery, 8, (2009), 579-591 https://doi.org/10.1038/nrd2803
  96. Zhengzhi Zou, Haocai Chang, Haolong Li, Songmao Wang, Induction of reactive oxygen species: an emerging approach for cancer therapy, Apoptosis, 22, 11, (2017), 1321-1335 https://doi.org/10.1007/s10495-017-1424-9
  97. David J. Stewart, Mechanisms of resistance to cisplatin and carboplatin, Critical Reviews in Oncology/Hematology, 63, 1, (2007), 12-31 https://doi.org/10.1016/j.critrevonc.2007.02.001
  98. Ding-Wu Shen, Lynn M. Pouliot, Matthew D. Hall, Michael M. Gottesman, Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes, Pharmacological Reviews, 64, 3, (2012), 706-721 https://doi.org/10.1124/pr.111.005637
  99. Darina Kohoutova, Matthew Banks, Jan Bures, Advances in the Aetiology & Endoscopic Detection and Management of Early Gastric Cancer, Cancers, 13, 24, (2021), 6242 https://doi.org/10.3390/cancers13246242
  100. Danyelle M. Townsend, Kenneth D. Tew, The role of glutathione-S-transferase in anti-cancer drug resistance, Oncogene, 22, (2003), 7369-7375 https://doi.org/10.1038/sj.onc.1206940
  101. Anupam Chatterjee, Sanjay Gupta, The multifaceted role of glutathione S-transferases in cancer, Cancer Letters, 433, (2018), 33-42 https://doi.org/10.1016/j.canlet.2018.06.028
  102. Branislav Ruttkay-Nedecky, Lukas Nejdl, Jaromir Gumulec, Ondrej Zitka, Michal Masarik, Tomas Eckschlager, Marie Stiborova, Vojtech Adam, Rene Kizek, The Role of Metallothionein in Oxidative Stress, International Journal of Molecular Sciences, 14, 3, (2013), 6044-6066 https://doi.org/10.3390/ijms14036044
  103. Mie Ø. Pedersen, Agnete Larsen, Meredin Stoltenberg, Milena Penkowa, The role of metallothionein in oncogenesis and cancer prognosis, Progress in Histochemistry and Cytochemistry, 44, 1, (2015), 29-64 https://doi.org/10.1016/j.proghi.2008.10.001
  104. L. P. Martin, T. C. Hamilton, R. J. Schilder, Platinum Resistance: The Role of DNA Repair Pathways, Clinical Cancer Research, 14, 5, (2016), 1291-1295 https://doi.org/10.1158/1078-0432.ccr-07-2238
  105. Jurgen A. Marteijn, Hannes Lans, Wim Vermeulen, Jan H. J. Hoeijmakers, Understanding nucleotide excision repair and its roles in cancer and ageing, Nature Reviews Molecular Cell Biology, 15, (2014), 465-481 https://doi.org/10.1038/nrm3822
  106. Takahisa Furuta, Takahiro Ueda, Gregory Aune, Alain Sarasin, Kenneth H. Kraemer, Yves Pommier, Transcription-coupled Nucleotide Excision Repair as a Determinant of Cisplatin Sensitivity of Human Cells, Cancer Research, 62, (2002), 4899-4902
  107. Ken A. Olaussen, Ariane Dunant, Pierre Fouret, Elisabeth Brambilla, Fabrice André, Vincent Haddad, Estelle Taranchon, Martin Filipits, Robert Pirker, Helmut H. Popper, Rolf Stahel, Laure Sabatier, Jean-Pierre Pignon, Thomas Tursz, Thierry Le Chevalier, Jean-Charles Soria, DNA Repair by ERCC1 in Non–Small-Cell Lung Cancer and Cisplatin-Based Adjuvant Chemotherapy, The New England Journal of Medicine, 355, 10, (2006), 983-991 https://doi.org/10.1056/nejmoa060570
  108. Josef Jiricny, Postreplicative mismatch repair, Cold Spring Harbor Perspectives in Biology, 5, (2013), a012633 http://doi.org/10.1101/cshperspect.a012633
  109. Daniel J. Crona, Aimee Faso, Tomohiro F. Nishijima, Kathleen A. McGraw, Matthew D. Galsky, Matthew I. Milowsky, A Systematic Review of Strategies to Prevent Cisplatin‐Induced Nephrotoxicity, Oncologist, 22, 5, (2017), 609-619 https://doi.org/10.1634/theoncologist.2016-0319
  110. Ronald P. Miller, Raghu K. Tadagavadi, Ganesan Ramesh, William Brian Reeves, Mechanisms of Cisplatin Nephrotoxicity, Toxins, 2, 11, (2010), 2490-2518 https://doi.org/10.3390/toxins2112490
  111. N. Pabla, Z. Dong, Cisplatin nephrotoxicity: mechanisms and renoprotective strategies, Kidney International, 73, 9, (2016), 994-1007 https://doi.org/10.1038/sj.ki.5002786
  112. Sara J. Holditch, Carolyn N. Brown, Andrew M. Lombardi, Khoa N. Nguyen, Charles L. Edelstein, Recent Advances in Models, Mechanisms, Biomarkers, and Interventions in Cisplatin-Induced Acute Kidney Injury, International Journal of Molecular Sciences, 20, 12, (2019), 3011 https://doi.org/10.3390/ijms20123011
  113. Neife Aparecida Guinaim dos Santos, Maria Augusta Carvalho Rodrigues, Nadia Maria Martins, Antonio Cardozo dos Santos, Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update, Archives of Toxicology, 86, (2012), 1233-1250 https://doi.org/10.1007/s00204-012-0821-7
  114. Stacy S. Shord, David M. Thompson, Greg A. Krempl, Marie H. Hanigan, Effect of concurrent medications on cisplatin-induced nephrotoxicity in patients with head and neck cancer, Anti-Cancer Drugs, 17, 2, (2006), 207-215
  115. K. Barabas, R. Milner, D. Lurie, C. Adin, Cisplatin: a review of toxicities and therapeutic applications, Veterinary and Comparative Oncology, 6, 1, (2008), 1-18 https://doi.org/10.1111/j.1476-5829.2007.00142.x
  116. A. Andreas Argyriou, Jordi Bruna, Paola Marmiroli, Guido Cavaletti, Chemotherapy-induced peripheral neurotoxicity (CIPN): An update, Critical Reviews in Oncology/Hematology, 82, 1, (2012), 51-77 https://doi.org/10.1016/j.critrevonc.2011.04.012
  117. S. J. L. Flatters, P. M. Dougherty, L. A. Colvin, Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review, British Journal of Anaesthesia, 119, 4, (2017), 737-749 https://doi.org/10.1093/bja/aex229
  118. R. Zajaczkowska, M. Kocot-Kepska, W. Leppert, A. Wrzosek, J. Mika, J. Wordliczek, Mechanisms of Chemotherapy-Induced Peripheral Neuropathy, International Journal of Molecular Sciences, 20, 6, (2019), 1451 https://doi.org/10.3390/ijms20061451
  119. Marta Seretny, Gillian L. Currie, Emily S. Sena, Sabrina Ramnarine, Robin Grant, Malcolm R. MacLeod, Leslie A. Colvin, Marie Fallon, Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis, PAIN®, 155, 12, (2014), 2461-2470 https://doi.org/10.1016/j.pain.2014.09.020
  120. Dawn L. Hershman, Christina Lacchetti, Robert H. Dworkin, Ellen M. Lavoie Smith, Jonathan Bleeker, Guido Cavaletti, Cynthia Chauhan, Patrick Gavin, Antoinette Lavino, Maryam B. Lustberg, Judith Paice, Bryan Schneider, Mary Lou Smith, Tom Smith, Shelby Terstriep, Nina Wagner-Johnston, Kate Bak, Charles L. Loprinzi, Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline, Journal of Clinical Oncology, 32, 18, (2014), 1941-1967 https://doi.org/10.1200/JCO.2013.54.0914
  121. Jochen Schacht, Andra E. Talaska, Leonard P. Rybak, Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its Prevention, The Anatomical Record, 295, 11, (2012), 1837-1850 https://doi.org/10.1002/ar.22578
  122. Takatoshi Karasawa, Peter S. Steyger, An integrated view of cisplatin-induced nephrotoxicity and ototoxicity, Toxicology Letters, 237, 3, (2015), 219-227 https://doi.org/10.1016/j.toxlet.2015.06.012
  123. Colin J. D. Ross, Hagit Katzov-Eckert, Marie-Pierre Dubé, Beth Brooks, S. Rod Rassekh, Amina Barhdadi, Yassamin Feroz-Zada, Henk Visscher, Andrew M. K. Brown, Michael J. Rieder, Paul C. Rogers, Michael S. Phillips, Bruce C. Carleton, Michael R. Hayden, Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy, Nature Genetics, 41, (2009), 1345-1349 https://doi.org/10.1038/ng.478
  124. David R. Freyer, Lu Chen, Mark D. Krailo, Kristin Knight, Doojduen Villaluna, Bonnie Bliss, Brad H. Pollock, Jagadeesh Ramdas, Beverly Lange, David Van Hoff, Michele L. VanSoelen, John Wiernikowski, Edward A. Neuwelt, Lillian Sung, Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial, The Lancet Oncology, 18, (2016), 63-74 https://doi.org/10.1016/S1470-2045(16)30625-8
  125. Nabil Adra, Lawrence H. Einhorn, Testicular Cancer Update, Clinical Advances in Hematology & Oncology, 15, 5, (2017), 386-396
  126. N. Colombo, C. Sessa, A. du Bois, J. Ledermann, W. G. McCluggage, I. McNeish, P. Morice, S. Pignata, I. Ray-Coquard, I. Vergote, T. Baert, I. Belaroussi, A. Dashora, S. Olbrecht, F. Planchamp, D. Querleu, ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease, Annals of Oncology, 30, 5, (2019), 672-705 https://doi.org/10.1093/annonc/mdz062
  127. Stephanie Lheureux, Marsela Braunstein, Amit M. Oza, Epithelial ovarian cancer: evolution of management in the era of precision medicine, CA: A Cancer Journal for Clinicians, 69, 4, (2019), 280-304 https://doi.org/10.3322/caac.21559
  128. Ann-Marie Patch, Elizabeth L. Christie, Dariush Etemadmoghadam, Dale W. Garsed, Joshy George, Sian Fereday, Katia Nones, Prue Cowin, Kathryn Alsop, Peter J. Bailey, Karin S. Kassahn, Felicity Newell, Michael C. J. Quinn, Stephen Kazakoff, Kelly Quek, Charlotte Wilhelm-Benartzi, Ed Curry, Huei San Leong, The Australian Ovarian Cancer Study Group, Anne Hamilton, Linda Mileshkin, George Au-Yeung, Catherine Kennedy, Jillian Hung, Yoke-Eng Chiew, Paul Harnett, Michael Friedlander, Michael Quinn, Jan Pyman, Stephen Cordner, Patricia O’Brien, Jodie Leditschke, Greg Young, Kate Strachan, Paul Waring, Walid Azar, Chris Mitchell, Nadia Traficante, Joy Hendley, Heather Thorne, Mark Shackleton, David K. Miller, Gisela Mir Arnau, Richard W. Tothill, Timothy P. Holloway, Timothy Semple, Ivon Harliwong, Craig Nourse, Ehsan Nourbakhsh, Suzanne Manning, Senel Idrisoglu, Timothy J. C. Bruxner, Angelika N. Christ, Barsha Poudel, Oliver Holmes, Matthew Anderson, Conrad Leonard, Andrew Lonie, Nathan Hall, Scott Wood, Darrin F. Taylor, Qinying Xu, J. Lynn Fink, Nick Waddell, Ronny Drapkin, Euan Stronach, Hani Gabra, Robert Brown, Andrea Jewell, Shivashankar H. Nagaraj, Emma Markham, Peter J. Wilson, Jason Ellul, Orla McNally, Maria A. Doyle, Ravikiran Vedururu, Collin Stewart, Ernst Lengyel, John V. Pearson, Nicola Waddell, Anna deFazio, Sean M. Grimmond, David D. L. Bowtell, Whole-genome characterization of chemoresistant ovarian cancer, Nature, 521, (2015), 489-494 https://doi.org/10.1038/nature14410
  129. Mark A. Socinski, Coleman Obasaju, David Gandara, Fred R. Hirsch, Philip Bonomi, Paul Bunn, Edward S. Kim, Corey J. Langer, Ronald B. Natale, Silvia Novello, Luis Paz-Ares, Maurice Pérol, Martin Reck, Suresh S. Ramalingam, Craig H. Reynolds, David R. Spigel, Thomas E. Stinchcombe, Heather Wakelee, Carlos Mayo, Nick Thatcher, Clinicopathologic features of advanced squamous NSCLC, Journal of Thoracic Oncology, 11, 9, (2016), 1411-1422 https://doi.org/10.1016/j.jtho.2016.05.024
  130. NSCLC Meta-analysis Collaborative Group, Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data, The Lancet, 383, 9917, (2015), 1561-1571 https://doi.org/10.1016/S0140-6736(13)62159-5
  131. Leora Horn, Aaron S. Mansfield, Aleksandra Szczęsna, Libor Havel, Maciej Krzakowski, Maximilian J. Hochmair, Florian Huemer, György Losonczy, Melissa L. Johnson, Makoto Nishio, Martin Reck, Tony Mok, Sivuonthanh Lam, David S. Shames, Juan Liu, Beiying Ding, Ariel Lopez-Chavez, Fairooz Kabbinavar, Wei Lin, Alan Sandler, Stephen V. Liu, First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer, The New England Journal of Medicine, 379, 23, (2018), 2220-2229 http://dx.doi.org/10.1056/NEJMoa1809064
  132. Pierre Blanchard, Bertrand Baujat, Victoria Holostenco, Abderrahmane Bourredjem, Charlotte Baey, Jean Bourhis, Jean-Pierre Pignon, Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site, Radiotherapy and Oncology, 100, 1, (2011), 33-40 https://doi.org/10.1016/j.radonc.2011.05.036
  133. James A. Bonner, Paul M. Harari, Jordi Giralt, Roger B. Cohen, Christopher U. Jones, Ranjan K. Sur, David Raben, Jose Baselga, Sharon A. Spencer, Junming Zhu, Hagop Youssoufian, Eric K. Rowinsky, Kian K. Ang, Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival, Lancet Oncology, 11, 1, (2010), 21-28 https://doi.org/10.1016/S1470-2045(09)70311-0
  134. Jan B. Vermorken, Ricard Mesia, Fernando Rivera, Eva Remenar, Andrzej Kawecki, Sylvie Rottey, Jozsef Erfan, Dmytro Zabolotnyy, Heinz-Roland Kienzer, Didier Cupissol, Frederic Peyrade, Marco Benasso, Ihor Vynnychenko, Dominique De Raucourt, Carsten Bokemeyer, Armin Schueler, Nadia Amellal, Ricardo Hitt, Platinum-Based Chemotherapy plus Cetuximab in Head and Neck Cancer, The New England Journal of Medicine, 359, (2008), 1116-1127 https://doi.org/10.1056/NEJMoa0802656
  135. Shane O’Grady, Stephen P. Finn, Sinead Cuffe, Derek J. Richard, Kenneth J. O’Byrne, Martin P. Barr, The role of DNA repair pathways in cisplatin resistant lung cancer, Cancer Treatment Reviews, 40, 10, (2014), 1161-1170 https://doi.org/10.1016/j.ctrv.2014.10.003
  136. Somaira Nowsheen, Khaled Aziz, Asef Aziz, Min Deng, Bo Qin, Kuntian Luo, Karthik B. Jeganathan, Henan Zhang, Tongzheng Liu, Jia Yu, Yibin Deng, Jian Yuan, Wei Ding, Jan M. van Deursen, Zhenkun Lou, L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage, Nature Cell Biology, 20, 4, (2018), 455-464 https://doi.org/10.1038/s41556-018-0071-x
  137. Yuki Makino, Hayato Hikita, Kenji Fukumoto, Ji Hyun Sung, Yoshihiro Sakano, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Ryotaro Sakamori, Jumpei Kondo, Shogo Kobayashi, Tomohide Tatsumi, Tetsuo Takehara, Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non-cell autonomous liver carcinogenesis, Cancer Research, 82, 16, (2022), 2860–2873 https://doi.org/10.1158/0008-5472.CAN-21-4390
  138. Christopher J. Lord, Alan Ashworth, PARP inhibitors: Synthetic lethality in the clinic, Science, 355, 6330, (2017), 1152-1158 https://doi.org/10.1126/science.aam7344
  139. Swati S. More, Shuanglian Li, Sook Wah Yee, Ligong Chen, Zhidong Xu, David M. Jablons, Kathleen M. Giacomini, Organic Cation Transporters Modulate the Uptake and Cytotoxicity of Picoplatin, a Third-Generation Platinum Analogue, Molecular Cancer Therapeutics, 9, 4, (2010), 1058-1069 https://doi.org/10.1158/1535-7163.MCT-09-1084
  140. Goli Samimi, Roohangiz Safaei, Kuniyuki Katano, Alison K. Holzer, Myriam Rochdi, Mika Tomioka, Murray Goodman, Stephen B. Howell, Increased Expression of the Copper Efflux Transporter ATP7A Mediates Resistance to Cisplatin, Carboplatin, and Oxaliplatin in Ovarian Cancer Cells, Clinical Cancer Research, 10, 14, (2004), 4661-4669 https://doi.org/10.1158/1078-0432.CCR-04-0137
  141. Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad, Stephen J. Lippard, Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles, Proceedings of the National Academy of Sciences of the United States of America, 105, 45, (2018), 17356-17361 https://doi.org/10.1073/pnas.0809154105
  142. Huan Meng, Min Xue, Tian Xia, Yan-Li Zhao, Fuyuhiko Tamanoi, J. Fraser Stoddart, Jeffrey I. Zink, Andre E. Nel, Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves, Journal of the American Chemical Society, 132, 36, (2010), 12690-12697 https://doi.org/10.1021/ja104501a
  143. G. P. Stathopoulos, D. Antoniou, J. Dimitroulis, P. Michalopoulou, A. Bastas, K. Marosis, J. Stathopoulos, A. Provata, P. Yiamboudakis, D. Veldekis, N. Lolis, N. Georgatou, M. Toubis, Ch. Pappas, G. Tsoukalas, Liposomal cisplatin combined with paclitaxel versus cisplatin and paclitaxel in non-small-cell lung cancer: a randomized phase III multicenter trial, Annals of Oncology, 21, 11, (2010), 2227-2232 https://doi.org/10.1093/annonc/mdq234
  144. Nuno Tiago Tavares, Saulė Gumauskaitė, João Lobo, Carmen Jerónimo, Rui Henrique, DNA Methylation Biomarkers for Prediction of Response to Platinum-Based Chemotherapy: Where Do We Stand?, Cancers, 14, 12, (2022), 2918 https://doi.org/10.3390/cancers14122918
  145. Jinjun Shi, Philip W. Kantoff, Richard Wooster, Omid C. Farokhzad, Cancer nanomedicine: progress, challenges and opportunities, Nature Reviews Cancer, 17, (2016), 20-37 https://doi.org/10.1038/nrc.2016.108
  146. Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel, Guido Kroemer, Immunological effects of conventional chemotherapy and targeted cancer therapies, Cancer Cell, 28, 6, (2015), 690-714 https://doi.org/10.1016/j.ccell.2015.10.012
  147. Y. Xie, W. Hou, X. Song, Y. Yu, J. Huang, X. Sun, R. Kang, D. Tang, Ferroptosis: process and function, Cell Death & Differentiation, 23, (2016), 369-379 https://doi.org/10.1038/cdd.2015.158

Last update:

No citation recorded.

Last update: 2026-09-15 04:26:03

No citation recorded.